Published in Cell on August 01, 1982
The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter. Nucleic Acids Res (1983) 4.93
cis and trans activation of globin gene transcription in transient assays. Proc Natl Acad Sci U S A (1983) 4.41
Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc Natl Acad Sci U S A (1986) 3.71
Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector. Mol Cell Biol (1987) 2.77
Effects of the position of the simian virus 40 enhancer on expression of multiple transcription units in a single plasmid. Mol Cell Biol (1986) 2.73
Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells. Mol Cell Biol (1985) 2.54
Inducible transcription of five globin genes in K562 human leukemia cells. Proc Natl Acad Sci U S A (1983) 2.35
Complex regulation of simian virus 40 early-region transcription from different overlapping promoters. Mol Cell Biol (1984) 2.28
Functional analysis of the transcription control region located within the avian retroviral long terminal repeat. Mol Cell Biol (1985) 2.12
An enhancer element lies 3' to the human A gamma globin gene. EMBO J (1987) 2.11
Partial purification of a nuclear protein that binds to the CCAAT box of the mouse alpha 1-globin gene. Mol Cell Biol (1986) 2.04
DNA sequences that mediate attenuation of transcription from the mouse protooncogene myc. Proc Natl Acad Sci U S A (1989) 1.94
Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity. Nucleic Acids Res (1986) 1.94
G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene. Proc Natl Acad Sci U S A (1984) 1.84
Transient expression of a mouse alpha-fetoprotein minigene: deletion analyses of promoter function. Mol Cell Biol (1983) 1.74
Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts. Proc Natl Acad Sci U S A (1983) 1.68
Targeted and highly efficient gene transfer into CD4+ cells by a recombinant human immunodeficiency virus retroviral vector. J Clin Invest (1991) 1.64
Elements in the long terminal repeat of murine retroviruses enhance stable transformation by thymidine kinase gene. Nucleic Acids Res (1983) 1.63
A block in full-length transcript maturation in cells nonpermissive for B19 parvovirus. J Virol (1992) 1.48
Structural and functional dissection of an MHC class I antigen-binding adenovirus glycoprotein. EMBO J (1986) 1.48
Differential activation of the mouse beta-globin promoter by enhancers. Mol Cell Biol (1983) 1.47
Promoter sequences required for function of the human gamma globin gene in erythroid cells. EMBO J (1986) 1.47
A human DNA-binding protein is methylation-specific and sequence-specific. Nucleic Acids Res (1986) 1.45
A functional map of the nopaline synthase promoter. Nucleic Acids Res (1984) 1.42
A negative regulatory sequence near the mouse beta-maj globin gene associated with a region of potential Z-DNA. EMBO J (1984) 1.40
"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA. Proc Natl Acad Sci U S A (1983) 1.25
Synthesis of predominantly unspliced cytoplasmic RNAs by chimeric herpes simplex virus type 1 thymidine kinase-human beta-globin genes. Mol Cell Biol (1985) 1.24
A beta-globin gene, inactive in the K562 leukemic cell, functions normally in a heterologous expression system. Proc Natl Acad Sci U S A (1984) 1.21
Activation of the human beta-globin promoter in K562 cells by DNA sequences 5' to the fetal gamma- or embryonic zeta-globin genes. J Clin Invest (1987) 1.19
Transcriptional promiscuity of the human alpha-globin gene. Mol Cell Biol (1989) 1.12
Sequence requirement for transcription in vivo of the human preproenkephalin A gene. EMBO J (1983) 1.11
Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells. J Virol (1997) 1.10
Beta-thalassemia resulting from a single nucleotide substitution in an acceptor splice site. Nucleic Acids Res (1985) 1.09
Regulation of cellular genes transduced by herpes simplex virus. J Virol (1989) 1.07
Transcriptional activity of the human pseudogene psi alpha globin compared with alpha globin, its functional gene counterpart. Nucleic Acids Res (1983) 1.06
Human globin gene transcription in injected Xenopus oocytes: enhancement by sodium butyrate. EMBO J (1984) 1.04
Selective transcription and DNase I protection of the rat prolactin gene by GH3 pituitary cell-free extracts. Proc Natl Acad Sci U S A (1987) 1.03
Promoter dependence of enhancer activity. Mol Cell Biol (1984) 1.01
DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11. Proc Natl Acad Sci U S A (1984) 1.01
High efficiency of replication and expression of foreign genes in SV40-transformed human fibroblasts. EMBO J (1983) 0.98
Genetic variation in rates of antipyrine metabolite formation: a study in uninduced twins. Proc Natl Acad Sci U S A (1981) 0.98
Beta zero thalassemia caused by a base substitution that creates an alternative splice acceptor site in an intron. EMBO J (1986) 0.97
Globin gene expression in erythroid human fetal liver cells. J Clin Invest (1989) 0.97
DNA sequences regulating human beta globin gene expression. Nucleic Acids Res (1985) 0.95
Gene transfer method for transient gene expression, stable transformation, and cotransformation of suspension cell cultures. Mol Cell Biol (1985) 0.95
Cis and trans activation of adenovirus IVa2 gene transcription. Nucleic Acids Res (1985) 0.94
Identification of DNA sequences required for mouse APRT gene expression. Nucleic Acids Res (1988) 0.93
Hormonally mediated negative regulation of human pro-opiomelanocortin gene expression after transfection into mouse L cells. Mol Cell Biol (1985) 0.92
Expression of transfected vimentin genes in differentiating murine erythroleukemia cells reveals divergent cis-acting regulation of avian and mammalian vimentin sequences. Mol Cell Biol (1987) 0.89
Nuclear protein-binding sites in a transcriptional control region of the rabbit alpha-globin gene. Mol Cell Biol (1993) 0.89
Subcellular localization of RNAs in transfected cells: role of sequences at the 5' terminus. Nucleic Acids Res (1984) 0.85
Activation of the human epsilon- and beta-globin promoters by SV40 T antigen. Biochem J (1989) 0.84
Changes in minor transcripts from the alpha 1 and beta maj globin and glutathione peroxidase genes during erythropoiesis. Nucleic Acids Res (1987) 0.83
Context dependent function of APPb enhancer identified using enhancer trap-containing BACs as transgenes in zebrafish. Nucleic Acids Res (2008) 0.83
Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes. Proc Natl Acad Sci U S A (1983) 0.82
A silencer element from the alpha-globin gene inhibits expression of beta-like genes. Mol Cell Biol (1988) 0.82
CpG islands from the alpha-globin gene cluster increase gene expression in an integration-dependent manner. Mol Cell Biol (1997) 0.82
CACCC and GATA-1 sequences make the constitutively expressed alpha-globin gene erythroid-responsive in mouse erythroleukemia cells. Nucleic Acids Res (1996) 0.79
A comparison of the promoter strengths of two eukaryotic genes in vitro reveals a region of DNA that can influence the rate of transcription in cis over long distances. Nucleic Acids Res (1983) 0.79
Analyses of linked beta-globin genes suggest that nondeletion forms of hereditary persistence of fetal hemoglobin are bona fide switching mutants. Am J Hum Genet (1988) 0.77
Thalassemic hemoglobinopathies. Am J Pathol (1983) 0.76
Erythroid specific activation of the Xenopus laevis adult alpha-globin promoter in transient heterokaryons. Nucleic Acids Res (1988) 0.75
Sequence composition similarities with the 7SL RNA are highly predictive of functional genomic features. Nucleic Acids Res (2010) 0.75
The genetics of hemoglobin A2 regulation in sickle cell anemia. Am J Hematol (2014) 0.75
Effects of atropine on heart-rate in healthy man. Lancet (1967) 5.10
Effect of homeopathic treatment on fibrositis (primary fibromyalgia) BMJ (1989) 5.00
Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. N Engl J Med (1994) 4.86
Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay. Cell (1977) 4.34
An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation. Mol Cell Biol (1988) 4.08
Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells. Genes Dev (1990) 4.07
The effects of a new beta-adrenoceptive receptor blocking drug on heart rate in man. Br J Pharmacol Chemother (1968) 3.95
A family of long reiterated DNA sequences, one copy of which is next to the human beta globin gene. Nucleic Acids Res (1980) 3.91
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev (1995) 3.81
Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc Natl Acad Sci U S A (1983) 3.76
Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Proc Natl Acad Sci U S A (1986) 3.71
Hox genes in hematopoiesis and leukemogenesis. Oncogene (2007) 3.55
Mucosal adherence of human enteropathogenic Escherichia coli. Lancet (1975) 3.54
Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci U S A (1990) 3.43
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev (1998) 3.40
The effect of propranolol on anxiety. Lancet (1966) 3.33
The Radical Cure of Inguinal Hernia in Children. Proc R Soc Med (1912) 3.29
5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia. N Engl J Med (1982) 3.29
The functional human dihydrofolate reductase gene. J Biol Chem (1984) 3.28
Preliminary investigations of a new beta-adrenoceptive receptor blocking drug, LB46, in man. Br J Pharmacol (1969) 3.25
Correction of sickle cell disease in transgenic mouse models by gene therapy. Science (2001) 3.25
Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci U S A (1994) 3.08
A human parvovirus-like virus inhibits haematopoietic colony formation in vitro. Nature (1983) 3.02
RNA processing errors in patients with beta-thalassemia. Proc Natl Acad Sci U S A (1982) 2.99
Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphism. Proc Natl Acad Sci U S A (1984) 2.99
Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med (1994) 2.80
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1996) 2.68
Chromosomal localization of human beta globin gene on human chromosome 11 in somatic cell hybrids. Proc Natl Acad Sci U S A (1978) 2.65
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol Cell Biol (1997) 2.61
Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood (1997) 2.55
Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease. N Engl J Med (1993) 2.50
Sensitive method for the routine determination tricyclic antidepressants in plasma using a specific nitrogen detector. J Chromatogr (1975) 2.48
Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest (1990) 2.37
Inducible transcription of five globin genes in K562 human leukemia cells. Proc Natl Acad Sci U S A (1983) 2.35
Continuous subcutaenous administration of deferoxamine in patients with iron overload. N Engl J Med (1977) 2.31
Studies of the interaction of desmethylimipramine with tyramine in man after a single oral dose, and its correlation with plasma concentration. Br J Clin Pharmacol (1976) 2.29
Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell (1985) 2.28
The socioemotional development of 5-year-old children of postnatally depressed mothers. J Child Psychol Psychiatry (1999) 2.23
Plasma concentrations of fenfluramine and its metabolite, norfenfluramine, after single and repeated oral administration. Br J Pharmacol (1971) 2.23
The severity of asthma in relation to beta agonist prescribing. N Z Med J (1991) 2.20
Beta O-39 thalassemia gene: a premature termination codon causes beta-mRNA deficiency without affecting cytoplasmic beta-mRNA stability. Blood (1984) 2.17
Developmental regulation of human globin genes. Annu Rev Biochem (1985) 2.16
Talking about drugs - the role of the clinical pharmacologist. J R Soc Med (1982) 2.15
Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis. Blood (1999) 2.14
Cardiac and pulmonary effects of acebutolol. Lancet (1975) 2.12
The interactions of local guanethidine and sympathomimetic amines in the human eye. Arch Ophthalmol (1969) 2.09
Effect of adrenergic receptor blockade of the tachycardia of thyrotoxicosis and anxiety state. Lancet (1965) 2.09
Critical flicker frequency and centrally-acting drugs. Br J Ophthalmol (1968) 2.08
A simple method to measure drug effects on human sperm motility. Br J Clin Pharmacol (1981) 2.06
Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. Mol Cell Biol (1993) 2.05
An investigation into the cardiac and pulmonary beta-adrenoceptor blocking activity of ICI 66,082 in man. Br J Clin Pharmacol (1975) 2.05
Cloning and characterization of DNA sequences surrounding the human gamma-, delta-, and beta-globin genes. Proc Natl Acad Sci U S A (1980) 2.04
Adrenergic blockade and the eye signs of thyrotoxicosis. Lancet (1966) 2.02
Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein. Nucleic Acids Res (1990) 2.01
Beta Thalassemia: mutations which affect processing of the beta-Globin mRNA precursor. Cell (1980) 1.98
Relative potencies of sympathetic amines in human smooth muscle. Br J Pharmacol (1969) 1.98
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A (1998) 1.98
Intravenous tyramine pressor response in depression. Lancet (1975) 1.98
Self-renewal of hemopoietic stem cells during mixed colony formation in vitro. Proc Natl Acad Sci U S A (1981) 1.96
Some central and peripheral effects of meclastine, a new antihistaminic drug, in man. J Clin Pharmacol New Drugs (1971) 1.94
Action of fenfluramine on isolated human smooth muscle. Lancet (1969) 1.94
Clonal hematopoiesis demonstrated by X-linked DNA polymorphisms after allogeneic bone marrow transplantation. N Engl J Med (1989) 1.89
The inhibitory action of procaine, (+)-propranolol and (+/-)-propranolol on human sperm motility: antagonism by caffeine. Br J Clin Pharmacol (1981) 1.88
Written information given to patients and families by palliative care units: a national survey. Lancet (2000) 1.88
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J (1995) 1.87
Some clinical pharmacological studies with terfenadine, a new antihistamine drug. Br J Clin Pharmacol (1978) 1.86
The role of HOX homeobox genes in normal and leukemic hematopoiesis. Stem Cells (1996) 1.86
Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia (2003) 1.85
Pure red-cell aplasia of 10 years' duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy. N Engl J Med (1989) 1.85
Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability. Blood (1989) 1.84
Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells. Proc Natl Acad Sci U S A (1989) 1.84
Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector. Proc Natl Acad Sci U S A (1992) 1.82
HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation. Exp Hematol (2001) 1.81
The bioavailability of quinine. J Trop Med Hyg (1976) 1.80
Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. Leukemia (1999) 1.80
Characterization of a virus that causes transient aplastic crisis. J Clin Invest (1984) 1.78
Expression of the human c-fms proto-oncogene product (colony-stimulating factor-1 receptor) on peripheral blood mononuclear cells and choriocarcinoma cell lines. J Clin Invest (1986) 1.77
Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol (1993) 1.76
Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells. Blood (1994) 1.75
Translation of rabbit haemoglobin messenger RNA by thalassaemic and non-thalassaemic ribosomes. Nat New Biol (1971) 1.75
Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA. Blood (2001) 1.74
Isolation and translation of hemoglobin messenger RNA from thalassemia, sickle cell anemia, and normal human reticulocytes. J Clin Invest (1971) 1.74
CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. J Immunol (1991) 1.73
Class experiment in clinical pharmacology with benzilonium bromide, an anticholinergic drug. Eur J Clin Pharmacol (1974) 1.72
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat Immunol (2001) 1.71
Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood (2001) 1.71
International trial of long-term dexfenfluramine in obesity. Lancet (1989) 1.70
A comparison of the effects of chlorphentermine, diethylpropion and phenmetrazine on critical flicker frequency. Br J Pharmacol Chemother (1967) 1.70
Inadequacy of iridium implant as sole radiation treatment for operable breast cancer. Eur J Cancer (1996) 1.70
Intronless human dihydrofolate reductase genes are derived from processed RNA molecules. Proc Natl Acad Sci U S A (1982) 1.69
Prescription of benzodiazepines in a London teaching hospital. J R Soc Med (1990) 1.69
Autonomic actions and interactions of mianserin hydrochloride (Org. GB 94) and amitriptyline in patients with depressive illness. Psychopharmacology (Berl) (1976) 1.68
Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci U S A (2010) 1.67