Published in Proc Natl Acad Sci U S A on September 01, 1986
Structure of human follicle-stimulating hormone in complex with its receptor. Nature (2005) 3.55
Folding of influenza hemagglutinin in the endoplasmic reticulum. J Cell Biol (1991) 3.20
Lateral diffusion in an archipelago. Distance dependence of the diffusion coefficient. Biophys J (1989) 3.12
TOXCAT: a measure of transmembrane helix association in a biological membrane. Proc Natl Acad Sci U S A (1999) 2.76
Lateral diffusion of membrane-spanning and glycosylphosphatidylinositol-linked proteins: toward establishing rules governing the lateral mobility of membrane proteins. J Cell Biol (1991) 2.28
Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies. Biochemistry (2006) 1.96
The extracellular regulation of bone morphogenetic protein signaling. Development (2009) 1.69
A dual binding mode for RhoGTPases in plexin signalling. PLoS Biol (2011) 1.63
Structural analysis of ligand stimulation of the histidine kinase NarX. Structure (2009) 1.59
Imaging fluorescence correlation spectroscopy: nonuniform IgE distributions on planar membranes. Biophys J (1996) 1.57
On the nature of low- and high-affinity EGF receptors on living cells. Proc Natl Acad Sci U S A (2006) 1.56
Extracellular domains drive homo- but not hetero-dimerization of erbB receptors. EMBO J (2000) 1.55
Sensor domains of two-component regulatory systems. Curr Opin Microbiol (2010) 1.55
Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev (2010) 1.54
The secrets of the Bcl-2 family. Cell Death Differ (2012) 1.48
Cooperativity between trans and cis interactions in cadherin-mediated junction formation. Proc Natl Acad Sci U S A (2010) 1.46
Lateral diffusion of membrane proteins in protein-rich membranes. A simple hard particle model for concentration dependence of the two-dimensional diffusion coefficient. Biophys J (1989) 1.35
Crystal structures of C4-dicarboxylate ligand complexes with sensor domains of histidine kinases DcuS and DctB. J Biol Chem (2008) 1.33
Crystal structure of a functional dimer of the PhoQ sensor domain. J Biol Chem (2008) 1.32
Characterization of the chloroplast cytochrome b6f complex as a structural and functional dimer. Biochemistry (1994) 1.32
Structural characterization of the predominant family of histidine kinase sensor domains. J Mol Biol (2010) 1.25
Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis. J Exp Med (2002) 1.23
Organism-scale modeling of early Drosophila patterning via bone morphogenetic proteins. Dev Cell (2010) 1.22
The extracellular domain of fibroblast growth factor receptor 3 inhibits ligand-independent dimerization. Sci Signal (2010) 1.22
Clustering class I MHC modulates sensitivity of T cell recognition. J Immunol (2006) 1.19
GPCR dimers fall apart. Sci Signal (2010) 1.17
Dramatic destabilization of transmembrane helix interactions by features of natural membrane environments. J Am Chem Soc (2011) 1.17
Method to measure strong protein-protein interactions in lipid bilayers using a steric trap. Proc Natl Acad Sci U S A (2010) 1.15
Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacol Rev (2008) 1.14
The lactose transport protein is a cooperative dimer with two sugar translocation pathways. EMBO J (2001) 1.12
Receptor density balances signal stimulation and attenuation in membrane-assembled complexes of bacterial chemotaxis signaling proteins. Proc Natl Acad Sci U S A (2008) 1.10
Crowding effects of membrane proteins. J Phys Chem B (2009) 1.10
Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation. J Biol Chem (2010) 1.10
Kinetic analysis of ligand binding to interleukin-2 receptor complexes created on an optical biosensor surface. Protein Sci (1996) 1.08
Assembly of mutant pilins in Pseudomonas aeruginosa: formation of pili composed of heterologous subunits. J Bacteriol (1989) 1.05
NMR analyses of the Gbetagamma binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 (GIRK1). J Biol Chem (2010) 1.01
Single-spanning transmembrane domains in cell growth and cell-cell interactions: More than meets the eye? Cell Adh Migr (2010) 1.01
Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling. Proc Natl Acad Sci U S A (2011) 1.00
A sequential dimerization mechanism for erythropoietin receptor activation. Proc Natl Acad Sci U S A (1996) 0.99
Steric and not structure-specific factors dictate the endocytic mechanism of glycosylphosphatidylinositol-anchored proteins. J Cell Biol (2009) 0.98
Coupled plasmon-waveguide resonance spectroscopy studies of the cytochrome b6f/plastocyanin system in supported lipid bilayer membranes. Biophys J (1998) 0.97
The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters. J Cell Biol (2009) 0.96
Two-dimensional continuum percolation threshold for diffusing particles of nonzero radius. Biophys J (2010) 0.95
Sequence-specific conformational flexibility of SNARE transmembrane helices probed by hydrogen/deuterium exchange. Biophys J (2008) 0.94
Calculating the free energy of association of transmembrane helices. Biophys J (2006) 0.90
Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Immunity (2016) 0.89
Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN). Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.88
Hydrodynamic properties of human erythrocyte band 3 solubilized in reduced Triton X-100. Biophys J (1999) 0.87
Fully quantified spectral imaging reveals in vivo membrane protein interactions. Integr Biol (Camb) (2016) 0.86
High-resolution three-dimensional imaging of the rich membrane structures of bone marrow-derived mast cells. Ultramicroscopy (2008) 0.86
Interleukin-22 forms dimers that are recognized by two interleukin-22R1 receptor chains. Biophys J (2007) 0.85
Reactions on cell membranes: comparison of continuum theory and Brownian dynamics simulations. J Chem Phys (2005) 0.85
Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalk. Biophys J (2008) 0.85
Quantitative experimental assessment of macromolecular crowding effects at membrane surfaces. Biophys J (2010) 0.84
FGFR3 unliganded dimer stabilization by the juxtamembrane domain. J Mol Biol (2015) 0.84
Structural aspects of the cytochrome b6f complex; structure of the lumen-side domain of cytochrome f. J Bioenerg Biomembr (1994) 0.82
Using antibodies against Dictyostelium membranes to identify an actin-binding membrane protein. J Cell Biol (1987) 0.82
Characterization of membrane protein interactions in plasma membrane derived vesicles with quantitative imaging Förster resonance energy transfer. Acc Chem Res (2015) 0.81
Ligand regulation of a constitutively dimeric EGF receptor. Nat Commun (2015) 0.81
The SAM domain inhibits EphA2 interactions in the plasma membrane. Biochim Biophys Acta (2016) 0.80
A T cell receptor V alpha domain expressed in bacteria: does it dimerize in solution? J Exp Med (1996) 0.80
Unified regression model of binding equilibria in crowded environments. Sci Rep (2011) 0.79
Concentration of transferrin receptor in human placental coated vesicles. J Cell Biol (1989) 0.79
Membrane association of a protein increases the rate, extent, and specificity of chemical cross-linking. Biochemistry (2013) 0.79
Enhancement of biological reactions on cell surfaces via macromolecular crowding. Nat Commun (2014) 0.78
Low-resolution structure and fluorescence anisotropy analysis of protein tyrosine phosphatase eta catalytic domain. Biophys J (2007) 0.78
Early assembly step of a retroviral envelope glycoprotein: analysis using a dominant negative assay. J Cell Biol (1999) 0.77
The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer. Mol Cell (2014) 0.77
A Lattice-Boltzmann scheme for the simulation of diffusion in intracellular crowded systems. BMC Bioinformatics (2015) 0.77
Three-dimensional stochastic off-lattice model of binding chemistry in crowded environments. PLoS One (2012) 0.77
Nanoallergens: A multivalent platform for studying and evaluating potency of allergen epitopes in cellular degranulation. Exp Biol Med (Maywood) (2016) 0.77
Dimeric Structure of the Bacterial Extracellular Foldase PrsA. J Biol Chem (2014) 0.77
Physical and genetic interaction between ammonium transporters and the signaling protein Rho1 in the plant pathogen Ustilago maydis. Eukaryot Cell (2014) 0.76
Dimerization of Tie2 mediated by its membrane-proximal FNIII domains. Proc Natl Acad Sci U S A (2017) 0.76
On the mobility, membrane location and functionality of mechanosensitive channels in Escherichia coli. Sci Rep (2016) 0.75
On the Control of TCR Phosphorylation. Front Immunol (2012) 0.75
The gramicidin dimer shows both EX1 and EX2 mechanisms of H/D exchange. J Am Soc Mass Spectrom (2009) 0.75
Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor. PLoS One (2017) 0.75
G proteins and dual control of adenylate cyclase. Cell (1984) 11.05
The detection and classification of membrane-spanning proteins. Biochim Biophys Acta (1985) 8.75
Structure of oriented lipid bilayers. Nat New Biol (1971) 5.05
The effect of volume occupancy upon the thermodynamic activity of proteins: some biochemical consequences. Mol Cell Biochem (1983) 4.70
Mechanism of lymphocyte-mediated cytotoxicity. Annu Rev Immunol (1985) 4.19
Bilayer structure in membranes. Nat New Biol (1971) 4.12
Immunoglobulin genes. Annu Rev Immunol (1983) 3.72
The receptor with high affinity for immunoglobulin E. Annu Rev Immunol (1986) 3.53
Direct demonstration that receptor crosslinking or aggregation is important in insulin action. Proc Natl Acad Sci U S A (1978) 3.15
The biophysics of ligand-receptor interactions. Q Rev Biophys (1980) 3.04
Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies. J Biol Chem (1983) 2.94
Density of newly synthesized plasma membrane proteins in intracellular membranes II. Biochemical studies. J Cell Biol (1984) 2.81
The membrane attack complex of complement. Annu Rev Immunol (1986) 2.57
Primary structures of beta- and delta-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences. Nature (1983) 2.55
Circular polymerization of the ninth component of complement. Ring closure of the tubular complex confers resistance to detergent dissociation and to proteolytic degradation. J Biol Chem (1982) 1.70
Surface area per lipid molecule in the intact membrane of the human red cell. Nature (1969) 1.65
Role of hydrophobicity in the binding of coenzymes. Appendix. Translational and rotational contribution to the free energy of dissociation. Biochemistry (1978) 1.61
Production of phosphoinositide-derived messengers. Cell (1984) 1.54
The detection and classification of membrane-spanning proteins. Biochim Biophys Acta (1985) 8.75
Macromolecular crowding: biochemical, biophysical, and physiological consequences. Annu Rev Biophys Biomol Struct (1993) 7.79
T-cell antigenic sites tend to be amphipathic structures. Proc Natl Acad Sci U S A (1985) 5.05
An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1988) 4.72
The effect of volume occupancy upon the thermodynamic activity of proteins: some biochemical consequences. Mol Cell Biochem (1983) 4.70
Affinity labeling of a phosphorylcholine binding mouse myeloma protein. Biochemistry (1972) 4.26
Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins. J Mol Biol (1987) 4.07
Characterization of a human macroglobulin. II. Distribution of the disulfide bonds. J Biol Chem (1965) 3.64
The receptor with high affinity for immunoglobulin E. Annu Rev Immunol (1986) 3.53
Determination of atomic desolvation energies from the structures of crystallized proteins. J Mol Biol (1997) 3.49
Structural basis of antibody function. Annu Rev Immunol (1983) 3.41
The interaction of IgE with rat basophilic leukemia cells. II. Quantitative aspects of the binding reaction. J Exp Med (1974) 3.33
Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation. Proc Natl Acad Sci U S A (1977) 3.07
The biophysics of ligand-receptor interactions. Q Rev Biophys (1980) 3.04
Complete structure and expression in transfected cells of high affinity IgE receptor. Nature (1989) 2.97
Genes linked by fusion events are generally of the same functional category: a systematic analysis of 30 microbial genomes. Proc Natl Acad Sci U S A (2001) 2.95
Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Kinetics of labeling and isolation of a labeled peptide. Biochemistry (1970) 2.88
Analysis of non-ideal behavior in concentrated hemoglobin solutions. J Mol Biol (1977) 2.81
Tracer diffusion of globular proteins in concentrated protein solutions. Proc Natl Acad Sci U S A (1988) 2.79
Lateral motion and valence of Fc receptors on rat peritoneal mast cells. Nature (1976) 2.69
The influence of polyvalency on the binding properties of antibodies. Immunochemistry (1972) 2.67
Two complementary methods for predicting peptides binding major histocompatibility complex molecules. J Mol Biol (1997) 2.57
Kinetic analysis of biosensor data: elementary tests for self-consistency. Trends Biochem Sci (1996) 2.55
The interaction of IgE with rat basophilic leukemia cells. I. Evidence for specific binding of IgE. J Exp Med (1974) 2.30
Assessment of compositional relatedness between proteins. Nature (1968) 2.30
Helper T-cell antigenic site identification in the acquired immunodeficiency syndrome virus gp120 envelope protein and induction of immunity in mice to the native protein using a 16-residue synthetic peptide. Proc Natl Acad Sci U S A (1987) 2.25
Characterization of gene expression in resting and activated mast cells. J Exp Med (1998) 2.24
Effect of nonspecific forces and finite receptor number on rate constants of ligand--cell bound-receptor interactions. Proc Natl Acad Sci U S A (1981) 2.21
Characterization of heterologous protein-protein interactions using analytical ultracentrifugation. Methods (1999) 2.16
Free energy landscapes of encounter complexes in protein-protein association. Biophys J (1999) 2.12
Signal transduction by Fc receptors: the Fc epsilon RI case. Immunol Today (1993) 2.04
Kinetics of desolvation-mediated protein-protein binding. Biophys J (2000) 2.03
Protein antigenic structures recognized by T cells: potential applications to vaccine design. Immunol Rev (1987) 1.95
Larger oligomers of IgE are more effective than dimers in stimulating rat basophilic leukemia cells. J Immunol (1980) 1.92
Magnesium-induced linear self-association of the FtsZ bacterial cell division protein monomer. The primary steps for FtsZ assembly. J Biol Chem (2000) 1.92
Direct observation of the self-association of dilute proteins in the presence of inert macromolecules at high concentration via tracer sedimentation equilibrium: theory, experiment, and biological significance. Biochemistry (1999) 1.88
Hard quasispherical model for the viscosity of hemoglobin solutions. Biochem Biophys Res Commun (1977) 1.84
A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E. Biochemistry (1987) 1.81
Distribution and valency of receptor for IgE on rodent mast cells and related tumour cells. Nature (1976) 1.78
Effect of conformational flexibility and solvation on receptor-ligand binding free energies. Biochemistry (1994) 1.78
Structure and function of gamma M macroglobulins. Adv Immunol (1970) 1.73
Nonspecific stabilization of stress-susceptible proteins by stress-resistant proteins: a model for the biological role of heat shock proteins. Proc Natl Acad Sci U S A (1982) 1.73
Characterization of a human macroglobulin. 3. The products of tryptic digestion. J Biol Chem (1966) 1.72
An unusual mechanism for ligand antagonism. Science (1998) 1.69
Predictions of gene family distributions in microbial genomes: evolution by gene duplication and modification. Phys Rev Lett (2000) 1.69
The IgE-mast cell system as a paradigm for the study of antibody mechanisms. Immunol Rev (1978) 1.68
Analysis of mass transport-limited binding kinetics in evanescent wave biosensors. Anal Biochem (1996) 1.64
Medical problems of civil disorders. Organization of a volunteer group of health professionals to provide medical services in a riot. N Engl J Med (1969) 1.63
Temperature dependence of nonideality in concentrated solutions of hemoglobin. Biopolymers (1978) 1.62
Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation. Proc Natl Acad Sci U S A (1994) 1.58
Characterization of a human macroglobulin. V. A Waldenström macroglobulin with antibody activity. Proc Natl Acad Sci U S A (1967) 1.56
Mechanism of binding of multivalent immune complexes to Fc receptors. 1. Equilibrium binding. Biochemistry (1981) 1.56
Effect of antigen binding on the properties of antibody. Adv Immunol (1974) 1.55
Effect of macromolecular crowding upon the structure and function of an enzyme: glyceraldehyde-3-phosphate dehydrogenase. Biochemistry (1981) 1.54
Adsorption of globular proteins on locally planar surfaces: models for the effect of excluded surface area and aggregation of adsorbed protein on adsorption equilibria. Biophys J (1996) 1.53
Further characterization of the beta-component of the receptor for immunoglobulin E. Mol Immunol (1982) 1.51
Surface IgE on human basophils during histamine release. J Exp Med (1973) 1.48
Direct observation of the enhancement of noncooperative protein self-assembly by macromolecular crowding: indefinite linear self-association of bacterial cell division protein FtsZ. Proc Natl Acad Sci U S A (2001) 1.48
Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase. Proc Natl Acad Sci U S A (1994) 1.47
An automated method for determination of the molecular weight of macromolecules via sedimentation equilibrium in a preparative ultracentrifuge. Anal Biochem (1983) 1.45
An automated method for rapid determination of diffusion coefficients via measurements of boundary spreading. Anal Biochem (1988) 1.41
Crosslinking of the receptors for immunoglobulin E depolarizes the plasma membrane of rat basophilic leukemia cells. Proc Natl Acad Sci U S A (1983) 1.41
Triggering of cultured neoplastic mast cells by antibodies to the receptor for IgE. J Immunol (1978) 1.40
The positive inotropic-acting forskolin, a potent adenylate cyclase activator. Arzneimittelforschung (1981) 1.40
Prediction of protein function from sequence properties. Discriminant analysis of a data base. Biochim Biophys Acta (1984) 1.40
The effect of cell size and receptor density on ligand--receptor reaction rate constants. Mol Immunol (1981) 1.39
Strong conformational propensities enhance T cell antigenicity. J Immunol (1987) 1.39
Investigation of the backbone dynamics of the IgG-binding domain of streptococcal protein G by heteronuclear two-dimensional 1H-15N nuclear magnetic resonance spectroscopy. Protein Sci (1994) 1.38
Expression of high-affinity binding of human immunoglobulin E by transfected cells. Science (1989) 1.36
Studies with a monoclonal antibody to the beta subunit of the receptor with high affinity for immunoglobulin E. Mol Immunol (1988) 1.35
Estimating the number of protein folds. J Mol Biol (1998) 1.33
Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. Proc Natl Acad Sci U S A (1988) 1.32
Computer analysis and structure prediction of nucleic acids and proteins. Nucleic Acids Res (1984) 1.30
Cell cycle-associated changes in receptors for IgE during growth and differentiation of a rat basophilic leukemia cell line. J Exp Med (1975) 1.29
A thermodynamic model for gelation of sickle-cell hemoglobin. J Mol Biol (1974) 1.28
On the mechanism of hemolytic plaque inhibition. Immunochemistry (1974) 1.27
Hidden self-association of proteins. J Mol Recognit (1989) 1.26
A Waldenström macroglobulin which binds nitrophenyl ligands. J Biol Chem (1969) 1.26
Noncytotoxic IgE-mediated release of histamine and serotonin from murine mastocytoma cells. J Immunol (1977) 1.22
mRNA is expected to form stable secondary structures. Nature (1974) 1.21
Structural principles that govern the peptide-binding motifs of class I MHC molecules. J Mol Biol (1998) 1.20
Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy water. J Biol Chem (1986) 1.20
The receptor on mast cells and related cells with high affinity for IgE. Contemp Top Mol Immunol (1983) 1.19
The effect of self-association on the interaction of the Escherichia coli regulatory protein TyrR with DNA. J Mol Biol (1996) 1.19
Binding properties of a Waldenström macroglobulin antibody. J Biol Chem (1968) 1.18
Myeloma proteins and antibodies. Am J Med (1969) 1.18
T cell multideterminant regions in the human immunodeficiency virus envelope: toward overcoming the problem of major histocompatibility complex restriction. Int Immunol (1989) 1.17
Initial characterization of the calcium channel activated by the cross-linking of the receptors for immunoglobulin E. J Biol Chem (1984) 1.17
The effect of non-aggregating proteins upon the gelation of sickle cell hemoglobin: model calculations and data analysis. Biochem Biophys Res Commun (1979) 1.17
Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Sequence and position of a labeled tryptic peptide. Biochemistry (1970) 1.17
The chemistry of the immunoglobulins. JAMA (1967) 1.17
Electron microscopic localization of immunoglobulin E on the surface membrane of human basophils. J Exp Med (1971) 1.15
Phospholipids stabilize the interaction between the alpha and beta subunits of the solubilized receptor for immunoglobulin E. Biochemistry (1982) 1.15
Interaction of IgE with rat basophilic leukemia cells. IV. Antibody-induced redistribution of IgE receptors. J Immunol (1974) 1.15
Isolation of IgE from reaginic rat serum. J Immunol (1974) 1.14
Interactions between globular proteins and F-actin in isotonic saline solution. J Biol Chem (1991) 1.14
Prediction of splice junctions in mRNA sequences. Nucleic Acids Res (1985) 1.14
Protein-protein recognition: exploring the energy funnels near the binding sites. Proteins (1999) 1.14
Qualitative characteristics of histamine release from human basophils by covalently cross-linked IgE. J Immunol (1981) 1.13
The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE. J Biol Chem (1997) 1.12