PubRank

H V Westerhoff

Author PubWeight™ 175.95‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat Biotechnol 2001 4.66
2 Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry. Eur J Biochem 2000 3.33
3 Quantification of the contribution of various steps to the control of mitochondrial respiration. J Biol Chem 1982 2.92
4 The danger of metabolic pathways with turbo design. Trends Biochem Sci 1998 2.66
5 Quantification of information transfer via cellular signal transduction pathways. FEBS Lett 1997 2.33
6 Why cytoplasmic signalling proteins should be recruited to cell membranes. Trends Cell Biol 2000 2.03
7 An alternative PII protein in the regulation of glutamine synthetase in Escherichia coli. Mol Microbiol 1996 1.97
8 Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway. FEBS Lett 2001 1.91
9 How enzymes can capture and transmit free energy from an oscillating electric field. Proc Natl Acad Sci U S A 1986 1.78
10 Modern theories of metabolic control and their applications (review). Biosci Rep 1984 1.75
11 GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition. J Mol Biol 1998 1.75
12 A minimal hypothesis for membrane-linked free-energy transduction. The role of independent, small coupling units. Biochim Biophys Acta 1984 1.74
13 Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes. J Biol Chem 1997 1.59
14 The use of lac-type promoters in control analysis. Eur J Biochem 1993 1.56
15 The macroworld versus the microworld of biochemical regulation and control. Trends Biochem Sci 1995 1.54
16 Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry 1993 1.53
17 Acetaldehyde mediates the synchronization of sustained glycolytic oscillations in populations of yeast cells. Eur J Biochem 1996 1.50
18 Structure and partitioning of bacterial DNA: determined by a balance of compaction and expansion forces? FEMS Microbiol Lett 1995 1.48
19 Understanding glucose transport by the bacterial phosphoenolpyruvate:glycose phosphotransferase system on the basis of kinetic measurements in vitro. J Biol Chem 2000 1.46
20 Sustained oscillations in free-energy state and hexose phosphates in yeast. Yeast 1996 1.45
21 FnrP and NNR of Paracoccus denitrificans are both members of the FNR family of transcriptional activators but have distinct roles in respiratory adaptation in response to oxygen limitation. Mol Microbiol 1997 1.44
22 The signal transduction function for oxidative phosphorylation is at least second order in ADP. J Biol Chem 1996 1.43
23 Mutational analysis of the nor gene cluster which encodes nitric-oxide reductase from Paracoccus denitrificans. Eur J Biochem 1996 1.39
24 Nitrite and nitric oxide reduction in Paracoccus denitrificans is under the control of NNR, a regulatory protein that belongs to the FNR family of transcriptional activators. FEBS Lett 1995 1.37
25 Quantifying heterogeneity: flow cytometry of bacterial cultures. Antonie Van Leeuwenhoek 1992 1.37
26 Can free energy be transduced from electric noise? Proc Natl Acad Sci U S A 1987 1.36
27 What controls glycolysis in bloodstream form Trypanosoma brucei? J Biol Chem 1999 1.35
28 The two opposing activities of adenylyl transferase reside in distinct homologous domains, with intramolecular signal transduction. EMBO J 1997 1.35
29 Control theory of regulatory cascades. J Theor Biol 1991 1.34
30 Compartmentation protects trypanosomes from the dangerous design of glycolysis. Proc Natl Acad Sci U S A 2000 1.34
31 The genes of the glutamine synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli. Mol Microbiol 1993 1.32
32 Transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations. Biophys J 2000 1.29
33 How yeast cells synchronize their glycolytic oscillations: a perturbation analytic treatment. Biophys J 2000 1.29
34 Magainin 2 amide and analogues. Antimicrobial activity, membrane depolarization and susceptibility to proteolysis. FEBS Lett 1989 1.28
35 Nitric oxide is a signal for NNR-mediated transcription activation in Paracoccus denitrificans. J Bacteriol 1999 1.26
36 DNA supercoiling depends on the phosphorylation potential in Escherichia coli. Mol Microbiol 1996 1.25
37 How do enzyme activities control metabolite concentrations? An additional theorem in the theory of metabolic control. Eur J Biochem 1984 1.22
38 Autoamplification of a two-component regulatory system results in "learning" behavior. J Bacteriol 2001 1.21
39 An additional PII in Escherichia coli: a new regulatory protein in the glutamine synthetase cascade. FEMS Microbiol Lett 1995 1.20
40 Excess capacity of H(+)-ATPase and inverse respiratory control in Escherichia coli. EMBO J 1993 1.20
41 Around the growth phase transition S. cerevisiae's make-up favours sustained oscillations of intracellular metabolites. FEBS Lett 1993 1.19
42 Intracellular glucose concentration in derepressed yeast cells consuming glucose is high enough to reduce the glucose transport rate by 50%. J Bacteriol 1998 1.18
43 A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle. Am J Physiol Cell Physiol 2000 1.18
44 Control of glycolytic dynamics by hexose transport in Saccharomyces cerevisiae. Biophys J 2001 1.16
45 Bacteriorhodopsin in liposomes. II. Experimental evidence in support of a theoretical model. Biochim Biophys Acta 1979 1.16
46 Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells. Eur J Biochem 1992 1.15
47 Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure? Atherosclerosis 2000 1.12
48 Thermodynamic efficiency of microbial growth is low but optimal for maximal growth rate. Proc Natl Acad Sci U S A 1983 1.12
49 The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate. Eur J Biochem 1994 1.11
50 Thermodynamics of growth. Non-equilibrium thermodynamics of bacterial growth. The phenomenological and the mosaic approach. Biochim Biophys Acta 1982 1.09
51 Yeast cells with a specific cellular make-up and an environment that removes acetaldehyde are prone to sustained glycolytic oscillations. FEBS Lett 1994 1.06
52 Implications of macromolecular crowding for signal transduction and metabolite channeling. Proc Natl Acad Sci U S A 1998 1.06
53 Energy buffering of DNA structure fails when Escherichia coli runs out of substrate. J Bacteriol 1995 1.04
54 Electric potentiation, cooperativity, and synergism of magainin peptides in protein-free liposomes. Biochemistry 1993 1.02
55 The Escherichia coli signal transducers PII (GlnB) and GlnK form heterotrimers in vivo: fine tuning the nitrogen signal cascade. Proc Natl Acad Sci U S A 2000 1.02
56 Control analysis of glycolytic oscillations. Biophys Chem 1996 1.01
57 Control of frequency and amplitudes is shared by all enzymes in three models for yeast glycolytic oscillations. Biochim Biophys Acta 1996 1.00
58 Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei. Proc Natl Acad Sci U S A 1999 1.00
59 Branched-chain alpha-keto acid catabolism via the gene products of the bkd operon in Enterococcus faecalis: a new, secreted metabolite serving as a temporary redox sink. J Bacteriol 2000 1.00
60 Regulation of oxidative phosphorylation: the flexible respiratory network of Paracoccus denitrificans. J Bioenerg Biomembr 1995 1.00
61 Mosaic protonic coupling hypothesis for free energy transduction. FEBS Lett 1984 0.99
62 Metabolic channelling and control of the flux. FEBS Lett 1993 0.98
63 Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein. Mol Microbiol 1999 0.97
64 Metabolic design: how to engineer a living cell to desired metabolite concentrations and fluxes. Biotechnol Bioeng 1998 0.97
65 Metabolic control by pump slippage and proton leakage in 'delocalized' and more localized chemiosmotic energy-coupling schemes. Biochem Soc Trans 1983 0.96
66 Control by enzymes, coenzymes and conserved moieties. A generalisation of the connectivity theorem of metabolic control analysis. Eur J Biochem 1994 0.94
67 Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. Mol Biochem Parasitol 2000 0.94
68 Redox interactions in cytochrome c oxidase: from the "neoclassical" toward "modern" models. Biophys J 1992 0.94
69 Glucose and the ATP paradox in yeast. Biochem J 2000 0.93
70 The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two. Eur J Biochem 1993 0.93
71 A critical appraisal of evidence for localized energy coupling. Kinetic studies on liposomes containing bacteriorhodopsin and ATP synthase. Biochem J 1985 0.92
72 Variation of efficiency with free-energy dissipation in models of biological energy transduction. Biophys Chem 1987 0.92
73 Bacteriorhodopsin in liposomes. I. A description using irreversible thermodynamics. Biochim Biophys Acta 1979 0.92
74 Dynamic regulation of yeast glycolytic oscillations by mitochondrial functions. J Cell Sci 1991 0.92
75 Control of mitochondrial respiration. Biochem Soc Trans 1983 0.91
76 Signal transduction in bacteria: phospho-neural network(s) in Escherichia coli? FEMS Microbiol Rev 1995 0.91
77 Mosaic nonequilibrium thermodynamics describes biological energy transduction. Proc Natl Acad Sci U S A 1981 0.91
78 Channelling can decrease pool size. Eur J Biochem 1992 0.91
79 Experimental determination of control by the H(+)-ATPase in Escherichia coli. J Bioenerg Biomembr 1995 0.91
80 Control analysis of the dependence of Escherichia coli physiology on the H(+)-ATPase. Proc Natl Acad Sci U S A 1993 0.90
81 Quasi-linear relationship between Gibbs free energy of ATP hydrolysis and power output in human forearm muscle. Am J Physiol 1995 0.90
82 The NosX and NirX proteins of Paracoccus denitrificans are functional homologues: their role in maturation of nitrous oxide reductase. J Bacteriol 2000 0.89
83 How to recognize monofunctional units in a metabolic system. J Theor Biol 1996 0.89
84 Defining control coefficients in non-ideal metabolic pathways. Biophys Chem 1995 0.89
85 Regulation of expression of terminal oxidases in Paracoccus denitrificans. Eur J Biochem 2001 0.89
86 THe proton-per-electron stoicheiometry of 'site 1' of oxidative phosphorylation at high protonmotive force is close to 1.5. Biochem J 1982 0.89
87 Relationship between chemiosomotic flows and thermodynamic forces in oxidative phosphorylation. Biochim Biophys Acta 1980 0.89
88 The potential role of adenosine in the pathophysiology of the insulin resistance syndrome. Atherosclerosis 2001 0.88
89 Modular analysis of the control of complex metabolic pathways. Biophys Chem 1993 0.88
90 The hypothesis of localized chemiosmosis is unsatisfactory. Biochem J 1981 0.88
91 Magainin oligomers reversibly dissipate delta microH+ in cytochrome oxidase liposomes. Biochemistry 1994 0.88
92 Two (completely) rate-limiting steps in one metabolic pathway? The resolution of a paradox using bacteriorhodopsin liposomes and the control theory. Biosci Rep 1984 0.88
93 On the origin of the limited control of mitochondrial respiration by the adenine nucleotide translocator. Arch Biochem Biophys 1987 0.88
94 [Kinetic modeling of energy metabolism and generation of active forms of oxygen in hepatocyte mitochondria]. Mol Biol (Mosk) 2001 0.88
95 Linear relations between proton current and pH gradient in bacteriorhodopsin liposomes. Biochemistry 1981 0.87
96 The present state of the chemiosmotic coupling theory. Acta Biochim Biophys Acad Sci Hung 1983 0.87
97 Limits to inducer exclusion: inhibition of the bacterial phosphotransferase system by glycerol kinase. Mol Microbiol 1998 0.87
98 Control analysis of metabolic systems involving quasi-equilibrium reactions. Biochim Biophys Acta 1998 0.87
99 Co-operativity and enzymatic activity in polymer-activated enzymes. A one-dimensional piggy-back binding model and its application to the DNA-dependent ATPase of DNA gyrase. J Mol Biol 1986 0.86
100 Demonstration of coupling between the protonmotive force across bacteriorhodopsin and the flow through its photochemical cycle. FEBS Lett 1978 0.86
101 Control, responses and modularity of cellular regulatory networks: a control analysis perspective. IET Syst Biol 2008 0.86
102 Crystallization and preliminary X-ray analysis of Escherichia coli GlnK. Acta Crystallogr D Biol Crystallogr 1998 0.86
103 Stochastic free energy transduction. Proc Natl Acad Sci U S A 1985 0.86
104 Coupling of vectorial proton flow to a biochemical reaction by local electric interactions. Proc Natl Acad Sci U S A 1988 0.85
105 Synchronized heat flux oscillations in yeast cell populations. J Biol Chem 1996 0.85
106 Magainins affect respiratory control, membrane potential and motility of hamster spermatozoa. FEBS Lett 1991 0.85
107 Sigmoidal relation between mitochondrial respiration and log ([ATP]/[ADP])out under conditions of extramitochondrial ATP utilization. Implications for the control and thermodynamics of oxidative phosphorylation. Biochemistry 1988 0.85
108 Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim Biophys Acta 1997 0.85
109 Macromolecular intelligence in microorganisms. Biol Chem 2001 0.85
110 Composite control of cell function: metabolic pathways behaving as single control units. FEBS Lett 1995 0.85
111 Regulation and control of compartmentalized glycolysis in bloodstream form Trypanosoma brucei. J Bioenerg Biomembr 1995 0.85
112 A method for studying plasma membrane transport with intact cells using computerized fluorometry. Anal Biochem 1998 0.84
113 Building the cellular puzzle: control in multi-level reaction networks. J Theor Biol 2001 0.84
114 Time-dependent hierarchical regulation analysis: deciphering cellular adaptation. Syst Biol (Stevenage) 2006 0.84
115 Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat heart mitochondria. Arch Biochem Biophys 1995 0.83
116 Control of glycolytic flux in Zymomonas mobilis by glucose 6-phosphate dehydrogenase activity. Biotechnol Bioeng 1996 0.83
117 Changes in the cellular energy state affect the activity of the bacterial phosphotransferase system. Eur J Biochem 1996 0.83
118 The regulatory strength: how to be precise about regulation and homeostasis. Acta Biotheor 1993 0.83
119 Determining and understanding the control of flux. An illustration in submitochondrial particles of how to validate schemes of metabolic control. Eur J Biochem 1999 0.82
120 Energization-induced redistribution of charge carriers near membranes. Biophys Chem 1988 0.82
121 Cytochromes c(550), c(552), and c(1) in the electron transport network of Paracoccus denitrificans: redundant or subtly different in function? J Bacteriol 2001 0.82
122 Cellular information transfer regarded from a stoichiometry and control analysis perspective. Biosystems 2000 0.81
123 Engineering a living cell to desired metabolite concentrations and fluxes: pathways with multifunctional enzymes. Metab Eng 2000 0.81
124 A structural basis for mosaic protonic energy coupling. Biochem Soc Trans 1984 0.81
125 'Channelled' pathways can be more sensitive to specific regulatory signals. FEBS Lett 1993 0.81
126 Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel. Biochim Biophys Acta 1996 0.81
127 Molecular biology for flux control. Biochem Soc Trans 1995 0.81
128 Live control of the living cell. Biochem Soc Trans 1999 0.81
129 'Slave' metabolites and enzymes. A rapid way of delineating metabolic control. Eur J Biochem 2000 0.80
130 The reduction state of the Q-pool regulates the electron flux through the branched respiratory network of Paracoccus denitrificans. Eur J Biochem 1999 0.80
131 Linear nonequilibrium thermodynamics describes the dynamics of an autocatalytic system. Biophys J 1991 0.80
132 A plasma membrane 'vacuum cleaner' for daunorubicin in non-P-glycoprotein multidrug-resistant SW-1573 human non-small cell lung carcinoma cells. A study using fluorescence resonance energy transfer. Eur J Biochem 1993 0.80
133 In vitro transepithelial drug transport by on-line measurement: cellular control of paracellular and transcellular transport. J Pharm Sci 1999 0.80
134 Summation theorems for flux and concentration control coefficients of dynamic systems. Syst Biol (Stevenage) 2006 0.80
135 Internal regulation of a modular system: the different faces of internal control. Biosystems 1997 0.80
136 Approaches to biosimulation of cellular processes. J Biol Phys 2006 0.79
137 Regulation of the expression of the Pseudomonas stutzeri recA gene. Antonie Van Leeuwenhoek 1993 0.79
138 BDI-modelling of complex intracellular dynamics. J Theor Biol 2007 0.79
139 The residual protonmotive force in mitochondria after an oxygen pulse. Eur J Biochem 1981 0.79
140 Control theory of one enzyme. Biochim Biophys Acta 1994 0.79
141 Extensive regulation compromises the extent to which DNA gyrase controls DNA supercoiling and growth rate of Escherichia coli. Eur J Biochem 1999 0.79
142 Control theory of metabolic channelling. Mol Cell Biochem 1995 0.79
143 Reversed electron transfer through the bc1 complex enables a cytochrome c oxidase mutant (delta aa3/cbb3) of Paracoccus denitrificans to grow on methylamine. FEBS Lett 1995 0.78
144 Simulation of the distribution of parental strains' genomes in RC strains of mice. Mamm Genome 1997 0.78
145 Effect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated. Biochem J 1996 0.78
146 Histones in Xenopus laevis' early development: the race against time. Biomed Biochim Acta 1990 0.78
147 Strong control on the transit time in metabolic channelling. FEBS Lett 1996 0.78
148 Pumping capacity of bacterial reaction centers and backpressure regulation of energy transduction. Eur J Biochem 2001 0.78
149 Cooperative P-glycoprotein mediated daunorubicin transport into DNA-loaded plasma membrane vesicles. FEBS Lett 1994 0.78
150 Dramatic changes in control properties that accompany channelling and metabolite sequestration. FEBS Lett 1993 0.78
151 Molecular control analysis: control within proteins and molecular processes. J Theor Biol 1996 0.78
152 Time-dependent regulation of yeast glycolysis upon nitrogen starvation depends on cell history. IET Syst Biol 2010 0.77
153 Thermodynamics and control of proton motive free-energy transduction. Biomed Biochim Acta 1985 0.77
154 The possible control of chaos in chronic inflammation. Clin Rheumatol 1996 0.77
155 Saturable P-glycoprotein kinetics assayed by fluorescence studies of drug efflux from suspended human KB8-5 cells. Biochim Biophys Acta 1996 0.77
156 Control theory of metabolic channelling. Mol Cell Biochem 1995 0.77
157 A series of cases in which metabolic channelling can decrease the pool size at constant net flux in a simple dynamic channel. Biochem Soc Trans 1995 0.77
158 An alternative model for haem ligation in nitrate reductase and analogous respiratory cytochrome b complexes. Mol Microbiol 1996 0.76
159 Kinetics of histone gene expression during early development of Xenopus laevis. J Theor Biol 1988 0.76
160 The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells. Eur J Biochem 2000 0.76
161 Subtleties in control by metabolic channelling and enzyme organization. Mol Cell Biochem 1998 0.76
162 Energy coupling and Hill cycles in enzymatic processes. Cell Biophys 1988 0.76
163 Metabolic control and compartmentation in single living cells. Cell Biochem Funct 1983 0.76
164 A model system for delocalized chemiosmotic coupling exhibited the features thought diagnostic of localized coupling. Biochem J 1986 0.75
165 Is there an optimal ribosome concentration for maximal protein production? Syst Biol (Stevenage) 2006 0.75
166 Reversal of multidrug resistance by valinomycin is overcome by CCCP. Biochem Biophys Res Commun 1996 0.75
167 How to determine control of growth rate in a chemostat. Using metabolic control analysis to resolve the paradox. Biochem Mol Biol Int 1994 0.75
168 Control in channelled pathways. A matrix method calculating the enzyme control coefficients. Biophys Chem 1995 0.75
169 Steady-state cyclic electron transfer through solubilized Rhodobacter sphaeroides reaction centres. Biophys Chem 2000 0.75
170 Evaluating limited specificity of drug pumps reduced relative resistance in human MDR phenotypes. Eur J Biochem 2000 0.75
171 Modular control analysis of slipping enzymes. Biosystems 1999 0.75
172 Do kinetics of ADP stimulation of mitochondria really change during myocardial maturation? Am J Physiol 1998 0.75
173 Coenzyme cycles and metabolic control analysis: the determination of the elasticity coefficients from the generalised connectivity theorem. Biochem Mol Biol Int 1995 0.75
174 Rate limitation within a single enzyme is directly related to enzyme intermediate levels. FEBS Lett 1994 0.75
175 A model for fluid secretion in the exocrine pancreas. Biochim Biophys Acta 1989 0.75
176 Multichannel analysis of intracellular control and intercellular transfer of molecules. Int J Biomed Comput 1980 0.75
177 How to distinguish between the vacuum cleaner and flippase mechanisms of the lmrA multi-drug transporter in Lactococcus lactis. Mol Biol Rep 2002 0.75
178 METASIM: object-oriented modelling of cell regulation. Comput Appl Biosci 1992 0.75
179 Proton gradients across energy-transducing membranes. Biochem Soc Trans 1977 0.75
180 New metabolic parameters for the characterization of cells. Blood Cells 1980 0.75