Published in J Clin Endocrinol Metab on December 01, 1983
Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab (2008) 4.61
1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci U S A (1996) 2.95
The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev (2012) 2.71
Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J Clin Invest (1984) 2.43
1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest (1984) 2.39
1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol (2009) 2.22
Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA. J Clin Invest (1987) 2.12
Retracted Measles-mumps-rubella vaccination timing and autism among young African American boys: a reanalysis of CDC data. Transl Neurodegener (2014) 2.05
Vitamin D, disease and therapeutic opportunities. Nat Rev Drug Discov (2010) 2.02
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Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol Cell Biol (1995) 1.90
1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proc Natl Acad Sci U S A (1987) 1.89
1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol (2011) 1.67
1 alpha,25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine, mononuclear cell factor. J Clin Invest (1984) 1.52
Circulating 25-hydroxyvitamin D and risk of non-hodgkin lymphoma: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol (2010) 1.52
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr (2007) 1.47
Vitamin D in atopic dermatitis, asthma and allergic diseases. Immunol Allergy Clin North Am (2010) 1.43
Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol (2014) 1.40
The vitamin D-antimicrobial peptide pathway and its role in protection against infection. Future Microbiol (2009) 1.40
IL6 genotypes and colon and rectal cancer. Cancer Causes Control (2007) 1.36
Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol. J Immunol (2009) 1.26
A prospective investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers. Int J Cancer (2009) 1.26
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev (2016) 1.25
Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates. BMC Genomics (2009) 1.22
The paradoxical effects of vitamin D on type 1 mediated immunity. Mol Aspects Med (2008) 1.20
Effects of adjunct low-dose vitamin d on relapsing-remitting multiple sclerosis progression: preliminary findings of a randomized placebo-controlled trial. Mult Scler Int (2012) 1.16
Vitamin D and cancer. Front Endocrinol (Lausanne) (2012) 1.15
Vitamin D regulation of immune function in the gut: why do T cells have vitamin D receptors? Mol Aspects Med (2011) 1.14
Vitamin D effects on lung immunity and respiratory diseases. Vitam Horm (2011) 1.12
Vitamin D metabolism and innate immunity. Mol Cell Endocrinol (2011) 1.11
Vitamin D, multiple sclerosis and inflammatory bowel disease. Arch Biochem Biophys (2011) 1.09
Vitamin D and its metabolites inhibit cell proliferation in human rectal mucosa and a colon cancer cell line. Gut (1992) 1.08
Synthesis of the active metabolite of vitamin D, 1,25(OH)2D3, by synovial fluid macrophages in arthritic diseases. Ann Rheum Dis (1989) 1.08
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Granulocyte-macrophage colony-stimulating factor. Sensitive and receptor-mediated regulation by 1,25-dihydroxyvitamin D3 in normal human peripheral blood lymphocytes. J Clin Invest (1987) 1.07
Minireview: Vitamin D: is there a role in extraskeletal health? Endocrinology (2011) 1.05
Phagocytic cells metabolize 25-hydroxyvitamin D3 in vitro. Proc Natl Acad Sci U S A (1984) 1.03
The vitamin d receptor and T cell function. Front Immunol (2013) 1.03
Breast cancer and the immune system. J Soc Integr Oncol (2008) 1.03
Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis. J Clin Invest (1989) 1.01
Vitamin D and multiple sclerosis. J Cell Biochem (2008) 0.99
A vitamin D analogue (MC 1288) has immunomodulatory properties and suppresses collagen-induced arthritis (CIA) without causing hypercalcaemia. Clin Exp Immunol (1998) 0.98
The effect of aging, nutrition, and exercise during HIV infection. HIV AIDS (Auckl) (2010) 0.97
1,25-Dihydroxyvitamin D3, but not retinoic acid, induces the differentiation of U937 cells. Clin Exp Immunol (1989) 0.96
1,25-Dihydroxyvitamin D3 maintains adherence of human monocytes and protects them from thermal injury. J Clin Invest (1986) 0.95
Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease. Front Immunol (2015) 0.91
Enhancement of human immunodeficiency virus 1 replication in monocytes by 1,25-dihydroxycholecalciferol. Proc Natl Acad Sci U S A (1991) 0.90
Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer. Therap Adv Gastroenterol (2011) 0.90
Cultured psoriatic fibroblasts from involved and uninvolved sites have a partial but not absolute resistance to the proliferation-inhibition activity of 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A (1985) 0.90
Why do T cells express the vitamin D receptor? Ann N Y Acad Sci (2010) 0.90
1, 25(OH)₂D₃ inhibits hepatocellular carcinoma development through reducing secretion of inflammatory cytokines from immunocytes. Curr Med Chem (2013) 0.90
Vitamin D and C-Reactive Protein: A Mendelian Randomization Study. PLoS One (2015) 0.90
Vitamin D supplementation for northern native communities. Indian and Inuit Health Committee, Canadian Paediatric Society. CMAJ (1988) 0.89
Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis. Ther Adv Neurol Disord (2013) 0.89
Impact of vitamin D on infectious disease. Am J Med Sci (2015) 0.89
1,25-Dihydroxyvitamin D3 increases the toxicity of hydrogen peroxide in the human monocytic line U937: the role of calcium and heat shock. J Cell Biol (1988) 0.89
Hormones and the immune response. Ann Rheum Dis (1989) 0.88
Vitamin D3 receptor is highly expressed in Hodgkin's lymphoma. BMC Cancer (2012) 0.88
Murine CD8+ T cells but not macrophages express the vitamin D 1α-hydroxylase. J Nutr Biochem (2013) 0.88
Lack of association of VDR gene polymorphisms with thyroid autoimmune disorders: familial and case/control studies. J Clin Immunol (2007) 0.88
Calcium and vitamin D in sarcoidosis: how to assess and manage. Semin Respir Crit Care Med (2010) 0.87
1α,25-dihydroxyvitamin D3 (vitamin D3) catalyzes suppressive activity on human natural regulatory T cells, uniquely modulates cell cycle progression, and augments FOXP3. Clin Immunol (2010) 0.86
A systematic review of the role of vitamin insufficiencies and supplementation in COPD. Respir Res (2010) 0.86
Single and combined effects of the vitamin D analogue KH1060 and cyclosporin A on mercuric-chloride-induced autoimmune disease in the BN rat. Clin Exp Immunol (1992) 0.86
Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS One (2014) 0.86
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Invariant NKT cell defects in vitamin D receptor knockout mice prevents experimental lung inflammation. J Immunol (2011) 0.85
Regulation of Dendritic Cell Function by Vitamin D. Nutrients (2015) 0.84
Demonstration of a 1,25-dihydroxyvitamin D3-responsive protein in human lymphocytes: immunologic crossreactivity and inverse regulation with the vitamin D receptor. Proc Natl Acad Sci U S A (1991) 0.84
1 alpha,25-dihydroxyvitamin D3 inhibits pokeweed mitogen-stimulated human B-cell activation: an analysis using serum-free culture conditions. Immunology (1985) 0.84
The role of vitamin D in pregnancy and lactation: emerging concepts. Womens Health (Lond Engl) (2012) 0.84
Prediction of in vitro metabolic stability of calcitriol analogs by QSAR. J Comput Aided Mol Des (2003) 0.83
Calcitriol modulates the CD46 pathway in T cells. PLoS One (2012) 0.83
Cross-sectional study of vitamin D levels, immunologic and virologic outcomes in HIV-infected adults. J Clin Endocrinol Metab (2013) 0.83
Metabolites: deciphering the molecular language between DCs and their environment. Semin Immunopathol (2016) 0.83
Defective binding and function of 1,25-dihydroxyvitamin D3 receptors in peripheral mononuclear cells of patients with end-organ resistance to 1,25-dihydroxyvitamin D. J Clin Invest (1985) 0.83
1,25(OH)2D3 regulates c-myc mRNA levels in tonsillar T lymphocytes. Immunology (1991) 0.82
Regulation of interleukin-1 and tumour necrosis factor gene expression in myelomonocytic cell lines by 1,25-dihydroxyvitamin D3. Immunology (1991) 0.82
Genes mediating environment interactions in type 1 diabetes. Rev Diabet Stud (2006) 0.82
Differential metabolism of 25-hydroxyvitamin D3 by cultured synovial fluid macrophages and fibroblast-like cells from patients with arthritis. Ann Rheum Dis (1992) 0.81
1,25-Dihydroxyvitamin D3-mediated inhibition of human B cell differentiation. Clin Exp Immunol (1987) 0.81
The relationship between 25-hydroxyvitamin D and homocysteine in asymptomatic adults. J Clin Endocrinol Metab (2013) 0.81
Changing incidence of inflammatory bowel disease: environmental influences and lessons learnt from the South asian population. Front Pediatr (2013) 0.81
Meta-analysis: the efficacy and safety of paricalcitol for the treatment of secondary hyperparathyroidism and proteinuria in chronic kidney disease. Biomed Res Int (2012) 0.81
Single-nucleotide polymorphism at CYP27B1-1260, but not VDR Taq I, is possibly associated with persistent hepatitis B virus infection. Genet Test Mol Biomarkers (2012) 0.79
Effect of anti-TNF therapy and vitamin D derivatives on the proliferation of peripheral blood mononuclear cells in Crohn's disease. Dig Dis Sci (2004) 0.79
Vitamin D and extra-skeletal health: causality or consequence. Int J Health Sci (Qassim) (2016) 0.79
1,25-Dihydroxyvitamin D3 induces collagen binding to the human monocyte line U937. J Clin Invest (1987) 0.79
Inhibition by prostaglandin E1 and E2 of 1,25-dihydroxyvitamin D3 synthesis by synovial fluid macrophages from arthritic joints. Ann Rheum Dis (1992) 0.79
Genetics of bone loss in rheumatoid arthritis--role of vitamin D receptor polymorphisms. Rheumatology (Oxford) (2009) 0.79
Comparison of cellular and transcriptional responses to 1,25-dihydroxyvitamin d3 and glucocorticoids in peripheral blood mononuclear cells. PLoS One (2013) 0.79
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells. Genes Immun (2016) 0.78
Effects of vitamin D on retinal nerve fiber layer in vitamin D deficient patients with optic neuritis: Preliminary findings of a randomized, placebo-controlled trial. J Res Med Sci (2015) 0.78
Tertiary excess of fibroblast growth factor 23 and hypophosphatemia following kidney transplantation. Pediatr Transplant (2010) 0.78
Immune Modulation by Vitamin D and Its Relevance to Food Allergy. Nutrients (2015) 0.78
Vitamin D and atopic dermatitis in childhood. J Immunol Res (2015) 0.78
Treatment of an intramammary bacterial infection with 25-hydroxyvitamin D(3). PLoS One (2011) 0.77
Inhibition of human natural killer activity by antiserum against vitamin D-binding protein, a group-specific component (Gc). Clin Exp Immunol (1989) 0.77
The comparative role of 1,25-dihydroxycholecalciferol and phorbol esters in the differentiation of the U937 cell line. Immunology (1992) 0.76
Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr (2000) 11.69
Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab (1988) 7.09
Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet (1982) 6.40
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Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest (1985) 3.59
Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells. J Clin Invest (1979) 3.34
A heritable disorder of connective tissue. Hydroxylysine-deficient collagen disease. N Engl J Med (1972) 3.32
An international comparison of serum 25-hydroxyvitamin D measurements. Osteoporos Int (1999) 3.07
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1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture. Science (1972) 2.50
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An endopeptidase from rheumatoid synovial tissue culture. Biochim Biophys Acta (1972) 2.25
A possible genetic defect in 25-hydroxylation as a cause of rickets. J Pediatr (1994) 2.22
Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. Science (1981) 2.20
Human collagenase: identification and characterization of an enzyme from rheumatoid synovium in culture. Science (1967) 2.15
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A new chromatographic system for vitamin D3 and its metabolites: resoluation of a new vitamin D3 metabolite. J Lipid Res (1971) 2.12
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Collagenases (first of three parts). N Engl J Med (1974) 2.06
Bone loss as well as bone formation is a feature of progressive ankylosing spondylitis. Br J Rheumatol (1990) 2.03
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Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation. Endocrinology (2000) 1.93
Hypervitaminosis D associated with drinking milk. N Engl J Med (1992) 1.90
Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. J Clin Invest (1988) 1.89
Age, vitamin D, and solar ultraviolet. Lancet (1989) 1.82
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Mortality associated with vertebral deformity in men and women: results from the European Prospective Osteoporosis Study (EPOS). Osteoporos Int (1998) 1.76
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Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Cancer Epidemiol Biomarkers Prev (1998) 1.69
Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. J Clin Invest (1999) 1.67
21,25-dihydroxycholecalciferol. A metabolite of vitamin D3 preferentially active on bone. Biochemistry (1970) 1.65
An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston. Am J Clin Nutr (1990) 1.65
Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice. J Clin Invest (1993) 1.64
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Modulation of surface antigens of a human monocyte cell line, U937, during incubation with T lymphocyte-conditioned medium: detection of T4 antigen and its presence on normal blood monocytes. J Immunol (1983) 1.57
Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts. J Biol Chem (1990) 1.54
Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production. Cell Immunol (1986) 1.53
1 alpha,25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine, mononuclear cell factor. J Clin Invest (1984) 1.52
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Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med (2001) 1.51
Pathogenesis of hereditary vitamin-D-dependent rickets. An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to 1 alpha,25-dihydroxyvitamin D. N Engl J Med (1973) 1.50
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One systemic administration of transforming growth factor-beta 1 reverses age- or glucocorticoid-impaired wound healing. J Clin Invest (1993) 1.42
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Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with Iliac bone formation rates and comparison with total alkaline phosphatase. J Bone Miner Res (1987) 1.42
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Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J Clin Invest (1996) 1.41
Synovial collagenase: its presence in culture from joint disease of diverse etiology. Arthritis Rheum (1969) 1.40
1,25-dihydroxycholecalciferol stimulates osteoclasts in rat bones in the absence of parathyroid hormone. Endocrinology (1981) 1.40
25,26-dihydroxycholecalciferol, a metabolite of vitamin D3 with intestinal calcium transport activity. Biochemistry (1970) 1.40
Osteoporosis in early ankylosing spondylitis: a primary pathological event? Lancet (1990) 1.39
Induction of dermal and subcutaneous inflammation by recombinant cachectin/tumor necrosis factor (TNF alpha) in the mouse. J Invest Dermatol (1988) 1.39
Nephrolithiasis and bone involvement in primary hyperparathyroidism. Am J Med (1990) 1.39
High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors. Osteoporos Int (2006) 1.39
Heterotopic ossification in the setting of neuromuscular blockade. Arthritis Rheum (1997) 1.37