Published in Nature on June 17, 1983
Characterization of human prorenin expressed in mammalian cells from cloned cDNA. Proc Natl Acad Sci U S A (1986) 3.60
Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors. Proc Natl Acad Sci U S A (1989) 1.47
X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin. Biochem J (1993) 0.99
The selectivity of statine-based inhibitors against various human aspartic proteinases. Biochem J (1990) 0.97
Synthesis of peptides related to the prosegment of mouse submaxillary gland renin precursor: an approach to renin inhibitors. Proc Natl Acad Sci U S A (1984) 0.85
Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules. Proc Natl Acad Sci U S A (1984) 6.45
Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide. J Virol (1985) 5.73
A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature (1989) 5.53
Fulminant neurogenic pulmonary oedema with hand, foot, and mouth disease. Lancet (1998) 3.78
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. J Med Chem (1988) 3.04
A new class of angiotensin-converting enzyme inhibitors. Nature (1980) 3.03
Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease. Lancet (1999) 3.02
Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes Dev (1991) 2.98
Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate. Science (1977) 2.88
Results in 107 hepatic lobectomies with a preliminary report on the use of a clamp to reduce blood loss. Ann Surg (1973) 2.77
Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998. Pediatr Infect Dis J (1999) 2.75
Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay. Biochemistry (1991) 2.59
Enalapril maleate and a lysine analogue (MK-521): disposition in man. Br J Clin Pharmacol (1982) 2.49
L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother (1995) 2.39
Ileal perforation caused by congenital or perinatal cytomegalovirus infection. J Pediatr (1996) 2.19
HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins. Biochem Biophys Res Commun (1988) 2.14
Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. J Biol Chem (1992) 2.13
Psychiatry and Chinese culture. West J Med (1983) 2.00
Surgical treatment of 109 patients with symptomatic and asymptomatic hepatocellular carcinoma. Surgery (1986) 1.98
Genetic analysis of enterovirus 71 isolated from fatal and non-fatal cases of hand, foot and mouth disease during an epidemic in Taiwan, 1998. Virus Res (2000) 1.95
Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between plasma drug levels and the renin angiotensin system. Br J Clin Pharmacol (1982) 1.95
Developmental regulation of transcription by a tissue-specific TAF homolog. Genes Dev (2001) 1.92
Measurement of the rate of nu(e) + d --> p + p + e(-) interactions produced by (8)B solar neutrinos at the Sudbury Neutrino Observatory. Phys Rev Lett (2001) 1.88
Virus infection in patients with histiocytic necrotizing lymphadenitis in Taiwan. Detection of Epstein-Barr virus, type I human T-cell lymphotropic virus, and parvovirus B19. Am J Clin Pathol (2000) 1.85
The physiological disposition and metabolism of enalapril maleate in laboratory animals. Drug Metab Dispos (1982) 1.79
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry (1991) 1.77
Treatment of non-parasitic cystic disease of the liver: a new approach to therapy with polycystic liver. Ann Surg (1968) 1.77
Metabolic function and regeneration of cirrhotic and non-cirrhotic livers after hepatic lobectomy in man. Ann Surg (1965) 1.77
Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate. J Bone Miner Res (2001) 1.76
Comparative evaluation of the BACTEC MGIT 960 system with solid medium for isolation of mycobacteria. Int J Tuberc Lung Dis (2003) 1.75
Conformationally restricted bicyclic analogs of somatostatin. Proc Natl Acad Sci U S A (1978) 1.69
A clinical trial comparing oral azithromycin, cefixime and no antibiotics in the treatment of acute uncomplicated Salmonella enteritis in children. J Paediatr Child Health (1999) 1.66
Alpha-isopropylmalate synthase from yeast: purification, kinetic studies, and effect of ligands on stability. J Bacteriol (1972) 1.66
Chloroplast coupling factor 1: A species-specific receptor for tentoxin. Proc Natl Acad Sci U S A (1976) 1.65
Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo. J Bone Miner Res (1997) 1.63
Proton magnetic resonance study of ferredoxin from Clostridium pasteurianum. Proc Natl Acad Sci U S A (1970) 1.58
Effective thrombolysis without marked plasminemia after bolus intravenous administration of vampire bat salivary plasminogen activator in rabbits. Circulation (1991) 1.57
Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin. Proc Natl Acad Sci U S A (1986) 1.53
A simplified technique for hepatic resection: the crush method. Ann Surg (1974) 1.50
Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A? J Exp Med (1991) 1.48
Pathway of algnic acid synthesis in the marine brown alga, Fucus gardneri Silva. J Biol Chem (1966) 1.47
Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution. Proc Natl Acad Sci U S A (1989) 1.46
Purification of cathepsin B by a new form of affinity chromatography. Biochem J (1986) 1.45
Effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro and its ethyl ester (MK-421) on angiotensin converting enzyme in vitro and angiotensin I pressor responses in vivo. J Pharmacol Exp Ther (1981) 1.44
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes. J Med Chem (1984) 1.44
Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin. Lancet (2004) 1.43
A potent cyclic hexapeptide analogue of somatostatin. Nature (1981) 1.42
Carriage of antibiotic-resistant pneumococci among Asian children: a multinational surveillance by the Asian Network for Surveillance of Resistant Pathogens (ANSORP). Clin Infect Dis (2001) 1.42
Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A. Proc Natl Acad Sci U S A (1995) 1.42
Specific membrane receptors for atrial natriuretic factor in renal and vascular tissues. Proc Natl Acad Sci U S A (1984) 1.41
Viral Harvey ras p21 expressed in Escherichia coli purifies as a binary one-to-one complex with GDP. J Biol Chem (1985) 1.38
Regeneration of human liver after hepatic lobectomy studied by repeated liver scanning and repeated needle biopsy. Ann Surg (1979) 1.38
Altered cellular but not humoral reactions in children with complicated enterovirus 71 infections in Taiwan. J Infect Dis (2001) 1.36
Alkylating derivatives of amino acids and peptides. Synthesis of N-maleoylamino acids, [1-(N-maleoylglycyl)cysteinyl]oxytocin. Effects on vasopressin-stimulated water loss from isolated toad bladder. J Med Chem (1975) 1.36
X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor. Proc Natl Acad Sci U S A (1990) 1.34
Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog. Science (1980) 1.32
4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells. J Med Chem (2000) 1.30
Cloning and functional characterization of a constitutively expressed nitrate transporter gene, OsNRT1, from rice. Plant Physiol (2000) 1.30
Effects of some pyrazinecarboxamides on sodium transport in frog skin. Br J Pharmacol (1978) 1.29
Icteric type hepatoma. Med Chir Dig (1975) 1.29
Renin release after hemorrhage and after suprarenal aortic constriction in dogs without sodium delivery to the macula densa. Circ Res (1970) 1.29
Contribution of the surface free energy perturbation to protein-solvent interactions. Biochemistry (1994) 1.29
Intron-exon organization and chromosomal localization of the human TIA-1 gene. J Immunol (1994) 1.28
Primary cancer of the liver. Quadrennial review. Scand J Gastroenterol Suppl (1970) 1.27
Proton magnetic resonance studies of Chromatium high-potential iron protein. Proc Natl Acad Sci U S A (1970) 1.26
Biosynthesis of the polygalacturonic acid chain of pectin by a particulate enzyme preparation from Phaseolus aureus seedlings. Proc Natl Acad Sci U S A (1965) 1.26
The structure and conformation of HC-toxin. Biochem Biophys Res Commun (1983) 1.25
Acute encephalomyelitis during an outbreak of enterovirus type 71 infection in Taiwan: report of an autopsy case with pathologic, immunofluorescence, and molecular studies. Mod Pathol (2000) 1.25
Clinical and radiographic spectrum of septic pulmonary embolism. Arch Dis Child (2002) 1.25
Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis. Biochemistry (1999) 1.24
Duration of enterovirus shedding in stool. J Microbiol Immunol Infect (2001) 1.24
Acetamidomethyl. A novel thiol protecting group for cysteine. J Am Chem Soc (1972) 1.23
THE NUTRITIONAL REQUIREMENTS FOR NITROGEN BALANCE IN SURGICAL PATIENTS DURING THE EARLY POSTOPERATIVE PERIOD. J Clin Invest (1947) 1.22
Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin. Acta Crystallogr D Biol Crystallogr (1995) 1.22
Multiple chemical forms of hepatitis B surface antigen produced in yeast. Proc Natl Acad Sci U S A (1985) 1.22
Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases. Biochemistry (1996) 1.21
Antimicrobial susceptibilities of Campylobacter jejuni and coli by using E-test in Taiwan. Scand J Infect Dis (1998) 1.20
Molecular investigation of two clusters of hospital-acquired bacteraemia caused by multi-resistant Klebsiella pneumoniae using pulsed-field gel electrophoresis and in frequent restriction site PCR. Infection Control Group. J Hosp Infect (2000) 1.20
Intraoperative hepatic ultrasonography--an indispensable procedure in resection of small hepatocellular carcinomas. Surgery (1985) 1.19
Predictors for extraintestinal infection of non-typhoidal Salmonella in patients without AIDS. Int J Clin Pract (2000) 1.18
Age-related differences of nontyphoid Salmonella bacteremia in clinical presentation and outcome: association with specific serovars but not necessarily with the virulence plasmids. Clin Infect Dis (2000) 1.17
Studies on the total synthesis of an enzyme. V. The preparation of enzymatically active material. J Am Chem Soc (1969) 1.17
Highly active cyclic and bicyclic somatostatin analogues of reduced ring size. Nature (1979) 1.16
Outer membrane protein change combined with co-existing TEM-1 and SHV-1 beta-lactamases lead to false identification of ESBL-producing Klebsiella pneumoniae. J Antimicrob Chemother (2001) 1.15
A super active cyclic hexapeptide analog of somatostatin. Life Sci (1984) 1.14
Typhoid fever in children: a fourteen-year experience. Acta Paediatr Taiwan (2000) 1.14
Effect of experimental diabetes on elimination kinetics of diflunisal in rats. Drug Metab Dispos (1989) 1.14
Interaction of human Clq with insoluble immunoglobulin aggregates. Immunochemistry (1978) 1.13
Antibodies of predetermined specificity to the major charged species of human interleukin 1. Proc Natl Acad Sci U S A (1986) 1.13
Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro. Anticancer Drugs (1997) 1.13
Differential effects of renin-angiotensin system blockade on atherogenesis in cholesterol-fed rabbits. J Clin Invest (1993) 1.12
Isolation of guanosine diphosphate uronic acids from a marine brown alga, Fucus gardneri Silva. J Biol Chem (1966) 1.11
Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids. Lipids (2001) 1.11
Design of potent and selective human cathepsin K inhibitors that span the active site. Proc Natl Acad Sci U S A (1997) 1.10
Vitamin K-dependent carboxylase: requirements for carboxylation of soluble peptide and substrate specificity. Biochem Biophys Res Commun (1979) 1.09