Published in J Exp Med on November 01, 1980
Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med (1985) 11.14
Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J Exp Med (1987) 5.64
Characterization of nonlymphoid cells derived from rat peripheral lymph. J Exp Med (1983) 5.63
Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release. J Exp Med (1984) 5.54
Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity. J Exp Med (1982) 5.33
Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon. J Exp Med (1983) 4.92
Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J Exp Med (1983) 4.57
Studies of the cell surface of mouse dendritic cells and other leukocytes. J Exp Med (1981) 4.36
Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man. Proc Natl Acad Sci U S A (1983) 3.25
Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J Exp Med (1983) 3.20
Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone. J Exp Med (1988) 2.98
Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells. J Exp Med (1987) 2.97
Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells. J Exp Med (1987) 2.94
Induction of Ia antigen in rat epidermal cells and gut epithelium by immunological stimuli. J Exp Med (1982) 2.92
Surface properties of bacillus Calmette-Guérin-activated mouse macrophages. Reduced expression of mannose-specific endocytosis, Fc receptors, and antigen F4/80 accompanies induction of Ia. J Exp Med (1981) 2.89
Dendritic cells initiate a two-stage mechanism for T lymphocyte proliferation. J Exp Med (1983) 2.76
Migration patterns of dendritic cells in the mouse. Traffic from the blood, and T cell-dependent and -independent entry to lymphoid tissues. J Exp Med (1988) 2.73
Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis. J Cell Biol (1983) 2.49
Dendritic cells induce T lymphocytes to release B cell-stimulating factors by an interleukin 2-dependent mechanism. J Exp Med (1983) 2.42
Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain. J Exp Med (1990) 2.39
An antigen-independent contact mechanism as an early step in T cell-proliferative responses to dendritic cells. J Exp Med (1989) 2.15
Influence of delayed immune reactions on human epidermal keratinocytes. Proc Natl Acad Sci U S A (1986) 2.11
Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture. Proc Natl Acad Sci U S A (1991) 2.06
Regulation of human peripheral blood monocyte DR antigen expression in vitro by lymphokines and recombinant interferons. J Clin Invest (1984) 2.00
Mast cell clones: a model for the analysis of cellular maturation. J Cell Biol (1982) 1.91
Expression of Ia-like antigens by human vascular endothelial cells is inducible in vitro: demonstration by monoclonal antibody binding and immunoprecipitation. Proc Natl Acad Sci U S A (1982) 1.87
Natural killer cells activated in a human mixed lymphocyte response culture identified by expression of Leu-11 and class II histocompatibility antigens. J Exp Med (1984) 1.80
Characterization of resident glomerular cells in the rat expressing Ia determinants and manifesting genetically restricted interactions with lymphocytes. J Clin Invest (1981) 1.72
Function and regulation of a murine macrophage-specific IgG Fc receptor, Fc gamma R-alpha. J Exp Med (1988) 1.72
Down-regulation of mannosyl receptor-mediated endocytosis and antigen F4/80 in bacillus Calmette-Guérin-activated mouse macrophages. Role of T lymphocytes and lymphokines. J Exp Med (1982) 1.61
Contrasting effect of alpha/beta- and gamma-interferons on expression of macrophage Ia antigens. J Exp Med (1986) 1.55
Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage tumor cell line. J Exp Med (1982) 1.42
Cutaneous leishmaniasis. The defect in T cell influx in BALB/c mice. J Exp Med (1987) 1.34
T-independent and T-dependent steps in the murine B cell response to antiimmunoglobulin. J Exp Med (1987) 1.33
Gamma-interferon induces expression of the HLA-D antigens on normal and leukemic human myeloid cells. Proc Natl Acad Sci U S A (1984) 1.29
Epidermal T lymphocytes and dendritic cells in chronic plaque psoriasis: the effects of PUVA treatment. Clin Exp Immunol (1985) 1.29
Interferon-gamma-like molecule induces Ia antigens on cultured mast cell progenitors. Proc Natl Acad Sci U S A (1982) 1.22
Is heterogeneous expression of HLA-dr antigens and CEA along with DNA-profile variations evidence of phenotypic instability and clonal proliferation in human large bowel carcinomas? Br J Cancer (1983) 1.20
The function of Ia+ dendritic cells and Ia- dendritic cell precursors in thymocyte mitogenesis to lectin and lectin plus interleukin 1. J Exp Med (1988) 1.17
Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3). J Exp Med (1987) 1.16
Localization of major histocompatibility complex class II molecules in phagolysosomes of murine macrophages infected with Leishmania amazonensis. Infect Immun (1991) 1.15
Differential expression of Ia molecules by human monocytes. J Clin Invest (1984) 1.15
Murine gamma interferon activates the release of a macrophage-derived Ia-inducing factor that transfers Ia inductive capacity. J Exp Med (1984) 1.13
Regulation of a murine macrophage haemagglutinin (sheep erythrocyte receptor) by a species-restricted serum factor. Immunology (1988) 1.11
Lysis of inducer T cell clones by activated macrophages and macrophage-like cell lines. J Exp Med (1983) 1.07
Association between colony forming units-granulocyte macrophage expression of Ia-like (HLA-DR) antigen and control of granulocyte and macrophage production. A new role for prostaglandin E. J Clin Invest (1982) 1.04
The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent. J Exp Med (1995) 1.04
Onset of apoprotein E secretion during differentiation of mouse bone marrow-derived mononuclear phagocytes. J Cell Biol (1983) 1.03
Relationship of cell-cycle expression of Ia-like antigenic determinants on normal and leukemia human granulocyte-macrophage progenitor cells to regulation in vitro by acidic isoferritins. J Clin Invest (1982) 1.02
Supernatants of human leukocytes contain mediator, different from interferon gamma, which induces expression of MHC class II antigens. J Exp Med (1986) 1.02
Association of an inflammatory I region-associated antigen-positive macrophage influx and genetic resistance of inbred mice to Rickettsia tsutsugamushi. Infect Immun (1983) 1.00
Properties of isolated red pulp macrophages from mouse spleen. J Exp Med (1988) 0.98
Independent regulation of IgM, IgD, and Ia antigen expression in cultured immature B lymphocytes. J Exp Med (1986) 0.96
Analysis of cells of the mononuclear phagocyte series in experimental mycobacterial granulomas by monoclonal antibodies. Infect Immun (1983) 0.95
In vivo modulation of CD1 and MHC class II expression by sheep afferent lymph dendritic cells. Comparison of primary and secondary immune responses. J Exp Med (1989) 0.95
Clustering with dendritic cells precedes and is essential for T-cell proliferation in a mitogenesis model. Immunology (1988) 0.94
Neuraminidase-treated macrophages stimulate allogenic CD8+ T cells in the presence of exogenous interleukin 2. J Exp Med (1988) 0.94
Macrophage activation: dissociation of cytotoxic activity from Ia-A antigen expression. Proc Natl Acad Sci U S A (1983) 0.92
T-independent and T-dependent B lymphoblasts: helper T cells prime for interleukin 2-induced growth and secretion of immunoglobulins that utilize downstream heavy chains. J Exp Med (1991) 0.91
Development of human connective tissue mast cells from purified blood monocytes. Immunology (1984) 0.89
Regulation of macrophage accessory cell activity by mycobacteria. I. Ia expression in normal and irradiated mice infected with Mycobacterium microti. Clin Exp Immunol (1986) 0.89
I-Ag7 is subject to post-translational chaperoning by CLIP. Int Immunol (2010) 0.85
Ontogeny of 'macrophage' function. III. Manifestation of high accessory cell activity for primary antibody response by Ia+ functional cells in newborn mouse spleen in collaboration with Ia- macrophages. Immunology (1982) 0.85
Low dose zymosan ameliorates both chronic and relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol (2012) 0.85
T-cell activation by dendritic cells: CD18-dependent clustering is not sufficient for mitogenesis. Immunology (1988) 0.85
Macrophages pulsed with Streptococcus pneumoniae elicit a T cell-dependent antibody response upon transfer into naive mice. J Immunol (2008) 0.83
Gamma interferon-mediated increase in the number of Ia-bearing macrophages during infection with Listeria monocytogenes. Infect Immun (1987) 0.83
Functional differences and complementation between dendritic cells and macrophages in T-cell activation. Immunology (1987) 0.82
Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading. Methods Mol Biol (2013) 0.81
Antigen transport. I. Demonstration and characterization of cells laden with antigen in thoracic duct lymph and blood. Immunology (1982) 0.79
Expression of Ia antigens by murine kidney epithelium after exposure to streptozotocin. Am J Pathol (1987) 0.78
Selective chemotaxis of Ia antigen-positive blood monocytes in response to a macrophage chemotactic lymphokine extractable from PPD-induced delayed hypersensitivity reaction site in guinea-pigs. Immunology (1984) 0.77
Modulation of macrophage Ia expression by lipopolysaccharide: stem cell requirements, accessory lymphocyte involvement, and IA-inducing factor production. Infect Immun (1989) 0.75
Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J Exp Med (1979) 12.22
Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc Natl Acad Sci U S A (1978) 8.72
Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur J Immunol (1978) 5.35
Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi. J Exp Med (1979) 5.22
Trypanosoma cruzi: in vitro induction of macrophage microbicidal activity. J Exp Med (1978) 4.29
Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes. J Exp Med (1980) 3.88
Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli. J Immunol (1980) 3.46
Macrophage tumor killing: influence of the local environment. Science (1977) 2.94
Selective iodination and polypeptide composition of pinocytic vesicles. J Cell Biol (1980) 2.91
Trypanosoma cruzi: modification of macrophage function during infection. J Exp Med (1977) 2.69
Specific T helper cells that activate B cells polyclonally. In vitro enrichment and cooperative function. J Exp Med (1980) 2.27
Trypanosoma cruzi: the immunological induction of macrophage plasminogen activator requires thymus-derived lymphocytes. J Exp Med (1977) 1.74
Dendritic cells and the control of immunity. Nature (1998) 56.54
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med (1992) 22.13
Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med (1973) 13.88
Endocytosis. Annu Rev Biochem (1977) 11.42
Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med (1985) 11.14
Dendritic cells: specialized and regulated antigen processing machines. Cell (2001) 10.44
Endocytosis and the recycling of plasma membrane. J Cell Biol (1983) 10.24
Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med (2001) 9.70
Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc Natl Acad Sci U S A (1978) 8.72
Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro. J Exp Med (1979) 8.32
Proliferating dendritic cell progenitors in human blood. J Exp Med (1994) 7.67
Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J Exp Med (1974) 7.58
Membrane flow during pinocytosis. A stereologic analysis. J Cell Biol (1976) 7.20
The interaction of soluble horseradish peroxidase with mouse peritoneal macrophages in vitro. J Cell Biol (1972) 6.64
Identification of a novel cell type in peripheral lymphoid organs of mice. 3. Functional properties in vivo. J Exp Med (1974) 6.60
Dendritic cells: features and functions. Immunol Rev (1980) 6.34
The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med (1990) 6.19
A monoclonal antibody specific for mouse dendritic cells. Proc Natl Acad Sci U S A (1982) 5.77
Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med (1989) 5.65
Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J Exp Med (1987) 5.64
Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science (1992) 5.61
Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release. J Exp Med (1984) 5.54
Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction. J Exp Med (1980) 5.50
Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J Exp Med (1990) 5.35
Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity (1999) 5.23
Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi. J Exp Med (1979) 5.22
Developmental regulation of MHC class II transport in mouse dendritic cells. Nature (1997) 5.17
Pinocytosis in fibroblasts. Quantitative studies in vitro. J Cell Biol (1974) 5.15
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature (1995) 5.13
Identification of proliferating dendritic cell precursors in mouse blood. J Exp Med (1992) 5.03
Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science (1998) 4.97
The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus. Cell Immunol (1989) 4.96
Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med (2001) 4.78
Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages. J Exp Med (1983) 4.68
Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J Exp Med (1983) 4.57
Human dendritic cells. Enrichment and characterization from peripheral blood. J Exp Med (1982) 4.49
Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med (1990) 4.48
Studies of the cell surface of mouse dendritic cells and other leukocytes. J Exp Med (1981) 4.36
Trypanosoma cruzi: mechanism of entry and intracellular fate in mammalian cells. J Exp Med (1976) 4.36
Trypanosoma cruzi: in vitro induction of macrophage microbicidal activity. J Exp Med (1978) 4.29
Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J Exp Med (1999) 4.20
Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy. N Engl J Med (1986) 4.05
Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell (1994) 4.04
Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes. J Exp Med (1980) 3.88
Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Methods (1996) 3.80
Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes. J Exp Med (1986) 3.74
The distinct surface of human blood dendritic cells, as observed after an improved isolation method. Proc Natl Acad Sci U S A (1990) 3.71
The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med (1994) 3.66
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med (1997) 3.59
Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J Exp Med (1998) 3.58
Structural Aspects and Heterogeneity of Immunoglobulin Fc Receptors. Adv Immunol (1981) 3.56
The anatomy of peripheral lymphoid organs with emphasis on accessory cells: light-microscopic immunocytochemical studies of mouse spleen, lymph node, and Peyer's patch. Am J Anat (1984) 3.52
The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes. N Engl J Med (1982) 3.52
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology (1994) 3.46
Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med (1993) 3.39
Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man. Proc Natl Acad Sci U S A (1983) 3.25
Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc Natl Acad Sci U S A (1993) 3.25
Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A. J Exp Med (1986) 3.24
Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol (1996) 3.24
Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells during primary antibody responses in vitro. J Exp Med (1984) 3.23
Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J Exp Med (1983) 3.20
Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc Natl Acad Sci U S A (1984) 3.14
Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J Exp Med (1993) 3.09
Accessory cell requirements for the mixed-leukocyte reaction and polyclonal mitogens, as studied with a new technique for enriching blood dendritic cells. Cell Immunol (1988) 3.05
Identification of a novel cell type in peripheral lymphoid organs of mice. IV. Identification and distribution in mouse spleen. J Exp Med (1975) 3.03
Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells. J Clin Invest (1999) 3.00
Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells. J Exp Med (1987) 2.97
Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid. Science (1996) 2.95
Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells. J Exp Med (1987) 2.94
Selective iodination and polypeptide composition of pinocytic vesicles. J Cell Biol (1980) 2.91
The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol (2000) 2.90
The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J Exp Med (2000) 2.80
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. J Biol Chem (1998) 2.80
Dendritic cells initiate a two-stage mechanism for T lymphocyte proliferation. J Exp Med (1983) 2.76
A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals. AIDS (1999) 2.75
Mouse spleen lymphoblasts generated in vitro. Recovery in high yield and purity after floatation in dense bovine plasma albumin solutions. J Exp Med (1978) 2.75
High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodes. J Exp Med (1997) 2.73
Purificaton of a functional mouse Fc receptor through the use of a monoclonal antibody. J Exp Med (1980) 2.72
The membrane proteins of the vacuolar system. II. Bidirectional flow between secondary lysosomes and plasma membrane. J Cell Biol (1980) 2.69
Trypanosoma cruzi: modification of macrophage function during infection. J Exp Med (1977) 2.69
Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion. J Immunol (1999) 2.65
Transport of peptide-MHC class II complexes in developing dendritic cells. Science (2000) 2.62
Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2. J Exp Med (1983) 2.61
Langerhans cell (eosinophilic) granulomatosis. A clinicopathologic study encompassing 50 years. Am J Surg Pathol (1996) 2.60
Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells. J Clin Invest (1994) 2.57
Protein-specific helper T-lymphocyte formation initiated by dendritic cells. Science (1985) 2.55