Published in J Exp Med on July 01, 1978
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med (1983) 14.08
Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes. J Clin Invest (1980) 12.41
Lymphokine enhances the expression and synthesis of Ia antigens on cultured mouse peritoneal macrophages. J Exp Med (1980) 5.24
Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi. J Exp Med (1979) 5.22
Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. Infect Immun (1985) 4.56
Activated human monocytes inhibit the intracellular multiplication of Legionnaires' disease bacteria. J Exp Med (1981) 4.08
Macrophage oxygen-dependent antimicrobial activity. III. Enhanced oxidative metabolism as an expression of macrophage activation. J Exp Med (1980) 3.43
Macrophage oxygen-dependent antimicrobial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates. J Exp Med (1979) 2.93
Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro. Infect Immun (1994) 2.35
Inhibition of the growth of Rickettsia prowazekii in cultured fibroblasts by lymphokines. J Exp Med (1983) 2.20
Regulation of murine macrophage Ia-antigen expression by products of activated spleen cells. J Exp Med (1980) 2.19
Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infect Immun (1996) 2.18
Inhibition of the intracellular growth of Histoplasma capsulatum by recombinant murine gamma interferon. Infect Immun (1987) 2.03
Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma. J Exp Med (1987) 1.85
Studies on the mechanisms of macrophage activation. II. Parasite destruction in macrophages activated by supernates from concanavalin A-stimulated lymphocytes. J Exp Med (1979) 1.81
Regulation of arachidonic acid metabolism by macrophage activation. J Exp Med (1982) 1.69
Trypanosoma cruzi. Surface antigens of blood and culture forms. J Exp Med (1981) 1.68
Activation of macrophages by lymphokines: enhancement of phagosome-lysosome fusion and killing of Coccidioides immitis. Infect Immun (1983) 1.67
Minichromosomal repetitive DNA in Trypanosoma cruzi: its use in a high-sensitivity parasite detection assay. Proc Natl Acad Sci U S A (1984) 1.65
Enhancing effects of gamma interferon on phagocytic cell association with and killing of Trypanosoma cruzi. Infect Immun (1985) 1.62
Elimination of Leishmania donovani amastigotes by activated macrophages. Infect Immun (1981) 1.58
An analysis of in vitro T cell responsiveness in lepromatous leprosy. J Exp Med (1985) 1.52
Role of lymphocytes in macrophage-induced killing of Coccidioides immitis in vitro. Infect Immun (1981) 1.38
Interaction of alveolar macrophages with Nocardia asteroides: immunological enhancement of phagocytosis, phagosome-lysosome fusion, and microbicidal activity. Infect Immun (1980) 1.31
Role of iron in intracellular growth of Trypanosoma cruzi. Infect Immun (1984) 1.23
Time course of antilisterial activity by immunologically activated murine peritoneal macrophages. Infect Immun (1983) 1.23
Lymphokine-induced inhibition of growth of Eimeria bovis and Eimeria papillata (Apicomplexa) in cultured bovine monocytes. Infect Immun (1985) 1.21
Trypanosoma cruzi. Factors modifying ingestion and fate of blood form trypomastigotes. J Exp Med (1980) 1.19
Dissociation of bactericidal activity from other functions of activated macrophages in exudates induced by thioglycolate medium. Infect Immun (1981) 1.18
Chagas' disease and the autoimmunity hypothesis. Clin Microbiol Rev (1999) 1.18
Amastigotes of Trypanosoma cruzi sustain an infective cycle in mammalian cells. J Exp Med (1988) 1.18
Evidence for a protective role of tumor necrosis factor in the acute phase of Trypanosoma cruzi infection in mice. Infect Immun (1997) 1.15
Specific glycoprotein antigens on the surface of insect and mammalian stages of Trypanosoma cruzi. Proc Natl Acad Sci U S A (1982) 1.09
Lectin receptors as markers for Trypanosoma cruzi. Developmental stages and a study of the interaction of wheat germ agglutinin with sialic acid residues on epimastigote cells. J Exp Med (1980) 1.09
Cytotoxicity of human macrophages for tumor cells. Enhancement by human lymphocyte mediators. J Clin Invest (1979) 1.09
Effector cells, molecules and mechanisms in host-protective immunity to parasites. Immunology (1979) 1.07
Effects of IL-4 on macrophage functions: increased uptake and killing of a protozoan parasite (Trypanosoma cruzi). Immunology (1989) 1.06
Lymphokine-induced mycobacteriostatic activity in mouse pleural macrophages. Infect Immun (1982) 1.00
Enhanced resistance to acute infection with Trypanosoma cruzi in mice treated with an interferon inducer. Infect Immun (1982) 0.97
Zanvil Alexander Cohn 1926-1993. J Exp Med (1994) 0.91
Trypanosomiasis in mice with naturally occurring immunodeficiencies. Infect Immun (1983) 0.90
Cellular immunity of mice to Leishmania donovani in vitro: lymphokine-mediated killing of intracellular parasites in macrophages. Proc Natl Acad Sci U S A (1981) 0.88
Acute heart inflammation: ultrastructural and functional aspects of macrophages elicited by Trypanosoma cruzi infection. J Cell Mol Med (2008) 0.87
Resistance to Mycobacterium lepraemurium is correlated with the capacity to generate macrophage activating factor(s) in response to mycobacterial antigens in vitro. Immunology (1986) 0.86
Binding of C3 fragments to the Trypanosoma cruzi surface in the absence of specific antibodies and without activation of the complement cascade. Clin Exp Immunol (1985) 0.85
T cell proliferation in Mycobacterium lepraemurium infection. I. Lack of correlation between antigen-specific proliferation of Lyt 1 + 23- cells and resistance in lethal infections. Immunology (1984) 0.85
Direct activation of human monocyte-derived macrophages by a bacterial glycoprotein extract inhibits the intracellular multiplication of virulent Legionella pneumophila serogroup 1. Infect Immun (1987) 0.83
Induction of the acute-phase protein serum amyloid P in experimental Chagas' disease. Infect Immun (1982) 0.82
Adoptive transfer of protection against Trypanosoma cruzi with lymphocytes and macrophages. Infect Immun (1979) 0.81
Induction of C3b-mediated phagocytosis in macrophages by distinct populations of lipopolysaccharide-stimulated lymphocytes. Infect Immun (1981) 0.81
Trypanosoma cruzi infection and host lipid metabolism. Mediators Inflamm (2014) 0.78
Immunomodulation of mouse macrophage killing of Mycobacterium avium in vitro. Infect Immun (1991) 0.78
Activation of mouse peritoneal macrophages by maintenance in serum-free medium. Immunology (1991) 0.77
Inhibition of growth of Listeria monocytogenes in vitro, by immunologically activated mouse resident macrophages. Br J Exp Pathol (1986) 0.77
Mechanisms of resistance against experimental Trypanosoma cruzi infection. Requirements for cellular destruction of circulating forms of T. cruzi in human and murine in vitro systems. Immunology (1980) 0.75
Rate and efficiency of complement-dependent phagocytosis in cytolytic and non-cytolytic inflammatory macrophages. Immunology (1986) 0.75
Cellular resistance to infection. J Exp Med (1962) 30.96
THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY. J Exp Med (1965) 21.86
The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med (1969) 20.62
THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE. J Exp Med (1964) 13.28
Requirement of thymus (T) lymphocytes for resistance to listeriosis. J Exp Med (1972) 8.25
Importance of thymus-derived lymphocytes in cell-mediated immunity to infection. Cell Immunol (1973) 7.68
Cellular immunity in vitro. I. Immunologically mediated enhancement of macrophage bactericidal capacity. J Exp Med (1971) 4.94
The enhancement of macrophage bacteriostasis by products of activated lymphocytes. J Exp Med (1973) 4.51
Effect of normal and activated human macrophages on Toxoplasma gondii. J Exp Med (1974) 4.39
Trypanosoma cruzi: mechanism of entry and intracellular fate in mammalian cells. J Exp Med (1976) 4.36
The monocyte in cellular immunity. Semin Hematol (1970) 4.10
In vitro induction of nonspecific resistance in macrophages by specifically sensitized lymphocytes. Infect Immun (1971) 3.81
Enhancement of macrophage bactericidal capacity by antigenically stimulated immune lymphocytes. Cell Immunol (1972) 3.56
Inhibition of multiplication of Toxoplasma gondii by human monocytes exposed to T-lymphocyte products. J Exp Med (1975) 3.17
Induction of resistance to Toxoplasma gondii in human macrophages by soluble lymphocyte products. J Immunol (1976) 2.79
Trypanosoma cruzi: modification of macrophage function during infection. J Exp Med (1977) 2.69
Studies on the selective lysis and purification of Trypanosoma cruzi. J Exp Med (1975) 2.54
Macrophage activation for tumor cytotoxicity: induction of tumoricidal macrophages by supernatants of PPD-stimulated Bacillus Calmette-Guérin-immune spleen cell cultures. J Immunol (1977) 1.91
Trypanosoma cruzi: the immunological induction of macrophage plasminogen activator requires thymus-derived lymphocytes. J Exp Med (1977) 1.74
The use of Metrizamide as a gradient medium for isopycnic separation of rat liver cells. FEBS Lett (1974) 1.37
Effect of human monocytes and macrophages on Trypanosoma cruzi. Immunology (1977) 1.18
The origin and kinetics of mononuclear phagocytes. J Exp Med (1968) 14.96
Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med (1973) 13.88
Endocytosis. Annu Rev Biochem (1977) 11.42
Endocytosis and the recycling of plasma membrane. J Cell Biol (1983) 10.24
The enzymatic iodination of the red cell membrane. J Cell Biol (1972) 8.62
Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro. J Exp Med (1979) 8.32
The isolation and selected properties of blood monocytes. J Exp Med (1966) 7.78
Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J Exp Med (1974) 7.58
In vitro synthesis and secretion of lysozyme by mononuclear phagocytes. J Exp Med (1974) 7.43
Membrane flow during pinocytosis. A stereologic analysis. J Cell Biol (1976) 7.20
The interaction of soluble horseradish peroxidase with mouse peritoneal macrophages in vitro. J Cell Biol (1972) 6.64
Identification of a novel cell type in peripheral lymphoid organs of mice. 3. Functional properties in vivo. J Exp Med (1974) 6.60
Increased superoxide anion production by immunologically activated and chemically elicited macrophages. J Exp Med (1978) 6.50
Activation of mononuclear phagocytes: fact, fancy, and future. J Immunol (1978) 6.22
Externally disposed plasma membrane proteins. I. Enzymatic iodination of mouse L cells. J Cell Biol (1975) 5.82
Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity. J Exp Med (1979) 5.38
Lymphokine enhances the expression and synthesis of Ia antigens on cultured mouse peritoneal macrophages. J Exp Med (1980) 5.24
Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi. J Exp Med (1979) 5.22
Pinocytosis in fibroblasts. Quantitative studies in vitro. J Cell Biol (1974) 5.15
The regulation of pinocytosis in mouse macrophages. I. Metabolic requirements as defined by the use of inhibitors. J Exp Med (1966) 5.10
The structure and function of monocytes and macrophages. Adv Immunol (1968) 5.06
The in vitro differentiation of mononuclear phagocytes. V. The formation of macrophage lysosomes. J Exp Med (1966) 4.84
Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages. J Exp Med (1983) 4.68
The separation, long-term cultivation, and maturation of the human monocyte. J Exp Med (1977) 4.46
Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. J Clin Invest (1981) 4.46
Induction of macrophage plasminogen activator by endotoxin stimulation and phagocytosis: evidence for a two-stage process. J Exp Med (1974) 4.45
Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med (1991) 4.43
Studies of the cell surface of mouse dendritic cells and other leukocytes. J Exp Med (1981) 4.36
Trypanosoma cruzi: mechanism of entry and intracellular fate in mammalian cells. J Exp Med (1976) 4.36
The macrophage as an effector cell. N Engl J Med (1980) 4.30
The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells. Bull World Health Organ (1972) 4.25
The regulation of pinocytosis in mouse macrophages. II. Factors inducing vesicle formation. J Exp Med (1967) 4.17
Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy. N Engl J Med (1986) 4.05
The in vitro differentiation of mononuclear phagocytes. 3. The reversibility of granule and hydrolytic enzyme formation and the turnover of granule constituents. J Exp Med (1965) 3.92
Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes. J Exp Med (1980) 3.88
Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates. J Exp Med (1979) 3.72
The uptake and digestion of iodinated human serum albumin by macrophages in vitro. J Exp Med (1967) 3.70
The uptake, storage, and intracellular hydrolysis of carbohydrates by macrophages. J Exp Med (1969) 3.66
Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide. J Exp Med (1979) 3.61
The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med (1987) 3.61
A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. J Exp Med (1989) 3.58
Effects of concanavalin A on mouse peritoneal macrophages. I. Stimulation of endocytic activity and inhibition of phago-lysosome formation. J Exp Med (1974) 3.52
The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes. N Engl J Med (1982) 3.52
Macrophage oxygen-dependent antimicrobial activity. III. Enhanced oxidative metabolism as an expression of macrophage activation. J Exp Med (1980) 3.43
The in vitro differentiation of mononuclear phagocytes. IV. The ultrastructure of macrophage differentiation in the peritoneal cavity and in culture. J Exp Med (1966) 3.41
Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules. Proc Natl Acad Sci U S A (1985) 3.31
In vitro induction of lysosomal enzymes by phagocytosis. J Exp Med (1970) 3.11
Plasma membrane synthesis in the macrophage following phagocytosis of polystyrene latex particles. J Biol Chem (1972) 3.10
Identification of a novel cell type in peripheral lymphoid organs of mice. IV. Identification and distribution in mouse spleen. J Exp Med (1975) 3.03
Regulation of arachidonic acid metabolites in macrophages. J Exp Med (1980) 3.00
The pinocytic rate of activated macrophages. J Exp Med (1975) 2.97
Macrophage oxygen-dependent antimicrobial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates. J Exp Med (1979) 2.93
Selective iodination and polypeptide composition of pinocytic vesicles. J Cell Biol (1980) 2.91
Phagosome-lysosome fusion. Characterization of intracellular membrane fusion in mouse macrophages. J Cell Biol (1980) 2.83
Mouse spleen lymphoblasts generated in vitro. Recovery in high yield and purity after floatation in dense bovine plasma albumin solutions. J Exp Med (1978) 2.75
The membrane proteins of the vacuolar system. II. Bidirectional flow between secondary lysosomes and plasma membrane. J Cell Biol (1980) 2.69
Trypanosoma cruzi: modification of macrophage function during infection. J Exp Med (1977) 2.69
Defective gamma interferon production in leprosy. Reversal with antigen and interleukin 2. J Exp Med (1983) 2.61
Studies on the selective lysis and purification of Trypanosoma cruzi. J Exp Med (1975) 2.54
Mouse peritoneal macrophages release leukotriene C in response to a phagocytic stimulus. Proc Natl Acad Sci U S A (1980) 2.53
The macrophage. Int Rev Cytol (1973) 2.52
The selective inhibition of macrophage phagocytic receptors by anti-membrane antibodies. J Exp Med (1972) 2.51
Mononuclear phagocytes of blood and bone marrow: comparative roles as viral reservoirs in human immunodeficiency virus type 1 infections. Proc Natl Acad Sci U S A (1989) 2.50
The fate of peptides pinocytosed by macrophages in vitro. J Exp Med (1969) 2.49
Prostaglandin synthesis by macrophages requires a specific receptor-ligand interaction. Proc Natl Acad Sci U S A (1980) 2.49
Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis. J Cell Biol (1983) 2.49
The membrane proteins of the vacuolar system I. Analysis of a novel method of intralysosomal iodination. J Cell Biol (1980) 2.48
The interaction of particulate horseradish peroxidase (HRP)-anti HRP immune complexes with mouse peritoneal macrophages in vitro. J Cell Biol (1972) 2.48
Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils. J Exp Med (1990) 2.42
Mechanism of membrane damage mediated by human eosinophil cationic protein. Nature (1986) 2.41
The induction of macrophage spreading: role of coagulation factors and the complement system. J Exp Med (1976) 2.41
Externally disposed plasma membrane proteins. II. Metabolic fate of iodinated polypeptides of mouse L cells. J Cell Biol (1975) 2.39
Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity. Cell (1986) 2.38
Aggregation of complement receptors on human neutrophils in the absence of ligand. J Cell Biol (1987) 2.38
Liver macrophages in murine listeriosis. Cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates. J Exp Med (1985) 2.37
Bacterial lipopolysaccharides prime macrophages for enhanced release of arachidonic acid metabolites. J Exp Med (1986) 2.34
The regulation of pinocytosis in mouse macrophages. IV. The immunological induction of pinocytic vesicles, secondary lysosomes, and hydrolytic enzymes. J Exp Med (1967) 2.29
Mycobacterium leprae antigen-induced suppression of T cell proliferation in vitro. J Immunol (1987) 2.27
Arachidonic acid metabolism by human monocytes. Studies with platelet-depleted cultures. J Exp Med (1983) 2.24
Lymphokines enhance the capacity of human monocytes to secret reactive oxygen intermediates. J Clin Invest (1982) 2.23
5'-Nucleotidase activity of mouse peritoneal macrophages. I. Synthesis and degradation in resident and inflammatory populations. J Exp Med (1976) 2.21
The alveolar macrophage. J Appl Physiol (1985) (1986) 2.21
Stimulus-dependent myristoylation of a major substrate for protein kinase C. Nature (1988) 2.21
The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities. Science (1986) 2.21
Properties of the major outer membrane protein from Neisseria gonorrhoeae incorporated into model lipid membranes. Proc Natl Acad Sci U S A (1983) 2.20
Cellular responses to the intradermal injection of recombinant human gamma-interferon in lepromatous leprosy patients. Am J Pathol (1987) 2.18
Vesicle fusion and formation at the surface of pinocytic vacuoles in macrophages. J Cell Biol (1968) 2.15
Autophagic vacuoles produced in vitro. I. Studies on cultured macrophages exposed to chloroquine. J Cell Biol (1968) 2.15
Influence of delayed immune reactions on human epidermal keratinocytes. Proc Natl Acad Sci U S A (1986) 2.11
Murine Kupffer cells. Mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. J Exp Med (1985) 2.03
Response of endocytosis to altered fatty acyl composition of macrophage phospholipids. Proc Natl Acad Sci U S A (1977) 2.01
Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor. Proc Natl Acad Sci U S A (1987) 1.96
Functional assembly of gap junction conductance in lipid bilayers: demonstration that the major 27 kd protein forms the junctional channel. Cell (1987) 1.94
Dynamics of leukotriene C production by macrophages. J Exp Med (1980) 1.93
Cholesterol metabolism in the macrophage. 3. Ingestion and intracellular fate of cholesterol and cholesterol esters. J Exp Med (1972) 1.92
Autophagic vacuoles produced in vitro. II. Studies on the mechanism of formation of autophagic vacuoles produced by chloroquine. J Cell Biol (1968) 1.91
Characterization of a membrane pore-forming protein from Entamoeba histolytica. J Exp Med (1982) 1.85
The increase in intracellular free calcium associated with IgG gamma 2b/gamma 1 Fc receptor-ligand interactions: role in phagocytosis. Proc Natl Acad Sci U S A (1984) 1.83
Fc-receptor variants of a mouse macrophage cell line. Proc Natl Acad Sci U S A (1979) 1.80