Published in J Biol Chem on November 25, 1984
Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proc Natl Acad Sci U S A (1995) 4.33
C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp. Proc Natl Acad Sci U S A (1987) 2.31
Cis- and trans-acting elements required for constitutive and cytokine-regulated expression of the mouse complement C3 gene. Biochem J (1992) 0.94
Cellular specificity of murine renal C3 expression in two models of inflammation. Immunology (1994) 0.83
Application of molecular cloning to studies on the complement system. Immunology (1985) 0.78
Mutants of complement component C3 cleaved by the C4-specific C1-s protease. Proc Natl Acad Sci U S A (1992) 0.75
Carbohydrate structures of the third component of rat complement. Presence of both high-mannose and complex type oligosaccharide chains. Biochem J (1986) 0.75
Lariat structures are in vivo intermediates in yeast pre-mRNA splicing. Cell (1984) 8.71
Nucleotide sequence and secondary structure of potato spindle tuber viroid. Nature (1978) 6.07
Preparation of high molecular weight RNA. Methods Enzymol (1991) 5.60
Large scale isolation of functionally active components of the human complement system. J Biol Chem (1981) 5.26
Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85
Complete DNA sequence of yeast chromosome XI. Nature (1994) 3.51
Human complement component C3: cDNA coding sequence and derived primary structure. Proc Natl Acad Sci U S A (1985) 3.37
Tritium labeling of proteins to high specific radioactivity by reduction methylation. J Biol Chem (1980) 3.04
Evidence for presence of an internal thiolester bond in third component of human complement. Proc Natl Acad Sci U S A (1980) 3.00
Dependence of yeast pre-mRNA 3'-end processing on CFT1: a sequence homolog of the mammalian AAUAAA binding factor. Science (1996) 2.81
Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am J Physiol Lung Cell Mol Physiol (2000) 2.55
Nucleotide sequence and secondary structure of citrus exocortis and chrysanthemum stunt viroid. Eur J Biochem (1982) 2.42
Formation of a 2'-phosphomonoester, 3',5'-phosphodiester linkage by a novel RNA ligase in wheat germ. Nature (1981) 2.40
The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. Cell (1986) 2.36
Bactericidal activity of mammalian cathelicidin-derived peptides. Infect Immun (2000) 2.24
Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun (1999) 2.19
Sequence and transcriptional start site of the Pseudomonas aeruginosa outer membrane porin protein F gene. J Bacteriol (1988) 2.13
Discovery of new human beta-defensins using a genomics-based approach. Gene (2001) 2.08
Structure and expression of the human cystatin C gene. Biochem J (1990) 2.07
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. EMBO J (1996) 2.06
Metabolism of gallic acid and syringic acid by Pseudomonas putida. J Biol Chem (1972) 2.04
Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase. J Biol Chem (1972) 2.04
Structure and structure formation of viroids. J Mol Biol (1979) 2.03
Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9. Proc Natl Acad Sci U S A (1984) 2.01
The nucleotide sequence of the 5S rRNA from the archaebacterium Thermoplasma acidophilum. Nucleic Acids Res (1981) 2.01
Complete DNA sequence of yeast chromosome II. EMBO J (1994) 1.97
Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA. Immunopharmacology (1999) 1.94
Binding of ribosomes to linear and circular forms of the 5'-terminal leader fragment of tobacco-mosaic-virus RNA. Eur J Biochem (1981) 1.79
Requirements for the solubilization of immune aggregates by complement: assembly of a factor B-dependent C3-convertase on the immune complexes. J Exp Med (1977) 1.79
Molecular cloning of human prostate specific antigen cDNA. FEBS Lett (1987) 1.74
Amino-terminal sequence of p36 and associated p10: identification of the site of tyrosine phosphorylation and homology with S-100. Proc Natl Acad Sci U S A (1985) 1.72
Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes. Proc Natl Acad Sci U S A (1987) 1.68
Third component of human complement: appearance of a sulfhydryl group following chemical or enzymatic inactivation. Biochemistry (1980) 1.67
Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene. Proc Natl Acad Sci U S A (1990) 1.66
Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells. J Biol Chem (1989) 1.60
Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock. J Immunol (2000) 1.59
Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B. J Immunol (2000) 1.55
Characterization of the human complement (c3b) receptor with a fluid phase C3b dimer. J Immunol (1981) 1.55
Identification of pre-mRNA polyadenylation sites in Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.54
Structural analysis of human complement protein H: homology with C4b binding protein, beta 2-glycoprotein I, and the Ba fragment of B2. J Immunol (1986) 1.53
Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. J Immunol (2001) 1.52
Cloning, characterization and heterologous expression of the SmaI restriction-modification system. Nucleic Acids Res (1989) 1.52
Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa. J Biol Chem (1989) 1.49
The structure of human complement component C7 and the C5b-7 complex. J Biol Chem (1988) 1.49
Human serum amyloid A (SAA): biosynthesis and postsynthetic processing of preSAA and structural variants defined by complementary DNA. Biochemistry (1985) 1.49
Fifth component of human complement: purification from plasma and polypeptide chain structure. Biochemistry (1979) 1.49
Localization of cloned unique DNA to three different regions of chromosome 19: screen for linkage probes for myotonic dystrophy. J Neurogenet (1985) 1.48
Synergistic action of interleukin-6 and glucocorticoids is mediated by the interleukin-6 response element of the rat alpha 2 macroglobulin gene. Mol Cell Biol (1992) 1.46
Third component of human complement: structural analysis of the polypeptide chains of C3 and C3b. Biochemistry (1979) 1.44
Type I human complement C2 deficiency. A 28-base pair gene deletion causes skipping of exon 6 during RNA splicing. J Biol Chem (1992) 1.40
A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6. Mol Cell Biol (1990) 1.39
Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation. Oncogene (1998) 1.39
A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells. Oncogene (1999) 1.39
Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA. J Biol Chem (1987) 1.38
Third component of human complement: structural requirements for its function. Biochemistry (1980) 1.38
Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung. J Immunol (1995) 1.38
Rab11b is essential for recycling of transferrin to the plasma membrane. Exp Cell Res (2000) 1.37
Attenuation of experimental autoimmune demyelination in complement-deficient mice. J Immunol (2000) 1.37
Murine protein H is comprised of 20 repeating units, 61 amino acids in length. Proc Natl Acad Sci U S A (1986) 1.37
Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C. FEBS Lett (1987) 1.34
Comparative oligonucleotide fingerprints of three plant viroids. Nucleic Acids Res (1977) 1.32
The genome of the archaeal virus SIRV1 has features in common with genomes of eukaryal viruses. Virology (2001) 1.32
Tight linkage of apolipoprotein C2 to myotonic dystrophy on chromosome 19. Neurology (1986) 1.31
Isolation and analysis of genomic DNA clones encoding the third component of mouse complement. Proc Natl Acad Sci U S A (1982) 1.30
Nucleotide sequence of complementary DNA and derived amino acid sequence of murine complement protein C3. Philos Trans R Soc Lond B Biol Sci (1984) 1.29
Common evolutionary origin of alpha 2-macroglobulin and complement components C3 and C4. Proc Natl Acad Sci U S A (1985) 1.29
Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J Biol Chem (1995) 1.29
Primary structure of bovine calpactin I heavy chain (p36), a major cellular substrate for retroviral protein-tyrosine kinases: homology with the human phospholipase A2 inhibitor lipocortin. Biochemistry (1986) 1.28
Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy. J Immunol (2001) 1.27
Orientation and dynamics of an antimicrobial peptide in the lipid bilayer by solid-state NMR spectroscopy. Biophys J (2001) 1.27
Herpes simplex virus type 1 glycoprotein gC mediates immune evasion in vivo. J Virol (1998) 1.26
Primary structure of bovine vitamin K-dependent protein S. Proc Natl Acad Sci U S A (1986) 1.26
Cloning and characterization of the ALG3 gene of Saccharomyces cerevisiae. Glycobiology (1996) 1.25
A test for intron function in the yeast actin gene. Nature (1985) 1.24
The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7. Br J Haematol (1994) 1.24
Physicochemical characterization of fluid phase (SC5b-9) and membrane derived (MC5b-9) attack complexes of human complement purified by immunoadsorbent affinity chromatography or selective detergent extraction. Mol Immunol (1981) 1.22
The acute phase response of the liver in inflammation. Prog Liver Dis (1990) 1.22
The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection. Antimicrob Agents Chemother (2001) 1.22
Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation. Proc Natl Acad Sci U S A (1986) 1.22
Mutations in a peptidylprolyl-cis/trans-isomerase gene lead to a defect in 3'-end formation of a pre-mRNA in Saccharomyces cerevisiae. J Biol Chem (1999) 1.22
beta-Hydroxyasparagine in domains homologous to the epidermal growth factor precursor in vitamin K-dependent protein S. Proc Natl Acad Sci U S A (1987) 1.20
The alpha-macroglobulin bait region. Sequence diversity and localization of cleavage sites for proteinases in five mammalian alpha-macroglobulins. J Biol Chem (1989) 1.20
Third component of human complement: localization of the internal thiolester bond. Proc Natl Acad Sci U S A (1982) 1.20
Sequence determination of the thiolester site of the fourth component of human complement. Proc Natl Acad Sci U S A (1981) 1.19
A severe and a mild potato spindle tuber viroid isolate differ in three nucleotide exchanges only. Biosci Rep (1981) 1.19
The beta-Cys-gamma-Glu thiolester bond in human C3, C4, and alpha 2-macroglobulin. Springer Semin Immunopathol (1983) 1.18
PTF1 encodes an essential protein in Saccharomyces cerevisiae, which shows strong homology with a new putative family of PPIases. FEBS Lett (1995) 1.18
Molecular heterogeneity of C2 deficiency. N Engl J Med (1992) 1.17
Binding of C3b proceeds by a transesterification reaction at the thiolester site. Nature (1982) 1.17
Fourth component of human complement: studies of an amine-sensitive site comprised of a thiol component. Biochemistry (1981) 1.17
Molecular consequences of truncations of the first exon for in vitro splicing of yeast actin pre-mRNA. Nucleic Acids Res (1988) 1.16
Pseudomonas aeruginosa outer membrane lipoprotein I gene: molecular cloning, sequence, and expression in Escherichia coli. J Bacteriol (1989) 1.16