Published in Proc Natl Acad Sci U S A on May 01, 1983
Mechanism and regulation of eukaryotic protein synthesis. Microbiol Rev (1992) 6.27
Initiation of protein synthesis in mammalian cells. Biochem J (1986) 2.99
Complex formation by positive and negative translational regulators of GCN4. Mol Cell Biol (1991) 2.79
Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis. Proc Natl Acad Sci U S A (1985) 2.53
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Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.88
Mechanism of translational control by partial phosphorylation of the alpha subunit of eukaryotic initiation factor 2. Proc Natl Acad Sci U S A (1984) 1.57
Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. Mol Cell Biol (1993) 1.39
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Distribution of reversing factor in reticulocyte lysates during active protein synthesis and on inhibition by heme deprivation or double-stranded RNA. Proc Natl Acad Sci U S A (1984) 1.23
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Amino acid microsequencing of internal tryptic peptides of heme-regulated eukaryotic initiation factor 2 alpha subunit kinase: homology to protein kinases. Proc Natl Acad Sci U S A (1991) 1.12
The association of NADPH with the guanine nucleotide exchange factor from rabbit reticulocytes: a role of pyridine dinucleotides in eukaryotic polypeptide chain initiation. Proc Natl Acad Sci U S A (1986) 1.08
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Biosynthesis of the transferrin receptor in rabbit reticulocytes. J Clin Invest (1985) 0.79
Protein synthesis in rabbit reticulocytes: a study of the mechanism of action of the protein factor RF that reverses protein synthesis inhibition in heme-deficient reticulocyte lysates. Proc Natl Acad Sci U S A (1984) 0.78
Effect of vasopressin on the regulation of protein synthesis initiation in liver cells. Biochem J (1988) 0.76
Formation of a translational inhibitor by interaction of phospholipid with the eukaryotic initiation factor 2. Proc Natl Acad Sci U S A (1986) 0.76
15-deoxyspergualin inhibits eukaryotic protein synthesis through eIF2alpha phosphorylation. Biochem J (2007) 0.76
Mechanism of activation of the heme-stabilized translational inhibitor of reticulocyte lysates by calcium ions and phospholipid. Proc Natl Acad Sci U S A (1985) 0.75
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Specificity of the protein kinase activity associated with the hemin-controlled repressor of rabbit reticulocyte. Proc Natl Acad Sci U S A (1976) 2.61
Additional evidence that the hemin-controlled translational repressor from rabbit reticulocytes is a protein kinase. Biochem Biophys Res Commun (1977) 2.01
Regulation of protein synthesis in rabbit reticulocyte lysates: purification and initial characterization of the cyclic 3':5'-AMP independent protein kinase of the heme-regulated translational inhibitor. Proc Natl Acad Sci U S A (1976) 1.85
Mechanism of polypeptide chain initiation in eukaryotes and its control by phosphorylation of the alpha subunit of initiation factor 2. Proc Natl Acad Sci U S A (1982) 1.78
Binding and release of eukaryotic initiation factor eIF-2 and GTP during protein synthesis initiation. Proc Natl Acad Sci U S A (1978) 1.72
Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2. Nature (1982) 1.70
Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA and oxidized glutathione: indirect mode of action on polypeptide chain initiation. Proc Natl Acad Sci U S A (1975) 1.68
Mode of action of the hemin-controlled inhibitor of protein synthesis: studies with factors from rabbit reticulocytes. Proc Natl Acad Sci U S A (1978) 1.54
Nucleotide regulation of a eukaryotic protein synthesis initiation complex;. Biochim Biophys Acta (1975) 1.52
Regulation of protein synthesis in rabbit reticulocyte lysates: additional initiation factor required for formation of ternary complex (eIF-2.GTP.Met-tRNAf) and demonstration of inhibitory effect of heme-regulated protein kinase. Proc Natl Acad Sci U S A (1979) 1.48
Regulation of protein synthesis in rabbit reticulocyte lysates: purification and characterization of heme-reversible translational inhibitor. Proc Natl Acad Sci U S A (1978) 1.47
Mode of action of the heme-controlled translational inhibitor: relationship of eukaryotic initiation factor 2-stimulating protein to translation restoring factor. Proc Natl Acad Sci U S A (1981) 1.42
Protein synthesis in rabbit reticulocytes: mechanism of protein synthesis inhibition by heme-regulated inhibitor. Proc Natl Acad Sci U S A (1979) 1.41
Regulation of protein synthesis by phosphorylation of eukaryotic initiation factor 2 alpha in intact reticulocytes and reticulocyte lysates. Proc Natl Acad Sci U S A (1982) 1.32
Purification and characterization of a protein factor that reverses the inhibition of protein synthesis by the heme-regulated translational inhibitor in rabbit reticulocyte lysates. Eur J Biochem (1979) 1.22
Evidence that glucose 6-phosphate regulates protein synthesis initiation in reticulocyte lysates. J Biol Chem (1978) 1.22
Role of eukaryotic initiation factor 5 in the formation of 80 S initiation complexes. J Biol Chem (1979) 1.21
Regulation of ternary (Met-tRNAf - GTP - eukaryotic initiation factor 2) protein synthesis initiation complex formation by the adenylate energy charge. Biochim Biophys Acta (1976) 1.13
Protein synthesis in rabbit reticulocytes: characteristics of a postribosomal supernatant factor that reverses inhibition of protein synthesis in heme-deficient lysates and inhibition of ternary complex (Met-tRNAfMet.eIF-2.GTP) formation by heme-regulated inhibitor. Proc Natl Acad Sci U S A (1979) 1.04
Protein synthesis in rabbit reticulocytes: characteristics of a ribosomal factor that reverses inhibition of protein synthesis in heme-deficient lysates. Proc Natl Acad Sci U S A (1978) 0.96
Initiation of protein synthesis in eukaryotes. Binding to Sepharose-heparin and partial purification of initiation factors from Krebs II ascites cells. Eur J Biochem (1977) 0.92
The "beta-like-globin" gene domain in human erythroid cells. Proc Natl Acad Sci U S A (1985) 8.35
An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes. Proc Natl Acad Sci U S A (1989) 4.11
Control of globin synthesis: the role of heme. J Mol Biol (1972) 3.47
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Regulation of protein synthesis in reticulocyte lysates: phosphorylation of methionyl-tRNAf binding factor by protein kinase activity of translational inhibitor isolated from hemedeficient lysates. Proc Natl Acad Sci U S A (1976) 3.00
Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Proc Natl Acad Sci U S A (1993) 2.90
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Mapping of DNase I-hypersensitive sites in the upstream DNA of human embryonic epsilon-globin gene in K562 leukemia cells. Proc Natl Acad Sci U S A (1984) 2.70
The mechanisms of reovirus uncoating and gene activation in vivo. Virology (1972) 2.60
Asynchronous synthesis of the complementary strands of the reovirus genome. Proc Natl Acad Sci U S A (1971) 2.42
Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase. Proc Natl Acad Sci U S A (1991) 2.34
Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase. Trends Biochem Sci (1995) 2.25
Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. J Biol Chem (1995) 2.09
Regulation of protein synthesis: activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2. Proc Natl Acad Sci U S A (1978) 2.03
Met-tRNAfMet binding to 40S ribosomal subunits: a site for the regulation of initiation of protein synthesis by hemin. Proc Natl Acad Sci U S A (1974) 1.96
Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.88
The stimulation of globin synthesis by heme. Proc Natl Acad Sci U S A (1966) 1.86
Regulation of protein synthesis in rabbit reticulocyte lysates: purification and initial characterization of the cyclic 3':5'-AMP independent protein kinase of the heme-regulated translational inhibitor. Proc Natl Acad Sci U S A (1976) 1.85
Protein initiation in eukaryotes: formation and function of a ternary complex composed of a partially purified ribosomal factor, methionyl transfer RNA, and guanosine triphosphate. Proc Natl Acad Sci U S A (1973) 1.83
Control of protein synthesis in reticulocyte lysates: effects of 3':5'-cyclic AMP, ATP, and GTP on inhibitions induced by hemedeficiency, double-stranded RNA, and a reticulocyte translationa inhibitor. Proc Natl Acad Sci U S A (1976) 1.82
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The reovirus replicative cycle: conservation of parental RNA and protein. Proc Natl Acad Sci U S A (1970) 1.76
Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA and oxidized glutathione: indirect mode of action on polypeptide chain initiation. Proc Natl Acad Sci U S A (1975) 1.68
Protein synthesis initiation in eukaryotes. Characterization of ribosomal factors from mouse fibroblasts. J Biol Chem (1973) 1.53
Regulation of protein synthesis in rabbit reticulocyte lysates: additional initiation factor required for formation of ternary complex (eIF-2.GTP.Met-tRNAf) and demonstration of inhibitory effect of heme-regulated protein kinase. Proc Natl Acad Sci U S A (1979) 1.48
Mechanism of reovirus double-stranded ribonucleic acid synthesis in vivo and in vitro. J Virol (1971) 1.47
Regulation of protein synthesis in rabbit reticulocyte lysates: purification and characterization of heme-reversible translational inhibitor. Proc Natl Acad Sci U S A (1978) 1.47
Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis. Oncogene (1999) 1.44
Characterization of double-stranded-RNA-activated kinase that phosphorylates alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha) in reticulocyte lysates. Proc Natl Acad Sci U S A (1980) 1.42
Regulation of protein synthesis in rabbit reticulocyte lysates by the heme-regulated protein kinase: inhibition of interaction of Met-tRNAfMet binding factor with another initiation factor in formation of Met-tRNAfMet.40S ribosomal subunit complexes. Proc Natl Acad Sci U S A (1978) 1.39
Inhibition of protein synthesis initiation by oxidized glutathione: activation of a protein kinase that phosphorylates the alpha subunit of eukaryotic initiation factor 2. Proc Natl Acad Sci U S A (1978) 1.39
The effects of hemin and double-stranded RNA on alpha and beta globin synthesis in reticulocyte and Krebs II ascites cell-free systems and the relationship of these effects to an initiation factor preparation. Proc Natl Acad Sci U S A (1974) 1.37
Detection of activated double-stranded RNA-dependent protein kinase in 3T3-F442A cells. Proc Natl Acad Sci U S A (1988) 1.37
Growth-related expression of a double-stranded RNA-dependent protein kinase in 3T3 cells. J Biol Chem (1984) 1.34
Association of a cyclic AMP-dependent protein kinase with a purified translational inhibitor isolated from hemin-deficient rabbit reticulocyte lysates. Proc Natl Acad Sci U S A (1975) 1.33
Regulation of protein synthesis by phosphorylation of eukaryotic initiation factor 2 alpha in intact reticulocytes and reticulocyte lysates. Proc Natl Acad Sci U S A (1982) 1.32
Regulation of protein synthesis in rabbit reticulocyte lysates: preparation of efficient protein synthesis lysates and the purification and characterization of the heme-regulated translational inhibitory protein kinase. Methods Enzymol (1979) 1.31
Regulation of the reovirus RNA transcriptase by a viral capsomere protein. Virology (1972) 1.27
Hemin enhances the differentiation of mouse 3T3 cells to adipocytes. Cell (1981) 1.27
Effect of geldanamycin on the kinetics of chaperone-mediated renaturation of firefly luciferase in rabbit reticulocyte lysate. Biochemistry (1996) 1.26
On the mechanism of delayed inhibition of protein synthesis in heme-defecient rabbit reticulocyte lysates. Proc Natl Acad Sci U S A (1976) 1.25
Distribution of reversing factor in reticulocyte lysates during active protein synthesis and on inhibition by heme deprivation or double-stranded RNA. Proc Natl Acad Sci U S A (1984) 1.23
Effect of hemin on the synthesis of hemoglobin and other proteins in mammalian cells. Proc Natl Acad Sci U S A (1973) 1.23
Site-specific phosphorylation of the alpha subunit of eukaryotic initiation factor eIF-2 by the heme-regulated and double-stranded RNA-activated eIF-2 alpha kinases from rabbit reticulocyte lysates. Proc Natl Acad Sci U S A (1980) 1.23
Evidence that glucose 6-phosphate regulates protein synthesis initiation in reticulocyte lysates. J Biol Chem (1978) 1.22
Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation. J Biol Chem (1997) 1.21
p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules. Biochemistry (2000) 1.13
Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion. J Biol Chem (2000) 1.13
Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates. Biochemistry (1999) 1.13
In situ phosphorylation of the alpha subunit of eukaryotic initiation factor 2 in reticulocyte lysates inhibited by heme deficiency, double-stranded RNA, oxidized glutathione, or the heme-regulated protein kinase. Proc Natl Acad Sci U S A (1979) 1.13
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Amino acid microsequencing of internal tryptic peptides of heme-regulated eukaryotic initiation factor 2 alpha subunit kinase: homology to protein kinases. Proc Natl Acad Sci U S A (1991) 1.12
Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase. J Biol Chem (2001) 1.11
The regulation of initiation of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2. J Biol Chem (1984) 1.10
Regulation of protein synthesis in rabbit reticulocyte lysates: characteristics of inhibition of protein synthesis by a translational inhibitor from heme-deficient lysates and its relationship to the initiation factor which binds Met-tRNAf. Proc Natl Acad Sci U S A (1976) 1.10
The regeneration of reduced glutathione in normal and glucose-6-phosphate dehydrogenase deficient human red blood cells. Blood (1967) 1.08
Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis. J Biol Chem (2000) 1.08
The 60 S ribosomal subunit as a carrier of eukaryotic initiation factor 2 and the site of reversing factor activity during protein synthesis. J Biol Chem (1985) 1.08
Relationship between phosphorylation and activity of heme-regulated eukaryotic initiation factor 2 alpha kinase. Proc Natl Acad Sci U S A (1981) 1.07
Disulfide bond formation in the regulation of eIF-2 alpha kinase by heme. J Biol Chem (1989) 1.06
Inhibition of rabbit reticulocyte lysate protein synthesis by heavy metal ions involves the phosphorylation of the alpha-subunit of the eukaryotic initiation factor 2. J Biol Chem (1987) 1.06
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Hsp90-mediated folding of the lymphoid cell kinase p56lck. Biochemistry (1996) 1.03
Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice. Proc Natl Acad Sci U S A (2000) 1.03
Regulation of hemoglobin synthesis and proliferation of differentiating erythroid cells by heme-regulated eIF-2alpha kinase. Blood (2000) 1.02
The role of the 90-kDa heat-shock protein and its associated cohorts in stabilizing the heme-regulated eIF-2alpha kinase in reticulocyte lysates during heat stress. Eur J Biochem (1997) 1.02
Characterization of purified double-stranded RNA-activated eIF-2 alpha kinase from rabbit reticulocytes. J Biol Chem (1981) 1.02
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Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90. Dev Biol (1999) 1.00
Characterization of a rat liver factor that inhibits initiation of protein synthesis in rabbit reticulocyte lysates. Proc Natl Acad Sci U S A (1977) 0.99
Separation and identification of type 1 and type 2 protein phosphatases from rabbit reticulocyte lysates. J Biol Chem (1983) 0.98
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Recycling and phosphorylation of eukaryotic initiation factor 2 on 60S subunits of 80S initiation complexes and polysomes. Proc Natl Acad Sci U S A (1992) 0.95
The role of hemin in the regulation of protein synthesis in erythroid cells. Fed Proc (1976) 0.94
Purification and characterization of a latent precursor of a double-stranded RNA dependent protein kinase from reticulocyte lysates. Biochem Biophys Res Commun (1980) 0.93
Characterization of a macromolecular inhibitor of polypeptide chain initiation from Ehrlich ascites tumor cells. Biochem Biophys Res Commun (1976) 0.93