Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes.

PubWeight™: 2.37‹?› | Rank: Top 2%

🔗 View Article (PMC 230887)

Published in Mol Cell Biol on November 01, 1995

Authors

T E Dever1, W Yang, S Aström, A S Byström, A G Hinnebusch

Author Affiliations

1: Section on Molecular Genetics of Lower Eukaryotes, National Institute of Child Health and Human Development, Bethesda, Maryland 20892-2785, USA.

Articles citing this

GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiae. Genes Dev (1997) 3.21

Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2. EMBO J (1999) 2.95

At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation. Mol Cell Biol (1998) 2.79

The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. Genes Dev (1998) 2.75

Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation. Mol Cell Biol (2001) 2.64

Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev (1998) 2.54

eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange. Genes Dev (1998) 2.43

What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame? Genes Dev (2003) 2.40

Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. EMBO J (2003) 2.12

Functions of eIF3 downstream of 48S assembly impact AUG recognition and GCN4 translational control. EMBO J (2004) 2.05

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2. Mol Cell Biol (1997) 1.89

Internal initiation in Saccharomyces cerevisiae mediated by an initiator tRNA/eIF2-independent internal ribosome entry site element. Proc Natl Acad Sci U S A (2001) 1.87

Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells. EMBO J (1997) 1.79

The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo. EMBO J (2005) 1.68

Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR. Genes Dev (2011) 1.62

Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev (2014) 1.59

GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae. Mol Cell Biol (1999) 1.59

Ligand interactions with eukaryotic translation initiation factor 2: role of the gamma-subunit. EMBO J (1996) 1.54

Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. Mol Cell Biol (1996) 1.42

Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. Mol Cell Biol (2000) 1.38

Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation. EMBO J (2002) 1.37

Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity. Mol Cell Biol (2004) 1.34

Eukaryotic translation initiation factor 5 is critical for integrity of the scanning preinitiation complex and accurate control of GCN4 translation. Mol Cell Biol (2005) 1.34

Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Mol Cell Biol (2000) 1.29

A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols. EMBO J (2001) 1.28

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation. Nature (2010) 1.21

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. Elife (2015) 1.19

Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12. Cell Death Dis (2011) 1.17

Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation. Mol Cell Biol (2007) 1.16

Identification of GCD14 and GCD15, novel genes required for translational repression of GCN4 mRNA in Saccharomyces cerevisiae. Genetics (1998) 1.14

Large G3BP-induced granules trigger eIF2α phosphorylation. Mol Biol Cell (2012) 1.10

Rex1p deficiency leads to accumulation of precursor initiator tRNAMet and polyadenylation of substrate RNAs in Saccharomyces cerevisiae. Nucleic Acids Res (2008) 1.07

The A1 x U72 base pair conserved in eukaryotic initiator tRNAs is important specifically for binding to the eukaryotic translation initiation factor eIF2. Mol Cell Biol (1996) 1.06

Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR. BMC Microbiol (2011) 1.05

Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications. BMC Biol (2008) 1.03

Conserved amino acids in each subunit of the heteroligomeric tRNA m1A58 Mtase from Saccharomyces cerevisiae contribute to tRNA binding. Nucleic Acids Res (2007) 1.00

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation. Genes Dev (2013) 0.99

Modulation of yeast genome expression in response to defective RNA polymerase III-dependent transcription. Mol Cell Biol (2005) 0.97

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange. Mol Cell Biol (2007) 0.96

In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents. Bioorg Med Chem Lett (2011) 0.95

Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon. Genes Dev (2014) 0.93

Minimum requirements for the function of eukaryotic translation initiation factor 2. Genetics (2001) 0.93

Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation. J Mol Biol (2009) 0.92

Identification of intersubunit domain interactions within eukaryotic initiation factor (eIF) 2B, the nucleotide exchange factor for translation initiation. J Biol Chem (2012) 0.89

Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae. BMC Biochem (2010) 0.89

Animal virus schemes for translation dominance. Curr Opin Virol (2011) 0.89

The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo. Mol Cell Biol (2010) 0.88

Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation. Proc Natl Acad Sci U S A (2014) 0.85

Guanine nucleotide pool imbalance impairs multiple steps of protein synthesis and disrupts GCN4 translational control in Saccharomyces cerevisiae. Genetics (2010) 0.83

Yeast strains with N-terminally truncated ribosomal protein S5: implications for the evolution, structure and function of the Rps5/Rps7 proteins. Nucleic Acids Res (2009) 0.83

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae. Genetics (2016) 0.82

Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase. J Med Chem (2013) 0.80

Rps5-Rps16 communication is essential for efficient translation initiation in yeast S. cerevisiae. Nucleic Acids Res (2014) 0.78

Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion. Brain Res (2013) 0.77

A yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM disease. PLoS One (2013) 0.77

Analysing GCN4 translational control in yeast by stochastic chemical kinetics modelling and simulation. BMC Syst Biol (2011) 0.76

Unleashing yeast genetics on a factor-independent mechanism of internal translation initiation. Proc Natl Acad Sci U S A (2001) 0.76

Expression of Escherichia coli methionyl-tRNA formyltransferase in Saccharomyces cerevisiae leads to formylation of the cytoplasmic initiator tRNA and possibly to initiation of protein synthesis with formylmethionine. Mol Cell Biol (2002) 0.76

GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells. Amino Acids (2016) 0.75

Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation. PLoS One (2015) 0.75

Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in eukaryotic initiation factor 2B (eIF2B)-mediated translation control and stress response. 3 Biotech (2017) 0.75

Articles cited by this

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30

Transformation of intact yeast cells treated with alkali cations. J Bacteriol (1983) 100.26

Multifunctional yeast high-copy-number shuttle vectors. Gene (1992) 19.47

Yeast/E. coli shuttle vectors with multiple unique restriction sites. Yeast (1986) 17.88

A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics (1987) 14.69

Multiple upstream AUG codons mediate translational control of GCN4. Cell (1986) 8.48

Positive regulation in the general amino acid control of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1983) 6.93

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell (1992) 6.89

Integration of amino acid biosynthesis into the cell cycle of Saccharomyces cerevisiae. J Mol Biol (1975) 6.65

Mechanism and regulation of eukaryotic protein synthesis. Microbiol Rev (1992) 6.27

Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae. Mol Cell Biol (1984) 5.08

Cloning genes by complementation in yeast. Methods Enzymol (1991) 4.72

Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae. Mol Cell Biol (1991) 4.23

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control. Mol Cell Biol (1991) 3.83

Mutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process. Cell (1988) 3.40

GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae. Mol Cell Biol (1991) 3.07

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit. Proc Natl Acad Sci U S A (1989) 3.03

Initiation of protein synthesis in mammalian cells. Biochem J (1986) 2.99

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Proc Natl Acad Sci U S A (1993) 2.90

tRNAi(met) functions in directing the scanning ribosome to the start site of translation. Science (1988) 2.84

Complex formation by positive and negative translational regulators of GCN4. Mol Cell Biol (1991) 2.79

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Mol Cell Biol (1992) 2.51

The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2. J Biol Chem (1988) 2.34

Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Mol Cell Biol (1986) 2.33

Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation. J Biol Chem (1983) 2.31

The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae. Genetics (1990) 2.15

Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.88

Molecular analysis of GCN3, a translational activator of GCN4: evidence for posttranslational control of GCN3 regulatory function. Mol Cell Biol (1988) 1.87

Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2. Mol Cell Biol (1992) 1.86

A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast. Proc Natl Acad Sci U S A (1993) 1.78

GCD11, a negative regulator of GCN4 expression, encodes the gamma subunit of eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.70

Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2. Mol Microbiol (1993) 1.70

Effect of phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 on the function of reversing factor in the initiation of protein synthesis. Proc Natl Acad Sci U S A (1983) 1.69

Mechanism of translational control by partial phosphorylation of the alpha subunit of eukaryotic initiation factor 2. Proc Natl Acad Sci U S A (1984) 1.57

Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2. Mol Cell Biol (1993) 1.57

Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation. Proc Natl Acad Sci U S A (1993) 1.48

Identification and characterization of four new GCD genes in Saccharomyces cerevisiae. Curr Genet (1986) 1.47

Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. Mol Cell Biol (1993) 1.39

Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA. Mol Cell Biol (1994) 1.36

Physiological stresses inhibit guanine-nucleotide-exchange factor in Ehrlich cells. Eur J Biochem (1988) 1.36

Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation. Mol Cell Biol (1994) 1.35

Mutational analysis of conserved positions potentially important for initiator tRNA function in Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.32

Molecular characterization of GCD1, a yeast gene required for general control of amino acid biosynthesis and cell-cycle initiation. Nucleic Acids Res (1988) 1.29

Amino acid sequence similarity between GCN3 and GCD2, positive and negative translational regulators of GCN4: evidence for antagonism by competition. Genetics (1989) 1.29

A functional analysis of the repeated methionine initiator tRNA genes (IMT) in yeast. Mol Gen Genet (1989) 1.20

The methionine initiator tRNA genes of yeast. Gene (1986) 1.09

Translational activation of GCN4 mRNA in a cell-free system is triggered by uncharged tRNAs. Mol Cell Biol (1990) 0.94

Articles by these authors

CHARMM: the biomolecular simulation program. J Comput Chem (2009) 27.71

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis (2001) 12.85

Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) (2008) 9.45

Multiple upstream AUG codons mediate translational control of GCN4. Cell (1986) 8.48

Evidence for translational regulation of the activator of general amino acid control in yeast. Proc Natl Acad Sci U S A (1984) 7.23

Positive regulation in the general amino acid control of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1983) 6.93

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell (1992) 6.89

Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae. J Biol Chem (1983) 6.88

A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci U S A (1998) 6.47

Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae. Microbiol Rev (1988) 6.13

Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol Cell Biol (2001) 6.05

Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication. Cell (2001) 5.93

Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci U S A (2000) 5.49

Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae. Mol Cell Biol (1984) 5.08

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA. Nature (2000) 4.63

Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae. Mol Cell Biol (1991) 4.23

A synthetic HIS4 regulatory element confers general amino acid control on the cytochrome c gene (CYC1) of yeast. Proc Natl Acad Sci U S A (1985) 4.13

A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Mol Cell Biol (1985) 3.98

Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A (1998) 3.88

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control. Mol Cell Biol (1991) 3.83

A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo. Genes Dev (2000) 3.39

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein. EMBO J (2001) 3.23

Hardness, softness, and the fukui function in the electronic theory of metals and catalysis. Proc Natl Acad Sci U S A (1985) 3.12

GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae. Mol Cell Biol (1991) 3.07

A primordial tRNA modification required for the evolution of life? EMBO J (2001) 3.01

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability. Proc Natl Acad Sci U S A (1989) 2.97

Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2. EMBO J (1999) 2.95

Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol (1998) 2.91

Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair. Cell (1999) 2.91

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Proc Natl Acad Sci U S A (1993) 2.90

Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron. Proc Natl Acad Sci U S A (1992) 2.87

Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae. Mol Cell Biol (1990) 2.83

Short-window spectral analysis of cortical event-related potentials by adaptive multivariate autoregressive modeling: data preprocessing, model validation, and variability assessment. Biol Cybern (2000) 2.81

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity. J Mol Biol (2001) 2.80

Complex formation by positive and negative translational regulators of GCN4. Mol Cell Biol (1991) 2.79

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain. Mol Cell (2000) 2.75

The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. Genes Dev (1998) 2.75

The use of global and local molecular parameters for the analysis of the gas-phase basicity of amines. J Am Chem Soc (1986) 2.64

Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation. Mol Cell Biol (2001) 2.64

Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancer. Br J Cancer (2007) 2.62

Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control. Genes Dev (1989) 2.57

Complex formation by all five homologues of mammalian translation initiation factor 3 subunits from yeast Saccharomyces cerevisiae. J Biol Chem (1998) 2.53

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Mol Cell Biol (1992) 2.51

Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair. Mol Cell (2001) 2.46

Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. Cell (1998) 2.46

Prevention of translational frameshifting by the modified nucleoside 1-methylguanosine. Science (1989) 2.43

eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange. Genes Dev (1998) 2.43

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2. Mol Cell Biol (1998) 2.39

Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Mol Cell Biol (1986) 2.33

Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res (2000) 2.32

Reovirus as an oncolytic agent against experimental human malignant gliomas. J Natl Cancer Inst (2001) 2.27

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression. Mol Cell Biol (1990) 2.26

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev (1999) 2.24

Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain. Mol Cell Biol (1998) 2.21

Survival among women with triple receptor-negative breast cancer and brain metastases. Ann Oncol (2009) 2.21

Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistron. Mol Cell Biol (1994) 2.17

Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control. Mol Cell Biol (1994) 2.17

Design of an expression system for detecting folded protein domains and mapping macromolecular interactions by NMR. Protein Sci (1997) 2.16

The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae. Genetics (1990) 2.15

A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. Clin Pharmacol Ther (2012) 2.12

A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcript. Proc Natl Acad Sci U S A (1987) 2.11

Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA. Proc Natl Acad Sci U S A (1989) 2.11

Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator. Mol Cell (1999) 2.09

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae. Mol Cell Biol (1991) 2.09

Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation. EMBO J (2001) 2.06

A versatile synthetic dimerizer for the regulation of protein-protein interactions. Proc Natl Acad Sci U S A (1997) 2.04

Initiator methionine tRNA is essential for Ty1 transposition in yeast. Proc Natl Acad Sci U S A (1992) 2.03

Physical evidence for distinct mechanisms of translational control by upstream open reading frames. EMBO J (2001) 2.02

Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. J Biol Chem (1997) 1.98

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining. EMBO J (2000) 1.94

Medium-chain acyl-CoA dehydrogenase deficiency in children with non-ketotic hypoglycemia and low carnitine levels. Pediatr Res (1983) 1.91

Identification of phosphorylation sites in proteins separated by polyacrylamide gel electrophoresis. Anal Chem (1998) 1.89

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2. Mol Cell Biol (1997) 1.89

Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.88

Molecular analysis of GCN3, a translational activator of GCN4: evidence for posttranslational control of GCN3 regulatory function. Mol Cell Biol (1988) 1.87

Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding. EMBO J (2001) 1.87

Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2. Mol Cell Biol (1992) 1.86

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3. Genes Dev (1995) 1.86

Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.84

Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases. EMBO J (1998) 1.84

Linearly polarized emission from colloidal semiconductor quantum rods. Science (2001) 1.82

Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop. J Biol Chem (2001) 1.82

Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Clin Pharmacol Ther (2008) 1.82

The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2000) 1.81

mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Brain Res Mol Brain Res (1998) 1.78

A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast. Proc Natl Acad Sci U S A (1993) 1.78

The general control of amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae. CRC Crit Rev Biochem (1986) 1.78

A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met. EMBO J (2001) 1.75

Activation of human lung mast cells by monomeric immunoglobulin E. Eur Respir J (2005) 1.74

Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study. Diabetologia (2010) 1.68

The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex. Mol Cell Biol (1998) 1.68

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol Cell Biol (1996) 1.68

Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation. Nucleic Acids Res (1995) 1.66

The transcriptional activator GCN4 contains multiple activation domains that are critically dependent on hydrophobic amino acids. Mol Cell Biol (1995) 1.66

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. Mol Cell Biol (1997) 1.65

The yeast TAF145 inhibitory domain and TFIIA competitively bind to TATA-binding protein. Mol Cell Biol (1998) 1.65

Density-functional theory of the electronic structure of molecules. Annu Rev Phys Chem (1995) 1.64

Concordance of DMET plus genotyping results with those of orthogonal genotyping methods. Clin Pharmacol Ther (2012) 1.62

Fragile X gene instability: anchoring AGGs and linked microsatellites. Am J Hum Genet (1995) 1.61