Published in J Biol Chem on July 10, 1984
Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C. Proc Natl Acad Sci U S A (1989) 2.75
Fluorescence ratio imaging microscopy: temporal and spatial measurements of cytoplasmic pH. J Cell Biol (1987) 2.28
Platelet-derived growth factor-induced alterations in vinculin and actin distribution in BALB/c-3T3 cells. J Cell Biol (1985) 2.26
Fc receptor-mediated phagocytosis occurs in macrophages at exceedingly low cytosolic Ca2+ levels. J Cell Biol (1988) 1.95
A transient rise in cytosolic calcium follows stimulation of quiescent cells with growth factors and is inhibitable with phorbol myristate acetate. J Cell Biol (1985) 1.41
Inositol phosphate metabolism in bradykinin-stimulated human A431 carcinoma cells. Relationship to calcium signalling. Biochem J (1987) 1.39
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Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae. Proc Natl Acad Sci U S A (1997) 1.31
Early changes in inositol lipids and their metabolites induced by platelet-derived growth factor in quiescent Swiss mouse 3T3 cells. Biochem J (1985) 1.29
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Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes. Proc Natl Acad Sci U S A (1986) 1.20
Epidermal growth factor, a vascular smooth muscle mitogen, induces rat aortic contraction. J Clin Invest (1985) 1.19
Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells. Proc Natl Acad Sci U S A (1987) 1.19
Dissociation of cellular responses to epidermal growth factor using anti-receptor monoclonal antibodies. EMBO J (1986) 1.15
Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654. Proc Natl Acad Sci U S A (1985) 1.12
Inhibition of proliferation, but not of Ca2+ mobilization, by cyclic AMP and GMP in rabbit aortic smooth-muscle cells. Biochem J (1992) 1.04
A peptide that inhibits the mitogenic stimulation of Swiss 3T3 cells by bombesin or vasopressin. Biochem J (1985) 1.03
Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin. J Clin Invest (1990) 1.03
Bombesin and platelet-derived growth factor stimulate formation of inositol phosphates and Ca2+ mobilization in Swiss 3T3 cells by different mechanisms. Biochem J (1989) 1.02
Retinoic acid stimulation of human dermal fibroblast proliferation is dependent on suboptimal extracellular Ca2+ concentration. Am J Pathol (1990) 0.98
Epidermal growth factor-urogastrone causes vasodilatation in the anesthetized dog. J Clin Invest (1987) 0.92
Stimulation of polyphosphoinositide hydrolysis by thrombin in membranes from human fibroblasts. Biochem J (1987) 0.91
The influx of Ca2+ induced by the administration of glucagon and Ca2+-mobilizing agents to the perfused rat liver could involve at least two separate pathways. Biochem J (1987) 0.90
PDGF stimulation induces phosphorylation of talin and cytoskeletal reorganization in skeletal muscle. J Cell Biol (1993) 0.89
Activation of single-channel currents in mouse fibroblasts by platelet-derived growth factor. Proc Natl Acad Sci U S A (1989) 0.87
Phospholipid turnover during cell-cycle traverse in synchronous Chinese-hamster ovary cells. Mitogenesis without phosphoinositide breakdown. Biochem J (1988) 0.86
Interaction of atriopeptin III and vasopressin on calcium kinetics and contraction of aortic smooth muscle cells. J Clin Invest (1988) 0.85
Modified kinetics of platelet-derived growth factor-induced Ca2+ increases in NIH-3T3 cells overexpressing phospholipase C gamma 1. Biochem J (1992) 0.84
Chronic ethanol administration to rats decreases receptor-operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5-inositol trisphosphate production: relevance to impaired liver regeneration. J Clin Invest (1996) 0.82
Structural and functional aspects of platelet-derived growth factor. Br J Cancer (1988) 0.82
Cellular mechanisms of adrenaline-induced hyperpolarization in renal epitheloid MDCK cells. Biochem J (1991) 0.80
Desensitization of the Ca2+-mobilizing system to serum growth factors by Ha-ras and v-mos. Mol Cell Biol (1988) 0.80
Epithelial impedance analysis in experimentally induced colon cancer. Biophys J (1987) 0.79
Platelet-derived growth factor receptor independent proliferation of human glioblastoma cells: selective tyrosine kinase inhibitors lack antiproliferative activity. J Cancer Res Clin Oncol (2006) 0.79
The free cytoplasmic calcium concentration of tumorigenic and non-tumorigenic human somatic cell hybrids. Br J Cancer (1985) 0.79
Activation of phospholipase A2 and stimulation of prostaglandin E2 production by transforming growth factor-alpha in rat thymic epithelial cells requires influx of calcium. Biochem J (1993) 0.79
Membrane conductance oscillations induced by serum in quiescent human skin fibroblasts. J Physiol (1989) 0.79
Vasoactive intestinal peptide in the human pituitary gland and adenomas. An immunocytochemical study. Am J Pathol (1989) 0.78
Inhibition of Ca2+ inflow causes an abrupt cessation of growth-factor-induced repetitive free Ca2+ transients in single NIH-3T3 cells. Biochem J (1991) 0.78
The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation. Biomaterials (2014) 0.76
NIH-3T3 cells transformed with a ras oncogene exhibit a protein kinase C-mediated inhibition of agonist-stimulated Ca2+ inflow. Biochem J (1990) 0.76
Activation of the Na+/H+ antiport is not required for epidermal growth factor-dependent gene expression, growth inhibition or proliferation in human breast cancer cells. Biochem J (1989) 0.75
Accumulation of PDGF+ cells and internalisation of the PDGF receptor at myotendinous junction following modified hindlimb muscle use in the rat. J Anat (2000) 0.75
Purification and characterization of the 27,000 Da calcium-binding protein of bovine brain. Biochem J (1987) 0.75
Future prospects for calcium antagonists. Drugs (1994) 0.75
Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins. Cell (1989) 4.88
Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J Cell Biol (1994) 3.65
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts. Nature (1983) 3.47
The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem J (1993) 3.01
Growth factor-like action of phosphatidic acid. Nature (1986) 2.87
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J Cell Biol (1998) 2.81
The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein. Curr Biol (1998) 2.80
Ionic currents in cultured mouse neuroblastoma cells under voltage-clamp conditions. J Physiol (1978) 2.59
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts. Proc Natl Acad Sci U S A (1993) 2.51
Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action. J Biol Chem (1990) 2.31
Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH. Nature (1984) 2.26
Effects of growth factors on intracellular pH regulation. Annu Rev Physiol (1986) 2.25
Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochem J (1992) 2.10
Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid. EMBO J (1992) 1.97
Epidermal growth factor induces electrically silent Na+ influx in human fibroblasts. J Biol Chem (1982) 1.96
Cell-cell adhesion mediated by a receptor-like protein tyrosine phosphatase. J Biol Chem (1993) 1.94
Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. EMBO J (1998) 1.92
Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. EMBO J (1996) 1.90
The epidermal growth factor-induced calcium signal in A431 cells. J Biol Chem (1986) 1.85
Rac mediates growth factor-induced arachidonic acid release. Cell (1995) 1.83
The calcium current and the activation of a slow potassium conductance in voltage-clamped mouse neuroblastoma cells. J Physiol (1979) 1.81
Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action. Cell Growth Differ (1993) 1.80
Gap junction protein connexin-43 interacts directly with microtubules. Curr Biol (2001) 1.76
Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction. Mol Biol Cell (1999) 1.76
Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers. J Cell Biol (1992) 1.76
Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway. J Biol Chem (1994) 1.72
Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors. J Cell Biol (1989) 1.68
Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1. Biochem J (1998) 1.67
Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase. FEBS Lett (1991) 1.66
Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids. Biochem J (1994) 1.64
Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. J Cell Biol (1997) 1.64
Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase. J Biol Chem (1999) 1.61
Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA. J Cell Sci (1997) 1.61
Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation. EMBO J (1993) 1.57
Sodium/proton exchange in mouse neuroblastoma cells. J Biol Chem (1981) 1.51
Ionic responses and growth stimulation induced by nerve growth factor and epidermal growth factor in rat pheochromocytoma (PC12) cells. J Cell Biol (1983) 1.51
Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain. J Biol Chem (1995) 1.48
Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts. J Biol Chem (1993) 1.48
New membrane formation during cytokinesis in normal and cytochalasin B-treated eggs of Xenopus laevis. I. Electron microscope observations. J Cell Biol (1973) 1.45
Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products. Cell (1993) 1.45
Epidermal growth factor activates calcium channels by phospholipase A2/5-lipoxygenase-mediated leukotriene C4 production. Cell (1992) 1.44
Rapid ionic events and the initiation of growth in serum-stimulated neuroblastoma cells. Cell (1981) 1.44
Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Mol Cell Biol (1993) 1.43
Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem (2001) 1.43
Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. J Biol Chem (2000) 1.41
Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances. J Biol Chem (1993) 1.40
Inositol phosphate metabolism in bradykinin-stimulated human A431 carcinoma cells. Relationship to calcium signalling. Biochem J (1987) 1.39
cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts. J Biol Chem (1994) 1.38
Malignant effusions contain lysophosphatidic acid (LPA)-like activity. Ann Oncol (1998) 1.35
Cell surface expression of receptor protein tyrosine phosphatase RPTP mu is regulated by cell-cell contact. J Cell Biol (1995) 1.34
Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator. Biochim Biophys Acta (1994) 1.33
Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. J Biol Chem (2000) 1.33
The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin. Biochem J (1992) 1.33
The calcium action potential and a prolonged calcium dependent after-hyperpolarization in mouse neuroblastoma cells. J Physiol (1979) 1.31
Activation of the osmo-sensitive chloride conductance involves P21rho and is accompanied by a transient reorganization of the F-actin cytoskeleton. Mol Biol Cell (1996) 1.30
Visualization of epidermal growth factor receptor in cryosections of cultured A431 cells by immuno-gold labeling. Eur J Cell Biol (1985) 1.30
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The regulation of cytoplasmic pH in human fibroblasts. J Biol Chem (1984) 1.25
Gi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc. EMBO J (1997) 1.23
Epidermal-growth-factor-induced formation of inositol phosphates in human A431 cells. Differences from the effect of bradykinin. Biochem J (1988) 1.23
Direct visualization and quantitative analysis of epidermal growth factor-induced receptor clustering. J Cell Physiol (1988) 1.21
Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn). J Biol Chem (2000) 1.21
Simple computer method for evaluation of lateral diffusion coefficients from fluorescence photobleaching recovery kinetics. Biophys J (1983) 1.18
In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation. Oncogene (2008) 1.17
Lateral diffusion of membrane lipids and proteins is increased specifically in neurites of differentiating neuroblastoma cells. Biochim Biophys Acta (1979) 1.15
Dissociation of cellular responses to epidermal growth factor using anti-receptor monoclonal antibodies. EMBO J (1986) 1.15
Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. Oncogene (2001) 1.15
The cell cycle, cell death, and cell morphology during retinoic acid-induced differentiation of embryonal carcinoma cells. Dev Biol (1984) 1.15
Short-term desensitization of the histamine H1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways. Br J Pharmacol (1992) 1.14
Acute loss of cell-cell communication caused by G protein-coupled receptors: a critical role for c-Src. J Cell Biol (1998) 1.14
Retinoic acid resistance of estradiol-independent breast cancer cells coincides with diminished retinoic acid receptor function. Mol Cell Endocrinol (1993) 1.10