Published in J Cell Biol on June 29, 1998
Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol (1999) 8.66
p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol (2000) 3.60
Microtubule targeting of substrate contacts promotes their relaxation and dissociation. J Cell Biol (1999) 3.53
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol (1999) 3.43
The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med (2009) 3.05
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The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts. J Cell Biol (2002) 2.05
Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol Biol Cell (2004) 1.98
Guiding neuronal growth cones using Ca2+ signals. Trends Cell Biol (2004) 1.97
Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J Cell Biol (2000) 1.94
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The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. J Cell Biol (2002) 1.86
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Mol Biol Cell (2003) 1.82
Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80
Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction. Mol Biol Cell (1999) 1.76
Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol (1999) 1.72
The Rho-associated protein kinase p160ROCK is required for centrosome positioning. J Cell Biol (2002) 1.65
Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions. Mol Biol Cell (2001) 1.64
Dendritic fibroblasts in three-dimensional collagen matrices. Mol Biol Cell (2003) 1.61
Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. Mol Biol Cell (2000) 1.58
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol (2005) 1.56
Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity. J Cell Biol (2002) 1.54
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ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J Cell Biol (2008) 1.37
Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering. Mol Biol Cell (2000) 1.31
Myosin IIA drives neurite retraction. Mol Biol Cell (2003) 1.24
Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells. Mol Cell Biol (2000) 1.24
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Gene expression profiles at different stages of human esophageal squamous cell carcinoma. World J Gastroenterol (2003) 1.19
Promotion of neurite and filopodium formation by CD47: roles of integrins, Rac, and Cdc42. Mol Biol Cell (2004) 1.16
p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis. Mol Biol Cell (2004) 1.13
A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells. Neural Dev (2008) 1.10
Cell-intrinsic drivers of dendrite morphogenesis. Development (2013) 1.06
Regulation of SNAREs by tomosyn and ROCK: implication in extension and retraction of neurites. J Cell Biol (2004) 1.05
GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction. Mol Biol Cell (2006) 1.04
A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases. Biochem J (2002) 0.99
Propagating cell-membrane waves driven by curved activators of actin polymerization. PLoS One (2011) 0.99
Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling. J Biol Chem (2009) 0.99
Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. Mol Cell Biol (2001) 0.99
ROCK and PRK-2 mediate the inhibitory effect of Y-27632 on polyglutamine aggregation. FEBS Lett (2008) 0.98
Rho kinases regulate the renewal and neural differentiation of embryonic stem cells in a cell plating density-dependent manner. PLoS One (2010) 0.97
Apical movement during interkinetic nuclear migration is a two-step process. Dev Biol (2012) 0.96
Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines: actin depolymerization by Ca(2+)-alpha-actinin and polymerization by rho. Mol Biol Cell (2002) 0.96
Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis. Dev Biol (2006) 0.94
Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants. Neurotoxicology (2008) 0.94
Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells. Oncotarget (2015) 0.94
Myosin II is a negative regulator of oligodendrocyte morphological differentiation. J Neurosci Res (2012) 0.93
ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity. J Cell Biol (2015) 0.93
Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines. Cytoskeleton (Hoboken) (2012) 0.93
Differential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowth. Am J Pathol (2009) 0.93
Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers. PLoS One (2014) 0.92
Outgrowth of neurites from NIE-115 neuroblastoma cells is prevented on repulsive substrates through the action of PAK. Mol Cell Biol (2005) 0.92
Calcium-sensing receptor modulates cell adhesion and migration via integrins. J Biol Chem (2011) 0.92
Inhibition of the Rho signaling pathway improves neurite outgrowth and neuronal differentiation of mouse neural stem cells. Int J Physiol Pathophysiol Pharmacol (2013) 0.90
New insights into the structure-function relationships of Rho-associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implications. Biochem J (2004) 0.89
Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: requirement for two different tyrosine kinases. Biochem J (1999) 0.89
Astrocyte stellation, a process dependent on Rac1 is sustained by the regulated exocytosis of enlargeosomes. Glia (2011) 0.89
Rapid microtubule-dependent induction of neurite-like extensions in NIH 3T3 fibroblasts by inhibition of ROCK and Cbl. Mol Biol Cell (2003) 0.89
Spatiotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA. Mol Biol Cell (2009) 0.89
Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth. J Biol Chem (2010) 0.88
Localized alteration of microtubule polymerization in response to guidance cues. J Neurosci Res (2010) 0.86
Molecular decipherment of Rho effector pathways regulating tight-junction permeability. Biochem J (2000) 0.86
Dopamine D2 receptor stimulation potentiates PolyQ-Huntingtin-induced mouse striatal neuron dysfunctions via Rho/ROCK-II activation. PLoS One (2009) 0.86
RhoA GTPase and F-actin dynamically regulate the permeability of Cx43-made channels in rat cardiac myocytes. J Biol Chem (2008) 0.86
Regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDIα. J Biol Chem (2012) 0.85
The flavonoid isoquercitrin promotes neurite elongation by reducing RhoA activity. PLoS One (2012) 0.85
Enhanced neurite outgrowth of human model (NT2) neurons by small-molecule inhibitors of Rho/ROCK signaling. PLoS One (2015) 0.83
Pharmacological inhibition of Rho-kinase (ROCK) signaling enhances cisplatin resistance in neuroblastoma cells. Int J Oncol (2010) 0.82
Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth. J Biol Chem (2010) 0.82
Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities. Int J Biochem Mol Biol (2012) 0.82
Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons. Mol Brain (2008) 0.81
Contribution of cytoskeletal elements to the axonal mechanical properties. J Biol Eng (2013) 0.81
Nir2, a novel regulator of cell morphogenesis. Mol Cell Biol (2002) 0.81
Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem (2011) 0.80
Neuronal differentiation by analogs of staurosporine. Neurochem Int (2010) 0.79
Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.79
Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons. J Neurosci (2013) 0.78
ROCK1 and ROCK2 inhibition alters dendritic spine morphology in hippocampal neurons. Cell Logist (2016) 0.78
Drosophila non-muscle myosin II motor activity determines the rate of tissue folding. Elife (2016) 0.77
Vital role of protein kinase C-related kinase in the formation and stability of neurites during hypoxia. J Neurochem (2010) 0.77
Lysophospholipid receptors LPA1-3 are not required for the inhibitory effects of LPA on mouse retinal growth cones. Eye Brain (2016) 0.77
Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling. J Cell Biol (2016) 0.76
Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling. Front Pharmacol (2013) 0.76
Unraveling the determinants of protrusion formation. Int J Cell Biol (2012) 0.76
ROCK inhibition enhances neurite outgrowth in neural stem cells by upregulating YAP expression in vitro. Neural Regen Res (2016) 0.76
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. J Neurosci Res (2016) 0.75
The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus. Int J Neuropsychopharmacol (2016) 0.75
Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression. PLoS One (2015) 0.75
Cytotoxic necrotizing factor-2 of Escherichia coli alters the morphology of cultured hippocampal neurons. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.75
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