Published in Biochemistry on October 14, 1980
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Scrapie prion proteins are synthesized in neurons. Am J Pathol (1986) 2.54
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Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. J Cell Biol (1990) 2.42
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Prions adhere to soil minerals and remain infectious. PLoS Pathog (2006) 2.32
Recombinant scrapie-like prion protein of 106 amino acids is soluble. Proc Natl Acad Sci U S A (1996) 2.12
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Propagation of prion strains through specific conformers of the prion protein. J Virol (1997) 1.35
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Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity. J Virol (1996) 1.30
Sulfated glycosaminoglycans in amyloid plaques of prion diseases. Acta Neuropathol (1989) 1.26
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Prion liposomes. Biochem J (1990) 1.23
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Three hamster species with different scrapie incubation times and neuropathological features encode distinct prion proteins. Mol Cell Biol (1990) 1.17
Primary structure of prion protein may modify scrapie isolate properties. Proc Natl Acad Sci U S A (1989) 1.12
Scrapie and Creutzfeldt-Jakob disease prion proteins share physical properties and antigenic determinants. Proc Natl Acad Sci U S A (1985) 1.07
Characterization of prion protein (PrP)-derived peptides that discriminate full-length PrPSc from PrPC. Proc Natl Acad Sci U S A (2007) 1.07
Ultrastructural studies on scrapie prion protein crystals obtained from reverse micellar solutions. Biophys J (1999) 0.97
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Inactivation of the scrapie agent by pronase. Can J Comp Med (1983) 0.84
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There is no safe dose of prions. PLoS One (2011) 0.82
Detergents modify proteinase K resistance of PrP Sc in different transmissible spongiform encephalopathies (TSEs). Vet Microbiol (2011) 0.81
Use of proteinase K nonspecific digestion for selective and comprehensive identification of interpeptide cross-links: application to prion proteins. Mol Cell Proteomics (2012) 0.77
Peroxymonosulfate Rapidly Inactivates the Disease-Associated Prion Protein. Environ Sci Technol (2016) 0.75
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Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature (1988) 10.69
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature (1992) 9.01
Eight prion strains have PrP(Sc) molecules with different conformations. Nat Med (1998) 9.01
A cellular gene encodes scrapie PrP 27-30 protein. Cell (1985) 8.86
Association of the APC gene product with beta-catenin. Science (1993) 8.20
Scrapie prions aggregate to form amyloid-like birefringent rods. Cell (1983) 7.92
Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region. Cell (1988) 7.14
Identification of a protein that purifies with the scrapie prion. Science (1982) 7.00
A protease-resistant protein is a structural component of the scrapie prion. Cell (1983) 6.72
Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity. Science (1996) 6.71
Purification and structural studies of a major scrapie prion protein. Cell (1984) 5.98
Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion. Biochemistry (1972) 5.71
Calculation of protein conformation from circular dichroism. Methods Enzymol (1986) 5.68
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein. Cell (1995) 5.16
Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell (1987) 5.12
A multiple sequence alignment program. Nucleic Acids Res (1986) 5.09
Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest (1987) 4.98
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell (1986) 4.82
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell (1989) 4.73
Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome. Nature (1989) 4.69
Separation and properties of cellular and scrapie prion proteins. Proc Natl Acad Sci U S A (1986) 4.38
Spontaneous neurodegeneration in transgenic mice with mutant prion protein. Science (1990) 4.19
Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible. Proc Natl Acad Sci U S A (1997) 4.10
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Further purification and characterization of scrapie prions. Biochemistry (1982) 4.01
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation. Proc Natl Acad Sci U S A (1997) 3.78
A transmembrane form of the prion protein in neurodegenerative disease. Science (1998) 3.76
An efficient method for finding repeats in molecular sequences. Nucleic Acids Res (1983) 3.74
Linkage of prion protein and scrapie incubation time genes. Cell (1986) 3.69
Measurement of the scrapie agent using an incubation time interval assay. Ann Neurol (1982) 3.68
Regional mapping of prion proteins in brain. Proc Natl Acad Sci U S A (1992) 3.68
Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J Cell Biol (1995) 3.66
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry (1993) 3.54
Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. J Cell Biol (1990) 3.46
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44
Structural clues to prion replication. Science (1994) 3.43
Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans. Proc Natl Acad Sci U S A (1999) 3.43
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform. Proc Natl Acad Sci U S A (1997) 3.42
Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc Natl Acad Sci U S A (2001) 3.39
Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins. J Virol (1988) 3.37
Distinct prion proteins in short and long scrapie incubation period mice. Cell (1987) 3.21
Isolation of the yeast calmodulin gene: calmodulin is an essential protein. Cell (1986) 3.17
Antibodies to a scrapie prion protein. Nature (1984) 3.09
Identification of prion amyloid filaments in scrapie-infected brain. Cell (1985) 3.04
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform. J Mol Biol (1997) 2.95
Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes. Cell (1993) 2.93
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J Mol Biol (1999) 2.92
Rapid detection of Creutzfeldt-Jakob disease and scrapie prion proteins. Neurology (1990) 2.90
Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters. Genes Dev (1992) 2.87
A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes. Proc Natl Acad Sci U S A (1988) 2.84
Transmissible and genetic prion diseases share a common pathway of neurodegeneration. Nature (1999) 2.83
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. Proc Natl Acad Sci U S A (1996) 2.79
Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature (2001) 2.78
Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1984) 2.74
Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein. Proc Natl Acad Sci U S A (1994) 2.70
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins. Cell (1994) 2.68
Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J Biol Chem (1992) 2.67
Chimeric prion protein expression in cultured cells and transgenic mice. Protein Sci (1992) 2.67
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid. Proc Natl Acad Sci U S A (1992) 2.64
Mapping the prion protein using recombinant antibodies. J Virol (1998) 2.64
Purified prion proteins and scrapie infectivity copartition into liposomes. Proc Natl Acad Sci U S A (1987) 2.61
Strain-specified relative conformational stability of the scrapie prion protein. Protein Sci (2001) 2.60
Scrapie prion proteins are synthesized in neurons. Am J Pathol (1986) 2.54
Pathologic conformations of prion proteins. Annu Rev Biochem (1998) 2.50
Copper binding to the prion protein: structural implications of four identical cooperative binding sites. Proc Natl Acad Sci U S A (1999) 2.44
Molecular cloning of a human prion protein cDNA. DNA (1986) 2.43
Prion protein gene variation among primates. J Mol Biol (1995) 2.43
Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. J Cell Biol (1990) 2.42
Scrapie PrP 27-30 is a sialoglycoprotein. J Virol (1985) 2.40
Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. Genes Dev (1996) 2.39
Cultured cell sublines highly susceptible to prion infection. J Virol (2000) 2.38
Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice. Proc Natl Acad Sci U S A (1994) 2.38
Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein. Proc Natl Acad Sci U S A (1994) 2.37
Purification and properties of the cellular and scrapie hamster prion proteins. Eur J Biochem (1988) 2.35
Prion protein selectively binds copper(II) ions. Biochemistry (1998) 2.32
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. J Virol (1997) 2.32
Changes in the localization of brain prion proteins during scrapie infection. Neurology (1987) 2.27
Nucleotide sequence of the yeast 5S ribosomal RNA gene and adjacent putative control regions. Nature (1977) 2.15
Synthesis and trafficking of prion proteins in cultured cells. Mol Biol Cell (1992) 2.14
Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time. Mol Cell Biol (1988) 2.14