Published in Am J Med Genet on March 01, 1983
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Family-based association tests for genomewide association scans. Am J Hum Genet (2007) 10.67
Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19
Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am J Hum Genet (1993) 4.13
An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. Am J Hum Genet (1998) 3.16
Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results. Am J Hum Genet (1999) 2.88
Genetics of brain fiber architecture and intellectual performance. J Neurosci (2009) 2.42
Determinants of coronary artery and aortic calcification in the Old Order Amish. Circulation (2007) 2.02
A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans. Am J Hum Genet (2001) 1.91
Heritability in the genome-wide association era. Hum Genet (2012) 1.76
Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism. Am J Hum Genet (1988) 1.68
Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment. Am J Hum Genet (2004) 1.51
Variance component methods for analysis of complex phenotypes. Cold Spring Harb Protoc (2010) 1.44
Genetic influences on behavioral inhibition and anxiety in juvenile rhesus macaques. Genes Brain Behav (2007) 1.35
Multivariate variance-components analysis of longitudinal blood pressure measurements from the Framingham Heart Study. BMC Genet (2003) 1.34
A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype. Am J Hum Genet (1990) 1.28
Genetic linkage analysis of a dichotomous trait incorporating a tightly linked quantitative trait in affected sib pairs. Am J Hum Genet (2003) 1.26
Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene. Proc Natl Acad Sci U S A (2012) 1.24
An approximate model of polygenic inheritance. Genetics (1997) 1.13
Human pedigree-based quantitative-trait-locus mapping: localization of two genes influencing HDL-cholesterol metabolism. Am J Hum Genet (1999) 1.08
Genetic determination and correlation of body mass index and bone mineral density at the spine and hip in Chinese Han ethnicity. Osteoporos Int (2005) 1.08
The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults. Am J Epidemiol (2008) 1.04
Genetic contribution to biological aging: the Framingham Study. J Gerontol A Biol Sci Med Sci (2004) 1.00
Human helminth co-infection: no evidence of common genetic control of hookworm and Schistosoma mansoni infection intensity in a Brazilian community. Int J Parasitol (2009) 0.95
Multivariate models for human genetic analysis: aggregation, coaggregation, and tracking of systolic blood pressure and weight. Am J Hum Genet (1983) 0.95
Mammographic breast density--evidence for genetic correlations with established breast cancer risk factors. Cancer Epidemiol Biomarkers Prev (2008) 0.95
Heritability and shared environment estimates for myopia and associated ocular biometric traits: the Genes in Myopia (GEM) family study. Hum Genet (2007) 0.95
Genetic influences on peripheral blood cell counts: a study in baboons. Blood (2005) 0.94
A genetic contribution to circulating cytokines and obesity in children. Cytokine (2008) 0.91
A nonsynonymous SNP within PCDH15 is associated with lipid traits in familial combined hyperlipidemia. Hum Genet (2009) 0.89
Genetic and household determinants of predisposition to human hookworm infection in a Brazilian community. J Infect Dis (2010) 0.89
The contribution of pleiotropy to blood pressure and body-mass index variation: the Gubbio Study. Am J Hum Genet (1994) 0.89
Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study. J Hypertens (2008) 0.89
Genomic susceptibility Loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships. Arch Neurol (2009) 0.88
Quantitative genetics of cortical bone mass in healthy 10-year-old children from the Fels Longitudinal Study. Bone (2006) 0.85
Genetic factors influence serological measures of common infections. Hum Hered (2011) 0.85
Mixed effects models for quantitative trait loci mapping with inbred strains. Genetics (2008) 0.84
Estimating polygenic models for multivariate data on large pedigrees. Genetics (1992) 0.84
Association of regions on chromosomes 6 and 7 with blood pressure in Nigerian families. Circ Cardiovasc Genet (2009) 0.83
Does the PI polymorphism alone control alpha-1-antitrypsin expression? Am J Hum Genet (1987) 0.82
Genetic integration of molar cusp size variation in baboons. Am J Phys Anthropol (2010) 0.80
Quantitative Genetics, Pleiotropy, and Morphological Integration in the Dentition of Papio hamadryas. Evol Biol (2009) 0.80
Modularity in the mammalian dentition: mice and monkeys share a common dental genetic architecture. J Exp Zool B Mol Dev Evol (2011) 0.79
Genetic epidemiology of cardiometabolic risk factors and their clustering patterns in Mexican American children and adolescents: the SAFARI Study. Hum Genet (2013) 0.79
Shared genetic architecture in the relationship between adult stature and subclinical coronary artery atherosclerosis. Atherosclerosis (2011) 0.79
Skeletal growth and the changing genetic landscape during childhood and adulthood. Am J Phys Anthropol (2013) 0.79
Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes. Hum Genet (2013) 0.78
Genetic and environmental correlations between bone phenotypes and anthropometric indices in Chinese. Osteoporos Int (2005) 0.78
Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens. Genet Epidemiol (2014) 0.77
Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study. PLoS One (2015) 0.76
Quantifying the relationship between gene expressions and trait values in general pedigrees. Genetics (2004) 0.76
A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes. Stat Biosci (2009) 0.75
Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil. Ann Hum Genet (2014) 0.75
Genetic architecture of knee radiographic joint space in healthy young adults. Hum Biol (2008) 0.75
Linkage analysis of obesity phenotypes in pre- and post-menopausal women from a United States mid-western population. BMC Med Genet (2010) 0.75
Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits. BMC Proc (2007) 0.75
Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children. Am J Clin Nutr (2017) 0.75
Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet (1996) 17.95
Extensions to pedigree analysis I. Likehood calculations for simple and complex pedigrees. Hum Hered (1975) 16.67
Programs for Pedigree Analysis: MENDEL, FISHER, and dGENE. Genet Epidemiol (1988) 13.73
The affected-pedigree-member method of linkage analysis. Am J Hum Genet (1988) 13.67
EM reconstruction algorithms for emission and transmission tomography. J Comput Assist Tomogr (1984) 6.54
Statistical analysis of multilocus recombination. Biometrics (1983) 6.49
An alternative model of recombination and interference. Ann Hum Genet (1979) 6.26
Estimating kinetic constants from single channel data. Biophys J (1983) 6.14
Extensions to pedigree analysis. III. Variance components by the scoring method. Ann Hum Genet (1976) 5.86
A conditional inference framework for extending the transmission/disequilibrium test. Hum Hered (1998) 5.70
How many polymorphic genes will it take to span the human genome? Am J Hum Genet (1982) 5.11
Loss of information due to ambiguous haplotyping of SNPs. Nat Genet (1999) 4.90
Computer programs for multilocus haplotyping of general pedigrees. Am J Hum Genet (1995) 4.51
Improved inference of relationship for pairs of individuals. Am J Hum Genet (2000) 4.47
Estimating the power of a proposed linkage study for a complex genetic trait. Am J Hum Genet (1989) 4.42
Use of population isolates for mapping complex traits. Nat Rev Genet (2000) 4.28
An algorithm for automatic genotype elimination. Am J Hum Genet (1987) 4.18
Metropolis sampling in pedigree analysis. Stat Methods Med Res (1993) 4.04
Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care (1998) 3.99
Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J Natl Cancer Inst (1997) 3.92
Localization of an ataxia-telangiectasia gene to chromosome 11q22-23. Nature (1988) 3.82
Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am J Hum Genet (1993) 3.76
The role of early HIV infection in the spread of HIV through populations. J Acquir Immune Defic Syndr Hum Retrovirol (1997) 3.75
Extensions to pedigree analysis. V. Optimal calculation of Mendelian likelihoods. Hum Hered (1983) 3.74
The affected sib-pair method using identity by state relations. Am J Hum Genet (1986) 3.63
Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers. Proc Natl Acad Sci U S A (1989) 3.50
The prior probability of autosomal linkage. Ann Hum Genet (1975) 3.45
A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data. Am J Hum Genet (2000) 3.22
Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies. Nat Genet (2001) 3.20
Identifying marker typing incompatibilities in linkage analysis. Am J Hum Genet (1996) 3.06
Statistical analysis of single sodium channels. Effects of N-bromoacetamide. Biophys J (1984) 3.01
Estimating the power of a proposed linkage study: a practical computer simulation approach. Am J Hum Genet (1986) 2.84
Genetic counseling for families with inherited susceptibility to breast and ovarian cancer. JAMA (1993) 2.51
EM algorithms without missing data. Stat Methods Med Res (1997) 2.39
The calcium scare--what would Austin Bradford Hill have thought? Osteoporos Int (2011) 2.35
A single dominant gene can account for eye tracking dysfunctions and schizophrenia in offspring of discordant twins. Arch Gen Psychiatry (1988) 2.21
Statistical methods for multipoint radiation hybrid mapping. Am J Hum Genet (1991) 2.16
Fast computation of genetic likelihoods on human pedigree data. Hum Hered (1992) 2.15
Statistical methods for polyploid radiation hybrid mapping. Genome Res (1995) 2.15
Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type. J Neurogenet (1987) 2.12
Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium. Am J Hum Genet (1995) 2.07
Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genet Epidemiol (1996) 2.06
Genetic linkage analysis of complex genetic traits by using affected sibling pairs. Biometrics (1998) 2.04
Application of a recombination model in calculating the variance of sib pair genetic identity. Ann Hum Genet (1979) 2.01
Genetic linkage of Beckwith-Wiedemann syndrome to 11p15. Am J Hum Genet (1989) 1.99
Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. Proc Natl Acad Sci U S A (1999) 1.91
BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. Am J Hum Genet (1993) 1.90
Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis. Medicine (Baltimore) (1991) 1.89
Ascertainment and goodness of fit of variance component models for pedigree data. Prog Clin Biol Res (1984) 1.89
A look at linkage disequilibrium. Nat Genet (2000) 1.87
Nephritis caused by Streptococcus zooepidemicus (Lancefield group C). Lancet (1983) 1.86
Accurate and superaccurate gene mapping. Am J Hum Genet (1985) 1.85
Stimulation of human leukocyte thromboplastic activity by endotoxin. Proc Soc Exp Biol Med (1971) 1.79
Multipoint linkage map of the human pseudoautosomal region, based on single-sperm typing: do double crossovers occur during male meiosis? Am J Hum Genet (1994) 1.78
Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators. Hum Hered (1999) 1.76
Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups. Am J Hum Genet (2001) 1.72
Routine immunohistology in renal diseases. Ann Intern Med (1966) 1.69
Ordering three DNA polymorphisms on human chromosome 3 by sperm typing. Genomics (1991) 1.69
The genetic transmission of schizophrenia: application of Mendelian latent structure analysis to eye tracking dysfunctions in schizophrenia and affective disorder. J Psychiatr Res (1986) 1.65
Sensor-augmented pump therapy from the diagnosis of childhood type 1 diabetes: results of the Paediatric Onset Study (ONSET) after 12 months of treatment. Diabetologia (2010) 1.48
A theoretical study of some maximum likelihood algorithms for emission and transmission tomography. IEEE Trans Med Imaging (1987) 1.48
Preliminary ranking procedures for multilocus ordering. Genomics (1987) 1.45
Mapping of a gene for autosomal dominant juvenile-onset open-angle glaucoma to chromosome Iq. Am J Hum Genet (1994) 1.44
Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science (1988) 1.44
Autosomal dominant nanophthalmos (NNO1) with high hyperopia and angle-closure glaucoma maps to chromosome 11. Am J Hum Genet (1998) 1.40
The effects of conditioning on probands to correct for multiple ascertainment. Am J Hum Genet (1984) 1.40
Multilocus ordering strategies based on sperm typing. Ann Hum Genet (1990) 1.40
Two models for a maternal factor in the inheritance of Huntington disease. Am J Hum Genet (1983) 1.37
Application of the lod method to the detection of linkage between a quantitative trait and a qualitative marker: a simulation experiment. Am J Hum Genet (1976) 1.37
A goodness-of-fit test for the polygenic threshold model: application to pyloric stenosis. Am J Med Genet (1978) 1.37
Approximate confidence intervals for risk prediction in genetic counseling. Am J Hum Genet (1986) 1.31
Gamete-competition models. Am J Hum Genet (2000) 1.28
The frequency of C4B variants of complement in familial and sporadic Alzheimer disease. Alzheimer Dis Assoc Disord (1987) 1.27
A multilocus extension of the affected-pedigree-member method of linkage analysis. Am J Hum Genet (1992) 1.26
Trials, tribulations, and triumphs of the EM algorithm in pedigree analysis. IMA J Math Appl Med Biol (1989) 1.25
A primary linkage map of the human chromosome 11q22-23 region. Genomics (1990) 1.25
Experimental design and error detection for polyploid radiation hybrid mapping. Genome Res (1995) 1.24
A new class of organic nitrates: investigations on bioactivation, tolerance and cross-tolerance phenomena. Br J Pharmacol (2009) 1.24
The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease. Am J Hum Genet (1994) 1.23
Partial characterization of antigenic streptococcal plasma membrane components in acute glomerulonephritis. J Clin Invest (1970) 1.20
Effects of reproductive compensation and genetic drift on X-linked lethals. Am J Hum Genet (1978) 1.20
Ethanol stimulates formation of leukotriene C4 in rat gastric mucosa. Prostaglandins (1986) 1.19
Grouped-coordinate ascent algorithms for penalized-likelihood transmission image reconstruction. IEEE Trans Med Imaging (1997) 1.18
Penalized regression for genome-wide association screening of sequence data. Pac Symp Biocomput (2011) 1.17
The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences. Diabetes (2001) 1.17
Multipoint mapping calculations for sperm-typing data. Am J Hum Genet (1994) 1.16
Diagnosis of human cytomegalovirus-induced retinitis in human immunodeficiency virus type 1-infected subjects by using the polymerase chain reaction. J Clin Microbiol (1991) 1.16
Evidence for the in situ origin of poststreptococcal glomerulonephritis: glomerular localization of endostreptosin and the clinical significance of the subsequent antibody response. Clin Nephrol (1983) 1.16
Comments on lack of interference in the four strand model of crossing over. J Math Biol (1977) 1.15
Computational advances in maximum likelihood methods for molecular phylogeny. Genome Res (1998) 1.15
Cosegregation of open-angle glaucoma and the nail-patella syndrome. Am J Ophthalmol (1997) 1.14
Toxic effects of indocyanine green, infracyanine green, and trypan blue on the human retinal pigmented epithelium. Graefes Arch Clin Exp Ophthalmol (2005) 1.14