Published in Hum Hered on June 01, 1999
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes (2009) 8.70
Etiology of insulin resistance. Am J Med (2006) 4.44
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev (2012) 2.22
The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci. Am J Hum Genet (2000) 1.53
Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease. Proc Natl Acad Sci U S A (2003) 1.35
Design of a family study among high-risk Caribbean Hispanics: the Northern Manhattan Family Study. Ethn Dis (2007) 1.25
Physiologic characterization of type 2 diabetes-related loci. Curr Diab Rep (2010) 1.24
Evidence for pancreatic beta-cell dysfunction in brothers of women with polycystic ovary syndrome. Metabolism (2008) 1.20
Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care (2012) 1.07
Genetic influences on type 2 diabetes and metabolic syndrome related quantitative traits in Mauritius. Twin Res Hum Genet (2009) 1.06
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes (2011) 1.05
Genetics of gestational diabetes mellitus and type 2 diabetes. Diabetes Care (2007) 1.03
Genetics of atrial fibrillation: implications for future research directions and personalized medicine. Circ Arrhythm Electrophysiol (2010) 1.01
Are there genetic paths common to obesity, cardiovascular disease outcomes, and cardiovascular risk factors? Circ Res (2015) 1.00
A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity. Nutr Metab Cardiovasc Dis (2011) 0.95
Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans. BMC Med Genet (2005) 0.90
The genetics of insulin resistance: Where's Waldo? Curr Diab Rep (2010) 0.89
Insulin sensitivity and insulin clearance are heritable and have strong genetic correlation in Mexican Americans. Obesity (Silver Spring) (2014) 0.89
Genetic liability to schizophrenia in Oceanic Palau: a search in the affected and maternal generation. Hum Genet (2007) 0.86
Genetics of glucose homeostasis: implications for insulin resistance and metabolic syndrome. Arterioscler Thromb Vasc Biol (2012) 0.85
Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose regulation: a meta-analysis. PLoS One (2012) 0.84
Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects. BMC Med Genet (2006) 0.82
Novel quantitative trait locus is mapped to chromosome 12p11 for left ventricular mass in Dominican families: the Family Study of Stroke Risk and Carotid Atherosclerosis. BMC Med Genet (2009) 0.80
Strategies and prospects for finding insulin resistance genes. J Clin Invest (2000) 0.79
Genetics of Insulin Resistance and the Metabolic Syndrome. Curr Cardiol Rep (2016) 0.78
Gene flow between the Korean peninsula and its neighboring countries. PLoS One (2010) 0.75
Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study. J Cell Mol Med (2017) 0.75
IRS-1 gene polymorphism and DNA damage in pregnant women with diabetes or mild gestational hyperglycemia. Diabetol Metab Syndr (2015) 0.75
A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20
Programs for Pedigree Analysis: MENDEL, FISHER, and dGENE. Genet Epidemiol (1988) 13.73
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet (2005) 13.18
Haplotype tagging for the identification of common disease genes. Nat Genet (2001) 11.27
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature (1995) 10.36
Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids Res (1991) 9.56
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell (1998) 8.73
Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (1997) 7.95
Inhibition of NF-kappa B by sodium salicylate and aspirin. Science (1994) 7.60
Directional cloning of DNA fragments at a large distance from an initial probe: a circularization method. Proc Natl Acad Sci U S A (1984) 7.38
Quantitative estimation of insulin sensitivity. Am J Physiol (1979) 7.37
The mammalian gene collection. Science (1999) 7.19
High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation (1992) 7.11
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell (1998) 7.03
Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations. Lancet (2000) 6.94
DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet (1992) 6.28
Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet (1998) 6.20
Preventing non-insulin-dependent diabetes. Diabetes (1995) 6.16
The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals. Nat Genet (1995) 5.83
Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest (1981) 5.82
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes (1993) 5.70
NF-kappaB and the immune response. Oncogene (2006) 5.62
Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet (1997) 5.58
The molecular genetics of human hemoglobin. Prog Nucleic Acid Res Mol Biol (1984) 5.50
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ (2001) 5.40
Early growth and coronary heart disease in later life: longitudinal study. BMJ (2001) 5.25
Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia (1992) 5.25
Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ (1999) 5.17
Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trends. Diabetologia (1999) 5.11
How many polymorphic genes will it take to span the human genome? Am J Hum Genet (1982) 5.11
Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science (1996) 5.06
The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell (1997) 4.99
Loss of information due to ambiguous haplotyping of SNPs. Nat Genet (1999) 4.90
Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet (1999) 4.79
Identification of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene. Proc Natl Acad Sci U S A (1990) 4.74
NICE guidance on CardioQ(TM) oesophageal Doppler monitoring. Anaesthesia (2011) 4.63
Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care (2000) 4.62
Mutation analysis for heterozygote detection and the prenatal diagnosis of cystic fibrosis. N Engl J Med (1990) 4.60
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol (1996) 4.56
Signal transduction through NF-kappa B. Immunol Today (1998) 4.54
Improved inference of relationship for pairs of individuals. Am J Hum Genet (2000) 4.47
Estimating the power of a proposed linkage study for a complex genetic trait. Am J Hum Genet (1989) 4.42
Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature (1992) 4.42
Direct sequencing of enzymatically amplified human genomic DNA. Proc Natl Acad Sci U S A (1988) 4.41
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell (1995) 4.34
The community-based strategy to prevent coronary heart disease: conclusions from the ten years of the North Karelia project. Annu Rev Public Health (1985) 4.30
Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature (1991) 4.27
Do cardiovascular risk factors explain the relation between socioeconomic status, risk of all-cause mortality, cardiovascular mortality, and acute myocardial infarction? Am J Epidemiol (1996) 4.23
Assessment of insulin sensitivity in vivo. Endocr Rev (1985) 4.21
Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis. Nat Genet (1996) 4.19
Genetic discrimination and health insurance: an urgent need for reform. Science (1995) 4.08
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science (2000) 4.04
Change in risk factors for coronary heart disease during 10 years of a community intervention programme (North Karelia project). Br Med J (Clin Res Ed) (1983) 4.00
Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care (1998) 3.99
I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell (1995) 3.95
The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes. Nat Genet (2000) 3.92
Changes in risk factors explain changes in mortality from ischaemic heart disease in Finland. BMJ (1994) 3.92
Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science (1993) 3.88
Construction of a general human chromosome jumping library, with application to cystic fibrosis. Science (1987) 3.87
Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A (1997) 3.76
Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science (1991) 3.76
Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am J Hum Genet (1993) 3.76
Changes in coronary risk factors during comprehensive five-year community programme to control cardiovascular diseases (North Karelia project). Br Med J (1979) 3.75
Extensions to pedigree analysis. V. Optimal calculation of Mendelian likelihoods. Hum Hered (1983) 3.74
Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer. Cell (1990) 3.70
Mother's weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study. BMJ (1997) 3.63
Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature (1995) 3.59
Phylogenetic footprinting reveals a nuclear protein which binds to silencer sequences in the human gamma and epsilon globin genes. Mol Cell Biol (1992) 3.57
Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study. Neurology (2001) 3.56
MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed (1986) 3.54
Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B. Genes Dev (1992) 3.47
High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry. Neurogastroenterol Motil (2004) 3.44
A review of the recent epidemiological data on the worldwide incidence of type 1 (insulin-dependent) diabetes mellitus. World Health Organization DIAMOND Project Group. Diabetologia (1993) 3.35
A de novo Alu insertion results in neurofibromatosis type 1. Nature (1991) 3.29
A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data. Am J Hum Genet (2000) 3.22
Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies. Nat Genet (2001) 3.20
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell (1999) 3.16
A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res (2010) 3.15
Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N Engl J Med (1993) 3.14
Concern Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up. BMJ (1992) 3.14
Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes. Science (1991) 3.12
The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med (2000) 3.10
Extensions to pedigree analysis. IV. Covariance components models for multivariate traits. Am J Med Genet (1983) 3.10
Educational level, relative body weight, and changes in their association over 10 years: an international perspective from the WHO MONICA Project. Am J Public Health (2000) 3.08
Identifying marker typing incompatibilities in linkage analysis. Am J Hum Genet (1996) 3.06
The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation. Diabetologia (2009) 3.05
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum Mol Genet (1995) 3.05