Published in Cancer Res on October 01, 1983
Cytosine methylation does not affect binding of transcription factor Sp1. Proc Natl Acad Sci U S A (1988) 2.56
The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia. Proc Natl Acad Sci U S A (1988) 2.14
Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer. Mol Cell Biol (1994) 1.74
Colorectal cancer: a model for epigenetic tumorigenesis. Gut (2006) 1.62
DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells. Mol Cell Biol (1984) 1.24
DNA methylation profiles in the human genes for tumor necrosis factors alpha and beta in subpopulations of leukocytes and in leukemias. Proc Natl Acad Sci U S A (1991) 1.01
Selection of strongly immunogenic "tum-" variants from tumors at high frequency using 5-azacytidine. J Exp Med (1984) 0.94
Induction of a step in carcinogenesis that is normally associated with mutagenesis by nonmutagenic concentrations of 5-azacytidine. Mol Cell Biol (1984) 0.91
Epigenetics in radiation biology: a new research frontier. Front Genet (2013) 0.85
Colorectal cancer carcinogenesis: a review of mechanisms. Cancer Biol Med (2016) 0.80
The CpG island in the murine foxl2 proximal promoter is differentially methylated in primary and immortalized cells. PLoS One (2013) 0.76
Cellular differentiation, cytidine analogs and DNA methylation. Cell (1980) 10.15
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell (1979) 6.47
5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science (1990) 4.80
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res (1999) 4.74
Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE). Nucleic Acids Res (1997) 4.65
Accumulation of nuclear p53 and tumor progression in bladder cancer. N Engl J Med (1994) 4.34
Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res (1995) 4.28
Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci U S A (1990) 4.06
Southern blot analysis of DNA extracted from formalin-fixed pathology specimens. Cancer Res (1986) 3.95
Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein. Proc Natl Acad Sci U S A (1987) 3.72
Increased cell division as a cause of human cancer. Cancer Res (1990) 3.38
5-methylcytosine, gene regulation, and cancer. Adv Cancer Res (1983) 3.27
Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res (1998) 2.83
Predicting survival using simple clinical variables: a case study in traumatic brain injury. J Neurol Neurosurg Psychiatry (1999) 2.83
Altering gene expression with 5-azacytidine. Cell (1985) 2.79
DNA methylation decreases in aging but not in immortal cells. Science (1983) 2.67
DNA methylation: past, present and future directions. Carcinogenesis (2000) 2.58
Cytosine methylation does not affect binding of transcription factor Sp1. Proc Natl Acad Sci U S A (1988) 2.56
The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol (1998) 2.53
p16 gene in uncultured tumours. Nature (1994) 2.47
Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment. Nature (1977) 2.44
The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA. Nucleic Acids Res (1994) 2.37
Role of intracranial pressure monitoring in severely head-injured patients without signs of intracranial hypertension on initial computerized tomography. J Neurosurg (1994) 2.36
Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation. Nucleic Acids Res (2001) 2.27
Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein. Proc Natl Acad Sci U S A (1989) 2.25
Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene. Genes Dev (1992) 2.19
Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. J Natl Cancer Inst (2001) 2.13
High frequency mutagenesis by a DNA methyltransferase. Cell (1992) 2.08
Effect of p21WAF1/CIP1 expression on tumor progression in bladder cancer. J Natl Cancer Inst (1998) 2.07
Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages. J Exp Med (1980) 2.00
Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA. J Mol Biol (1982) 1.89
Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas. J Natl Cancer Inst (1993) 1.88
PAX6 methylation and ectopic expression in human tumor cells. Int J Cancer (2000) 1.87
p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer. Am J Pathol (1993) 1.85
Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine. Proc Natl Acad Sci U S A (1982) 1.84
Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer. Hum Mol Genet (2001) 1.83
Phenotypic conversion of cultured mouse embryo cells by aza pyrimidine nucleosides. Dev Biol (1978) 1.76
Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer. Mol Cell Biol (1994) 1.74
A psychogeriatric survey of old people's homes. Br Med J (Clin Res Ed) (1981) 1.74
The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines. Cancer Res (1998) 1.73
Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. Nucleic Acids Res (2000) 1.73
Changes in the allelic methylation patterns of c-H-ras-1, insulin and retinoblastoma genes in human development. Dev Suppl (1990) 1.73
DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture. J Biol Chem (1986) 1.72
Glycoprotein, elastin, and collagen secretion by rat smooth muscle cells. Proc Natl Acad Sci U S A (1979) 1.71
Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells. Nucleic Acids Res (1981) 1.70
Inhibition of DNA methylation by chemical carcinogens in vitro. Cell (1983) 1.68
Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer. Cancer Res (1990) 1.67
Involvement of DNA methylation in human carcinogenesis. Biol Chem (1998) 1.65
Head injury in the elderly. Age Ageing (1986) 1.65
Scar formation after stereotactic vacuum-assisted core biopsy of benign breast lesions. Clin Radiol (2006) 1.60
Destruction of extracellular matrices containing glycoproteins, elastin, and collagen by metastatic human tumor cells. Cancer Res (1980) 1.59
Prescription of oxygen concentrators: adherence to published guidelines. Thorax (1989) 1.57
Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR. Cancer Res (1997) 1.51
Contiguous patches of normal human mammary epithelium derived from a single stem cell: implications for breast carcinogenesis. Cancer Res (1996) 1.51
DNA methylation differences associated with tumor tissues identified by genome scanning analysis. Genomics (1998) 1.51
HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair. Nucleic Acids Res (1995) 1.50
Zebularine: a new drug for epigenetic therapy. Biochem Soc Trans (2004) 1.49
Roles of cell division and gene transcription in the methylation of CpG islands. Mol Cell Biol (1999) 1.49
Fibrinolytic activity in a human fibrosarcoma cell line and evidence for the induction of plasminogen activator secretion during tumor formation. Cell (1975) 1.48
DNA methylation and cancer. Cancer Res (1986) 1.47
Home intravenous antibiotic therapy programme, 1999. J Infect (2001) 1.46
Effect of cell shape change on the function and differentiation of rabbit mammary cells in culture. J Cell Biol (1983) 1.45
Adherence to guidelines on empiric use of antibiotics in the emergency room. Infection (2008) 1.43
Bone marrow aplasia associated with ticlopidine therapy. Am J Hematol (1993) 1.43
Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis (1997) 1.43
Glasgow Outcome Scale: an inter-rater reliability study. Brain Inj (1993) 1.42
Change in serum hyaluronan: a simple index of short-term drug-induced changes in hepatic sinusoidal perfusion. Gastroenterology (1993) 1.41
Field evaluation of an albendazole intraruminal capsule against benzimidazole-resistant Haemonchus contortus. Vet Rec (1992) 1.40
Initial experience of intramammary prostheses in breast conservation surgery. Eur J Surg Oncol (1999) 1.38
Mutagenic and epigenetic effects of DNA methylation. Mutat Res (1997) 1.38
Ferritinaemia in leukaemia and Hodgkin's disease. Br J Cancer (1973) 1.37
p53 and treatment of bladder cancer. Nature (1997) 1.36
Variable effects of DNA-synthesis inhibitors upon DNA methylation in mammalian cells. Nucleic Acids Res (1986) 1.34
Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors. Cancer Res (1997) 1.33
In vitro correlates of transformation in C3H/10T1/2 clone 8 mouse cells. Cancer Res (1976) 1.33
Changes in phenotypic expression in embryonic and adult cells treated with 5-azacytidine. J Cell Physiol (1982) 1.32
Allele-specific methylation of the human c-Ha-ras-1 gene. Cell (1987) 1.31
Temporal acquistion of enhanced fibrinolytic activity by syrian hamster embryo cells following treatment with benzo(a)pyrene. Cancer Res (1977) 1.31
DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene. Oncogene (1997) 1.29
Letter: Penile size in the newborn infant. J Pediatr (1975) 1.28
Recurrent nephrotic syndrome associated with Kimura's disease in a young non-Oriental male. Nephron (1994) 1.28
Critical thresholds of intracranial pressure and cerebral perfusion pressure related to age in paediatric head injury. J Neurol Neurosurg Psychiatry (2005) 1.28
DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells. Mol Cell Biol (1984) 1.24
Primary torsion of the omentum. Ann R Coll Surg Engl (1981) 1.24
Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance. Mol Cell Biol (1987) 1.23
A new in vivo model to study invasion and metastasis of human bladder carcinoma. Cancer Res (1987) 1.23
Progressive increases in the methylation status and heterochromatinization of the myoD CpG island during oncogenic transformation. Mol Cell Biol (1994) 1.22
Evaluation of Pyrosequencing technology for the identification of clinically relevant non-dematiaceous yeasts and related species. Eur J Clin Microbiol Infect Dis (2008) 1.21
Inhibition of DNA methylation in L1210 leukemic cells by 5-aza-2'-deoxycytidine as a possible mechanism of chemotherapeutic action. Cancer Res (1983) 1.19
Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time. Cancer Res (2001) 1.19
Progress in the management of head injury. Br J Surg (1992) 1.19
Mutagenicity of 5-azacytidine and related nucleosides in C3H/10T 1/2 clone 8 and V79 cells. Cancer Res (1982) 1.19
Relationship between fibrinolysis of cultured cells and malignancy. J Natl Cancer Inst (1975) 1.18
Progressing toward a molecular description of colorectal cancer development. FASEB J (1992) 1.18
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol (2001) 1.17
The work of a regional head injury service. Lancet (1985) 1.16
Induction of morphological transformation in mouse C3H/10T1/2 clone 8 cells and chromosomal damage in hamster A(T1)C1-3 cells by cancer chemotherapeutic agents. Cancer Res (1977) 1.16
The rate of CpG mutation in Alu repetitive elements within the p53 tumor suppressor gene in the primate germline. J Mol Biol (1996) 1.15