Published in Nature on May 28, 1981
Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities. Proc Natl Acad Sci U S A (1986) 6.16
Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proc Natl Acad Sci U S A (1984) 5.81
Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. Proc Natl Acad Sci U S A (1985) 3.95
T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 3.56
P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci U S A (1997) 3.09
Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J Exp Med (1989) 3.03
Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J (1995) 2.90
Characterization of a murine lymphokine distinct from interleukin 2 and interleukin 3 (IL-3) possessing a T-cell growth factor activity and a mast-cell growth factor activity that synergizes with IL-3. Proc Natl Acad Sci U S A (1986) 2.84
Structure of the chromosomal gene for murine interleukin 3. Proc Natl Acad Sci U S A (1985) 2.33
Mast cells and mastocytosis. Blood (2008) 2.32
Identification of mast cell progenitors in adult mice. Proc Natl Acad Sci U S A (2005) 2.19
Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor. Proc Natl Acad Sci U S A (1987) 1.96
Mast cell clones: a model for the analysis of cellular maturation. J Cell Biol (1982) 1.91
Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Mol Cell Biol (1993) 1.80
Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines. Mol Cell Biol (1988) 1.70
Gut mucosal mast cells. Origin, traffic, and differentiation. J Exp Med (1984) 1.61
Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand. J Exp Med (1992) 1.56
Development of IgE and IgG antibodies to food and inhalant allergens in children at risk of allergic disease. Arch Dis Child (1985) 1.40
Neutralization of IL-9 ameliorates experimental autoimmune encephalomyelitis by decreasing the effector T cell population. J Immunol (2010) 1.30
Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells. J Exp Med (1987) 1.29
Nerve growth factor promotes human hemopoietic colony growth and differentiation. Proc Natl Acad Sci U S A (1988) 1.28
Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7. Proc Natl Acad Sci U S A (1992) 1.26
Infection of immune mast cells by Harvey sarcoma virus: immortalization without loss of requirement for interleukin-3. Mol Cell Biol (1985) 1.20
Sequential expression of new gene programs in inducer T-cell clones. Proc Natl Acad Sci U S A (1983) 1.19
Antigen-induced increase in protein kinase C activity in plasma membrane of mast cells. Proc Natl Acad Sci U S A (1985) 1.13
Vesicular uptake of eosinophil peroxidase by guinea pig basophils and by cloned mouse mast cells and granule-containing lymphoid cells. Am J Pathol (1985) 1.13
Effects of interleukin-3 with or without the c-kit ligand, stem cell factor, on the survival and cytoplasmic granule formation of mouse basophils and mast cells in vitro. Am J Pathol (1994) 1.13
Partial agonist/antagonist mouse interleukin-2 proteins indicate that a third component of the receptor complex functions in signal transduction. EMBO J (1990) 1.11
Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases. Endocr Rev (2012) 1.11
Cloned mouse cells with natural killer function and cloned suppressor T cells express ultrastructural and biochemical features not shared by cloned inducer T cells. J Exp Med (1983) 1.10
Loss of histochemical identity in mast cells lacking carboxypeptidase A. Mol Cell Biol (2005) 1.09
Genetic factors controlling the intestinal mast cell response in mice infected with Trichinella spiralis. Clin Exp Immunol (1982) 1.08
Mast cell function: a new vision of an old cell. J Histochem Cytochem (2014) 1.08
Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1. J Exp Med (1996) 1.04
Factor-dependent in vitro growth of human normal bone marrow-derived basophil-like cells. J Exp Med (1983) 1.04
Proliferation of peritoneal mast cells in the skin of W/Wv mice that genetically lack mast cells. J Exp Med (1984) 1.04
Transforming and differentiation-inducing potential of constitutively activated c-kit mutant genes in the IC-2 murine interleukin-3-dependent mast cell line. Am J Pathol (1996) 1.01
Mast cell-committed progenitors. Proc Natl Acad Sci U S A (2005) 0.98
Mast cells and metabolic syndrome. Biochim Biophys Acta (2010) 0.95
Mast cell and histamine content of human bronchoalveolar lavage fluid. Thorax (1985) 0.95
Blood flow, histamine content and histidine decarboxylase activity in rat skin grafts and their modification by cyclosporin-A. Br J Pharmacol (1982) 0.93
Antigen-induced, IgE-mediated degranulation of cloned immature mast cells derived from normal mice. Am J Pathol (1987) 0.92
Two classes of mouse mast cells delineated by monoclonal antibodies. Proc Natl Acad Sci U S A (1983) 0.92
Interleukin 3 promotes erythroid burst formation in "serum-free" cultures without detectable erythropoietin. Proc Natl Acad Sci U S A (1985) 0.90
Cloned mouse mast cells derived from immunized lymph node cells and from foetal liver cells exhibit characteristics of bone marrow-derived mast cells containing chondroitin sulphate E proteoglycan. Immunology (1984) 0.88
In vitro studies on mast cell proliferation in N. brasiliensis infection. Immunology (1984) 0.88
The Mast Cell-IgE Paradox: From Homeostasis to Anaphylaxis. Am J Pathol (2016) 0.88
Borrelia burgdorferi spirochetes induce mast cell activation and cytokine release. Infect Immun (1999) 0.87
Mast cell differentiation depends on T cells and granule synthesis on fibroblasts. Immunology (1983) 0.87
Heterogeneity of murine bone marrow-derived mast cells: analysis of their proteinase content. Immunology (1991) 0.86
Interleukin 2-dependent release of interleukin 3 activity by T4+ human T-cell clones. Proc Natl Acad Sci U S A (1985) 0.85
Delayed-type hypersensitivity and allograft rejection in the mouse: correlation of effector cell phenotype. Immunology (1982) 0.84
Surface phenotype of T cells producing growth of mucosal mast cells in normal rat bone marrow culture. Immunology (1985) 0.84
Mast cells protect against airway Mycoplasma pneumoniae under allergic conditions. Clin Exp Allergy (2010) 0.81
Effect of Treponema hyodysenteriae infection on mucosal mast cells and T cells in the murine cecum. Infect Immun (1990) 0.81
Growth of human basophil lines derived from chronic myelocytic leukaemia cells in vitro: ultrastructure and X-ray microanalysis studies. Immunology (1985) 0.79
A crucial door to the mast cell mystery knocked in. J Immunol (2009) 0.78
A Mast Cell Degranulation Screening Assay for the Identification of Novel Mast Cell Activating Agents. Medchemcomm (2013) 0.77
Acceleration of IgE responses by treatment with recombinant interleukin-3 prior to infection with Trichinella spiralis in mice. Immunology (1996) 0.77
Concanavalin A-stimulated rat spleen cells produce a soluble factor that supports growth of the mouse IL-3-dependent cell line Ea3.123, but not three other IL-3-dependent lines. Immunology (1986) 0.75
Effect of lipopolysaccharide on mouse mast cell induction by a splenic cell culture system. Infect Immun (1994) 0.75
Establishment of a mast cell line, NCL-2, without Kit mutation, derived from NC mouse bone marrow. FEBS Open Bio (2014) 0.75
Mast Cells and IgE can Enhance Survival During Innate and Acquired Host Responses to Venoms. Trans Am Clin Climatol Assoc (2017) 0.75
An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature (1987) 19.23
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med (1986) 17.64
Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. J Exp Med (1975) 17.16
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science (1983) 15.43
Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity. J Exp Med (1975) 13.69
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol (1995) 10.61
Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition. J Exp Med (1978) 6.29
Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proc Natl Acad Sci U S A (1984) 5.81
Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice. J Exp Med (1978) 5.48
Separation of caveolae from associated microdomains of GPI-anchored proteins. Science (1995) 5.25
Regulation of cellular and humoral immune responses by T-cell subclasses. Cold Spring Harb Symp Quant Biol (1977) 5.21
T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells. J Exp Med (1976) 5.11
Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science (2000) 5.10
Lymphocytes as models for the study of mammalian cellular differentiation. Immunol Rev (1977) 5.01
Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell (1992) 4.90
Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med (1992) 4.39
Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature (1990) 4.21
Synergy among lymphoid cells mediating the graft-versus-host response. II. Synergy in graft-versus-host reactions produced by Balb-c lymphoid cells of differing anatomic origin. J Exp Med (1970) 4.14
A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res (1986) 4.12
Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev (1993) 3.96
Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science (1996) 3.84
Synergy among lymphoid cells mediating the graft-versus-host response. 3. Evidence for interaction between two types of thymus-derived cells. J Exp Med (1972) 3.77
Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol (1994) 3.76
Immunological circuits: cellular composition. Fed Proc (1979) 3.72
Idiotype-specific T helper cells are required to induce idiotype-positive B memory cells to secrete antibody. Eur J Immunol (1978) 3.55
Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat. J Cell Biol (1989) 3.44
Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr Top Microbiol Immunol (1999) 3.42
Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res (1990) 3.35
Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses. J Exp Med (1976) 3.21
Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection. Science (1998) 3.15
Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med (1994) 3.09
Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am J Pathol (1988) 3.06
Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J Exp Med (1989) 3.03
Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses. J Exp Med (1976) 2.99
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res (1993) 2.98
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum Pathol (1995) 2.96
Multiple biologic activities of a cloned inducer T-cell population. Proc Natl Acad Sci U S A (1981) 2.95
Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor. Lab Invest (2000) 2.92
Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am J Pathol (1993) 2.85
Contrasuppression. A novel immunoregulatory activity. J Exp Med (1981) 2.84
Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature (1998) 2.82
Role of the clotting system in cell-mediated hypersensitivity. I. Fibrin deposition in delayed skin reactions in man. J Exp Med (1973) 2.75
The effects of anti-theta antiserum upon graft-versus-host activity of spleen and lymph node cells. Cell Immunol (1972) 2.69
Pulmonary responses to bronchoconstrictor agonists in the mouse. J Appl Physiol (1985) (1988) 2.64
Cutaneous basophil hypersensitivity. II. A light and electron microscopic description. J Exp Med (1970) 2.61
Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP. J Exp Med (1998) 2.61
Development and function of subpopulations of thymocytes and T lymphocytes. Prog Allergy (1976) 2.57
A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: multiple activities of interleukin 3. J Immunol (1985) 2.56
Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. Clin Cancer Res (1999) 2.55
Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med (1994) 2.54
Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition. J Exp Med (1978) 2.53
Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells. J Autoimmun (2001) 2.49
IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med (1997) 2.48
Mast cells as a source of multifunctional cytokines. Immunol Today (1990) 2.46
Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med (2000) 2.46
Cytochemical localization of certain phosphatases in Escherichia coli. J Bacteriol (1970) 2.43
Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci U S A (1991) 2.41
Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition. Biochim Biophys Acta (1989) 2.40
Glomeruloid microvascular proliferation follows adenoviral vascular permeability factor/vascular endothelial growth factor-164 gene delivery. Am J Pathol (2001) 2.38
Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res (1996) 2.36
Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin. J Exp Med (1996) 2.26
Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells. Am J Pathol (1991) 2.26
Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation. Cancer Res (1995) 2.24
Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine. EXS (1997) 2.24
Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins. Proc Natl Acad Sci U S A (1988) 2.22
Cutaneous basophil hypersensitivity. I. A new look at the Jones-Mote reaction, general characteristics. J Exp Med (1970) 2.21
Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Lab Invest (1987) 2.20
The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens. J Exp Med (1978) 2.20
Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor. Proc Natl Acad Sci U S A (1991) 2.17
The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation. J Leukoc Biol (1996) 2.15
Induction of a fibrin-gel investment: an early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products. J Immunol (1979) 2.15
Synergy among lymphoid cells mediating the graft-versus-host response. I. Synergy in graft-versus-host reactions produced by cells from NZB-Bl mice. J Exp Med (1970) 2.15
Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent. Partial inhibition of the reaction with antiserum against tumor necrosis factor-alpha. J Clin Invest (1991) 2.14
Cloning of Ly-5 cDNA. Proc Natl Acad Sci U S A (1985) 2.12
Regulation of extravascular coagulation by microvascular permeability. Science (1985) 2.11
Regulation of mast cell survival by IgE. Immunity (2001) 2.11
Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization. J Invest Dermatol (1982) 2.10