Published in Eur J Biochem on February 01, 1981
Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli. Proc Natl Acad Sci U S A (1983) 2.37
The metabolism of neuropeptides. Endopeptidase-24.11 in human synaptic membrane preparations hydrolyses substance P. Biochem J (1985) 1.07
Precursor forms of substance P (SP) in nervous tissue: detection with antisera to SP, SP-Gly, and SP-Gly-Lys. Proc Natl Acad Sci U S A (1985) 0.92
Synergistic effect with Phe-Gly-Leu-Met-NH2 of the C-terminal of substance P and insulin-like growth factor-1 on epithelial wound healing of rabbit cornea. Br J Pharmacol (1999) 0.91
Local cardiac effects of substance P: roles of acetylcholine and noradrenaline. Br J Pharmacol (1995) 0.82
Involvement of enzymatic degradation in the inactivation of tachykinin neurotransmitters in neonatal rat spinal cord. Br J Pharmacol (1994) 0.82
Tachykininergic synaptic transmission in the coeliac ganglion of the guinea-pig. Br J Pharmacol (1996) 0.81
Proteolysis controls endogenous substance P levels. PLoS One (2013) 0.78
Solubilization and characterization of substance P-binding sites from chick brain membranes. Biochem J (1988) 0.78
A peptide-hormone-inactivating endopeptidase in Xenopus laevis skin secretion. Proc Natl Acad Sci U S A (1992) 0.75
Still degrading after all these years. Biochem J (1989) 0.75
Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues. ACS Med Chem Lett (2014) 0.75
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. Proc Natl Acad Sci U S A (1990) 13.34
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J (1982) 8.16
Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Neurochem (1966) 7.91
The uptake of [3H]GABA by slices of rat cerebral cortex. J Neurochem (1968) 5.05
Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J Biol Chem (1991) 4.92
Neural and developmental actions of lithium: a unifying hypothesis. Cell (1989) 4.13
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A (1986) 3.97
Role of transmitter uptake mechanisms in synaptic neurotransmission. Br J Pharmacol (1971) 3.82
Effects of 6-hydroxydopamine on catecholamine containing neurones in the rat brain. J Neurochem (1970) 3.42
The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart. Br J Pharmacol (1969) 3.25
Inhibition of catecholamine Uptake-2 by steroids in the isolated rat heart. Br J Pharmacol (1970) 3.07
Opiate analgesics inhibit substance P release from rat trigeminal nucleus. Nature (1977) 2.74
Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after 3 years of therapy. Hepatology (2001) 2.72
The retrograde axonal transport of nerve growth factor. Brain Res (1974) 2.60
Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents Actions (1989) 2.59
The mas oncogene encodes an angiotensin receptor. Nature (1988) 2.53
A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells. Biochem J (1988) 2.49
Release of gamma-aminobutyric acid from inhibitory nerves of lobster. Proc Natl Acad Sci U S A (1966) 2.47
Multiple opiate receptor sites on primary afferent fibres. Nature (1980) 2.34
Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration. Proc Natl Acad Sci U S A (2000) 2.34
Scaffold proteins of MAP-kinase modules. Oncogene (2007) 2.30
The possible existence of multiple receptors for substance P. Naunyn Schmiedebergs Arch Pharmacol (1982) 2.18
Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands. Mol Pharmacol (1980) 2.14
The physiologic disposition and metabolism of norepinephrine in immunosympathectomized animals. J Pharmacol Exp Ther (1966) 2.03
GABA uptake in rat central nervous system: comparison of uptake in slices and homogenates and the effects of some inhibitors. J Neurochem (1971) 2.00
Trans-synaptic regulation of growth and development of adrenergic neurones in a mouse sympathetic ganglion. Brain Res (1971) 1.99
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A (1988) 1.99
Release of dopamine from dendrites in rat substantia nigra. Nature (1976) 1.95
Reduced uptake of tritiated noradrenaline in tissues of immunosympathectomized animals. Nature (1965) 1.91
Autoradiographic localization of 3 H-GABA in rat retina. Nat New Biol (1972) 1.90
Effects of phenoxybenzamine on the uptake and metabolism of noradrenaline in the rat heart and vas deferens. Br J Pharmacol (1969) 1.90
Multiple tachykinin binding sites in peripheral tissues and in brain. Eur J Pharmacol (1986) 1.86
Surgical management of subfoveal choroidal neovascularization. Ophthalmology (1992) 1.84
Catecholamine uptake processes. Br Med Bull (1973) 1.83
Uptake and metabolism of gamma-aminobutyric acid by neurones and glial cells. Biochem Pharmacol (1975) 1.83
The inhibition of noradrenaline uptake by drugs. Adv Drug Res (1965) 1.82
Use of catechol O-methyltransferase for the enzyme radiochemical assay of dopamine. J Neurochem (1973) 1.82
Capsaicin-induced depletion of substance P from primary sensory neurones. Brain Res (1978) 1.80
Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death. Proc Natl Acad Sci U S A (1994) 1.79
Dopamine receptors in the brain. Science (1975) 1.79
Neurochemical characteristics of early and late onset types of Alzheimer's disease. Br Med J (Clin Res Ed) (1984) 1.78
Uptake mechanisms for neurotransmitter amines. Biochem Pharmacol (1974) 1.73
Torsion of wandering spleen and distal pancreas. AJR Am J Roentgenol (1984) 1.73
Induction of tryptophan degradation in vitro and in vivo: a gamma-interferon-stimulated activity. J Interferon Res (1986) 1.70
Tissue selectivity of substance P alkyl esters: suggesting multiple receptors. Eur J Pharmacol (1983) 1.65
Sodium dependence of transmitter uptake at adrenergic nerve terminals. Mol Pharmacol (1966) 1.63
Occurrence and extracellular actions of inositol pentakis- and hexakisphosphate in mammalian brain. Nature (1988) 1.63
A post-mortem study of the cholinergic and GABA systems in senile dementia. Brain (1982) 1.62
Receptor coupled events in bradykinin action: rapid production of inositol phosphates and regulation of cytosolic free Ca2+ in a neural cell line. EMBO J (1987) 1.59
The release of gamma-aminobutyric acid during inhibition in the cat visual cortex. J Physiol (1971) 1.59
Uptake, storage and metabolism of norepinephrine in tissues of the developing rat. J Pharmacol Exp Ther (1967) 1.58
HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. J Biol Chem (1999) 1.57
myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate. Biochem J (1991) 1.57
Huntington's chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia. Brain (1974) 1.57
Differences in the regulation of tyrosine hydroxylase and dopa decarboxylase in sympathetic ganglia and adrenals. Nat New Biol (1971) 1.54
Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site. Proc Natl Acad Sci U S A (1990) 1.53
Biochemical and anatomical observations on the degeneration of peptide-containing primary afferent neurons after neonatal capsaicin. Neuroscience (1981) 1.50
Peptide sequencing using the combination of edman degradation, carboxypeptidase digestion and fast atom bombardment mass spectrometry. Biochem Biophys Res Commun (1982) 1.48
Pharmacological characterization of a receptor for calcitonin gene-related peptide on rat, L6 myocytes. Br J Pharmacol (1992) 1.45
A quantitative ultrastructural and biochemical analysis of the process of reinnervation of the superior cervical ganglion in the adult rat. Brain Res (1974) 1.43
Thapsigargin, a new calcium-dependent epithelial anion secretagogue. Br J Pharmacol (1989) 1.41
Naloxone as a GABA antagonist: evidence from iontophoretic, receptor binding and convulsant studies. Eur J Pharmacol (1978) 1.38
Smoking...harmful to the brain. Nature (1996) 1.37
Cystoid macular edema associated with latanoprost therapy in a case series of patients with glaucoma and ocular hypertension. Ophthalmology (1999) 1.36
Enhancement of H-3-norepinephrine uptake in rat tissues by O-methylated metabolites of catecholamines. J Pharmacol Exp Ther (1966) 1.36
Subcellular distribution of endogenous and (3H) gamma-aminobutyric acid in rat cerebral cortex. J Neurochem (1969) 1.35
The uptake and storage of H3-norepinephrine in the reserpine-pretreated rat heart. J Pharmacol Exp Ther (1965) 1.30
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev (1995) 1.29
Effects of surgical decentralization and nerve growth factor on the maturation of adrenergic neurons in a mouse sympathetic ganglion. J Neurochem (1972) 1.28
PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group. Leukemia (2004) 1.28
Acute adverse reactions to magnetic resonance contrast media--gadolinium chelates. Br J Radiol (2006) 1.25
Glycine uptake in rat central nervous system slices and homogenates: evidence for different uptake systems in spinal cord and cerebral cortex. J Neurochem (1971) 1.24
Release and metabolism of substance P in rat hypothalamus. Nature (1976) 1.24
Regional studies of catecholamines in the rat brain. II. Rate of turnover of catecholamines in various brain regions. J Neurochem (1966) 1.23
Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type. Neurosci Lett (1980) 1.21
Studies on the coupling step in solid phase peptide synthesis. Further competition experiments and attempts to assess formation of ion pairs. J Org Chem (1974) 1.21
Calcium-dependent release of somatostatin and neurotensin from rat brain in vitro. Nature (1978) 1.21
Epidemiologic study of Parkinson's disease in Hong Kong. Neurology (1989) 1.21
Effects of 6-hydroxydopamine on noradrenaline-containing neurones in the rat brain. Nature (1969) 1.20
Faecal indicator bacteria enumeration in beach sand: a comparison study of extraction methods in medium to coarse sands. J Appl Microbiol (2009) 1.20
Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proc Natl Acad Sci U S A (1992) 1.19
Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J (1997) 1.19
The metabolism of gamma-aminobutyric acid (GABA) in the lobster nervous system--uptake of GABA in the nerve-muscle preparations. J Neurochem (1968) 1.19
Pasteurella multocida bacteremia due to non-bite animal exposure in cirrhotic patients: report of two cases. J Microbiol Immunol Infect (2001) 1.19
Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat. J Neurosci (1983) 1.18
Mechanism of inositol monophosphatase, the putative target of lithium therapy. Proc Natl Acad Sci U S A (1994) 1.18
Regional studies of catecholamines in the rat brain. IV. Effects of drugs on the disposition and metabolism of H3-norepinephrine and H3-dopamine. J Pharmacol Exp Ther (1966) 1.18
Studies of the uptake of 3 H-gaba and ( 3 H)glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography. Brain Res (1972) 1.18
Localizing 3H-GABA in nerve terminals of rat cerebral cortex by electron microscopic autoradiography. Nature (1971) 1.18
Molecular cloning and characterization of an isolate of hepatitis delta virus from Taiwan. Hepatology (1991) 1.17
Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium stores. Proc Natl Acad Sci U S A (1999) 1.17
Total knee arthroplasty after patellectomy. J Bone Joint Surg Br (1994) 1.16
Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen). J Med Chem (1991) 1.16