Role of transmitter uptake mechanisms in synaptic neurotransmission.

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Published in Br J Pharmacol on April 01, 1971

Authors

L L Iversen

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Release of (3H)gamma-aminobutyric acid from glial cells in rat dorsal root ganglia. J Neurochem (1974) 1.09

The uptake of catechol amines at high perfusion concentrations in the rat isolated heart: A novel catechol amine uptake process. Br J Pharmacol Chemother (1965) 1.08

Synaptosomes: different populations storing catecholamines and gamma-aminobutyric acid in homogenates of rat brain. Nature (1968) 1.08

Dopamine selectively increases 3H-GABA release from slices of rat substantia nigra in vitro. Nature (1977) 1.08

Neuronal degeneration in locus ceruleus and cortical correlates of Alzheimer disease. Alzheimer Dis Assoc Disord (1987) 1.06

Trans-synaptic regulation of tyrosine hydroxylase activity in adrenergic neurones: effect of potassium concentration on cultured sympathetic ganglia. Naunyn Schmiedebergs Arch Pharmacol (1972) 1.06

The substantia innominata in Alzheimer's disease: an histochemical and biochemical study of cholinergic marker enzymes. Neurosci Lett (1982) 1.05

Relative affinities of drugs acting at cholinoceptors in displacing agonist and antagonist radioligands: the NMS/Oxo-M ratio as an index of efficacy at cortical muscarinic receptors. Br J Pharmacol (1988) 1.05

Neuronal uptake processes for amines and amino acids. Adv Biochem Psychopharmacol (1970) 1.05

Thermoregulation: effects of environmental temperature on turnover of hypothalamic norepinephrine. Science (1969) 1.03

Modification of an enzyme radiochemical assay procedure for noradrenaline. Biochem Pharmacol (1970) 1.02

Catecholamine-sensitive adenylate cyclases in nervous tissues. J Neurochem (1977) 1.02

Differences in the uptake, storage and metabolism of (+)- and (-)-noradrenaline. Br J Pharmacol (1971) 1.02

Effect of chlorpromazine and some of its metabolites on the dopamine-sensitive adenylate cyclase of rat brain striatum. J Pharm Pharmacol (1974) 1.02

Substance P. J Med Chem (1982) 1.01

Comparison of the effects of neuroleptic drugs on pre- and postsynaptic dopaminergic mechanisms in the rat striatum. Mol Pharmacol (1976) 1.00

Inhibition of the extraneuronal metabolism of noradrenaline in the isolated heart by adrenergic blocking agents. Nature (1967) 1.00

Release of enkephalin from rat globus pallidus in vitro. Nature (1978) 1.00

Stimulation of a dopamine-sensitive adenylate cyclase in homogenates of rat striatum by a metabolite of piribedil (ET 495). Naunyn Schmiedebergs Arch Pharmacol (1974) 1.00

Substance P: localization in synaptic vesicles in rat central nervous system. J Neurochem (1977) 0.99

Monoamine oxidase and catechol-O-methyl transferase activities in cat nictitating membrane and rat and guinea-pig vas deferens after sympathectomy. Br J Pharmacol (1968) 0.99

Muscarinic cholinergic receptors in rat corpus striatum and regulation of guanosine cyclic 3',5'-monophosphate. Mol Pharmacol (1978) 0.99

Vasoactive intestinal polypeptide (VIP): vesicular localization and potassium evoked release from rat hypothalamus. Brain Res (1978) 0.99

Vasopressin, oxytocin and neurophysins in the human brain and spinal cord. Brain Res (1984) 0.98

Characteristics of noradrenaline uptake in the iris ciliary body and other peripheral tissues of the rat. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol (1968) 0.98

Reduced glutamic-acid-decarboxylase activity of post-mortem brain in Huntington's chorea. Lancet (1973) 0.98

The Ferrier Lecture, 1983. Amino acids and peptides: fast and slow chemical signals in the nervous system? Proc R Soc Lond B Biol Sci (1984) 0.98

Calcitonin gene-related peptide: novel neuropeptide. Life Sci (1986) 0.97

Use of ADTN to define specific 3H-spirerone binding to receptors in brain. Nature (1978) 0.97

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. Proc Natl Acad Sci U S A (1990) 0.96

Increased brain dopamine and dopamine receptors in schizophrenia. Arch Gen Psychiatry (1982) 0.96

Dopamine receptors in the retina may all be linked to adenylate cyclase. Nature (1979) 0.96

Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neurons. Science (1985) 0.96

Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia. Brain (1984) 0.95

The interaction between MK-801 and receptors for N-methyl-D-aspartate: functional consequences. Neuropharmacology (1987) 0.95