Biochemical and biological effects of nonionic nucleic acid methylphosphonates.

Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5. Proc Natl Acad Sci U S A (1986) 4.92

Physicochemical properties of phosphorothioate oligodeoxynucleotides. Nucleic Acids Res (1988) 4.49

Characterization of oligonucleotide transport into living cells. Proc Natl Acad Sci U S A (1989) 3.27

Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides. Proc Natl Acad Sci U S A (1984) 3.03

Comparative hybrid arrest by tandem antisense oligodeoxyribonucleotides or oligodeoxyribonucleoside methylphosphonates in a cell-free system. Nucleic Acids Res (1988) 2.10

Nucleotides that determine Escherichia coli tRNA(Arg) and tRNA(Lys) acceptor identities revealed by analyses of mutant opal and amber suppressor tRNAs. Proc Natl Acad Sci U S A (1990) 1.92

Partial protection of oncogene, anti-sense oligodeoxynucleotides against serum nuclease degradation using terminal methylphosphonate groups. Br J Cancer (1989) 1.64

Antisense properties of duplex- and triplex-forming PNAs. Nucleic Acids Res (1996) 1.63

In vitro study of E.coli tRNA(Arg) and tRNA(Lys) identity elements. Nucleic Acids Res (1992) 1.62

Targeted degradation of mRNA in Xenopus oocytes and embryos directed by modified oligonucleotides: studies of An2 and cyclin in embryogenesis. Nucleic Acids Res (1990) 1.55

Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4. Proc Natl Acad Sci U S A (1989) 1.54

Preparation of oligodeoxyribonucleoside methylphosphonates on a polystyrene support. Nucleic Acids Res (1983) 1.51

Oligodeoxyribonucleoside methylphosphonates. NMR and UV spectroscopic studies of Rp-Rp and Sp-Sp methylphosphonate (Me) modified duplexes of (d[GGAATTCC])2. Nucleic Acids Res (1987) 1.31

Number and distribution of methylphosphonate linkages in oligodeoxynucleotides affect exo- and endonuclease sensitivity and ability to form RNase H substrates. Nucleic Acids Res (1989) 1.26

Hitting bacteria at the heart of the central dogma: sequence-specific inhibition. Microb Cell Fact (2007) 1.22

Synthesis of well-defined phosphate-methylated DNA fragments: the application of potassium carbonate in methanol as deprotecting reagent. Nucleic Acids Res (1990) 1.17

Interactions of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes). Nucleic Acids Res (1991) 1.15

Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages. Nucleic Acids Res (1991) 1.13

Intracellular availability of unmodified, phosphorothioated and liposomally encapsulated oligodeoxynucleotides for antisense activity. Nucleic Acids Res (1992) 1.11

Evaluation of some properties of a phosphorodithioate oligodeoxyribonucleotide for antisense application. Nucleic Acids Res (1993) 1.10

Thermal denaturation profiles and gel mobility shift analysis of oligodeoxynucleotide triplexes. Nucleic Acids Res (1990) 1.06

Sequence dependent effects in methylphosphonate deoxyribonucleotide double and triple helical complexes. Nucleic Acids Res (1990) 1.05

Synthesis of nucleic acid methylphosphonates via the 1-hydroxybenzotriazole phosphotriester approach. Nucleic Acids Res (1986) 0.98

Alpha-DNA. IV: Alpha-anomeric and beta-anomeric tetrathymidylates covalently linked to intercalating oxazolopyridocarbazole. Synthesis, physicochemical properties and poly (rA) binding. Nucleic Acids Res (1987) 0.96

Physical properties of oligonucleotides containing phosphoramidate-modified internucleoside linkages. Nucleic Acids Res (1991) 0.95

Primitive genetic polymers. Cold Spring Harb Perspect Biol (2010) 0.95

Use of methylphosphonic dichloride for the synthesis of oligonucleoside methylphosphonates. Nucleic Acids Res (1983) 0.90

Effect of a neutralized phosphate backbone on the minor groove of B-DNA: molecular dynamics simulation studies. Nucleic Acids Res (2002) 0.89

Boron-containing oligodeoxyribonucleotide 14mer duplexes: enzymatic synthesis and melting studies. Nucleic Acids Res (1995) 0.87

Preparation of trimers and tetramers of mixed sequence oligodeoxynucleoside methylphosphonates and assignment of configurations at the chiral phosphorus. Nucleic Acids Res (1993) 0.83

Regiospecific inhibition of DNA duplication by antisense phosphate-methylated oligodeoxynucleotides. Nucleic Acids Res (1989) 0.83

Photochemically and chemically activatable antisense oligonucleotides: comparison of their reactivities towards DNA and RNA targets. Nucleic Acids Res (1994) 0.83

The spherulites(TM): a promising carrier for oligonucleotide delivery. Nucleic Acids Res (2000) 0.82

Alternative for anti-TNF antibodies for arthritis treatment. Mol Ther (2011) 0.81

Synergistic antiviral activities of oligonucleoside methylphosphonates complementary to herpes simplex virus type 1 immediate-early mRNAs 4, 5, and 1. Antimicrob Agents Chemother (1994) 0.79

Anti-human immunodeficiency virus type 1 activity of phosphorothioate analogs of oligodeoxynucleotides: penetration and localization of oligodeoxynucleotides in HIV-1-infected MOLT-4 cells. Nucleic Acids Res (1994) 0.79

Zwitterionic oligodeoxyribonucleotide N3'-->P5' phosphoramidates: synthesis and properties. Nucleic Acids Res (1998) 0.79

Detecting Darwinism from Molecules in the Enceladus Plumes, Jupiter's Moons, and Other Planetary Water Lagoons. Astrobiology (2017) 0.78

Cellular uptake and biological effects of antisense oligodeoxynucleotide analogs targeted to herpes simplex virus. Antimicrob Agents Chemother (1996) 0.77

Synthesis of nucleic acid methylphosphonothioates. Nucleic Acids Res (1988) 0.75

Synthesis of oligodeoxynucleoside methylphosphonates utilizing the tert-butylphenoxyacetyl group for exocyclic amine protection. Nucleic Acids Res (1994) 0.75

Antisense Oligonucleotides: Treatment Strategies and Cellular Internalization. RNA Dis (2016) 0.75

Biological availability and nuclease resistance extend the in vitro activity of a phosphorothioate-3'hydroxypropylamine oligonucleotide. Nucleic Acids Res (1994) 0.75

Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5. Proc Natl Acad Sci U S A (1986) 4.92

Detection of a guanine X adenine base pair in a decadeoxyribonucleotide by proton magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (1983) 2.85

Hybridization arrest of globin synthesis in rabbit reticulocyte lysates and cells by oligodeoxyribonucleoside methylphosphonates. Biochemistry (1985) 2.60

Nonionic nucleic acid analogues. Synthesis and characterization of dideoxyribonucleoside methylphosphonates. Biochemistry (1979) 2.57

Control of ribonucleic acid function by oligonucleoside methylphosphonates. Biochimie (1986) 2.43

Inhibition of rabbit globin mRNA translation by sequence-specific oligodeoxyribonucleotides. Biochemistry (1985) 2.39

Analysis of the interactions of actin depolymerizing factor with G- and F-actin. Biochemistry (1993) 2.28

Inhibition of vesicular stomatitis virus protein synthesis and infection by sequence-specific oligodeoxyribonucleoside methylphosphonates. Biochemistry (1986) 2.26

Inhibition of the synthesis of beta-galactosidase in Escherichia coli by 2-nitrophenyl-beta-D-fucoside. J Mol Biol (1966) 2.24

Selective inhibition of Escherichia coli protein synthesis and growth by nonionic oligonucleotides complementary to the 3' end of 16S rRNA. Proc Natl Acad Sci U S A (1981) 2.20

Syntheses and properties of adenine and thymine nucleoside alkyl phosphotriesters, the neutral analogs of dinucleoside monophosphates. J Am Chem Soc (1971) 2.14

Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset. J Clin Invest (1993) 2.00

Evidence for the progressive nature of neoplastic transformation in vitro. Proc Natl Acad Sci U S A (1978) 2.00

Solid-phase syntheses of oligodeoxyribonucleoside methylphosphonates. Biochemistry (1986) 2.00

Selective N-debenzoylation of N,O-polybenzoylucleosides. Tetrahedron Lett (1968) 1.93

Characterization of sequence-specific oligodeoxyribonucleoside methylphosphonates and their interaction with rabbit globin mRNA. Biochemistry (1985) 1.91

Conformation and interaction of short nucleic acid double-stranded helices. I. Proton magnetic resonance studies on the nonexchangeable protons of ribosyl ApApGpCpUpU. Biochemistry (1975) 1.79

Duplex formation of a nonionic oligo(deoxythymidylate) analogue (heptadeoxythymidylyl-(3'-5')-deoxythymidine heptaethyl ester (d-(Tp(Et))7T)) with poly(deoxyadenylate). Evaluation of the electrostatic interaction. Biochemistry (1977) 1.78

Oligothymidylate analogues having stereoregular, alternating methylphosphonate/phosphodiester backbones. Synthesis and physical studies. J Biol Chem (1980) 1.74

Role of superoxide in deoxyribonucleic acid strand scission. Biochemistry (1980) 1.70

Effects of a trinucleotide ethyl phosphotriester, Gmp(Et)Gmp(Et)U, on mammalian cells in culture. Biochemistry (1977) 1.69

Tumorigenic transformation induced by a specific fragment of DNA from herpes simplex virus type 2. Proc Natl Acad Sci U S A (1980) 1.66

Interaction of psoralen-derivatized oligodeoxyribonucleoside methylphosphonates with single-stranded DNA. Biochemistry (1988) 1.66

Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4. Proc Natl Acad Sci U S A (1989) 1.54

Ring-current effects in the Nmr of nucleic acids: a graphical approach. Biopolymers (1976) 1.52

High levels of spontaneous and parasite antigen-driven interleukin-10 production are associated with antigen-specific hyporesponsiveness in human lymphatic filariasis. J Infect Dis (1996) 1.51

Preparation of oligodeoxyribonucleoside methylphosphonates on a polystyrene support. Nucleic Acids Res (1983) 1.51

Phyllanthus amarus and hepatitis B. Lancet (1990) 1.49

Synthesis of oligodeoxyribonucleotide ethyl phosphotriesters and their specific complex formation with transfer ribonucleic acid. Biochemistry (1974) 1.49

Preparation of a decadeoxyribonucleotide helix for studies by nuclear magnetic resonance. Biochemistry (1980) 1.47

In vivo transcription of a progesterone-responsive gene is specifically inhibited by a triplex-forming oligonucleotide. Nucleic Acids Res (1993) 1.46

Interaction and association of bases and nucleosides in aqueous solutions. IV. Proton magnetic resonance studies of the association of pyrimidine nucleosides and their interactions with purine. J Am Chem Soc (1965) 1.45

The Wuchereria bancrofti orthologue of Brugia malayi SXP1 and the diagnosis of bancroftian filariasis. Mol Biochem Parasitol (2000) 1.44

A new approach to chemotherapy based on molecular biology and nucleic acid chemistry: Matagen (masking tape for gene expression). Anticancer Drug Des (1987) 1.43

Proton nuclear magnetic resonance studies on dideoxyribonucleoside methylphosphonates. Biochemistry (1980) 1.42

Studies of the conformation and interaction in dinucleoside mono- and diphosphates by proton magnetic resonance. Biochemistry (1969) 1.42

Identification and characterization of circulating prostate carcinoma cells. Cancer (2000) 1.41

Antisense inhibition of ras p21 expression that is sensitive to a point mutation. Biochemistry (1991) 1.39

IL-4- and IL-5-secreting lymphocyte populations are preferentially stimulated by parasite-derived antigens in human tissue invasive nematode infections. J Immunol (1993) 1.39

Synthesis and template properties of an ethyl phosphotriester modified decadeoxyribonucleotide. Biochemistry (1982) 1.37

Structural requirements of the rI n -rC n complex for induction of human interferon. J Mol Biol (1972) 1.33

Oligonucleotide syntheses utilizing beta-benzoylpropionyl, a blocking group with a trigger for selective cleavage. J Am Chem Soc (1967) 1.33

Temporal acquistion of enhanced fibrinolytic activity by syrian hamster embryo cells following treatment with benzo(a)pyrene. Cancer Res (1977) 1.31

Studies of inter- and intramolecular interaction in mononucleotides by proton magnetic resonance. J Am Chem Soc (1968) 1.31

Metabolism of glutamic acid in a mutant of Escherichia coli. J Bacteriol (1965) 1.25

Interaction of poly-L-lysine and nucleic acids. J Mol Biol (1966) 1.25

Nuclear Overhauser effect as a tool for the complete assignment of nonexchangeable proton resonances in short deoxyribonucleic acid helices. Biochemistry (1983) 1.25

Molecular structure of deoxyadenylyl-3'-methylphosphonate-5'-thymidine dihydrate, (d-ApT x 2H2O), a dinucleoside monophosphate with neutral phosphodiester backbone. An X-ray crystal study. Nucleic Acids Res (1983) 1.25

Immunologic tolerance in lymphatic filariasis. Diminished parasite-specific T and B lymphocyte precursor frequency in the microfilaremic state. J Clin Invest (1992) 1.24

Photochemical cross-linking of psoralen-derivatized oligonucleoside methylphosphonates to rabbit globin messenger RNA. Biochemistry (1988) 1.19

Use of EDTA derivatization to characterize interactions between oligodeoxyribonucleoside methylphosphonates and nucleic acids. Biochemistry (1989) 1.18

RNA polymerase from Micrococcus luteus: comparative effect of ribosyl and deoxyribosyl oligomers on the homopolymer. Directed reaction. Biochem Biophys Res Commun (1971) 1.18

L'adenylyl-(3'-5')-L-adenosine and L-adenylyl-(2'-5')-L-adenosine. Biochemistry (1970) 1.17

An alternative view of mammalian DNA sequence organization. II. Short repetitive sequences are organized into scrambled tandem clusters in Syrian hamster DNA. J Mol Biol (1981) 1.15

Synthesis and properties of the dinucleoside monophosphate of adenine 8-thiocyclonucleoside. J Am Chem Soc (1972) 1.15

Neoplastic transformation induced by a direct perturbation of DNA. Nature (1978) 1.14

Oligothymidylate analogues having stereoregular, alternating methylphosphonate/phosphodiester backbones as primers for DNA polymerase. Biochemistry (1982) 1.13

Synthesis and characterization of DNA duplexes containing an N(4)C-ethyl-N(4)C interstrand cross-link. J Am Chem Soc (2001) 1.12

A novel procedure for the synthesis of 2'-O-alkyl nucleotides. Biochemistry (1972) 1.12

Activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells by 2'-O-methylated poly (inosinic acid) . poly(cytidylic acid), Correlations with interferon-inducing activity. J Biol Chem (1980) 1.11

Correlation of in vitro growth properties and tumorigenicity of Syrian hamster cell lines. Cancer Res (1979) 1.10

Azole substituted oligonucleotides promote antiparallel triplex formation at non-homopurine duplex targets. Nucleic Acids Res (1995) 1.09

Relationship between somatic mutation and neoplastic transformation. Proc Natl Acad Sci U S A (1978) 1.09

Regulation of parasite antigen-driven immune responses by interleukin-10 (IL-10) and IL-12 in lymphatic filariasis. Infect Immun (1997) 1.09

Conformation and interaction of short nucleic acid double-stranded helices. II. Proton magnetic resonance studies on the hydrogen-bonded NH-N protons of ribosyl ApApGpCpUpU helix. Biochemistry (1975) 1.07

A mammalian cellular system for the concomitant study of neoplastic transformation and somatic mutation. Mutat Res (1978) 1.07

Quantitation of fibrinolytic activity of Syrian hamster fibroblasts using 3H-labeled fibrinogen prepared by reductive alkylation. Cancer Res (1977) 1.07

Proton nuclear magnetic resonance study of a self-complementary decadeoxyribonucleotide, C-C-A-A-G-C-T-T-G-G. Biochemistry (1982) 1.07

Influence of the furanose on the conformation of adenine dinucleoside monophosphates in solution. Biochemistry (1972) 1.06

A probabilistic analysis of DNA sequence organization. J Mol Biol (1981) 1.06

1H nuclear magnetic resonance studies of transfer RNA: the methyl and methylene resonances of baker's yeast phenylalanine transfer RNA and its fragments. Biochemistry (1977) 1.06

Elevated IL-10 mRNA expression and downregulation of Th1-type cytokines in microfilaraemic individuals with Wuchereria bancrofti infection. Parasite Immunol (1997) 1.05

Neoplastic transformation of cultured Syrian hamster embryo cells by DNA of herpes simplex virus type 2. J Virol (1979) 1.05

Conformational properties of the furanose phosphate backbone in nucleic acids. A carbon-13 nuclear magnetic resonance study. Biochemistry (1977) 1.05

Recognition of triple-helical DNA structures by transposon Tn7. Proc Natl Acad Sci U S A (2000) 1.04

Immortalization and neoplastic transformation of normal diploid cells by defined cloned DNA fragments of herpes simplex virus type 2. Proc Natl Acad Sci U S A (1983) 1.04

Quantitative assessment of circulating antigens in human lymphatic filariasis: a field evaluation of monoclonal antibody-based ELISA using blood collected on filter strips. Trop Med Int Health (1998) 1.03

Biocide gene(s) and biocidal activity in different strains of Bacillus sphaericus. Expression of the gene(s) in E. coli maxicells. Mol Gen Genet (1984) 1.00

Proton magnetic resonance studies on the conformation of the hexanucleotide, GmpApApYpApsiP, and Related fragments from the anticodong loop of baker's yeast phenylalanine transfer ribonucleic acid. Biochemistry (1975) 1.00