Published in Thorax on February 01, 1981
Medical treatment for reflux oesophagitis does not consistently improve asthma control: a systematic review. Thorax (2001) 1.71
Parasympathetic nervous system in nocturnal asthma. Br Med J (Clin Res Ed) (1988) 1.57
Simultaneous tracheal and oesophageal pH measurements in asthmatic patients with gastro-oesophageal reflux. Thorax (1995) 1.42
Gastro-oesophageal reflux and childhood asthma: the acid test. Thorax (1985) 1.29
Gastroesophageal reflux: clinical presentations, diagnosis and management. CMAJ (1986) 1.15
Ambulatory pH monitoring of gastro-oesophageal reflux in "morning dipper" asthmatics. BMJ (1988) 1.09
Metered dose inhaler and nebuliser in acute asthma. Arch Dis Child (1995) 1.06
Nocturnal asthma: mechanisms and treatment. Br Med J (Clin Res Ed) (1984) 1.06
Omeprazole in the treatment of asthmatics with nocturnal symptoms and gastro-oesophageal reflux: a placebo-controlled cross-over study. Postgrad Med J (1994) 0.97
Gastroesophageal reflux disease in asthma: effects of medical and surgical antireflux therapy on asthma control. Ann Surg (2000) 0.95
Chronic cough and gastroesophageal reflux. CMAJ (1989) 0.93
Asthma: 2. Trends in pharmacologic therapy. CMAJ (1987) 0.90
Esophageal dysmotility and gastroesophageal reflux in intrinsic asthma. Dig Dis Sci (1997) 0.84
Tracheal microaspiration in adult cystic fibrosis. J R Soc Med (1998) 0.80
Paradoxical response to nebulised salbutamol in wheezy infants. Thorax (1987) 0.79
Gastro-oesophageal reflux and asthma; a common association, but of what clinical importance? Gut (1990) 0.77
The two-period cross-over clinical trial. Br J Clin Pharmacol (1979) 13.21
A clinical test for esophagitis. Gastroenterology (1958) 3.79
The use of non-parametric methods in the statistical analysis of the two-period change-over design. Biometrics (1972) 2.62
Inhibition of gastric acid secretion by cimetidine in patients with duodenal ulcer. N Engl J Med (1975) 2.17
Gastroesophageal reflux and asthma: a possible reflex mechanism. Ann Allergy (1978) 1.95
Inhibition of food-stimulated gastric acid secretion by cimetidine. Gut (1976) 1.82
Bronchodilatation after inhalation of the antihistamine clemastine. Thorax (1978) 1.76
Intrinsic asthma in adults. Association with gastroesophageal reflux. JAMA (1976) 1.57
The evaluation of objective measurements of gastroesophageal reflux and their contribution to patient management. Surg Clin North Am (1976) 1.52
Inhaled antihistamines--bronchodilatation and effects on histamine- and methacholine-induced bronchoconstriction. Thorax (1978) 1.31
Gastroesophageal reflux and pulmonary aspiration: incidence, functional abnormality, and results of surgical therapy. Surgery (1979) 1.25
Assessment of a technique for scintigraphic monitoring of pulmonary aspiration of gastric contents in asthmatics with gastroesophageal reflux. Ann Allergy (1979) 1.15
Evaluation of gastro-pulmonary aspiration by a radioactive technique: concise communication. J Nucl Med (1977) 1.08
Hiatal hernia and intractable bronchial asthma. Ann Allergy (1971) 1.00
Esophageal reflux as a trigger in asthma. Dis Chest (1966) 0.99
Esophageal reflux as trigger in asthma. N Y State J Med (1966) 0.94
Wheezing: a clue to gastroesophageal reflux. Am J Gastroenterol (1970) 0.91
Incidence of chronic pulmonary disease among patients with esophageal disorders. Dis Chest (1957) 0.91
Effects of H1- and H2-receptor blocking agents on histamine-induced bronchoconstriction in non-asthmatic subjects. Br J Clin Pharmacol (1979) 0.89
Hiatal hernia in bronchial asthma: the importance of concomitant pulmonary emphysema. Gastroenterologia (1961) 0.86
Hiatal hernia and chronic unremitting asthma. Pediatr Radiol (1973) 0.83
Application of the Belsey hiatal hernia repair to infants and children with recurrent bronchitis, bronchiolitis, and pneumonitis due to regurgitation and aspiration. Ann Thorac Surg (1967) 0.80
The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: causes and consequences. Hum Genet (1992) 8.20
W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature (1995) 8.08
Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice. Cell (1985) 6.88
Human gene mutation database-a biomedical information and research resource. Hum Mutat (2000) 6.87
The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature (1988) 6.35
An estimate of unique DNA sequence heterozygosity in the human genome. Hum Genet (1985) 4.75
Galectins. Structure and function of a large family of animal lectins. J Biol Chem (1994) 4.29
Galectins: a family of animal beta-galactoside-binding lectins. Cell (1994) 3.99
A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell (1997) 3.65
Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1. Genes Dev (1991) 3.54
Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment. Hum Genet (1991) 3.48
Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice. Genes Dev (1989) 3.29
The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. EMBO J (1995) 3.16
Neighboring-nucleotide effects on the rates of germ-line single-base-pair substitution in human genes. Am J Hum Genet (1998) 3.12
Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus. Nature (1985) 2.98
Stroke in users of low-dose oral contraceptives. N Engl J Med (1996) 2.98
Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev (1999) 2.90
DNA restriction fragment length polymorphisms and heterozygosity in the human genome. Hum Genet (1984) 2.79
W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev (1990) 2.77
The human gene mutation database. Trends Genet (1997) 2.72
Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver. Proc Natl Acad Sci U S A (1991) 2.66
Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity (2000) 2.59
Unmethylated domains in vertebrate DNA. Nucleic Acids Res (1983) 2.58
Reforming higher specialist training in the United Kingdom--a step along the continuum of medical education. Med Educ (1999) 2.57
Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nat Genet (1999) 2.48
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature (1997) 2.46
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol (1989) 2.45
A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J (1991) 2.38
Mutational and functional analysis of the neurofibromatosis type 1 (NF1) gene. Hum Genet (1997) 2.37
Human Gene Mutation Database: towards a comprehensive central mutation database. J Med Genet (2008) 2.37
Pleiotropic properties and genetic organization of the tolA,B locus of Escherichia coli K-12. J Bacteriol (1972) 2.27
Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science (1987) 2.27
Regional mapping of six cloned DNA sequences on human chromosome 7. Am J Hum Genet (1986) 2.26
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol (1998) 2.26
Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes. Nature (1995) 2.22
Report of the DNA committee and catalogues of cloned and mapped genes and DNA polymorphisms. Cytogenet Cell Genet (1990) 2.21
Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells. Nature (1983) 2.20
Friend virus-induced erythroleukemia and the multistage nature of cancer. Cell (1991) 2.16
The Friend virus genome: evidence for the stable association of MuLV sequences and sequences involved in erythroleukemic transformation. Cell (1977) 2.12
Nebulised salbutamol with and without ipratropium bromide in acute airflow obstruction. Lancet (1989) 2.04
Potential hazards of mechanized surgical retractors. Br J Surg (1990) 2.02
Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development. Trends Genet (1990) 2.01
SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Mol Cell Biol (1992) 2.00
Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virus. Oncogene (1988) 1.96
Retrovirus transduction: segregation of the viral transforming function and the herpes simplex virus tk gene in infectious Friend spleen focus-forming virus thymidine kinase vectors. Mol Cell Biol (1983) 1.94
p53 mutations increase resistance to ionizing radiation. Proc Natl Acad Sci U S A (1993) 1.93
Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat Cell Biol (2000) 1.92
Modulation of gene expression in multiple hematopoietic cell lineages following retroviral vector gene transfer. Proc Natl Acad Sci U S A (1987) 1.86
Discoidin I is implicated in cell-substratum attachment and ordered cell migration of Dictyostelium discoideum and resembles fibronectin. Cell (1984) 1.82
Human gene cloning: the storm before the lull? Nature (1986) 1.78
Developmental origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine. Dev Dyn (1998) 1.78
The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol Cell Biol (1991) 1.76
Transformation-defective mutants of avian sarcoma viruses: the genetic relationship between conditional and nonconditional mutants. Virology (1976) 1.75
Retrovirus transduction: generation of infectious retroviruses expressing dominant and selectable genes is associated with in vivo recombination and deletion events. Mol Cell Biol (1983) 1.72
Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth. Mol Cell Biol (1992) 1.70
Deletion of 5'-coding sequences of the cellular p53 gene in mouse erythroleukemia: a novel mechanism of oncogene regulation. Mol Cell Biol (1987) 1.69
Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus. Proc Natl Acad Sci U S A (1990) 1.67
Management of spontaneous pneumothorax using a Heimlich flutter valve. Thorax (1973) 1.66
A new pathway for protein export in Saccharomyces cerevisiae. J Cell Biol (1996) 1.66
Stroke and cocaine or amphetamine use. Epidemiology (1998) 1.62
Efflux of radiolabeled polyethylene glycols and albumin from rat brain. Am J Physiol (1981) 1.62
Use of home health services: some findings from the National Medical Care Expenditure Survey. Home Health Care Serv Q (1985) 1.61
Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: correlation of disease severity with mutation type and location. Hum Mol Genet (2000) 1.61
Retrovirus long terminal repeats activate expression of coding sequences for the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci U S A (1982) 1.61
Factor VIII gene inversions in severe hemophilia A: results of an international consortium study. Blood (1995) 1.59
Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J (1991) 1.58
Eukaryotic DNA methylation. Hum Genet (1983) 1.57
A long-term prospective assessment of home nebulizer treatment. Respir Med (1992) 1.57
Each domain of the N-ethylmaleimide-sensitive fusion protein contributes to its transport activity. J Biol Chem (1995) 1.53
Assessment of reversibility of airway obstruction in patients with chronic obstructive airways disease. Thorax (1990) 1.53
Diagnosis of genetic disease using recombinant DNA. Supplement. Hum Genet (1987) 1.50
A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J (1992) 1.49
A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat Genet (1995) 1.49
Gene targeting with retroviral vectors: recombination by gene conversion into regions of nonhomology. Mol Cell Biol (1989) 1.48
L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativity. Biochemistry (1993) 1.47
p53 mutations, benzo[a]pyrene and lung cancer. Mutagenesis (1998) 1.47
Clonal analysis of early and late stages of erythroleukemia induced by molecular clones of integrated spleen focus-forming virus. Proc Natl Acad Sci U S A (1981) 1.46
Acoustic parameters of snoring sound to compare natural snores with snores during 'steady-state' propofol sedation. Clin Otolaryngol (2006) 1.45
Update on adolescent health care in pediatric practice. J Adolesc Health (1996) 1.45
Simple point-of-care risk stratification in acute coronary syndromes: the AMIS model. Heart (2008) 1.45
Expression of human adenosine deaminase in murine haematopoietic progenitor cells following retroviral transfer. Nature (1986) 1.44
Late-onset homozygous protein C deficiency. Lancet (1991) 1.43
The c-kit receptor ligand functions as a mast cell chemoattractant. Blood (1992) 1.42
Retrovirus vectors containing an internal attachment site: evidence that circles are not intermediates to murine retrovirus integration. J Virol (1989) 1.42
An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes. Mol Cell Biol (1995) 1.40
Research in higher surgical training--the West Midlands view. Ann R Coll Surg Engl (1993) 1.40
Adult-onset genetic disease: mechanisms, analysis and prediction. QJM (1997) 1.39
Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia. Mol Cell Biol (1996) 1.38
A retractor for cholecystectomy. Ann R Coll Surg Engl (1991) 1.38
Erythroleukemia induction by replication-competent type C viruses cloned from the anemia- and polycythemia-inducing isolates of Friend leukemia virus. J Exp Med (1980) 1.38
Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene. Mol Cell Biol (2001) 1.38
Quantitative colony method for tumorigenic cells transformed by two distinct strains of Friend leukemia virus. Proc Natl Acad Sci U S A (1981) 1.35
The reproducibility of the station pullthrough technique for measuring lower oesophageal sphincter pressure. Br J Surg (1979) 1.35
Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development. Development (1999) 1.33
The molecular genetics of growth hormone deficiency. Hum Genet (1998) 1.33
Misuse of pressurised nebulisers. Br Med J (1978) 1.33
The Bennett-Jones retractor. J R Coll Surg Edinb (1976) 1.33
Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci. Development (1991) 1.33