Published in Genes Dev on November 01, 1999
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev (2004) 4.41
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev (2002) 3.55
A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep (2002) 3.53
Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol (2011) 3.51
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A (2003) 2.69
Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev (2001) 2.26
The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev (2001) 2.15
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J Cell Biol (2000) 2.11
Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proc Natl Acad Sci U S A (2001) 1.74
RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development (2010) 1.72
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proc Natl Acad Sci U S A (2005) 1.69
Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (2006) 1.67
Vertebrate segmentation: from cyclic gene networks to scoliosis. Cell (2011) 1.65
Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes Dev (2004) 1.63
Mutations of presenilin genes in dilated cardiomyopathy and heart failure. Am J Hum Genet (2006) 1.63
Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A (2007) 1.61
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members. Proc Natl Acad Sci U S A (2001) 1.54
Proteolytic processing of Alzheimer's β-amyloid precursor protein. J Neurochem (2011) 1.50
Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development (2011) 1.42
Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A (2009) 1.38
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. J Biol Chem (2009) 1.33
Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. Mol Cell Biol (2001) 1.31
An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production. Nat Struct Mol Biol (2010) 1.24
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. J Neurosci (2009) 1.23
Presenilin-dependent receptor processing is required for axon guidance. Cell (2011) 1.22
Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proc Natl Acad Sci U S A (2004) 1.21
Presenilins are required for maintenance of neural stem cells in the developing brain. Mol Neurodegener (2008) 1.14
Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genet (2009) 1.14
Notch signaling and the bone marrow hematopoietic stem cell niche. Bone (2009) 1.14
Presenilin-dependent gamma-secretase activity modulates thymocyte development. Proc Natl Acad Sci U S A (2001) 1.13
Role of glycosylation of Notch in development. Semin Cell Dev Biol (2010) 1.10
Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. PLoS One (2010) 1.10
Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa. J Neurosci (2011) 1.09
Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis. PLoS One (2011) 1.09
Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation (2010) 1.08
Canonical Notch signaling is dispensable for early cell fate specifications in mammals. Mol Cell Biol (2005) 1.08
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes Dev (2009) 1.08
Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem (2012) 1.07
Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proc Natl Acad Sci U S A (2005) 1.07
Presenilins in synaptic function and disease. Trends Mol Med (2011) 1.02
Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex. Dis Model Mech (2010) 1.02
Presenilins regulate alphabeta T cell development by modulating TCR signaling. J Exp Med (2007) 1.02
Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB. Mol Cell Biol (2006) 1.02
Protease regulation: the Yin and Yang of neural development and disease. Neuron (2011) 1.00
FGF-dependent Notch signaling maintains the spinal cord stem zone. Genes Dev (2005) 0.99
Presenilin transgenic mice as models of Alzheimer's disease. Brain Struct Funct (2009) 0.98
The presenilins turned inside out: implications for their structures and functions. Proc Natl Acad Sci U S A (2004) 0.97
Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex. J Biol Chem (2011) 0.97
Adult neurogenesis is functionally associated with AD-like neurodegeneration. Neurobiol Dis (2007) 0.97
spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily. Proc Natl Acad Sci U S A (2000) 0.96
Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch. Proc Natl Acad Sci U S A (2000) 0.96
Phosphorylation of amyloid beta (Aβ) peptides - a trigger for formation of toxic aggregates in Alzheimer's disease. Aging (Albany NY) (2011) 0.95
Signature amyloid β profiles are produced by different γ-secretase complexes. J Biol Chem (2013) 0.94
Notch receptor cleavage depends on but is not directly executed by presenilins. Proc Natl Acad Sci U S A (2002) 0.93
Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. J Neurosci (2012) 0.92
Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch. J Biol Chem (2011) 0.92
The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci U S A (2002) 0.91
Notch signaling in Sertoli cells regulates cyclical gene expression of Hes1 but is dispensable for mouse spermatogenesis. Mol Cell Biol (2011) 0.91
Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins. Mol Cell Biol (2014) 0.91
Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases. Neurodegener Dis (2010) 0.90
Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Hum Mol Genet (2013) 0.89
Control of intracellular calcium signaling as a neuroprotective strategy. Molecules (2010) 0.89
Botch promotes neurogenesis by antagonizing Notch. Dev Cell (2012) 0.89
A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo. Development (2015) 0.88
Notch signaling represses p63 expression in the developing surface ectoderm. Development (2013) 0.87
Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci U S A (2014) 0.87
Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines. Exp Neurol (2013) 0.87
Defective signal transduction in B lymphocytes lacking presenilin proteins. Proc Natl Acad Sci U S A (2008) 0.86
Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity. Neural Plast (2012) 0.86
Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab (2010) 0.86
Function and dysfunction of presenilin. Neurodegener Dis (2013) 0.86
Transgenic animal models of neurodegeneration based on human genetic studies. J Neural Transm (Vienna) (2010) 0.85
RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development. Mol Cell Biol (2006) 0.85
Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. Curr Alzheimer Res (2011) 0.85
Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors. BMC Biotechnol (2010) 0.85
Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex. J Neurosci (2014) 0.84
Dynamic self-guiding analysis of Alzheimer's disease. Oncotarget (2015) 0.84
Notch/Rbpjκ signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons. Development (2013) 0.84
Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci (2010) 0.84
The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing. J Biol Chem (2010) 0.84
Effects of varying Notch1 signal strength on embryogenesis and vasculogenesis in compound mutant heterozygotes. BMC Dev Biol (2010) 0.82
Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase. PLoS One (2013) 0.82
ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development. BMC Genet (2012) 0.82
A revised model of Xenopus dorsal midline development: differential and separable requirements for Notch and Shh signaling. Dev Biol (2011) 0.81
Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain. BMC Neurosci (2007) 0.81
Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. PLoS Genet (2015) 0.81
The γ-secretase complex: from structure to function. Front Cell Neurosci (2014) 0.81
Restricted growth and insulin-like growth factor-1 deficiency in mice lacking presenilin-1 in the neural crest cell lineage. Int J Dev Neurosci (2009) 0.81
Presenilins regulate the cellular level of the tumor suppressor PTEN. Neurobiol Aging (2007) 0.80
Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study. Free Radic Biol Med (2013) 0.80
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proc Natl Acad Sci U S A (2002) 0.79
Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. J Biol Chem (2013) 0.79
An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum. J Cell Sci (2014) 0.79
The synchrony and cyclicity of developmental events. Cold Spring Harb Perspect Biol (2012) 0.79
L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells. Acta Pharmacol Sin (2012) 0.79
An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures. Proc Natl Acad Sci U S A (2006) 0.78
gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes. PLoS One (2010) 0.78
Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations. FEBS Open Bio (2014) 0.78
Molecular basis for skeletal variation: insights from developmental genetic studies in mice. Birth Defects Res B Dev Reprod Toxicol (2007) 0.78
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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature (1999) 10.36
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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature (1999) 8.28
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Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature (1998) 2.56
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