Published in Nature on February 18, 1982
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98
DNA methylation and gene expression. Microbiol Rev (1991) 4.44
Epigenetic inheritance during the cell cycle. Nat Rev Mol Cell Biol (2009) 4.43
MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome. Nucleic Acids Res (2009) 3.29
Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. EMBO J (1992) 3.06
Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation. Proc Natl Acad Sci U S A (1994) 2.73
DNA methylation, vernalization, and the initiation of flowering. Proc Natl Acad Sci U S A (1993) 2.69
Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. Proc Natl Acad Sci U S A (1983) 2.64
DNA methylation dynamics in health and disease. Nat Struct Mol Biol (2013) 2.58
Evidence for cytosine methylation of non-symmetrical sequences in transgenic Petunia hybrida. EMBO J (1994) 2.57
Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability. Proc Natl Acad Sci U S A (1990) 2.51
CpG island promoter region methylation patterns of the inactive-X-chromosome hypoxanthine phosphoribosyltransferase (Hprt) gene. Mol Cell Biol (1994) 2.15
DNA methylation. The effect of minor bases on DNA-protein interactions. Biochem J (1990) 2.09
Characterization of an Arabidopsis thaliana DNA hypomethylation mutant. Nucleic Acids Res (1995) 1.93
Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene. Proc Natl Acad Sci U S A (1996) 1.80
Differentiation of two mouse cell lines is associated with hypomethylation of their genomes. Mol Cell Biol (1984) 1.79
Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet (2007) 1.79
Regulation of X-chromosome inactivation in development in mice and humans. Microbiol Mol Biol Rev (1998) 1.72
DNA methylation is a reversible biological signal. Proc Natl Acad Sci U S A (1999) 1.69
Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts. Proc Natl Acad Sci U S A (1983) 1.68
Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation. Proc Natl Acad Sci U S A (1992) 1.64
Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi. Nucleic Acids Res (2005) 1.63
Human DNA (cytosine-5)methyltransferase selectively methylates duplex DNA containing mispairs. Nucleic Acids Res (1987) 1.57
Site specific demethylation in the promoter of human gamma-globin gene does not alleviate methylation mediated suppression. EMBO J (1987) 1.56
Genomic sequencing and in vivo footprinting of an expression-specific DNase I-hypersensitive site of avian vitellogenin II promoter reveal a demethylation of a mCpG and a change in specific interactions of proteins with DNA. Proc Natl Acad Sci U S A (1988) 1.52
Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc Natl Acad Sci U S A (2011) 1.52
Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial. Mol Cell Biol (1995) 1.45
Epimutation of repeated genes in Ascobolus immersus. EMBO J (1992) 1.44
The marks, mechanisms and memory of epigenetic states in mammals. Biochem J (2001) 1.43
The reduced expression of endogenous duplications (REED) in the maize R gene family is mediated by DNA methylation. EMBO J (1995) 1.43
Expression of transferred thymidine kinase genes is controlled by methylation. Proc Natl Acad Sci U S A (1982) 1.39
Free radical adducts induce alterations in DNA cytosine methylation. Proc Natl Acad Sci U S A (1994) 1.38
Identifying 5-methylcytosine and related modifications in DNA genomes. Nucleic Acids Res (1998) 1.38
Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol Cell Biol (2006) 1.35
Sequence and substrate specificity of isolated DNA methylases from Escherichia coli C. J Bacteriol (1983) 1.28
Developmental changes in the methylation of the rat albumin and alpha-fetoprotein genes. EMBO J (1983) 1.25
High-frequency conversion to a "fluffy" developmental phenotype in Aspergillus spp. by 5-azacytidine treatment: evidence for involvement of a single nuclear gene. Mol Cell Biol (1983) 1.23
DNA methylation profile of the mouse skeletal alpha-actin promoter during development and differentiation. Mol Cell Biol (1999) 1.19
Primary DNA sequence determines sites of maintenance and de novo methylation by mammalian DNA methyltransferases. Mol Cell Biol (1986) 1.19
Methylation of replicating and post-replicated mouse L-cell DNA. Proc Natl Acad Sci U S A (1983) 1.17
The characteristics of DNA methylation in an in vitro DNA synthesizing system from mouse fibroblasts. Nucleic Acids Res (1985) 1.16
Supercoiling-dependent sequence specificity of mammalian DNA methyltransferase. Nucleic Acids Res (1987) 1.14
Introduction and expression of the bacterial PaeR7 methylase gene in mammalian cells. Proc Natl Acad Sci U S A (1986) 1.10
A domain of methylation change at the albumin locus in rat hepatoma cell variants. Mol Cell Biol (1985) 1.09
In vitro methylation of specific regions of the cloned Moloney sarcoma virus genome inhibits its transforming activity. Mol Cell Biol (1983) 1.08
DNA methyltransferase induced by frog virus 3. J Virol (1984) 1.07
Growth-dependent expression of multiple species of DNA methyltransferase in murine erythroleukemia cells. Proc Natl Acad Sci U S A (1985) 1.07
Human placental DNA methyltransferase: DNA substrate and DNA binding specificity. Nucleic Acids Res (1984) 1.04
Transformation of Tetrahymena thermophila with hypermethylated rRNA genes. Mol Cell Biol (1988) 1.03
The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life. Epigenetics (2011) 1.03
DNA methylation: sequences flanking C-G pairs modulate the specificity of the human DNA methylase. Nucleic Acids Res (1985) 1.03
DNA methylation: a phoenix rises. Proc Natl Acad Sci U S A (1993) 1.02
DNA methylation signatures for breast cancer classification and prognosis. Genome Med (2012) 1.01
Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs. Curr Med Chem (2010) 0.99
CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer. Nature (2015) 0.99
Regulation of Pdha-2 expression is mediated by proximal promoter sequences and CpG methylation. Mol Cell Biol (1997) 0.97
The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation. Toxicol Sci (2011) 0.96
DNA Methylation is Reduced in DNasel-Sensitive Regions of Plant Chromatin. Plant Physiol (1989) 0.93
Ethylation of poly(dC-dG).poly(dC-dG) by ethyl methanesulfonate stimulates the activity of mammalian DNA methyltransferase in vitro. Proc Natl Acad Sci U S A (1985) 0.92
DNA methylation and differentiation. Environ Health Perspect (1989) 0.91
Loss of chloroplast DNA methylation during dedifferentiation of Chlamydomonas reinhardi gametes. Mol Cell Biol (1984) 0.87
DNA methylation and carcinogenesis in digestive neoplasms. World J Gastroenterol (1998) 0.87
Examination of the DNA substrate selectivity of DNA cytosine methyltransferases using mass tagging. Nucleic Acids Res (2000) 0.86
Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndrome. PLoS One (2011) 0.85
Human DNA mismatch repair in vitro operates independently of methylation status at CpG sites. Nucleic Acids Res (2001) 0.85
DNA hypermethylation in Drosophila melanogaster causes irregular chromosome condensation and dysregulation of epigenetic histone modifications. Mol Cell Biol (2003) 0.85
In vitro methylation of CpG-rich islands. Nucleic Acids Res (1989) 0.84
Molecular analysis of N6-methyladenine patterns in Tetrahymena thermophila nuclear DNA. Mol Cell Biol (1989) 0.83
Integrating DNA methylation dynamics into a framework for understanding epigenetic codes. Bioessays (2013) 0.83
DNA methyltransferase is developmentally expressed in replicating and non-replicating male germ cells. Nucleic Acids Res (1992) 0.82
De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins. J Biol Chem (2010) 0.81
Phenotypic variation associated with molecular alterations at a cluster of thymidine kinase genes. Mol Cell Biol (1983) 0.80
Activation of a nonexpressed hypoxanthine phosphoribosyltransferase allele in mutant H23 HeLa cells by agents that inhibit DNA methylation. Mol Cell Biol (1986) 0.80
Can we observe epigenetic effects on human brain function? Trends Cogn Sci (2015) 0.80
Aberrant DNA methylation in ES cells. PLoS One (2014) 0.80
Naturally occurring methylation inhibitor: DNA hypomethylation and hemoglobin synthesis in human K562 cells. Mol Cell Biol (1987) 0.78
Duplication-dependent CG suppression of the seed storage protein genes of maize. Genetics (2003) 0.78
Crystal Structure of Human DNA Methyltransferase 1. J Mol Biol (2015) 0.77
Decreased DNA Methylation in the Shati/Nat8l Promoter in Both Patients with Schizophrenia and a Methamphetamine-Induced Murine Model of Schizophrenia-Like Phenotype. PLoS One (2016) 0.77
Eyes on DNA methylation: current evidence for DNA methylation in ocular development and disease. J Ocul Biol Dis Infor (2012) 0.77
Epigenetic Mechanisms in Developmental Alcohol-Induced Neurobehavioral Deficits. Brain Sci (2016) 0.77
Perturbation of maintenance and de novo DNA methylation in vitro by UVB (280-340 nm)-induced pyrimidine photodimers. Proc Natl Acad Sci U S A (1985) 0.77
Structure and extent of DNA methylation-based epigenetic variation in wild emmer wheat (T. turgidum ssp. dicoccoides) populations. BMC Plant Biol (2015) 0.76
Mouse DNA-cytosine-5-methyltransferase: sequence specificity of the methylation reaction and electron microscopy of enzyme-DNA complexes. EMBO J (1985) 0.76
Transmission of Metabolic Dysfunction Across Generations. Physiology (Bethesda) (2017) 0.75
5-Methyldeoxycytidine in the Physarum minichromosome containing the ribosomal RNA genes. Nucleic Acids Res (1984) 0.75
Different levels of DNA modification at 5'CCGG in murine erythroleukemia cells and the tissues of normal mouse spleen. Nucleic Acids Res (1982) 0.75
Inter-individual variation in DNA methylation is largely restricted to tissue-specific differentially methylated regions in maize. BMC Plant Biol (2017) 0.75
Expression level and immunolocalization of de novo methyltransferase 3 protein (TuDNMT3) in adult females and males of the two-spotted spider mite, Tetranychus urticae. Exp Appl Acarol (2015) 0.75
DNA methylation and gene function. Science (1980) 14.01
Intragenic DNA spacers interrupt the ovalbumin gene. Proc Natl Acad Sci U S A (1978) 11.03
Sequence specificity of methylation in higher plant DNA. Nature (1981) 7.58
Allelic inactivation regulates olfactory receptor gene expression. Cell (1994) 5.93
Sp1 elements protect a CpG island from de novo methylation. Nature (1994) 5.60
Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell (1993) 5.22
DNA methylation affects the formation of active chromatin. Cell (1986) 4.65
DNA methylation and gene expression. Microbiol Rev (1991) 4.44
Effect of CpG methylation on Msp I. Nucleic Acids Res (1983) 4.32
Efficient correction of a mutation by use of chemically synthesized DNA. Proc Natl Acad Sci U S A (1978) 4.13
Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. Genes Dev (1992) 4.02
Direct detection of methylated cytosine in DNA by use of the restriction enzyme MspI. Nucleic Acids Res (1979) 3.99
Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro. Proc Natl Acad Sci U S A (1973) 3.93
Replication structure of the human beta-globin gene domain. Nature (1993) 3.84
Methylation of CpG sequences in eukaryotic DNA. FEBS Lett (1981) 3.39
Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. Mol Biol Cell (2000) 3.30
Structure of the DNA of bacteriophage phiX174. VII. Methylation. J Mol Biol (1970) 3.23
Pattern of methylation of two genes coding for housekeeping functions. Proc Natl Acad Sci U S A (1983) 3.03
Methylation of foreign DNA sequences in eukaryotic cells. Proc Natl Acad Sci U S A (1980) 3.01
Mapping replication units in animal cells. Cell (1989) 2.99
Delineation of DNA replication time zones by fluorescence in situ hybridization. EMBO J (1992) 2.94
In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. Proc Natl Acad Sci U S A (1982) 2.92
DNA methylation represses transcription in vivo. Nat Genet (1999) 2.92
Restriction enzyme digestion of hemimethylated DNA. Nucleic Acids Res (1981) 2.87
Cloning, characterization, and expression in Escherichia coli of the gene coding for the CpG DNA methylase from Spiroplasma sp. strain MQ1(M.SssI). Nucleic Acids Res (1990) 2.86
Role of DNA methylation in the regulation of transcription. Curr Opin Genet Dev (1994) 2.61
Characteristic folding pattern of polytene chromosomes in Drosophila salivary gland nuclei. Nature (1984) 2.60
The process of infection with Bacteriophage phi-X174. XXIX. In vivo studies on the synthesis of the single-stranded DNA of progeny phi-X174 bacteriophage. J Mol Biol (1969) 2.59
The absence of detectable methylated bases in Drosophila melanogaster DNA. FEBS Lett (1982) 2.57
DNA methylation and its possible biological roles. Prog Nucleic Acid Res Mol Biol (1981) 2.55
Clonal inheritance of the pattern of DNA methylation in mouse cells. Proc Natl Acad Sci U S A (1982) 2.52
DNA methylation and genomic imprinting. Cell (1994) 2.51
Spatial organization of chromosomes in the salivary gland nuclei of Drosophila melanogaster. J Cell Biol (1986) 2.39
DNA methylation patterns. Formation and function. Biochim Biophys Acta (1984) 2.36
The ontogeny of allele-specific methylation associated with imprinted genes in the mouse. EMBO J (1993) 2.32
The asparagine synthetase of Escherhic coli. I. Biosynthetic role of the enzyme, purification, and characterization of the reaction products. J Biol Chem (1969) 2.30
Expression of a cloned adenovirus gene is inhibited by in vitro methylation. Proc Natl Acad Sci U S A (1982) 2.23
Selective degradation of integrated murine leukemia proviral DNA by deoxyribonucleases. Cell (1977) 2.22
A role for nuclear NF-kappaB in B-cell-specific demethylation of the Igkappa locus. Nat Genet (1996) 2.16
Effect of regional DNA methylation on gene expression. Proc Natl Acad Sci U S A (1985) 2.11
C. elegans nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis. Mol Biol Cell (2000) 2.11
Allele-specific replication timing of imprinted gene regions. Nature (1993) 2.08
DNA demethylation in vitro: involvement of RNA. Cell (1996) 2.07
DNA methylation models histone acetylation. Nature (1998) 2.04
Studies on the biological role of dna methylation; IV. Mode of methylation of DNA in E. coli cells. Nucleic Acids Res (1980) 2.04
Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern. Proc Natl Acad Sci U S A (1997) 2.04
The structure of the globin genes in chromatin. Biochemistry (1975) 2.02
Production of L-asparaginase II by Escherichia coli. J Bacteriol (1968) 2.01
Demethylation of CpG islands in embryonic cells. Nature (1991) 1.92
Distribution of 5-methylcytosine in chromatin. Proc Natl Acad Sci U S A (1977) 1.90
Asynchronous replication and allelic exclusion in the immune system. Nature (2001) 1.89
Transcription of chromatin in vitro. J Mol Biol (1973) 1.84
Transcriptional repression, apoptosis, human disease and the functional evolution of the nuclear lamina. Trends Biochem Sci (2001) 1.82
Kappa chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev (1998) 1.81
Dynamics of demethylation and activation of the alpha-actin gene in myoblasts. Cell (1990) 1.79
Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation. Proc Natl Acad Sci U S A (1986) 1.79
Active gene sequences are undermethylated. Proc Natl Acad Sci U S A (1981) 1.79
Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science (2000) 1.77
DNA methylation: a molecular lock. Curr Biol (1997) 1.73
Asynchronous replication of imprinted genes is established in the gametes and maintained during development. Nature (1999) 1.70
Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse. Proc Natl Acad Sci U S A (1991) 1.68
Cyclic adenosine monophosphate in the nervous system of Aplysia californica. II. Effect of serotonin and dopamine. J Gen Physiol (1972) 1.66
Procaryotic and eucaryotic traits of DNA methylation in spiroplasmas (mycoplasmas). J Bacteriol (1985) 1.62
Organization of 5-methylcytosine in chromosomal DNA. Biochemistry (1978) 1.62
Muscle-specific activation of a methylated chimeric actin gene. Cell (1986) 1.60
Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. Proc Natl Acad Sci U S A (1984) 1.59
DNA methylation and development. Biochim Biophys Acta (1990) 1.58
Localization of the two-L-asparaginases in anaerobically grown Escherichia coli. J Biol Chem (1967) 1.55
Sequential changes in DNA methylation patterns of the rat phosphoenolpyruvate carboxykinase gene during development. Proc Natl Acad Sci U S A (1985) 1.55
Methylated bases in mycoplasmal DNA. Nucleic Acids Res (1980) 1.51
Inhibition of promoter activity by methylation: possible involvement of protein mediators. Proc Natl Acad Sci U S A (1991) 1.47
In vitro methylation of DNA with Hpa II methylase. Nucleic Acids Res (1981) 1.46
Mapping of DNAase I sensitive regions on mitotic chromosomes. Cell (1984) 1.45
Developmental regulation of DNA replication timing at the human beta globin locus. EMBO J (2001) 1.45
Spatial organization of the Drosophila nucleus: a three-dimensional cytogenetic study. J Cell Sci Suppl (1984) 1.44
Increased MHC H-2K gene transcription in cultured mouse embryo cells after adenovirus infection. Nature (1985) 1.41
DNA methylation in eukaryotic cells. Int Rev Cytol (1984) 1.40
The asparagine synthetase of Escherichia coli. II. Studies on mechanism. J Biol Chem (1969) 1.40