Published in Proc Natl Acad Sci U S A on July 01, 1973
Intragenic DNA spacers interrupt the ovalbumin gene. Proc Natl Acad Sci U S A (1978) 11.03
Prolonged transcription in a cell-free system involving nuclei and cytoplasm. Proc Natl Acad Sci U S A (1974) 6.74
Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei. Proc Natl Acad Sci U S A (1976) 5.27
A new procedure for purifying histone pairs H2A + H2B and H3 + H4 from chromatin using hydroxylapatite. Nucleic Acids Res (1979) 3.62
Specific sites of interaction between histones and DNA in chromatin. Proc Natl Acad Sci U S A (1974) 3.25
Analysis of DNA of isolated chromatin subunits. Proc Natl Acad Sci U S A (1975) 3.17
Selective association of the trout-specific H6 protein with chromatin regions susceptible to DNase I and DNase II: possible location of HMG-T in the spacer region between core nucleosomes. Proc Natl Acad Sci U S A (1977) 2.36
Partial purification of the template-active fraction of chromatin: a preliminary report. Proc Natl Acad Sci U S A (1974) 2.25
Genes transcribed at diverse rates have a similar conformation in chromatin. Proc Natl Acad Sci U S A (1977) 2.17
Distribution of 5-methylcytosine in chromatin. Proc Natl Acad Sci U S A (1977) 1.90
The in vitro synthesis of avian myeloblastosis viral RNA sequences. Proc Natl Acad Sci U S A (1974) 1.74
Renaturation kinetics of cDNA complementary to cytoplamic polyadenylated RNA from rainbow trout testis. Accessibility of transcribed genes to pancreatic DNase. Nucleic Acids Res (1977) 1.66
Cell-free transcription of mammalian chromatin: transcription of globin messenger RNA sequences from bone-marrow chromatin with mammalian RNA polymerase. Proc Natl Acad Sci U S A (1974) 1.54
Transcription in vitro of immunoglobulin kappa light chain genes in isolated mouse myeloma nuclei and chromatin. Proc Natl Acad Sci U S A (1976) 1.38
Nonhistone proteins control gene expression in reconstituted chromatin. Proc Natl Acad Sci U S A (1974) 1.37
Selective and accurate transcription of the Xenopus laevis 5S RNA genes in isolated chromatin by purified RNA polymerase III. Proc Natl Acad Sci U S A (1977) 1.33
Nucleotide sequence analysis of RNA synthesized from rabbit globin complementary DNA. Proc Natl Acad Sci U S A (1974) 1.31
Preferential transcription of the ovalbumin gene in isolated hen oviduct nuclei by RNA polymerase B. Proc Natl Acad Sci U S A (1978) 1.30
In vitro transcription of chromatin in the presence of a mercurated nucleotide. Proc Natl Acad Sci U S A (1976) 1.25
RNA aggregation during sulfhydryl-agarose chromatography of mercurated RNA. Nucleic Acids Res (1977) 1.18
Reconstitution of a deoxyribonuclease I-sensitive structure on active genes. Proc Natl Acad Sci U S A (1980) 1.16
Limited accessibility of chromatin satellite DNA to RNA polymerase from Escherichia coli. Proc Natl Acad Sci U S A (1977) 1.01
Chromatin directed transcription of 5S and tRNA genes. Proc Natl Acad Sci U S A (1975) 1.01
Strand-selective transcription of globin genes in rabbit erythroid cells and chromatin. Proc Natl Acad Sci U S A (1975) 0.96
In vitro transcription of heat-shock-specific RNA from chromatin of Drosophila melanogaster cells. Proc Natl Acad Sci U S A (1978) 0.95
A RNA-dependent RNA polymerase activity: implications for chromatin transcription experiments. Nucleic Acids Res (1977) 0.95
Methylation of chromatin DNA. Nucleic Acids Res (1976) 0.94
Is there specific transcription from isolated chromatin? Nucleic Acids Res (1978) 0.92
Effect of estrogen on gene expression: purification of vitellogenin messenger RNA. Proc Natl Acad Sci U S A (1975) 0.92
Double-stranded RNA in chromatin transcripts formed by exogenous RNA polymerase. Proc Natl Acad Sci U S A (1976) 0.88
Histones H2A and H2B are neighbors along DNA in chromatin: characterization of subnucleosomal particles containing H2A+H2B. Nucleic Acids Res (1977) 0.84
Changes in the number of binding sites for ribonucleic acid polymerase in chromatin of WI-38 fibroblasts stimulated to proliferate. Biochem J (1974) 0.82
Satellite DNA sequence content of polylysine-titratable and nuclease-resistant fractions of mouse liver hepatoma chromatin. Nucleic Acids Res (1976) 0.81
Accurate initiation of human epsilon-globin RNA synthesis by Escherichia coli RNA polymerase in isolated nuclei of K562 erythroleukemia cells. Proc Natl Acad Sci U S A (1984) 0.80
The specificity of in vitro chromatin transcription. Nucleic Acids Res (1979) 0.80
Transcription of viral genes in chromatin from adenovirus 2 transformed cells by exogenous eukaryotic RNA polymerases. Nucleic Acids Res (1979) 0.78
Characterization of double-stranded ribonucleic acid sequences present in the initial transcription products of rat liver chromatin. Biochem J (1977) 0.77
In vitro DNA dependent synthesis of globin RNA sequences from erythroleukemic cell chromatin. Nucleic Acids Res (1979) 0.75
Control of RNA synthesis by chromatin proteins. Nucleic Acids Res (1976) 0.75
Effect of non-histone chromosomal proteins on transcription in vitro in sea-urchin. Biochem J (1978) 0.75
Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. Science (1968) 30.37
In vitro synthesis of DNA complementary to purified rabbit globin mRNA (RNA-dependent DNA polymerase-reticulocyte-hemoglobin-density gradient centrifugation-oligo(dT) primer). Proc Natl Acad Sci U S A (1972) 7.89
Purification of the DNA polymerase of avian myeloblastosis virus. Biochim Biophys Acta (1971) 6.64
In vitro synthesis of DNA complementary to rabbit reticulocyte 10S RNA. Nat New Biol (1972) 4.01
Organ-specific restriction of transcription in mammalian chromatin. J Mol Biol (1968) 3.61
Giant-size rapidly labeled nuclear ribonucleic acid and cytoplasmic messenger ribonucleic acid in immature duck erythrocytes. J Mol Biol (1966) 3.29
In vitro synthesis of DNA components of human genes for globins. Nat New Biol (1972) 3.23
DNA-RNA hybridization in vast DNA excess. Nat New Biol (1971) 3.05
The Biology of Isolated Chromatin: Chromosomes, biologically active in the test tube, provide a powerful tool for the study of gene action. Science (1968) 2.84
Sequence-specific interaction of DNA and chromosomal protein. J Mol Biol (1969) 2.48
Isolation of eukaryotic messenger RNA on cellulose and its translation in vitro. Biochem Biophys Res Commun (1972) 2.21
Evidence for translation of viral-specific RNA in cells of a mouse mammary carcinoma. Proc Natl Acad Sci U S A (1972) 1.76
Circular dichroism of calf liver nucleohistone. Biochemistry (1970) 1.60
Fractionation of chromatin by thermal chromatography. Biochemistry (1972) 1.54
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell (1986) 22.26
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell (1978) 19.44
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell (1977) 18.95
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell (1991) 18.19
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature (2000) 14.91
Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell (1981) 12.73
Intragenic DNA spacers interrupt the ovalbumin gene. Proc Natl Acad Sci U S A (1978) 11.03
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell (1999) 9.74
Visualizing an olfactory sensory map. Cell (1996) 8.79
Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC). Proc Natl Acad Sci U S A (1981) 8.07
A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell (1993) 8.05
Sequence specificity of methylation in higher plant DNA. Nature (1981) 7.58
Nucleosome structure. Annu Rev Biochem (1980) 7.16
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell (1985) 7.16
A 200 base pair region at the 5' end of the chicken adult beta-globin gene is accessible to nuclease digestion. Cell (1981) 6.43
A spatial map of olfactory receptor expression in the Drosophila antenna. Cell (1999) 6.42
A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature (1988) 6.39
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell (1978) 6.38
The erythroid-specific transcription factor Eryf1: a new finger protein. Cell (1989) 6.14
Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science (2001) 6.00
Allelic inactivation regulates olfactory receptor gene expression. Cell (1994) 5.93
Chromatin. Nature (1978) 5.89
A novel ras-related gene family. Cell (1985) 5.81
Sp1 elements protect a CpG island from de novo methylation. Nature (1994) 5.60
Insulators and boundaries: versatile regulatory elements in the eukaryotic genome. Science (2001) 5.37
An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proc Natl Acad Sci U S A (1988) 5.29
An olfactory sensory map in the fly brain. Cell (2000) 5.29
Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei. Proc Natl Acad Sci U S A (1976) 5.27
Structure of chromatin. Nat New Biol (1971) 5.23
Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell (1993) 5.22
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12
A novel family of genes encoding putative pheromone receptors in mammals. Cell (1995) 4.88
Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature (1990) 4.81
Topographic organization of sensory projections to the olfactory bulb. Cell (1994) 4.74
DNA methylation affects the formation of active chromatin. Cell (1986) 4.65
A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell (2001) 4.64
DNA methylation and gene expression. Microbiol Rev (1991) 4.44
Effect of CpG methylation on Msp I. Nucleic Acids Res (1983) 4.32
The organization of histones and DNA in chromatin: evidence for an arginine-rich histone kernel. Cell (1976) 4.31
Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci. EMBO J (2001) 4.28
A new method for the purification and identification of covalently closed circular DNA molcules. Nucleic Acids Res (1978) 4.09
Specific factor conferring nuclease hypersensitivity at the 5' end of the chicken adult beta-globin gene. Proc Natl Acad Sci U S A (1984) 4.03
Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. Genes Dev (1992) 4.02
Direct detection of methylated cytosine in DNA by use of the restriction enzyme MspI. Nucleic Acids Res (1979) 3.99
Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult beta-globin gene: nature of the binding domain. Cell (1985) 3.99
Transforming DNA integrates into the host chromosome. Cell (1981) 3.98
The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Cell (1985) 3.91
Replication structure of the human beta-globin gene domain. Nature (1993) 3.84
Altering genotype and phenotype by DNA-mediated gene transfer. Science (1980) 3.82
NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science (1993) 3.74
Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes Dev (1998) 3.70
Integration, transcription, and control of a Drosophila heat shock gene in mouse cells. Proc Natl Acad Sci U S A (1981) 3.70
A new procedure for purifying histone pairs H2A + H2B and H3 + H4 from chromatin using hydroxylapatite. Nucleic Acids Res (1979) 3.62
Characterization of the chicken beta-globin insulator. Proc Natl Acad Sci U S A (1997) 3.57
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 3.53
Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell (1993) 3.53
A comparison of the digestion of nuclei and chromatin by staphylococcal nuclease. Biochemistry (1975) 3.52
Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1987) 3.50
Substrate and sequence specificity of a eukaryotic DNA methylase. Nature (1982) 3.42
Transformation of mammalian cells with an amplifiable dominant-acting gene. Proc Natl Acad Sci U S A (1980) 3.39
Methylation of CpG sequences in eukaryotic DNA. FEBS Lett (1981) 3.39
Conformation of polyribouridylic acid in solution. J Mol Biol (1970) 3.28
Specific sites of interaction between histones and DNA in chromatin. Proc Natl Acad Sci U S A (1974) 3.25
A neighbor-interaction analysis of the hypochromism and spectra of DNA. J Mol Biol (1965) 3.24
Cleavage of DNA in nuclei and chromatin with staphylococcal nuclease. Biochemistry (1975) 3.20
Analysis of DNA of isolated chromatin subunits. Proc Natl Acad Sci U S A (1975) 3.17
Regulated gene expression in transfected primary chicken erythrocytes. Proc Natl Acad Sci U S A (1986) 3.17
Pattern of methylation of two genes coding for housekeeping functions. Proc Natl Acad Sci U S A (1983) 3.03
Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science (1988) 3.02
Methylation of foreign DNA sequences in eukaryotic cells. Proc Natl Acad Sci U S A (1980) 3.01
Mice deficient in G(olf) are anosmic. Neuron (1998) 3.00
Mapping replication units in animal cells. Cell (1989) 2.99
A study of polyadenylic acid at neutral pH. J Mol Biol (1966) 2.99
Supercoiling energy and nucleosome formation: the role of the arginine-rich histone kernel. Nucleic Acids Res (1977) 2.94
Delineation of DNA replication time zones by fluorescence in situ hybridization. EMBO J (1992) 2.94
In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. Proc Natl Acad Sci U S A (1982) 2.92
DNA methylation represses transcription in vivo. Nat Genet (1999) 2.92
Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature (1987) 2.89
Structural and functional conservation at the boundaries of the chicken beta-globin domain. EMBO J (2000) 2.88
HIV infection does not require endocytosis of its receptor, CD4. Cell (1988) 2.88
Restriction enzyme digestion of hemimethylated DNA. Nucleic Acids Res (1981) 2.87
Mechanism of transcription through the nucleosome by eukaryotic RNA polymerase. Science (1997) 2.81
Mutational analysis of the chicken beta-globin enhancer reveals two positive-acting domains. Proc Natl Acad Sci U S A (1988) 2.80
The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell (1983) 2.75
Isolation of transforming DNA: cloning the hamster aprt gene. Cell (1980) 2.73
An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene. EMBO J (1999) 2.68
The solution structure of a specific GAGA factor-DNA complex reveals a modular binding mode. Nat Struct Biol (1997) 2.67
Role of DNA methylation in the regulation of transcription. Curr Opin Genet Dev (1994) 2.61
Odorant receptors govern the formation of a precise topographic map. Cell (1998) 2.60
Regulated expression of human growth hormone genes in mouse cells. Cell (1982) 2.58
Clonal inheritance of the pattern of DNA methylation in mouse cells. Proc Natl Acad Sci U S A (1982) 2.52
DNA methylation and genomic imprinting. Cell (1994) 2.51
A histone octamer can step around a transcribing polymerase without leaving the template. Cell (1994) 2.48
DNAase I, DNAase II and staphylococcal nuclease cut at different, yet symmetrically located, sites in the nucleosome core. Cell (1978) 2.48
Structure and evolution of a human erythroid transcription factor. Nature (1990) 2.47