Published in Life Sci on June 21, 1982
Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man. Drug Metab Dispos (1978) 1.61
Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor. Pharm Res (1999) 1.42
Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine. J Med Chem (1980) 1.41
Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica. J Org Chem (1973) 1.32
Metabolism of trimethoprim in man and measurement of a new metabolite: a new fluorescence assay. J Infect Dis (1973) 1.09
Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors. Drug Metab Dispos (2001) 1.09
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogues of trimethoprim. J Med Chem (1981) 1.05
The isolation and structural elucidation of bruceantin and bruceantinol, new potent antileukemic quassinoids from Brucea antidysenterica. J Org Chem (1975) 1.00
Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitor. J Am Chem Soc (1976) 0.97
High-performance liquid chromatographic assay for the measurement of atovaquone in plasma. J Chromatogr (1994) 0.96
Failure of trimethoprim-sulfamethoxazole therapy in experimental enterococcal endocarditis. Antimicrob Agents Chemother (1990) 0.94
Modulation of hematoporphyrin derivative-sensitized phototherapy with corynebacterium parvum in murine transitional cell carcinoma. Urology (1989) 0.91
Survey of antenatal women's knowledge of maternal and fetal risks of tobacco smoking and acceptability of nicotine replacement products in pregnancy. J Obstet Gynaecol (2005) 0.89
High-performance liquid chromatographic assay for the simultaneous measurement of trimethoprim and sulfamethoxazole in plasma or urine. Ther Drug Monit (1990) 0.89
Preclinical biochemical pharmacology and toxicology of piritrexim, a lipophilic inhibitor of dihydrofolate reductase. NCI Monogr (1987) 0.89
Effects of aerosolized synthetic surfactant, atovaquone, and the combination of these on murine Pneumocystis carinii pneumonia. J Infect Dis (1998) 0.88
A phase I clinical and pharmacological study of weekly intravenous infusions of piritrexim (BW301U). Eur J Cancer Clin Oncol (1989) 0.88
Pharmacokinetics of trimethoprim and sulfadiazine in the dog: urine concentrations after oral administration. Am J Vet Res (1981) 0.88
Metabolism and disposition by the rat of 35S-sulfadiazine alone and in the presence of trimethoprim. Drug Metab Dispos (1979) 0.85
A robotics-based liquid chromatographic assay for the measurement of atovaquone in plasma. J Pharm Biomed Anal (1995) 0.83
Superiority of intralesional immunotherapy with Corynebacterium parvum and Allium sativum in control of murine transitional cell carcinoma. J Urol (1986) 0.81
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 9. Lipophilic trimethoprim analogues as antigonococcal agents. J Med Chem (1988) 0.81
Metabolic disposition and pharmacokinetics of [14C]-amprenavir, a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, administered as a single oral dose to healthy male subjects. J Clin Pharmacol (2001) 0.79
Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med (1999) 0.79
Tumor inhibitors. LXV. Bersenogenin, berscillogenin, and 3-epiberscillogenin, three new cytotoxic bufadienolides from Bersama abyssinica. J Org Chem (1971) 0.79
Datiscacin, a novel cytotoxic cucurbitacin 20-acetate from Datisca glomerata. J Org Chem (1973) 0.79
Diffusion of trimethoprim and sulfamethoxazole from susceptibility disks into agar medium. Antimicrob Agents Chemother (1975) 0.78
Baquiloprim, a new antifolate antibacterial: in vitro activity and pharmacokinetic properties in cattle. Res Vet Sci (1993) 0.78
Cranial isotopic section scanning. Clin Radiol (1977) 0.78
Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol (1991) 0.78
Serum concentrations of trimethoprim and sulfadiazine following oral paste administration to the horse. Am J Vet Res (1981) 0.77
Reaction of biological thiols with the tumor inhibitor jatrophone. Inhibition of RNA polymerase. Biochim Biophys Acta (1973) 0.77
Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y/TK +/- mouse lymphoma assay. Mutat Res (1987) 0.76
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms. J Med Chem (1989) 0.76
A kinetic study of the ninhydrin reaction. Biochemistry (1966) 0.76
The pharmacokinetics of 1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)quinazoline, in dogs and rats after intravenous and oral administration. Biopharm Drug Dispos (1997) 0.76
Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase. Cancer Treat Rep (1977) 0.75
Use of 1-H nuclear magnetic resonance spectroscopy for sequence and configuration analysis of cyclic tetrapeptides. The structure of Tentoxin-1,2a--d. J Am Chem Soc (1975) 0.75
II. Novel deaminated sulfadiazine metabolites in neonatal calf tissue, plasma, and urine following oral treatment of 14C-sulfadiazine. Life Sci (1980) 0.75
The disposition and metabolism of [14C]piritrexim in dogs after intravenous and oral administration. Drug Metab Dispos (1992) 0.75
Experimental induction of Proteus mirabilis cystitis in the pony and evaluation of therapy with trimethoprim-sulfadiazine. Am J Vet Res (1981) 0.75
Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model. Cancer Treat Rep (1982) 0.75
Specific TLC tissue residue determination of sulfadiazine following fluorescamine derivatization. J Pharm Sci (1975) 0.75
The disposition and metabolism of [14C]piritrexim in rats after intravenous and oral administration. Drug Metab Dispos (1991) 0.75
Superiority of intravesical immunotherapy with Corynebacterium parvum and Allium sativum in control of murine bladder cancer. J Urol (1987) 0.75
Emission and transmission tomography of the brain in cerebrovascular disease. Surg Neurol (1984) 0.75
Trimethoprim and sulfadiazine concentrations in aqueous and vitreous humors of the dog. Vet Med Small Anim Clin (1981) 0.75
Thin layer chromatographic screening method for sulfadiazine residues in calf tissues, plasma, and urine. J Assoc Off Anal Chem (1978) 0.75
Development of pharmacokinetic models for sulfonamides in food animals: metabolic depletion profile of sulfadiazine in the calf. Am J Vet Res (1982) 0.75
Pharmacokinetics and hematological effects of the PEGylated thrombopoietin peptide mimetic GW395058 in rats and monkeys after intravenous or subcutaneous administration. Stem Cells (1999) 0.75
An evaluation of static cerebral studies with a nuclear data (Selektronik) radicamera II. Br J Radiol (1973) 0.75
Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos (1991) 0.75
Identification of trimethoprim 3-oxide as a new urinary metabolite of trimethoprim in man. J Pharm Sci (1973) 0.75
Competitive protein binding assay for piritrexim. J Pharm Sci (1989) 0.75
A new fluorescence assay of trimethoprim and metabolites using quantitative thin-layer chromatography. J Chromatogr (1973) 0.75
Datiscoside, a novel antileukemic cucurbitacin glycoside from Datisca glomerata. J Am Chem Soc (1972) 0.75
Specific TLC determination of trimethoprim and sulfamethoxazole in plasma. J Pharm Sci (1974) 0.75
Pharmacokinetics and disposition in the rat of a DNA intercalator 502U83. Drug Metab Dispos (1993) 0.75
Tumor inhibitors. 33. Cytotoxic flavones from eupatorium species. Tetrahedron (1969) 0.75
Cerebral scintigraphy with a Nuclear Chicago 1206 high performance gamma camera. Br J Radiol (1974) 0.75