Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice.

PubWeight™: 1.61‹?› | Rank: Top 4%

🔗 View Article (PMC 390672)

Published in Proc Natl Acad Sci U S A on September 01, 1985

Authors

M Fukui, T Yamamoto, S Kawai, K Maruo, K Toyoshima

Articles citing this

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J (1989) 3.67

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis. Mol Cell Biol (1989) 2.90

The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene. Nucleic Acids Res (1986) 2.50

Autoregulation of the Raf-1 serine/threonine kinase. Proc Natl Acad Sci U S A (1998) 2.47

Mutational activation of c-raf-1 and definition of the minimal transforming sequence. Mol Cell Biol (1990) 2.24

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. Nucleic Acids Res (1987) 1.98

B-raf, a new member of the raf family, is activated by DNA rearrangement. Mol Cell Biol (1988) 1.78

Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa. Proc Natl Acad Sci U S A (1986) 1.71

Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene. EMBO J (1988) 1.48

Rat c-raf oncogene activation by a rearrangement that produces a fused protein. Mol Cell Biol (1987) 1.42

Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences. Mol Cell Biol (1987) 1.39

Characterization of murine A-raf, a new oncogene related to the v-raf oncogene. Mol Cell Biol (1986) 1.32

Activation of rat c-raf during transfection of hepatocellular carcinoma DNA. Proc Natl Acad Sci U S A (1986) 1.29

Activation of human c-raf-1 by replacing the N-terminal region with different sequences. Nucleic Acids Res (1987) 1.14

Induction of transformation and DNA synthesis after microinjection of raf proteins. Mol Cell Biol (1990) 1.08

Molecular cloning and characterization of an activated human c-raf-1 gene. Mol Cell Biol (1987) 1.08

Human cancer and cellular oncogenes. Biochem J (1987) 1.07

Replacement of lys 622 in the ATP binding domain of P100gag-mil abolishes the in vitro autophosphorylation of the protein and the biological properties of the v-mil oncogene of MH2 virus. EMBO J (1988) 0.97

Induction of proliferation of neuroretina cells by long terminal repeat activation of the carboxy-terminal part of c-mil. Mol Cell Biol (1987) 0.94

Tumorigenicity of simian virus 40-hepatocyte cell lines: effect of in vitro and in vivo passage on expression of liver-specific genes and oncogenes. Mol Cell Biol (1988) 0.89

Optimisation of conditions for detection of activated oncogenes by transfection of NIH 3T3 cells. Br J Cancer (1987) 0.75

Articles cited by this

Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol (1977) 205.11

A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell (1978) 19.44

Mechanism of activation of a human oncogene. Nature (1982) 12.09

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature (1982) 11.92

Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells. J Virol (1969) 11.78

Ubiquitous, interspersed repeated sequences in mammalian genomes. Proc Natl Acad Sci U S A (1980) 9.48

The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature (1981) 8.44

Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell (1982) 6.93

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature (1982) 6.09

Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature (1983) 5.90

Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature (1984) 5.85

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci U S A (1982) 5.39

Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci U S A (1979) 5.32

Structure and activation of the human N-ras gene. Cell (1983) 5.25

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A (1983) 4.82

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts. Nature (1981) 4.72

Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus. J Virol (1980) 4.63

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature (1983) 4.44

Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA. Proc Natl Acad Sci U S A (1977) 4.35

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene. Nature (1983) 4.34

Human-tumor-derived cell lines contain common and different transforming genes. Cell (1981) 4.29

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations. Nature (1983) 4.15

Transforming activity of human tumor DNAs. Proc Natl Acad Sci U S A (1981) 4.02

Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1. Nature (1983) 3.86

Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A (1983) 3.52

Characterization of a human colon/lung carcinoma oncogene. Nature (1983) 3.26

The HL-60 transforming sequence: a ras oncogene coexisting with altered myc genes in hematopoietic tumors. Cell (1983) 3.00

Oncogenes in solid human tumours. Nature (1982) 3.00

Three different human tumor cell lines contain different oncogenes. Cell (1981) 2.77

Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc Natl Acad Sci U S A (1982) 2.55

Activation of related transforming genes in mouse and human mammary carcinomas. Proc Natl Acad Sci U S A (1981) 2.41

Stage-specific transforming genes of human and mouse B- and T-lymphocyte neoplasms. Cell (1982) 2.20

Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity? Nature (1984) 2.14

Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype. Proc Natl Acad Sci U S A (1983) 2.04

Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes. Proc Natl Acad Sci U S A (1984) 1.89

A transforming gene present in human sarcoma cell lines. Nature (1982) 1.67

A novel transforming gene in a human malignant melanoma cell line. Nature (1984) 1.63

Identification and molecular cloning of the human Blym transforming gene activated in Burkitt's lymphomas. Nature (1983) 1.58

An activated rasN gene: detected in late but not early passage human PA1 teratocarcinoma cells. Science (1984) 1.56

Activation of N-ras gene in bone marrow cells from a patient with acute myeloblastic leukaemia. Nature (1984) 1.16

Articles by these authors

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell (1984) 12.54

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06

New procedure for DNA transfection with polycation and dimethyl sulfoxide. Mol Cell Biol (1984) 8.63

The effects of reciprocal changes in temperature on the transformed state of cells infected with a rous sarcoma virus mutant. Virology (1971) 7.83

A high-density rice genetic linkage map with 2275 markers using a single F2 population. Genetics (1998) 6.82

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature (1986) 6.67

Enhancement and inhibition of avian sarcoma viruses by polycations and polyanions. Virology (1969) 6.24

Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell (1980) 5.51

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14

Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants. J Exp Med (1977) 4.79

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62

Human immunodeficiency viruses. Science (1986) 4.34

Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus. Nature (1982) 4.33

Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology (2004) 4.24

Genetic recombination with avian tumor virus. Virology (1972) 4.23

Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor. Cell (1984) 4.21

Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature (1992) 3.96

Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet (1986) 3.93

Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science (1991) 3.86

The erbB gene of avian erythroblastosis virus is a member of the src gene family. Cell (1983) 3.82

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. Proc Natl Acad Sci U S A (1985) 3.80

The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity. Science (1986) 3.74

Location of envelope-specific and sarcoma-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus. Proc Natl Acad Sci U S A (1976) 3.73

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells (1999) 3.69

Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity. Proc Natl Acad Sci U S A (1980) 3.58

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science (1996) 3.42

Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID). Nature (1990) 3.42

BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med (2001) 3.40

Isolation of defective mutant of avian sarcoma virus. Proc Natl Acad Sci U S A (1973) 3.38

Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR. J Clin Microbiol (1998) 3.34

Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection. Proc Natl Acad Sci U S A (1990) 3.31

Analysis of myocilin mutations in 1703 glaucoma patients from five different populations. Hum Mol Genet (1999) 3.24

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc Natl Acad Sci U S A (1986) 3.19

A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles. Neuropathol Appl Neurobiol (1986) 3.09

Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science (1984) 3.06

Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. Biochem Biophys Res Commun (1999) 3.03

Characterization of a Rous sarcoma virus mutant defective in packaging its own genomic RNA: biochemical properties of mutant TK15 and mutant-induced transformants. J Virol (1984) 2.95

Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab. Neurology (2008) 2.85

Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem (1996) 2.85

Purification and properties of the dnaJ replication protein of Escherichia coli. J Biol Chem (1985) 2.84

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene (1997) 2.80

Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage (2002) 2.78

Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science (1986) 2.76

Acquired Chiari I malformation and syringomyelia associated with bilateral chronic subdural hematoma. Case report. J Neurosurg (1995) 2.75

CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J Biol Chem (1991) 2.75

Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell (1989) 2.73

Temperature sensitive mutants of an avian sarcoma virus. Virology (1969) 2.73

Guidelines for the diagnosis and treatment of spontaneous occlusion of the circle of Willis ('moyamoya' disease). Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease) of the Ministry of Health and Welfare, Japan. Clin Neurol Neurosurg (1997) 2.65

K-ras is essential for the development of the mouse embryo. Oncogene (1997) 2.57

Correlation of the highest-energy cosmic rays with nearby extragalactic objects. Science (2007) 2.57

Focal adhesion kinase: at the crossroads of signal transduction. J Cell Sci (1997) 2.51

Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. Genes Cells (1998) 2.50

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity (1995) 2.50

Unifected avian cells contain structurally unrelated progenitors of viral sarcoma genes. Nature (1980) 2.50

Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans. J Biol Chem (1984) 2.48

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem (2001) 2.46

Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. J Biol Chem (2001) 2.45

Unusual features in the nucleotide sequence of a cDNA clone derived from the common region of avian sarcoma virus messenger RNA. Proc Natl Acad Sci U S A (1980) 2.45

The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol (1987) 2.44

Transformation-defective mutants of Rous sarcoma virus with src gene deletions of varying length. J Virol (1977) 2.43

Expression of functional acetylcholine receptor from cloned cDNAs. Nature (1984) 2.41

RNA of replication-defective strains of Rous sarcoma virus. Proc Natl Acad Sci U S A (1975) 2.37

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J (2001) 2.37

Isolation of different kinds of non-virus producing chick cells transformed by Schmidt-Ruppin strain (subgroup A) of Rous sarcoma virus. Jpn J Exp Med (1970) 2.35

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line. Mol Cell Biol (1986) 2.33

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc Natl Acad Sci U S A (1996) 2.31

Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated. J Cell Biol (1991) 2.29

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J Exp Med (1994) 2.26

Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis. Neurology (2006) 2.25

Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus. EMBO J (1988) 2.25

v-maf, a viral oncogene that encodes a "leucine zipper" motif. Proc Natl Acad Sci U S A (1989) 2.24

Surgery on a saccular vertebral artery-posterior inferior cerebellar artery aneurysm via the transcondylar fossa (supracondylar transjugular tubercle) approach or the transcondylar approach: surgical results and indications for using two different lateral skull base approaches. J Neurosurg (2001) 2.24

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A (1992) 2.23

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc Natl Acad Sci U S A (1991) 2.22

Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene (1995) 2.22

Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer Res (1993) 2.22

Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus. Virology (1981) 2.16

Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. Gene (1986) 2.14

Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam. J Clin Microbiol (1996) 2.12

Characterization of cDNA clones for the human c-yes gene. Mol Cell Biol (1987) 2.11

Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis (2008) 2.11

Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos (1996) 2.11

Molecular mechanism of active calcium transport by sarcoplasmic reticulum. Physiol Rev (1978) 2.11