Published in Br J Cancer on April 01, 1980
Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses. Br J Cancer (1977) 5.58
Clinical phase I study of the hypoxic cell radiosensitizer RO-07-0582, a 2-nitroimidazole derivative. Radiology (1977) 2.55
Applied electrophysiology in nerve and muscle disease [abridged]. Proc R Soc Med (1966) 2.48
Serum concentration measurements in man of the radiosensitizer Ro-07-0582: some preliminary results. Br J Cancer (1975) 2.39
Radiosensitizers of hypoxic cells in solid tumors. Cancer Treat Rev (1976) 2.33
The degeneration of peripheral nerve fibers. J Neurol Neurosurg Psychiatry (1950) 2.15
Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo. Cancer Res (1976) 2.03
In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique. Br J Radiol (1975) 1.86
The morphological basis for alterations in nerve conduction in peripheral neuropathy. Proc R Soc Med (1971) 1.66
Peripheral neuropathy related to misonidazole: incidence and pathology. Br J Cancer Suppl (1978) 1.42
The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum. Br J Cancer Suppl (1978) 1.38
Pharmacokinetic and metabolic studies of the hypoxic cell radiosensitizer misonidazole. Xenobiotica (1978) 1.24
Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and Chinese hamster ovary cells. Cancer Res (1978) 1.19
Initial United States clinical and pharmacologic evaluation of misonidazole (Ro-07-0582), an hypoxic cell radiosensitizer. Int J Radiat Oncol Biol Phys (1979) 1.06
The effect of the radiosensitizer misonidazole on motor nerve conduction velocity in the mouse. Br J Cancer Suppl (1978) 1.02
Misonidazole neurotoxicity in the mouse: evaluation of functional, pharmacokinetic, electrophysiologic and morphologic parameters. Int J Radiat Oncol Biol Phys (1979) 1.00
Acrylamide autonomic neuropathy in the cat. Part 1. Neurophysiological and histological studies. J Neurol Sci (1977) 0.95
Changes in nerve conduction velocity in the mouse after acute and chronic administration of nitroimidazoles. Br J Cancer (1979) 0.95
Radiosensitization of solid tumors by nitroimidazoles. Int J Radiat Oncol Biol Phys (1978) 0.94
Further clinical experiences of a phase I study with the hypoxic cell radiosensitizer misonidazole. Br J Cancer Suppl (1978) 0.90
Peripheral electrophysiological parameters in mice treated with misonidazole. Br J Cancer (1979) 0.85
A simple method for long-term drug infusion in mice: evaluation of guanazole as a model (38488). Proc Soc Exp Biol Med (1975) 0.79
Pulmonary retention of ultrafine and fine particles in rats. Am J Respir Cell Mol Biol (1992) 3.22
Growth of multicell spheroids in tissue culture as a model of nodular carcinomas. J Natl Cancer Inst (1971) 2.83
Resistance to adriamycin in multicellular spheroids. Int J Radiat Oncol Biol Phys (1979) 2.78
Radiation response of multicell spheroids--an in vitro tumour model. Curr Top Radiat Res Q (1976) 2.73
Selective chemotherapy of noncycling cells in an in vitro tumor model. Cancer Res (1974) 2.44
Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo. J Immunol (2001) 2.41
Oxygen in human tumors: correlations between methods of measurement and response to therapy. Summary of a workshop held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland. Radiat Res (1993) 1.99
Erythrocyte membrane sulfhydryl groups and cation permeability. J Cell Physiol (1967) 1.83
Metronidazole (Flagyl): characterization as a cytotoxic drug specific for hypoxic tumour cells. Br J Cancer (1976) 1.77
Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH. J Cell Physiol (1992) 1.77
Effects of intercellular contact on repair of radiation damage. Exp Cell Res (1972) 1.76
Regulation of growth saturation and development of necrosis in EMT6/Ro multicellular spheroids by the glucose and oxygen supply. Cancer Res (1986) 1.59
Induction characteristics of oxygen regulated proteins. Int J Radiat Oncol Biol Phys (1986) 1.58
CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose. Proc Natl Acad Sci U S A (1999) 1.55
Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutinin. J Cell Physiol (1972) 1.55
Selective dissociation and characterization of cells from different regions of multicell tumor spheroids. Cancer Res (1980) 1.50
Oxygenation and differentiation in multicellular spheroids of human colon carcinoma. Cancer Res (1986) 1.42
Enhanced uptake of calcium by transforming lymphocytes. Cell Immunol (1972) 1.42
The interaction between bleomycin and radiation on cell survival and DNA damage in mammalian cell cultures. Int J Radiat Oncol Biol Phys (1985) 1.36
Glucose diffusivity in multicellular tumor spheroids. Cancer Res (1988) 1.33
Characterization of two major populations of lung fibroblasts: distinguishing morphology and discordant display of Thy 1 and class II MHC. Am J Respir Cell Mol Biol (1989) 1.33
In vivo response of KHT sarcomas to combination chemotherapy with radiosensitizers and BCNU. Br J Cancer (1981) 1.32
Oxygen diffusion distance and development of necrosis in multicell spheroids. Radiat Res (1979) 1.28
Letter: Hypoxic radiosensitizers and cellular respiration. Br J Radiol (1976) 1.27
A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth. J Cell Physiol (1985) 1.26
Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism. Br J Cancer (1990) 1.23
Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res (1999) 1.18
Influence of convection in the growth medium on oxygen tensions in multicellular tumor spheroids. Cancer Res (1982) 1.18
In situ oxygen consumption rates of cells in V-79 multicellular spheroids during growth. J Cell Physiol (1984) 1.17
Mathematical modelling of microenvironment and growth in EMT6/Ro multicellular tumour spheroids. Cell Prolif (1992) 1.17
Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids. Br J Cancer (1986) 1.14
Differential collagen and fibronectin production by Thy 1+ and Thy 1- lung fibroblast subpopulations. Am J Physiol (1992) 1.14
Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia. J Natl Cancer Inst (1989) 1.11
Oxygen tensions in multicell spheroids of two cell lines. Br J Cancer (1982) 1.10
31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia. Cancer Res (1988) 1.09
The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells. Br J Cancer (1991) 1.08
Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker. Cancer Res (1995) 1.08
Growth and cellular characteristics of multicell spheroids. Recent Results Cancer Res (1984) 1.07
31P-NMR spectroscopy demonstrates decreased ATP levels in vivo as an early response to photodynamic therapy. Biochem Biophys Res Commun (1986) 1.06
Isolation of quiescent cells from multicellular tumor spheroids using centrifugal elutriation. Cancer Res (1982) 1.04
Age dependence of ultrasonically induced lung hemorrhage in mice. Ultrasound Med Biol (1997) 1.04
Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex "re-presentation" of exogenous antigen by tumor-infiltrating antigen-presenting cells. Proc Natl Acad Sci U S A (1996) 1.04
Hypoxic cells in an in vitro tumour model. Int J Radiat Biol Relat Stud Phys Chem Med (1973) 1.02
Proliferative and clonogenic heterogeneity of cells from EMT6/Ro multicellular spheroids induced by the glucose and oxygen supply. Cancer Res (1986) 1.01
Radiation survival of cells from spheroids grown in different oxygen concentrations. Radiat Res (1979) 1.01
Phytohemagglutinin (PHA)-induced transformation of lymphocytes from patients with cancer. Cancer (1971) 1.00
Misonidazole neurotoxicity in the mouse: evaluation of functional, pharmacokinetic, electrophysiologic and morphologic parameters. Int J Radiat Oncol Biol Phys (1979) 1.00
Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance. Br J Cancer (1991) 1.00
Early and late pulmonary toxicity in mice evaluated 180 and 420 days following localized lung irradiation. Radiat Res (1982) 1.00
Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy, and cryospectrophotometry. Cancer Res (1990) 1.00
Cytokine mediated effects in mucosal immunity. Immunol Cell Biol (1995) 1.00
Misonidazole cytotoxicity in vivo: a comparison of large single doses with smaller doses and extended contact of the drug with tumor cells. Radiat Res (1980) 1.00
Electrophysiological investigations of methylmercury intoxication in humans. Evaluation of peripheral nerve by conduction velocity and electromyography. Electroencephalogr Clin Neurophysiol (1974) 1.00
Repair of radiation damage to erythrocyte membranes. The reduction of radiation-induced disulfide groups. Radiat Res (1968) 0.99
Optical detection of antibody-antigen reactions at a glass-liquid interface. Clin Chem (1984) 0.99
Differences in growth and morphology between the spontaneous C3H mammary carcinoma in the mouse and its syngeneic transplants. Cancer (1971) 0.99
Effect of postoperative radiotherapy on peripheral blood lymphocytes in patients with carcinoma of the breast. Cancer (1972) 0.98
A multi-component radiation survival curve using an in vitro tumour model. Int J Radiat Biol Relat Stud Phys Chem Med (1970) 0.98
Thresholds for ultrasonically induced lung hemorrhage in neonatal swine. Ultrasound Med Biol (1996) 0.98
CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation. J Immunol (2000) 0.97
Early biochemical responses to photodynamic therapy monitored by NMR spectroscopy. Photochem Photobiol (1987) 0.97
Rate of death of hypoxic cells in multicell spheroids. Radiat Res (1978) 0.97
Remnants of Albunex nucleate acoustic cavitation. Ultrasound Med Biol (1997) 0.97
In vivo tumor response to single and multiple exposures of adriamycin. Eur J Cancer (1980) 0.96
Regulation of c-jun expression during hypoxic and low-glucose stress. Mol Cell Biol (1994) 0.96
Growth of nodular carcinomas in rodents compared with multi-cell spheroids in tissue culture. Growth (1970) 0.96
Nonperturbing test for cytotoxicity in isolated cells and spheroids, using electron paramagnetic resonance. Magn Reson Med (1991) 0.96
Evidence for a major role of glucose in controlling development of necrosis in EMT6/Ro multicell tumor spheroids. Adv Exp Med Biol (1983) 0.95
Enhancement of sensitivity of human squamous carcinoma cells to radiation by epidermal growth factor. J Natl Cancer Inst (1989) 0.95
Enhancement of transforming growth factor-alpha synthesis in multicellular tumour spheroids of A431 squamous carcinoma cells. Br J Cancer (1992) 0.95
Differential expression of interleukin 1 alpha by Thy-1+ and Thy-1- lung fibroblast subpopulations: enhancement of interleukin 1 alpha production by tumor necrosis factor-alpha. Eur J Immunol (1990) 0.95
Neonatal screening for hypothyroidism in Scotland: results of a pilot study. Scott Med J (1981) 0.94
Nitrosourea-misonidazole combination chemotherapy: effect on KHT sarcomas, marrow stem cells and gut. Br J Cancer (1982) 0.94
Enhanced synthesis of specific proteins, RNA, and DNA caused by hypoxia and reoxygenation. Int J Radiat Oncol Biol Phys (1989) 0.94
Cytotoxicity of hypoxic cell sensitizers in multicell spheroids. Cancer Clin Trials (1980) 0.94
In vitro hypoxic cytotoxicity of nitroimidazoles: uptake and cell cycle phase specificity. Int J Radiat Oncol Biol Phys (1982) 0.93
Importance of critical metabolites and cellular interactions in the biology of microregions of tumors. Cancer (1986) 0.93
The influence of contrast agents on hemorrhage produced by lithotripter fields. Ultrasound Med Biol (1997) 0.93
Differences in EGF related radiosensitisation of human squamous carcinoma cells with high and low numbers of EGF receptors. Br J Cancer (1991) 0.92
Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells. Microb Pathog (1995) 0.92
On the nature of the radiobiologically hypoxic fraction in tumors. Int J Radiat Oncol Biol Phys (1980) 0.92
Adaptation of EGF receptor signal transduction to three-dimensional culture conditions: changes in surface receptor expression and protein tyrosine phosphorylation. J Cell Physiol (1994) 0.92
A comparison of the pharmacokinetics of multiple and single dose administrations of adriamycin. Int J Radiat Oncol Biol Phys (1979) 0.92
Hair methylmercury levels in U.S. women. Arch Environ Health (1998) 0.92
Changes in growth characteristics and macromolecular synthesis on recovery from severe hypoxia. Br J Cancer (1990) 0.91
Multicellular spheroids: a new model target for in vitro studies of immunity to solid tumor allografts. J Natl Cancer Inst (1977) 0.91
Shedding of mitotic cells from the surface of multicell spheroids during growth. J Cell Physiol (1981) 0.91
Regrowth and radiation sensitivity of quiescent cells isolated from EMT6/Ro-fed plateau monolayers. Cancer Res (1985) 0.91
Specific early fine structural changes in the lung irradiation. Int J Radiat Oncol Biol Phys (1978) 0.90
Characteristics of calcium accumulation by lymphocytes and alterations in the process induced by phytohemagglutinin. J Cell Physiol (1973) 0.90
Involvement of sulphhydryl groups in radiation damage to the human erythrocyte membrane. Int J Radiat Biol Relat Stud Phys Chem Med (1967) 0.90
Changes in cellular glutathione content during adriamycin treatment in human ovarian cancer--a possible indicator of chemosensitivity. Br J Cancer (1989) 0.90