Published in Virology on November 10, 1995
Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol (1997) 9.18
A new reporter cell line to monitor HIV infection and drug susceptibility in vitro. Proc Natl Acad Sci U S A (1997) 2.52
Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. J Virol (1999) 2.37
Identification of novel import and export signals of human TAP, the protein that binds to the constitutive transport element of the type D retrovirus mRNAs. Mol Cell Biol (1999) 2.09
Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha. Mol Cell Biol (1999) 1.91
The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: a green fluorescent protein study. J Cell Biol (1997) 1.89
Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin. J Cell Biol (2001) 1.86
Functional analysis of the human cytomegalovirus US28 gene by insertion mutagenesis with the green fluorescent protein gene. J Virol (1998) 1.52
The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal. J Virol (1996) 1.42
A nucleolar TAR decoy inhibitor of HIV-1 replication. Proc Natl Acad Sci U S A (2002) 1.39
Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol Cell Biol (2002) 1.38
Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Mol Cell Biol (1999) 1.30
A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins. Mol Cell Biol (2003) 1.16
Involvement of human CRM1 (exportin 1) in the export and multimerization of the Rex protein of human T-cell leukemia virus type 1. J Virol (1998) 1.13
Regulation of ubiquitin ligase dynamics by the nucleolus. J Cell Biol (2005) 1.13
The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-independent mechanism. J Virol (2001) 1.11
Functional analysis of the human immunodeficiency virus type 1 Rev protein oligomerization interface. J Virol (1998) 1.10
Molding a peptide into an RNA site by in vivo peptide evolution. Proc Natl Acad Sci U S A (1997) 1.06
Diminished rev-mediated stimulation of human immunodeficiency virus type 1 protein synthesis is a hallmark of human astrocytes. J Virol (1999) 1.06
Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap. J Virol (2001) 1.02
Potent inhibition of HIV-1 replication by a Tat mutant. PLoS One (2009) 1.00
Identification and characterization of the mouse nuclear export factor (Nxf) family members. Nucleic Acids Res (2005) 0.98
Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs. J Virol (1997) 0.98
The human T-cell lymphotropic virus type 1 Tof protein contains a bipartite nuclear localization signal that is able to functionally replace the amino-terminal domain of Rex. J Virol (1997) 0.98
Identification and characterization of transcription factor IIIA and ribosomal protein L5 from Arabidopsis thaliana. Nucleic Acids Res (2003) 0.97
Human immunodeficiency virus type 1 Rev function requires continued synthesis of its target mRNA. J Virol (1996) 0.96
Role of polypyrimidine tract binding protein in the function of the hepatitis B virus posttranscriptional regulatory element. J Virol (2001) 0.96
The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production. J Biol Chem (2013) 0.95
Interaction of the DNA modifying proteins VirD1 and VirD2 of Agrobacterium tumefaciens: analysis by subcellular localization in mammalian cells. Proc Natl Acad Sci U S A (1998) 0.92
The carboxy-terminal region of the human immunodeficiency virus type 1 protein Rev has multiple roles in mediating CRM1-related Rev functions. J Virol (2002) 0.90
Multimer formation is not essential for nuclear export of human T-cell leukemia virus type 1 Rex trans-activator protein. J Virol (1998) 0.88
Retroviral Rem protein requires processing by signal peptidase and retrotranslocation for nuclear function. Proc Natl Acad Sci U S A (2010) 0.88
Identification of a novel Rev-interacting cellular protein. BMC Cell Biol (2005) 0.87
A nucleolar localizing Rev binding element inhibits HIV replication. AIDS Res Ther (2006) 0.84
hMSH5 is a nucleocytoplasmic shuttling protein whose stability depends on its subcellular localization. Nucleic Acids Res (2010) 0.82
Human chromosome 6- and 11-encoded factors support human immunodeficiency virus type 1 Rev function in A9 cells. J Virol (1996) 0.82
Substitution of the Rev-response element in an HIV-1-based gene delivery system with that of SIVmac239 allows efficient delivery of Rev M10 into T-lymphocytes. AIDS Res Ther (2008) 0.81
Characterization of the bipartite nuclear localization signal of protein LANA2 from Kaposi's sarcoma-associated herpesvirus. Biochem J (2003) 0.81
Restriction of human immunodeficiency virus type 1 Rev function in murine A9 cells involves the Rev C-terminal domain. J Virol (2003) 0.81
Requirements for mouse mammary tumor virus Rem signal peptide processing and function. J Virol (2011) 0.80
Taspase1: a 'misunderstood' protease with translational cancer relevance. Oncogene (2015) 0.78
Production of HIV particles is regulated by altering sub-cellular localization and dynamics of Rev induced by double-strand RNA binding protein. PLoS One (2011) 0.78
Proteolytic activity assayed by subcellular localization switching of a substrate. Biochem Biophys Rep (2016) 0.75
rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA. Proc Natl Acad Sci U S A (1989) 8.76
The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science (1985) 6.60
Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1. J Virol (1990) 5.64
Expression and characterization of the trans-activator of HTLV-III/LAV virus. Science (1986) 5.15
The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region. J Virol (1989) 5.07
Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein. J Virol (1992) 3.44
Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAs. J Virol (1990) 3.42
Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation. J Virol (1997) 3.28
Sequence and secondary structure of Drosophila melanogaster 5.8S and 2S rRNAs and of the processing site between them. Nucleic Acids Res (1979) 3.15
Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expression. J Virol (1992) 3.14
Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer. Proc Natl Acad Sci U S A (1986) 3.12
Regulation of a metallothionein-growth hormone hybrid gene in bovine papilloma virus. Proc Natl Acad Sci U S A (1983) 3.06
A quantitative bioassay for HIV-1 based on trans-activation. Science (1988) 2.99
The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs. Mol Cell Biol (1992) 2.83
The structural basis for spectral variations in green fluorescent protein. Nat Struct Biol (1997) 2.79
Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J (1997) 2.57
Improved DNA: liposome complexes for increased systemic delivery and gene expression. Nat Biotechnol (1997) 2.52
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I. J Virol (1992) 2.52
Expression of human immunodeficiency virus type 1 vif and vpr mRNAs is Rev-dependent and regulated by splicing. Virology (1991) 2.43
The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm. J Biol Chem (1998) 2.23
Tat and Rev: positive regulators of HIV gene expression. AIDS (1990) 2.18
Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein. J Virol (1990) 2.17
Identification of trans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells. Nucleic Acids Res (1990) 2.14
Cooperation of GroEL/GroES and DnaK/DnaJ heat shock proteins in preventing protein misfolding in Escherichia coli. Proc Natl Acad Sci U S A (1992) 2.04
Different sites of interaction for Rev, Tev, and Rex proteins within the Rev-responsive element of human immunodeficiency virus type 1. J Virol (1990) 1.90
Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA. J Virol (1994) 1.88
A novel human immunodeficiency virus type 1 protein, tev, shares sequences with tat, env, and rev proteins. J Virol (1990) 1.87
The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function. J Virol (1996) 1.85
The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding. J Biol Chem (1997) 1.75
A bioassay for HIV-1 based on Env-CD4 interaction. AIDS Res Hum Retroviruses (1990) 1.70
Development and applications of enhanced green fluorescent protein mutants. Biotechniques (1998) 1.68
Cross-activation of the Rex proteins of HTLV-I and BLV and of the Rev protein of HIV-1 and nonreciprocal interactions with their RNA responsive elements. New Biol (1989) 1.66
Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc Natl Acad Sci U S A (1993) 1.65
Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs. Mol Cell Biol (1992) 1.61
Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia. J Biol Chem (1994) 1.57
Intracellular trafficking and interactions of the HIV-1 Tat protein. Virology (1998) 1.57
Rapidly and slowly replicating human immunodeficiency virus type 1 isolates can be distinguished according to target-cell tropism in T-cell and monocyte cell lines. Proc Natl Acad Sci U S A (1989) 1.51
The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptor. J Exp Med (1999) 1.43
Evaluation of novel human immunodeficiency virus type 1 Gag DNA vaccines for protein expression in mammalian cells and induction of immune responses. J Virol (1999) 1.43
Expression of two human growth hormone genes in monkey cells infected by simian virus 40 recombinants. Proc Natl Acad Sci U S A (1981) 1.39
Binding of trans-dominant mutant Rev protein of human immunodeficiency virus type 1 to the cis-acting Rev-responsive element does not affect the fate of viral mRNA. New Biol (1990) 1.37
Preferential binding of poly(A)-binding protein 1 to an inhibitory RNA element in the human immunodeficiency virus type 1 gag mRNA. J Biol Chem (1997) 1.35
Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression. Proc Natl Acad Sci U S A (1998) 1.32
Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Mol Cell Biol (1999) 1.30
Molecular biology of HIV-1: positive and negative regulatory elements important for virus expression. AIDS (1993) 1.27
The Rex regulatory protein of human T-cell lymphotropic virus type I binds specifically to its target site within the viral RNA. Proc Natl Acad Sci U S A (1991) 1.26
Visualization of G protein-coupled receptor trafficking with the aid of the green fluorescent protein. Endocytosis and recycling of cholecystokinin receptor type A. J Biol Chem (1997) 1.23
Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function. J Virol (1995) 1.23
Splicing variability in HIV type 1 revealed by quantitative RNA polymerase chain reaction. AIDS Res Hum Retroviruses (1994) 1.20
Intracellular trafficking of the human immunodeficiency virus type 1 Rev protein: involvement of continued rRNA synthesis in nuclear retention. AIDS Res Hum Retroviruses (1995) 1.19
Potentiation of simian immunodeficiency virus (SIV)-specific CD4(+) and CD8(+) T cell responses by a DNA-SIV and NYVAC-SIV prime/boost regimen. J Immunol (2001) 1.19
NIH conference. Antiretroviral therapy in AIDS. Ann Intern Med (1990) 1.15
Pathologic human GR mutant has a transdominant negative effect on the wild-type GR by inhibiting its translocation into the nucleus: importance of the ligand-binding domain for intracellular GR trafficking. J Clin Endocrinol Metab (2001) 1.13
Menkes' disease: abnormal metallothionein gene regulation in response to copper. Cell (1985) 1.08
CD4+ T-cell loss and delayed expression of modulators of immune responses at mucosal sites of vaccinated macaques following SIV(mac251) infection. Mucosal Immunol (2008) 1.07
Activation of tat-defective human immunodeficiency virus by ultraviolet light. New Biol (1990) 1.06
HHR23A, the human homologue of the yeast repair protein RAD23, interacts specifically with Vpr protein and prevents cell cycle arrest but not the transcriptional effects of Vpr. Virology (1998) 1.03
Analysis of intracellular trafficking and interactions of cytoplasmic HIV-1 Rev mutants in living cells. Virology (1998) 1.02
Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap. J Virol (2001) 1.02
Conservative mutations in the putative metal-binding region of human immunodeficiency virus tat disrupt virus replication. AIDS Res Hum Retroviruses (1990) 1.02
Analysis of human immunodeficiency virus type 1 mRNA splicing patterns during disease progression in peripheral blood mononuclear cells from infected individuals. AIDS Res Hum Retroviruses (1996) 1.00
Decreased human immunodeficiency virus type 1 plasma viremia during antiretroviral therapy reflects downregulation of viral replication in lymphoid tissue. Proc Natl Acad Sci U S A (1995) 0.99
Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia. FEBS Lett (1994) 0.98
Rapid activation and subsequent down-regulation of the human immunodeficiency virus type 1 promoter in the presence of Tat: possible mechanisms contributing to latency. J Virol (1991) 0.97
Nucleocytoplasmic transport in human astrocytes: decreased nuclear uptake of the HIV Rev shuttle protein. J Cell Sci (2001) 0.91
Macaques co-immunized with SIVgag/pol-HIVenv and IL-12 plasmid have increased cellular responses. J Med Primatol (2007) 0.90
CCAAT-enhancer-binding protein beta (C/EBP beta) activates CCR5 promoter: increased C/EBP beta and CCR5 in T lymphocytes from HIV-1-infected individuals. J Immunol (2001) 0.90
Retracted Inhibition of Rev-mediated HIV-1 expression by an RNA binding protein encoded by the interferon-inducible 9-27 gene. Science (1993) 0.90
CXCR4 mediates entry and productive infection of syncytia-inducing (X4) HIV-1 strains in primary macrophages. Virology (2000) 0.90
Identification of the caprine arthritis encephalitis virus Rev protein and its cis-acting Rev-responsive element. Virology (1994) 0.89
Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes. J Infect Dis (1996) 0.88
Inhibition of DnaK autophosphorylation by heat shock proteins and polypeptide substrates. J Biol Chem (1994) 0.87
Reduced viral load and lack of CD4 depletion in SCID-hu mice infected with Rev-independent clones of human immunodeficiency virus type 1. J Virol (1997) 0.87
Unusual CD4+CD8+ phenotype in a greek patient diagnosed with adult T-cell leukemia positive for human T-cell leukemia virus type I (HTLV-I). Leuk Res (2000) 0.86
Isolation and characterization of an Escherichia coli DnaK mutant with impaired ATPase activity. J Mol Biol (1994) 0.85
Expression of cloned growth hormone and metallothionein genes in heterologous cells. Recent Prog Horm Res (1983) 0.85
Sulfonic acid dyes: inhibition of the human immunodeficiency virus and mechanism of action. J Acquir Immune Defic Syndr (1992) 0.85
Inflammatory polyarthropathy and bone remodeling in HTLV-I Tax-transgenic mice. J Acquir Immune Defic Syndr Hum Retrovirol (1997) 0.82
Inhibitory activity of the equine infectious anemia virus major 5' splice site in the absence of Rev. J Virol (1996) 0.82
Expression of human immunodeficiency virus long terminal repeat in the human promonocyte cell line U937: effect of endotoxin and cytokines. Cell Immunol (1990) 0.79
Molecular characterization of a recombinant HIV type 1 isolate (A/G/E/?): unidentified regions may be derived from parental subtype E sequences. AIDS Res Hum Retroviruses (2000) 0.79
Properties of human growth hormone polypeptides: purified from pituitary extracts and synthesized in monkey kidney cells and bacteria. J Clin Endocrinol Metab (1982) 0.78
Cosmid vector systems for genomic DNA cloning. Methods Enzymol (1987) 0.78
Tat and Rev: positive regulators of HIV gene expression. AIDS (1990) 0.76
Reconstitution of an operon from overlapping fragments: use of the lambda SV2 integrative cloning system. Gene (1986) 0.76
HIV: molecular mechanisms. Mol Med Today (1995) 0.75
Inhibition of Rev-mediated HIV-1 expression. Science (1994) 0.75