Continuous propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes.

PubWeight™: 2.41‹?› | Rank: Top 2%

🔗 View Article (PMC 237257)

Published in J Virol on December 01, 1994

Authors

A S Zolotukhin1, A Valentin, G N Pavlakis, B K Felber

Author Affiliations

1: Human Retrovirus Pathogenesis Group, National Cancer Institute--Frederick Cancer Research and Development Center, Maryland 21702-1201.

Articles citing this

The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. Genes Dev (1999) 3.24

The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway. EMBO J (1997) 3.10

TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. EMBO J (1999) 2.83

Transport of macromolecules between the nucleus and the cytoplasm. RNA (1998) 2.63

Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. J Virol (1999) 2.37

Identification of novel import and export signals of human TAP, the protein that binds to the constitutive transport element of the type D retrovirus mRNAs. Mol Cell Biol (1999) 2.09

A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA. Mol Cell Biol (1997) 2.07

A Rev-independent human immunodeficiency virus type 1 (HIV-1)-based vector that exploits a codon-optimized HIV-1 gag-pol gene. J Virol (2000) 2.00

Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1. J Virol (1998) 1.97

Leptomycin B inhibits equine infectious anemia virus Rev and feline immunodeficiency virus rev function but not the function of the hepatitis B virus posttranscriptional regulatory element. J Virol (1998) 1.90

The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function. J Virol (1996) 1.85

Avian retroviral RNA element promotes unspliced RNA accumulation in the cytoplasm. J Virol (1996) 1.85

The effect of viral regulatory protein expression on gene delivery by human immunodeficiency virus type 1 vectors produced in stable packaging cell lines. J Virol (1997) 1.78

The retrovirus RNA trafficking granule: from birth to maturity. Retrovirology (2006) 1.63

The hepatitis B virus posttranscriptional regulatory element is composed of two subelements. J Virol (1996) 1.61

Tap and NXT promote translation of unspliced mRNA. Genes Dev (2003) 1.48

Characterization of a cis-acting sequence in the Pol region required to transfer human foamy virus vectors. J Virol (1998) 1.46

An intact TAR element and cytoplasmic localization are necessary for efficient packaging of human immunodeficiency virus type 1 genomic RNA. J Virol (1999) 1.45

NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells. Mol Cell Biol (2001) 1.44

Efficient expression of the human papillomavirus type 16 L1 protein in epithelial cells by using Rev and the Rev-responsive element of human immunodeficiency virus or the cis-acting transactivation element of simian retrovirus type 1. J Virol (1995) 1.43

PSF acts through the human immunodeficiency virus type 1 mRNA instability elements to regulate virus expression. Mol Cell Biol (2003) 1.43

Evaluation of novel human immunodeficiency virus type 1 Gag DNA vaccines for protein expression in mammalian cells and induction of immune responses. J Virol (1999) 1.43

A role for RNA helicase A in post-transcriptional regulation of HIV type 1. Proc Natl Acad Sci U S A (1999) 1.41

The Rev protein of human immunodeficiency virus type 1 counteracts the effect of an AU-rich negative element in the human papillomavirus type 1 late 3' untranslated region. J Virol (1995) 1.40

Multiple copies of the Mason-Pfizer monkey virus constitutive RNA transport element lead to enhanced HIV-1 Gag expression in a context-dependent manner. Nucleic Acids Res (2000) 1.32

Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression. Proc Natl Acad Sci U S A (1998) 1.32

The 5' RNA terminus of spleen necrosis virus contains a novel posttranscriptional control element that facilitates human immunodeficiency virus Rev/RRE-independent Gag production. J Virol (1999) 1.28

Rous sarcoma virus DR posttranscriptional elements use a novel RNA export pathway. J Virol (2000) 1.25

Effects of 3' untranslated region mutations on plus-strand priming during moloney murine leukemia virus replication. J Virol (1999) 1.18

Identification of an RNA sequence within an intracisternal-A particle element able to replace Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1. J Virol (1997) 1.18

Production of avian leukosis virus particles in mammalian cells can be mediated by the interaction of the human immunodeficiency virus protein Rev and the Rev-responsive element. Proc Natl Acad Sci U S A (1995) 1.16

The human T-cell leukemia virus Rex protein. Front Biosci (2005) 1.14

RNA trafficking signals in human immunodeficiency virus type 1. Mol Cell Biol (2001) 1.13

Rous sarcoma virus direct repeat cis elements exert effects at several points in the virus life cycle. J Virol (1997) 1.12

Genetic evidence for a connection between Rous sarcoma virus gag nuclear trafficking and genomic RNA packaging. J Virol (2009) 1.11

R region sequences in the long terminal repeat of a murine retrovirus specifically increase expression of unspliced RNAs. J Virol (1999) 1.10

RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA. Proc Natl Acad Sci U S A (2001) 1.08

Deletion of a short, untranslated region adjacent to the polypurine tract in Moloney murine leukemia virus leads to formation of aberrant 5' plus-strand DNA ends in vivo. J Virol (2000) 1.07

Human immunodeficiency virus type 1 (HIV-1) induces the cytoplasmic retention of heterogeneous nuclear ribonucleoprotein A1 by disrupting nuclear import: implications for HIV-1 gene expression. J Biol Chem (2009) 1.06

Mutational analysis of the rous sarcoma virus DR posttranscriptional control element. J Virol (1998) 1.06

The signal peptide of a simple retrovirus envelope functions as a posttranscriptional regulator of viral gene expression. J Virol (2009) 1.04

Identification of a novel posttranscriptional regulatory element by using a rev- and RRE-mutated human immunodeficiency virus type 1 DNA proviral clone as a molecular trap. J Virol (2001) 1.02

Point mutations in the avian sarcoma/leukosis virus 3' untranslated region result in a packaging defect. J Virol (1999) 1.01

Tap and Dbp5, but not Gag, are involved in DR-mediated nuclear export of unspliced Rous sarcoma virus RNA. Virology (2007) 1.01

A new RNA element located in the coding region of a murine endogenous retrovirus can functionally replace the Rev/Rev-responsive element system in human immunodeficiency virus type 1 Gag expression. J Virol (2001) 0.98

The carboxyl terminus of RNA helicase A contains a bidirectional nuclear transport domain. Mol Cell Biol (1999) 0.97

The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway. RNA (2011) 0.97

RTE and CTE mRNA export elements synergistically increase expression of unstable, Rev-dependent HIV and SIV mRNAs. Retrovirology (2006) 0.96

Role of polypyrimidine tract binding protein in the function of the hepatitis B virus posttranscriptional regulatory element. J Virol (2001) 0.96

An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element. RNA (2002) 0.93

Identification and mutational analysis of a Rej response element in Jaagsiekte sheep retrovirus RNA. J Virol (2009) 0.92

An intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production. J Biol Chem (2010) 0.91

A lentivirus packaging system based on alternative RNA transport mechanisms to express helper and gene transfer vector RNAs and its use to study the requirement of accessory proteins for particle formation and gene delivery. J Virol (1999) 0.90

Gammaretrovirus mRNA expression is mediated by a novel, bipartite post-transcriptional regulatory element. Nucleic Acids Res (2014) 0.89

Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair. PLoS Pathog (2011) 0.89

Splicing-independent expression of the herpes simplex virus type 1 thymidine kinase gene is mediated by three cis-acting RNA subelements. J Virol (1998) 0.89

Retroviral constitutive transport element evolved from cellular TAP(NXF1)-binding sequences. J Virol (2001) 0.88

Structural and functional analysis of the RNA transport element, a member of an extensive family present in the mouse genome. J Virol (2005) 0.87

Reduced viral load and lack of CD4 depletion in SCID-hu mice infected with Rev-independent clones of human immunodeficiency virus type 1. J Virol (1997) 0.87

Formation of a Tap/NXF1 homotypic complex is mediated through the amino-terminal domain of Tap and enhances interaction with nucleoporins. Mol Biol Cell (2007) 0.86

Trafficking through the Rev/RRE pathway is essential for efficient inhibition of human immunodeficiency virus type 1 by an antisense RNA derived from the envelope gene. J Virol (2008) 0.86

Multi-low-dose mucosal simian immunodeficiency virus SIVmac239 challenge of cynomolgus macaques immunized with "hyperattenuated" SIV constructs. J Virol (2009) 0.85

Selective inhibition of splicing at the avian sarcoma virus src 3' splice site by direct-repeat posttranscriptional cis elements. J Virol (2000) 0.84

Analysis of synergy between divergent simple retrovirus posttranscriptional control elements. Virology (2003) 0.84

DDX5 facilitates HIV-1 replication as a cellular co-factor of Rev. PLoS One (2013) 0.84

Inhibitory activity of the equine infectious anemia virus major 5' splice site in the absence of Rev. J Virol (1996) 0.82

Production of lentiviral vectors. Mol Ther Methods Clin Dev (2016) 0.82

Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by HIV-1-based lentivirus vectors expressing transdominant Rev. J Virol (2001) 0.81

Novel Tat-encoding bicistronic human immunodeficiency virus type 1-based gene transfer vectors for high-level transgene expression. J Virol (2000) 0.81

Construction and in vitro properties of a series of attenuated simian immunodeficiency viruses with all accessory genes deleted. J Virol (2001) 0.81

HIV-1 and M-PMV RNA Nuclear Export Elements Program Viral Genomes for Distinct Cytoplasmic Trafficking Behaviors. PLoS Pathog (2016) 0.80

Implication of a cis-acting element in the cytoplasmic accumulation of unspliced Borna disease virus RNAs. J Virol (1997) 0.79

Persistent infection of rhesus macaques by the rev-independent Nef(-) simian immunodeficiency virus SIVmac239: replication kinetics and genomic stability. J Virol (1999) 0.79

Rev-independent simian immunodeficiency virus strains are nonpathogenic in neonatal macaques. J Virol (2002) 0.78

Rev-free HIV-1 gene delivery system for targeting Rev-RRE-Crm1 nucleocytoplasmic RNA transport pathway. PLoS One (2011) 0.78

Evolutionary conservation of a molecular machinery for export and expression of mRNAs with retained introns. RNA (2015) 0.77

DHX9/RHA Binding to the PBS-Segment of the Genomic RNA during HIV-1 Assembly Bolsters Virion Infectivity. J Mol Biol (2016) 0.76

ORF57 overcomes the detrimental sequence bias of Kaposi's sarcoma-associated herpesvirus lytic genes. J Virol (2015) 0.76

Rev-RRE Functional Activity Differs Substantially Among Primary HIV-1 Isolates. AIDS Res Hum Retroviruses (2016) 0.75

Articles cited by this

A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol (1986) 37.70

Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol (1987) 26.70

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature (1989) 13.92

Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science (1992) 9.30

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA. Proc Natl Acad Sci U S A (1989) 8.76

A molecular clone of HTLV-III with biological activity. Nature (1985) 8.30

Regulation of human immunodeficiency virus env expression by the rev gene product. J Virol (1989) 5.79

Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1. J Virol (1990) 5.64

The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region. J Virol (1989) 5.07

HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region. Cell (1990) 4.50

A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. Proc Natl Acad Sci U S A (1994) 4.43

HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. Cell (1991) 4.43

Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein. Nature (1988) 3.31

Human immunodeficiency virus as a prototypic complex retrovirus. J Virol (1991) 3.19

Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expression. J Virol (1992) 3.14

Secondary structure is the major determinant for interaction of HIV rev protein with RNA. Science (1990) 3.11

Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements. Genes Dev (1989) 3.09

Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs. Genes Dev (1991) 3.06

Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element. Proc Natl Acad Sci U S A (1991) 3.06

The biochemistry of AIDS. Annu Rev Biochem (1991) 3.06

The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs. Mol Cell Biol (1992) 2.83

Simple, sensitive, and specific detection of human immunodeficiency virus type 1 in clinical specimens by polymerase chain reaction with nested primers. J Clin Microbiol (1990) 2.71

Functional analysis of CAR, the target sequence for the Rev protein of HIV-1. Science (1989) 2.62

Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action. Genes Dev (1990) 2.24

Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs. Proc Natl Acad Sci U S A (1991) 2.19

Tat and Rev: positive regulators of HIV gene expression. AIDS (1990) 2.18

Packaging of human immunodeficiency virus type 1 RNA requires cis-acting sequences outside the 5' leader region. J Virol (1993) 2.15

Sequence relationships of type D retroviruses which cause simian acquired immunodeficiency syndrome. Virology (1987) 2.04

Identification of a cis-acting element in human immunodeficiency virus type 2 (HIV-2) that is responsive to the HIV-1 rev and human T-cell leukemia virus types I and II rex proteins. J Virol (1990) 1.96

Characterization of HIV-1 REV protein: binding stoichiometry and minimal RNA substrate. Nucleic Acids Res (1991) 1.96

Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structure. J Virol (1990) 1.94

Different sites of interaction for Rev, Tev, and Rex proteins within the Rev-responsive element of human immunodeficiency virus type 1. J Virol (1990) 1.90

Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA. J Virol (1994) 1.88

A novel human immunodeficiency virus type 1 protein, tev, shares sequences with tat, env, and rev proteins. J Virol (1990) 1.87

The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements. Proc Natl Acad Sci U S A (1991) 1.68

Regulation of HIV-1 gene expression. Annu Rev Immunol (1990) 1.66

Cross-activation of the Rex proteins of HTLV-I and BLV and of the Rev protein of HIV-1 and nonreciprocal interactions with their RNA responsive elements. New Biol (1989) 1.66

The HIV-1 Rev protein: a model system for coupled RNA transport and translation. New Biol (1991) 1.50

Extensive sequence-specific information throughout the CAR/RRE, the target sequence of the human immunodeficiency virus type 1 Rev protein. J Virol (1992) 1.43

Binding of trans-dominant mutant Rev protein of human immunodeficiency virus type 1 to the cis-acting Rev-responsive element does not affect the fate of viral mRNA. New Biol (1990) 1.37

HIV with multiple gene deletions as a live attenuated vaccine for AIDS. AIDS Res Hum Retroviruses (1992) 1.36

Molecular biology of HIV-1: positive and negative regulatory elements important for virus expression. AIDS (1993) 1.27

The Rex regulatory protein of human T-cell lymphotropic virus type I binds specifically to its target site within the viral RNA. Proc Natl Acad Sci U S A (1991) 1.26

A proposal for a new approach to a preventive vaccine against human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1993) 1.13

HTLV-1 rex and HIV-1 rev act through similar mechanisms to relieve suppression of unspliced RNA expression. Oncogene (1989) 1.05

A specific sequence with a bulged guanosine residue(s) in a stem-bulge-stem structure of Rev-responsive element RNA is required for trans activation by human immunodeficiency virus type 1 Rev. J Virol (1992) 0.98

Articles by these authors

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA. Proc Natl Acad Sci U S A (1989) 8.76

The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science (1985) 6.60

TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol Cell (1998) 5.85

Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1. J Virol (1990) 5.64

Expression and characterization of the trans-activator of HTLV-III/LAV virus. Science (1986) 5.15

The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region. J Virol (1989) 5.07

Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein. J Virol (1992) 3.44

Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAs. J Virol (1990) 3.42

Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation. J Virol (1997) 3.28

Sequence and secondary structure of Drosophila melanogaster 5.8S and 2S rRNAs and of the processing site between them. Nucleic Acids Res (1979) 3.15

Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expression. J Virol (1992) 3.14

Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer. Proc Natl Acad Sci U S A (1986) 3.12

Regulation of a metallothionein-growth hormone hybrid gene in bovine papilloma virus. Proc Natl Acad Sci U S A (1983) 3.06

A quantitative bioassay for HIV-1 based on trans-activation. Science (1988) 2.99

The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs. Mol Cell Biol (1992) 2.83

The structural basis for spectral variations in green fluorescent protein. Nat Struct Biol (1997) 2.79

Duplicated heavy metal control sequences of the mouse metallothionein-I gene. Proc Natl Acad Sci U S A (1984) 2.69

Prognostic performance and customization of the SAPS II: results of a multicenter Austrian study. Simplified Acute Physiology Score. Intensive Care Med (1999) 2.61

Regulation of expression of human immunodeficiency virus. New Biol (1990) 2.60

Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J (1997) 2.57

Improved DNA: liposome complexes for increased systemic delivery and gene expression. Nat Biotechnol (1997) 2.52

Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I. J Virol (1992) 2.52

Prospectively defined indicators to improve the safety and quality of care for critically ill patients: a report from the Task Force on Safety and Quality of the European Society of Intensive Care Medicine (ESICM). Intensive Care Med (2012) 2.49

Expression of human immunodeficiency virus type 1 vif and vpr mRNAs is Rev-dependent and regulated by splicing. Virology (1991) 2.43

Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. J Virol (1999) 2.37

The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm. J Biol Chem (1998) 2.23

Tat and Rev: positive regulators of HIV gene expression. AIDS (1990) 2.18

Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein. J Virol (1990) 2.17

[Change in therapy target and therapy limitations in intensive care medicine. Position paper of the Ethics Section of the German Interdisciplinary Association for Intensive Care and Emergency Medicine]. Anaesthesist (2013) 2.14

Identification of trans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells. Nucleic Acids Res (1990) 2.14

Secondary structure of mouse and rabbit alpha- and beta-globin mRNAs: differential accessibility of alpha and beta initiator AUG codons towards nucleases. Cell (1980) 2.09

Identification of novel import and export signals of human TAP, the protein that binds to the constitutive transport element of the type D retrovirus mRNAs. Mol Cell Biol (1999) 2.09

Different sites of interaction for Rev, Tev, and Rex proteins within the Rev-responsive element of human immunodeficiency virus type 1. J Virol (1990) 1.90

Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA. J Virol (1994) 1.88

A novel human immunodeficiency virus type 1 protein, tev, shares sequences with tat, env, and rev proteins. J Virol (1990) 1.87

The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function. J Virol (1996) 1.85

Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm. Virology (1995) 1.79

Competition for cellular factors that activate metallothionein gene transcription. Nature (1985) 1.76

The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding. J Biol Chem (1997) 1.75

A bioassay for HIV-1 based on Env-CD4 interaction. AIDS Res Hum Retroviruses (1990) 1.70

Development and applications of enhanced green fluorescent protein mutants. Biotechniques (1998) 1.68

Cross-activation of the Rex proteins of HTLV-I and BLV and of the Rev protein of HIV-1 and nonreciprocal interactions with their RNA responsive elements. New Biol (1989) 1.66

Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs. Mol Cell Biol (1992) 1.61

Evaluation of the logistic organ dysfunction system for the assessment of organ dysfunction and mortality in critically ill patients. Intensive Care Med (2001) 1.61

Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia. J Biol Chem (1994) 1.57

Intracellular trafficking and interactions of the HIV-1 Tat protein. Virology (1998) 1.57

Evaluation of an interdisciplinary data set for national intensive care unit assessment. Crit Care Med (1999) 1.56

The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p. RNA (2000) 1.52

Evaluation of vasomotor reactivity by transcranial Doppler and acetazolamide test before and after extracranial-intracranial bypass in patients with internal carotid artery occlusion. Stroke (1992) 1.52

Rapidly and slowly replicating human immunodeficiency virus type 1 isolates can be distinguished according to target-cell tropism in T-cell and monocyte cell lines. Proc Natl Acad Sci U S A (1989) 1.51

Sex-related differences in acetazolamide-induced cerebral vasomotor reactivity. Stroke (1996) 1.45

Assessment of functional knee bracing: an in vivo three-dimensional kinematic analysis of the anterior cruciate deficient knee. Clin Biomech (Bristol, Avon) (2001) 1.44

Efficient expression of the human papillomavirus type 16 L1 protein in epithelial cells by using Rev and the Rev-responsive element of human immunodeficiency virus or the cis-acting transactivation element of simian retrovirus type 1. J Virol (1995) 1.43

The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptor. J Exp Med (1999) 1.43

Evaluation of novel human immunodeficiency virus type 1 Gag DNA vaccines for protein expression in mammalian cells and induction of immune responses. J Virol (1999) 1.43

Abnormal RNA splicing causes one form of alpha thalassemia. Cell (1982) 1.41

Expression of two human growth hormone genes in monkey cells infected by simian virus 40 recombinants. Proc Natl Acad Sci U S A (1981) 1.39

Virions released from cells transfected with a molecular clone of human T-cell leukemia virus type I give rise to primary and secondary infections of T cells. J Virol (1995) 1.37

Binding of trans-dominant mutant Rev protein of human immunodeficiency virus type 1 to the cis-acting Rev-responsive element does not affect the fate of viral mRNA. New Biol (1990) 1.37

Preferential binding of poly(A)-binding protein 1 to an inhibitory RNA element in the human immunodeficiency virus type 1 gag mRNA. J Biol Chem (1997) 1.35

Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1. J Biol Chem (1997) 1.33

Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression. Proc Natl Acad Sci U S A (1998) 1.32

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Mol Cell Biol (1999) 1.30

Molecular biology of HIV-1: positive and negative regulatory elements important for virus expression. AIDS (1993) 1.27

The Rex regulatory protein of human T-cell lymphotropic virus type I binds specifically to its target site within the viral RNA. Proc Natl Acad Sci U S A (1991) 1.26

In contrast to other Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated. Cell (1983) 1.26

The molecular basis of a familial apoE deficiency. An acceptor splice site mutation in the third intron of the deficient apoE gene. J Biol Chem (1987) 1.25

V3 sequences of paired HIV-1 isolates from blood and cerebrospinal fluid cluster according to host and show variation related to the clinical stage of disease. Virology (1993) 1.24

Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function. J Virol (1995) 1.23

Visualization of G protein-coupled receptor trafficking with the aid of the green fluorescent protein. Endocytosis and recycling of cholecystokinin receptor type A. J Biol Chem (1997) 1.23

Expression and characterization of proteins produced by mRNAs spliced into the X region of the human T-cell leukemia/lymphotropic virus type II. Virology (1995) 1.20

Splicing variability in HIV type 1 revealed by quantitative RNA polymerase chain reaction. AIDS Res Hum Retroviruses (1994) 1.20

Intracellular trafficking of the human immunodeficiency virus type 1 Rev protein: involvement of continued rRNA synthesis in nuclear retention. AIDS Res Hum Retroviruses (1995) 1.19