PubRank

V M Dixit

Author PubWeight™ 351.01‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Death receptors: signaling and modulation. Science 1998 16.95
2 FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell 1996 12.07
3 FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995 9.81
4 Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995 9.22
5 Caspases: intracellular signaling by proteolysis. Cell 1997 7.46
6 TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science 1995 6.41
7 The receptor for the cytotoxic ligand TRAIL. Science 1997 6.39
8 IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997 6.30
9 Apoptosis signaling. Annu Rev Biochem 2000 6.18
10 An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997 6.10
11 Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 1999 4.54
12 Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell 2000 4.19
13 An induced proximity model for caspase-8 activation. J Biol Chem 1998 4.18
14 Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem 1996 3.97
15 Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A 1999 3.86
16 Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem 1995 3.83
17 FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 1996 3.72
18 Keratinocytes as initiators of inflammation. Lancet 1991 3.68
19 Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence. Nature 1985 3.53
20 Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 1997 3.51
21 Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem 1997 3.41
22 The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem 1990 3.41
23 Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. J Biol Chem 1992 3.36
24 Caspase-9 can be activated without proteolytic processing. J Biol Chem 1999 3.20
25 A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem 1994 3.13
26 The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B. J Biol Chem 1992 3.13
27 The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol Chem 1992 2.90
28 RAIDD is a new 'death' adaptor molecule. Nature 1997 2.89
29 Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science 1995 2.88
30 Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996 2.87
31 Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol 2001 2.85
32 Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol 2000 2.78
33 Role of CED-4 in the activation of CED-3. Nature 1997 2.76
34 Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr Biol 2001 2.75
35 RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. J Biol Chem 1998 2.58
36 The domains of death: evolution of the apoptosis machinery. Trends Biochem Sci 1999 2.56
37 Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr Biol 2000 2.29
38 Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J Biol Chem 1998 2.25
39 Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. Am J Pathol 1991 2.24
40 ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem 1996 2.20
41 The cell-death machine. Curr Biol 1996 2.18
42 RIP3, a novel apoptosis-inducing kinase. J Biol Chem 1999 2.15
43 ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem 1996 2.12
44 Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem 1999 2.09
45 A role for FADD in T cell activation and development. Immunity 1998 2.09
46 Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J Biol Chem 1995 2.05
47 A monoclonal antibody against human thrombospondin inhibits platelet aggregation. Proc Natl Acad Sci U S A 1985 2.04
48 FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J Biol Chem 1997 2.01
49 ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol 2000 2.01
50 Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science 2001 1.97
51 Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat Genet 1999 1.96
52 ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell 2000 1.95
53 Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science 2000 1.95
54 New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem 1996 1.94
55 Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin. J Biol Chem 1984 1.94
56 Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J Cell Biol 1988 1.94
57 TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat Immunol 2001 1.92
58 Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. J Immunol 1995 1.91
59 The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids. J Biol Chem 1985 1.90
60 A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis. J Biol Chem 1997 1.88
61 Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene 1995 1.87
62 I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J Biol Chem 1997 1.86
63 The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem 1996 1.84
64 Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. Cancer Res 2000 1.81
65 Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett 1998 1.75
66 The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem 1995 1.72
67 Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes. J Biol Chem 1986 1.69
68 Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo. J Cell Biol 1988 1.69
69 Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing. J Cell Biol 1985 1.62
70 Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor. J Biol Chem 1987 1.62
71 Thrombospondin-induced attachment and spreading of human squamous carcinoma cells. Exp Cell Res 1986 1.61
72 Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases. J Biol Chem 1996 1.57
73 Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1). J Biol Chem 1997 1.56
74 TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett 1998 1.54
75 Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J Biol Chem 1997 1.54
76 Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors. J Clin Invest 1990 1.54
77 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J Biol Chem 1996 1.53
78 CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis. J Biol Chem 1995 1.53
79 Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis. J Cell Sci 2001 1.43
80 Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. J Immunol 1992 1.40
81 Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopy. J Cell Biol 1987 1.36
82 Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. J Biol Chem 1995 1.36
83 Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis. Am J Pathol 1994 1.34
84 Localization of the hemagglutinating activity of platelet thrombospondin to a 140 000-dalton thermolytic fragment. Biochemistry 1984 1.33
85 Thrombospondin-induced adhesion of human keratinocytes. J Clin Invest 1988 1.33
86 CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases. Oncogene 1996 1.33
87 CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem 1995 1.31
88 The inhibition of pro-apoptotic ICE-like proteases enhances HIV replication. Nat Med 1997 1.30
89 Modulation of keratinocyte motility. Correlation with production of extracellular matrix molecules in response to growth promoting and antiproliferative factors. Am J Pathol 1988 1.29
90 The PYRIN domain: a member of the death domain-fold superfamily. Protein Sci 2001 1.29
91 Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J Biol Chem 1994 1.28
92 Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development. J Biol Chem 1992 1.27
93 Ceramide in apoptosis--does it really matter? Trends Biochem Sci 1998 1.26
94 A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. Mol Cell Biol 1990 1.25
95 Modulation of keratinocyte-derived interleukin-8 which is chemotactic for neutrophils and T lymphocytes. Am J Pathol 1991 1.24
96 Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs). J Biol Chem 1998 1.24
97 Regulation of death receptor signaling by the ubiquitin system. Cell Death Differ 2010 1.24
98 Boo, a novel negative regulator of cell death, interacts with Apaf-1. EMBO J 1999 1.23
99 B94, a primary response gene inducible by tumor necrosis factor-alpha, is expressed in developing hematopoietic tissues and the sperm acrosome. J Biol Chem 1994 1.22
100 Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis. J Biol Chem 1997 1.21
101 Effects of anti-thrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin. Biochemistry 1985 1.21
102 Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Curr Biol 1996 1.20
103 Deposition and role of thrombospondin in the histogenesis of the cerebellar cortex. J Cell Biol 1990 1.20
104 T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection. EMBO J 1997 1.18
105 Properties of recombinant mouse thrombospondin 2 expressed in Spodoptera cells. J Biol Chem 1994 1.17
106 Isolation of the fibrinogen-binding region of platelet thrombospondin. Biochem Biophys Res Commun 1984 1.17
107 Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappa B. J Biol Chem 1993 1.16
108 Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin. Proc Natl Acad Sci U S A 1986 1.15
109 A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome. J Biol Chem 1991 1.15
110 Src-like adaptor protein (Slap) is a negative regulator of mitogenesis. Curr Biol 1998 1.13
111 Detection of interferon-gamma mRNA in psoriatic epidermis by polymerase chain reaction. J Dermatol Sci 1991 1.13
112 Portrait of an executioner: the molecular mechanism of FAS/APO-1-induced apoptosis. Semin Immunol 1997 1.11
113 Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J Exp Med 2000 1.11
114 High level thrombospondin 1 expression in two NIH 3T3 cloned lines confers serum- and anchorage-independent growth. J Biol Chem 1993 1.09
115 Monocyte chemotaxis and activating factor production by keratinocytes in response to IFN-gamma. J Immunol 1991 1.09
116 Recent advances in tumor necrosis factor and CD40 signaling. Curr Opin Genet Dev 1996 1.09
117 ERICE, a novel FLICE-activatable caspase. J Biol Chem 1998 1.06
118 Inhibition of platelet aggregation by a monoclonal antibody against human fibronectin. Proc Natl Acad Sci U S A 1985 1.06
119 cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. J Biol Chem 1994 1.05
120 Stimulation of fibroblast proliferation by thrombospondin. Biochem Biophys Res Commun 1989 1.04
121 Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene. J Biol Chem 1992 1.03
122 Thrombospondin and a 140 kd fragment promote adhesion and neurite outgrowth from embryonic central and peripheral neurons and from PC12 cells. Neuron 1991 1.03
123 Caspase-14 is a novel developmentally regulated protease. J Biol Chem 1998 1.03
124 All-trans retinoic acid stimulates growth and extracellular matrix production in growth-inhibited cultured human skin fibroblasts. J Invest Dermatol 1990 1.03
125 Cell signalling. Receptor orphans find a family. Curr Biol 1995 1.02
126 CD95 (APO-1/Fas)-associating signalling proteins. Cell Death Differ 1996 1.02
127 Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase. J Biol Chem 1995 1.02
128 All-trans retinoic acid stimulates growth of adult human keratinocytes cultured in growth factor-deficient medium, inhibits production of thrombospondin and fibronectin, and reduces adhesion. J Invest Dermatol 1989 1.01
129 Human keratinocytes synthesize and secrete the extracellular matrix protein, thrombospondin. J Invest Dermatol 1987 1.01
130 Characterization of thrombospondin synthesis, secretion and cell surface expression by human tumor cells. Clin Exp Metastasis 1989 1.00
131 Expression and initial characterization of a recombinant human thrombospondin heparin binding domain. J Biol Chem 1989 0.99
132 Activated T-cell adhesion to thrombospondin is mediated by the alpha 4 beta 1 (VLA-4) and alpha 5 beta 1 (VLA-5) integrins. J Immunol 1993 0.99
133 Human neutrophil adherence to thrombospondin occurs through a CD11/CD18-independent mechanism. J Immunol 1991 0.99
134 The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10. J Biol Chem 1995 0.99
135 Apoptosis. Searching for FLASH domains. Nature 1999 0.97
136 Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice. J Exp Med 2001 0.97
137 Thrombospondin 3 is a developmentally regulated heparin binding protein. J Biol Chem 1994 0.96
138 Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7. J Biol Chem 1996 0.96
139 Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases. Immunol Today 1998 0.95
140 Activation of caspases triggered by cytochrome c in vitro. FEBS Lett 1998 0.95
141 Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers. J Biol Chem 1992 0.95
142 Characterization of the promoter region of the human thrombospondin gene. DNA sequences within the first intron increase transcription. J Biol Chem 1989 0.94
143 Thrombospondin functions as a cytoadhesion molecule for human hematopoietic progenitor cells. Blood 1990 0.94
144 Keratinocyte activation following T-lymphocyte binding. J Invest Dermatol 1992 0.94
145 Reciprocal expression of the Eph receptor Cek5 and its ligand(s) in the early retina. Dev Biol 1997 0.94
146 Human carcinoma cells bind thrombospondin through a Mr 80,000/105,000 receptor. Cancer Res 1991 0.93
147 Type I insulin-like growth factor receptor activation regulates apoptotic proteins. J Biol Chem 1996 0.93
148 Elevated levels of syndecan-1 expression confer potent serum-dependent growth in human 293T cells. Cancer Res 1995 0.93
149 Role of the extracellular matrix protein thrombospondin in the early development of the mouse embryo. J Cell Biol 1990 0.92
150 Proteolysis of poly(ADP-ribose) polymerase by caspase 3: kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates. Radiat Res 1998 0.92
151 Inhibitory effect of gamma interferon on cultured human keratinocyte thrombospondin production, distribution, and biologic activities. J Invest Dermatol 1988 0.92
152 Characterization of calcium release-activated apoptosis of LNCaP prostate cancer cells. J Biol Chem 2000 0.91
153 Thrombospondin binding by human squamous carcinoma and melanoma cells: relationship to biological activity. Exp Cell Res 1988 0.91
154 Characterization of the platelet agglutinating activity of thrombospondin. Biochemistry 1985 0.90
155 Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction. Cell Death Differ 2006 0.90
156 Structure and chromosomal localization of the human thrombospondin gene. Genomics 1990 0.89
157 Expression and analysis of COOH-terminal deletions of the human thrombospondin molecule. J Cell Biol 1989 0.88
158 Monocyte diapedesis through an in vitro vessel wall construct: inhibition with monoclonal antibodies to thrombospondin. J Leukoc Biol 1992 0.88
159 Thrombospondin-1 suppresses tumorigenesis and angiogenesis in serum- and anchorage-independent NIH 3T3 cells. Lab Invest 1997 0.87
160 Oligomeric assembly of thrombospondin in the endoplasmic reticulum of thyroid epithelial cells. Eur J Cell Biol 1996 0.87
161 Motility of human carcinoma cells in response to thrombospondin: relationship to metastatic potential and thrombospondin structural domains. Cancer Res 1993 0.85
162 Production and utilization of extracellular matrix components by human melanocytes. Exp Cell Res 1989 0.84
163 The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease. J Biol Chem 1998 0.84
164 cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases. J Biol Chem 1995 0.84
165 Synthesis of a thrombospondin-like cytoadhesion molecule by cells of the trabecular meshwork. Invest Ophthalmol Vis Sci 1991 0.83
166 Activation of human neutrophils increases thrombospondin receptor expression. J Immunol 1991 0.83
167 Expression of thrombospondin in the adult nervous system. J Comp Neurol 1994 0.81
168 Human carcinoma cells express receptors for distinct domains of thrombospondin. Cancer Res 1991 0.80
169 Modulation of squamous carcinoma cell growth, morphology, adhesiveness and extracellular matrix production by interferon-gamma and tumor necrosis factor-alpha. Pathobiology 1990 0.80
170 Baculovirus-based genetic screen for antiapoptotic genes identifies a novel IAP. J Biol Chem 1999 0.80
171 Age-dependent injury in human umbilical vein endothelial cells: relationship to apoptosis and correlation with a lack of A20 expression. Lab Invest 1995 0.79
172 Induction of thrombospondin 1 by retinoic acid is important during differentiation of neuroblastoma cells. J Clin Invest 1992 0.79
173 Structure of human thrombospondin: complete amino acid sequence derived from cDNA. Semin Thromb Hemost 1987 0.79
174 Modulation of fibronectin production in normal human melanocytes and malignant melanoma cells by interferon-gamma and tumor necrosis factor-alpha. Am J Pathol 1989 0.78
175 Cause of depression in chronic scurvy. Lancet 1979 0.78
176 Modulation of thrombospondin receptor expression during HL-60 cell differentiation. J Immunol 1994 0.76
177 Solid-phase extraction of fluoxetine and norfluoxetine from serum with gas chromatography-electron-capture detection. J Chromatogr 1991 0.75
178 Purification of the death substrate poly(ADP-ribose) polymerase. Anal Biochem 1997 0.75
179 Thioacetylation method of protein sequencing: derivatization of 2-methyl-5(4H)-thiazolones for high-performance liquid chromatographic detection. Anal Biochem 1989 0.75
180 The mechanism of hyperlipidaemia in the nephrotic syndrome. Med Hypotheses 1979 0.75
181 Solid-phase extraction and GC/MS confirmation of barbiturates from human urine. J Anal Toxicol 1992 0.75
182 Solid-phase extraction of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid from human urine with gas chromatographic-mass spectrometric confirmation. J Chromatogr 1991 0.75
183 A study of subacute sclerosing panencephalitis in Kenya. Dev Med Child Neurol 1981 0.75
184 The use of antithyroid therapy in the treatment of neoplastic conditions with cytotoxic drugs. Med Hypotheses 1979 0.75
185 Thrombospondin binding by keratinocytes: modulation under conditions which alter thrombospondin biosynthesis. Dermatologica 1990 0.75
186 RIPs: an emerging family of kinases involved in pro-inflammatory and apoptotic signaling. Cold Spring Harb Symp Quant Biol 1999 0.75