Published in J Biol Chem on May 26, 1995
NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol (2001) 4.55
Frequent inactivation of A20 in B-cell lymphomas. Nature (2009) 4.22
The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc Natl Acad Sci U S A (1996) 4.03
Molecular mechanism and function of CD40/CD40L engagement in the immune system. Immunol Rev (2009) 3.56
Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation. Mol Cell Biol (1996) 3.22
NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol Cell Biol (2001) 3.02
Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor. EMBO J (1998) 3.01
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J (2004) 2.23
BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma. Am J Pathol (2004) 2.20
Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene. J Virol (1996) 2.03
Deubiquitinases in the regulation of NF-κB signaling. Cell Res (2010) 2.00
The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity (2010) 1.97
Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20. J Mol Biol (2007) 1.82
A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Mol Cell Biol (2002) 1.77
I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc Natl Acad Sci U S A (1996) 1.74
A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression. Nat Med (2008) 1.65
Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells. J Clin Invest (2011) 1.54
CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily. Mol Cell Biol (2000) 1.35
Interaction of tumor necrosis factor receptor-associated factor signaling proteins with the latent membrane protein 1 PXQXT motif is essential for induction of epidermal growth factor receptor expression. Mol Cell Biol (1998) 1.24
A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets. J Exp Med (1999) 1.22
Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci U S A (2002) 1.13
A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme. J Exp Med (2009) 1.12
The expression and function of Epstein-Barr virus encoded latent genes. Mol Pathol (2000) 1.12
Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation. Proc Natl Acad Sci U S A (1999) 1.07
Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus. J Virol (1999) 1.04
miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR. Sci Signal (2013) 1.02
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Nat Med (2015) 1.00
Nuclear factor kappa B-dependent activation of the antiapoptotic bfl-1 gene by the Epstein-Barr virus latent membrane protein 1 and activated CD40 receptor. J Virol (2004) 0.96
Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways. J Leukoc Biol (2012) 0.94
Synergistic induction of tissue factor by coagulation factor Xa and TNF: evidence for involvement of negative regulatory signaling cascades. Proc Natl Acad Sci U S A (2005) 0.91
The role of A20 in the pathogenesis of lymphocytic malignancy. Cancer Cell Int (2012) 0.87
Mutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kappaB-regulated cell death inhibitors important for v-Rel transforming activity. Mol Cell Biol (2003) 0.85
Fas apoptosis inhibitory molecule enhances CD40 signaling in B cells and augments the plasma cell compartment. J Immunol (2009) 0.83
Synovial fibroblasts and the sphingomyelinase pathway: sphingomyelin turnover and ceramide generation are not signaling mechanisms for the actions of tumor necrosis factor-alpha. Am J Pathol (1998) 0.80
Inhibitors of nuclear factor kappa B cause apoptosis in cultured macrophages. Mediators Inflamm (1997) 0.77
A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomes. FASEB J (2015) 0.77
The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes. Front Mol Neurosci (2015) 0.77
NF-kappaB activation and zinc finger protein A20 expression in mature dendritic cells derived from liver allografts undergoing acute rejection. World J Gastroenterol (2003) 0.77
Generating CTLs against the subdominant EBV LMP antigens by transient expression of an A20 inhibitor with EBV LMP proteins in human DCs. Gene Ther (2011) 0.76
A20 deficiency leads to angiogenesis of pulmonary artery endothelial cells through stronger NF-κB activation under hypoxia. J Cell Mol Med (2016) 0.75
Hypomorphic A20 expression confers susceptibility to psoriasis. PLoS One (2017) 0.75
The Ensembl genome database project. Nucleic Acids Res (2002) 40.87
Death receptors: signaling and modulation. Science (1998) 16.95
Ensembl 2002: accommodating comparative genomics. Nucleic Acids Res (2003) 12.26
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell (1996) 12.07
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell (1995) 9.81
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell (1995) 9.22
Caspases: intracellular signaling by proteolysis. Cell (1997) 7.46
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science (1995) 6.41
The receptor for the cytotoxic ligand TRAIL. Science (1997) 6.39
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science (1997) 6.30
Apoptosis signaling. Annu Rev Biochem (2000) 6.18
An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science (1997) 6.10
Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J (2001) 5.94
Visualization of specific B and T lymphocyte interactions in the lymph node. Science (1998) 5.04
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature (1999) 5.03
Apoptosis control by death and decoy receptors. Curr Opin Cell Biol (1999) 4.54
Mice deficient for the CD40 ligand. Immunity (1994) 4.45
Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell (2000) 4.19
An induced proximity model for caspase-8 activation. J Biol Chem (1998) 4.18
Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem (1996) 3.97
Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A (1999) 3.86
Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem (1995) 3.83
FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem (1996) 3.72
Keratinocytes as initiators of inflammation. Lancet (1991) 3.68
Immune regulation by CD40 and its ligand GP39. Annu Rev Immunol (1996) 3.56
Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence. Nature (1985) 3.53
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science (1997) 3.51
CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med (2001) 3.51
Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem (1997) 3.41
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem (1990) 3.41
Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. J Biol Chem (1992) 3.36
Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol (1995) 3.34
Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science (1993) 3.30
Caspase-9 can be activated without proteolytic processing. J Biol Chem (1999) 3.20
Risk factors for prematurity and premature rupture of membranes: a prospective study of the vaginal flora in pregnancy. Am J Obstet Gynecol (1984) 3.15
A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem (1994) 3.13
The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B. J Biol Chem (1992) 3.13
Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction. Nat Med (1997) 3.03
Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Mol Psychiatry (2007) 2.94
The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol Chem (1992) 2.90
RAIDD is a new 'death' adaptor molecule. Nature (1997) 2.89
Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science (1995) 2.88
Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science (1996) 2.87
gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J Exp Med (1994) 2.87
Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol (2001) 2.85
Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol (2000) 2.78
Gastric pacing improves emptying and symptoms in patients with gastroparesis. Gastroenterology (1998) 2.78
Role of CED-4 in the activation of CED-3. Nature (1997) 2.76
Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr Biol (2001) 2.75
In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J Exp Med (1993) 2.72
Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature (2002) 2.59
RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. J Biol Chem (1998) 2.58
The domains of death: evolution of the apoptosis machinery. Trends Biochem Sci (1999) 2.56
The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells. J Immunol (1993) 2.53
B-cell growth factor (B-cell growth factor I or B-cell-stimulating factor, provisional 1) is a differentiation factor for resting B cells and may not induce cell growth. Proc Natl Acad Sci U S A (1985) 2.41
CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci U S A (1996) 2.38
The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol Today (1994) 2.36
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation. Nature (1999) 2.31
Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr Biol (2000) 2.29
Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene (2008) 2.26
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J Biol Chem (1998) 2.25
Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. Am J Pathol (1991) 2.24
ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem (1996) 2.20
The cell-death machine. Curr Biol (1996) 2.18
RIP3, a novel apoptosis-inducing kinase. J Biol Chem (1999) 2.15
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem (1996) 2.12
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem (1999) 2.09
Epidemiologists in the United States: an assessment of the current supply and the anticipated need. Am J Prev Med (1988) 2.09
A role for FADD in T cell activation and development. Immunity (1998) 2.09
Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci U S A (1995) 2.06
A monoclonal antibody against human thrombospondin inhibits platelet aggregation. Proc Natl Acad Sci U S A (1985) 2.04
The Family Health Project: psychosocial adjustment of children whose mothers are HIV infected. J Consult Clin Psychol (1998) 2.03
Reflection impulsivity and response inhibition in first-episode psychosis: relationship to cannabis use. Psychol Med (2013) 2.02
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J Biol Chem (1997) 2.01
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol (2000) 2.01
Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science (2001) 1.97
Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat Genet (1999) 1.96
ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell (2000) 1.95
Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science (2000) 1.95
CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency. Proc Natl Acad Sci U S A (1994) 1.94
New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem (1996) 1.94
Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin. J Biol Chem (1984) 1.94
Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J Cell Biol (1988) 1.94
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene (2011) 1.94
Mast cell degranulation breaks peripheral tolerance. Am J Transplant (2009) 1.94
The impact of workplace smoking ordinances in California on smoking cessation. Am J Public Health (2000) 1.92
TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat Immunol (2001) 1.92
Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. J Immunol (1995) 1.91
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc Natl Acad Sci U S A (1996) 1.90
The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids. J Biol Chem (1985) 1.90
A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis. J Biol Chem (1997) 1.88
Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene (1995) 1.87
I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J Biol Chem (1997) 1.86
The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. J Exp Med (2001) 1.86
Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons. Brain (2000) 1.85
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem (1996) 1.84