Published in J Biol Chem on July 03, 1998
The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J (2004) 4.85
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J (2000) 3.83
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem (2006) 3.51
Mechanisms of apoptosis. Am J Pathol (2000) 3.23
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J (2007) 2.72
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci U S A (2006) 2.59
Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev (2005) 2.50
NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog (2009) 2.31
Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem J (2007) 1.98
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med (2006) 1.95
XIAP mediates NOD signaling via interaction with RIP2. Proc Natl Acad Sci U S A (2009) 1.95
PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex. Mol Cell Biol (2000) 1.82
NLR proteins: integral members of innate immunity and mediators of inflammatory diseases. J Leukoc Biol (2007) 1.73
NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J Clin Invest (2010) 1.64
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J (1999) 1.59
Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast. Nano Lett (2005) 1.53
Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB. Ann Rheum Dis (2000) 1.48
Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB. Mol Cell Biol (1999) 1.45
Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. Mol Cell Biol (2000) 1.39
Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses. Genes Dev (2010) 1.39
CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily. Mol Cell Biol (2000) 1.35
TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem (2007) 1.30
The cytosolic pattern recognition receptor NOD1 induces inflammatory interleukin-8 during Chlamydia trachomatis infection. Infect Immun (2008) 1.28
Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. Arthritis Res Ther (2008) 1.28
Quantitative phosphoproteomic analysis of the tumor necrosis factor pathway. J Proteome Res (2006) 1.23
RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. EMBO Rep (2002) 1.23
Modifications to the peptidoglycan backbone help bacteria to establish infection. Infect Immun (2010) 1.22
Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB. Biochem J (1999) 1.14
RIP kinases: key decision makers in cell death and innate immunity. Cell Death Differ (2014) 1.14
A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade. Mol Ther (2012) 1.13
Regulation of NF-κB by the CARD proteins. Immunol Rev (2012) 1.12
Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB. J Clin Invest (1999) 1.11
NOD1 and NOD2 signalling links ER stress with inflammation. Nature (2016) 1.10
Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol (2010) 1.07
Gene expression in periodontal tissues following treatment. BMC Med Genomics (2008) 1.05
The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responses. J Biol Chem (2009) 1.02
Regulation of NF-κB signaling by caspases and MALT1 paracaspase. Cell Res (2010) 0.98
NOD-Like Receptors: Master Regulators of Inflammation and Cancer. Front Immunol (2014) 0.97
The role of RIP2 in p38 MAPK activation in the stressed heart. J Biol Chem (2008) 0.96
Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation. Proc Natl Acad Sci U S A (2006) 0.95
Receptor-interacting protein 2 controls pulmonary host defense to Escherichia coli infection via the regulation of interleukin-17A. Infect Immun (2011) 0.92
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nat Immunol (2013) 0.92
Substitutions of prolines examine their role in kinetic trap formation of the caspase recruitment domain (CARD) of RICK. Protein Sci (2006) 0.91
ARTS and Siah collaborate in a pathway for XIAP degradation. Mol Cell (2010) 0.91
Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease. Biochim Biophys Acta (2012) 0.90
TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. Cell Signal (2011) 0.89
RIP2, a checkpoint in myogenic differentiation. Mol Cell Biol (2002) 0.89
Stored packed red blood cell transfusion up-regulates inflammatory gene expression in circulating leukocytes. Ann Surg (2007) 0.89
Life and death of lymphocytes: a role in immunesenescence. Immun Ageing (2005) 0.88
Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins. Infect Immun (2009) 0.87
Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2. J Biol Chem (2013) 0.87
Emerging significance of NLRs in inflammatory bowel disease. Inflamm Bowel Dis (2014) 0.86
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1. Inflamm Bowel Dis (2011) 0.85
p62/SQSTM1 enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomerization. PLoS One (2013) 0.85
A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling. Mol Cell Biol (2012) 0.85
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production. Nat Commun (2015) 0.84
Exploiting features of adenovirus replication to support mammalian kinase production. Nucleic Acids Res (2003) 0.84
Role of tumour necrosis factor-alpha and other cytokines in ischemia-reperfusion-induced injury in the heart. Exp Clin Cardiol (2005) 0.83
Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Res (2014) 0.82
Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation. Mol Cell Proteomics (2012) 0.81
Inhibiting the inflammasome: one domain at a time. Immunol Rev (2015) 0.81
Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis. ScientificWorldJournal (2016) 0.80
Inactivation of DNA-dependent protein kinase promotes heat-induced apoptosis independently of heat-shock protein induction in human cancer cell lines. PLoS One (2013) 0.79
HIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2. Retrovirology (2015) 0.79
Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation. Retrovirology (2005) 0.79
Tumor necrosis factor alpha-induced inflammation is increased but apoptosis is inhibited by common food additive carrageenan. J Biol Chem (2010) 0.78
An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes. Endocrinology (2015) 0.78
Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death. PLoS One (2014) 0.78
An association study of TOLL and CARD with leprosy susceptibility in Chinese population. Hum Mol Genet (2013) 0.78
Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cultures. BMC Cancer (2008) 0.77
Tissue-specific down-regulation of RIPK 2 in Mycobacterium leprae-infected nu/nu mice. Mediators Inflamm (2004) 0.77
H11/HspB8 and Its Herpes Simplex Virus Type 2 Homologue ICP10PK Share Functions That Regulate Cell Life/Death Decisions and Human Disease. Autoimmune Dis (2012) 0.76
Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens. Front Microbiol (2017) 0.75
Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1β and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells. J Immunol (2016) 0.75
The expression of B & T cell activation markers in children's tonsils following live attenuated influenza vaccine. Hum Vaccin Immunother (2015) 0.75
Andrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore A23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice model. Drug Des Devel Ther (2016) 0.75
Synthetic Biology Reveals the Uniqueness of the RIP Kinase Domain. J Immunol (2016) 0.75
A CD4+ T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function. Retrovirology (2014) 0.75
The RIPK2 gene: a positional candidate for tick burden supported by genetic associations in cattle and immunological response of knockout mouse. Immunogenetics (2012) 0.75
Death receptors: signaling and modulation. Science (1998) 16.95
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell (1996) 12.07
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell (1995) 9.81
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell (1995) 9.22
Caspases: intracellular signaling by proteolysis. Cell (1997) 7.46
LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol (1999) 7.27
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science (1995) 6.41
The receptor for the cytotoxic ligand TRAIL. Science (1997) 6.39
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science (1997) 6.30
Apoptosis signaling. Annu Rev Biochem (2000) 6.18
An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science (1997) 6.10
Apoptosis control by death and decoy receptors. Curr Opin Cell Biol (1999) 4.54
Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell (2000) 4.19
An induced proximity model for caspase-8 activation. J Biol Chem (1998) 4.18
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol (2001) 4.10
Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem (1996) 3.97
Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A (1999) 3.86
Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem (1995) 3.83
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem (1999) 3.81
FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem (1996) 3.72
Keratinocytes as initiators of inflammation. Lancet (1991) 3.68
Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence. Nature (1985) 3.53
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science (1997) 3.51
Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem (1997) 3.41
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem (1990) 3.41
Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. J Biol Chem (1992) 3.36
Caspase-9 can be activated without proteolytic processing. J Biol Chem (1999) 3.20
A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem (1994) 3.13
The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B. J Biol Chem (1992) 3.13
The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol Chem (1992) 2.90
RAIDD is a new 'death' adaptor molecule. Nature (1997) 2.89
Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science (1995) 2.88
Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science (1996) 2.87
Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol (2001) 2.85
Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol (2000) 2.78
Role of CED-4 in the activation of CED-3. Nature (1997) 2.76
Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr Biol (2001) 2.75
The domains of death: evolution of the apoptosis machinery. Trends Biochem Sci (1999) 2.56
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem (1998) 2.48
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem (1999) 2.44
Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase. J Biol Chem (1999) 2.41
Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr Biol (2000) 2.29
Antisense snoRNAs: a family of nucleolar RNAs with long complementarities to rRNA. Trends Biochem Sci (1995) 2.29
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol (2000) 2.27
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J Biol Chem (1998) 2.25
Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. Am J Pathol (1991) 2.24
ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem (1996) 2.20
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nat Med (2000) 2.18
The cell-death machine. Curr Biol (1996) 2.18
RIP3, a novel apoptosis-inducing kinase. J Biol Chem (1999) 2.15
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem (1996) 2.12
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem (1999) 2.09
A role for FADD in T cell activation and development. Immunity (1998) 2.09
Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J Biol Chem (1995) 2.05
A monoclonal antibody against human thrombospondin inhibits platelet aggregation. Proc Natl Acad Sci U S A (1985) 2.04
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J Biol Chem (1997) 2.01
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol (2000) 2.01
A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. J Biol Chem (1997) 2.00
A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem (1999) 1.98
Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science (2001) 1.97
Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat Genet (1999) 1.96
ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell (2000) 1.95
Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science (2000) 1.95
New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem (1996) 1.94
Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J Cell Biol (1988) 1.94
Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin. J Biol Chem (1984) 1.94
TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat Immunol (2001) 1.92
Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. J Immunol (1995) 1.91
The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids. J Biol Chem (1985) 1.90
LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J Clin Invest (1998) 1.89
A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis. J Biol Chem (1997) 1.88
Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene (1995) 1.87
I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J Biol Chem (1997) 1.86
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem (1996) 1.84
Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. Cancer Res (2000) 1.81
Association of viral genome with graft loss in children after cardiac transplantation. N Engl J Med (2001) 1.78
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood (2000) 1.76
Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett (1998) 1.75
Detection of microorganisms in the tracheal aspirates of preterm infants by polymerase chain reaction: association of adenovirus infection with bronchopulmonary dysplasia. Pediatr Res (2000) 1.72
The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem (1995) 1.72
Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes. J Biol Chem (1986) 1.69
Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo. J Cell Biol (1988) 1.69
Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG. Cancer Res (1997) 1.66
Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing. J Cell Biol (1985) 1.62
Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor. J Biol Chem (1987) 1.62
Thrombospondin-induced attachment and spreading of human squamous carcinoma cells. Exp Cell Res (1986) 1.61
Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily. J Biol Chem (2000) 1.59
Acute myocarditis. Rapid diagnosis by PCR in children. Circulation (1994) 1.58
Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases. J Biol Chem (1996) 1.57
Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1). J Biol Chem (1997) 1.56
The pharmacology of bimatoprost (Lumigan). Surv Ophthalmol (2001) 1.54
TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett (1998) 1.54