PubRank

S L Schreiber

Author PubWeight™ 366.01‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991 15.76
2 A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 1996 12.64
3 Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 1999 12.52
4 A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 1994 11.50
5 Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. J Mol Biol 1993 11.24
6 Printing proteins as microarrays for high-throughput function determination. Science 2000 10.77
7 Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 1997 8.99
8 Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 1995 8.58
9 Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature 1995 7.05
10 A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature 1989 7.02
11 Controlling signal transduction with synthetic ligands. Science 1993 6.70
12 Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A 1999 6.50
13 Structural basis for the binding of proline-rich peptides to SH3 domains. Cell 1994 6.34
14 Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 1997 6.27
15 Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science 1996 5.92
16 Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc Natl Acad Sci U S A 1999 5.89
17 Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 1998 5.84
18 Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J 1998 5.25
19 Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A 2000 5.18
20 Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science 1994 4.57
21 PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science 1995 4.51
22 Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci U S A 1995 3.87
23 A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc Natl Acad Sci U S A 1998 3.85
24 Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nat Struct Biol 1999 3.72
25 Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc Natl Acad Sci U S A 1990 3.70
26 CoREST is an integral component of the CoREST- human histone deacetylase complex. Proc Natl Acad Sci U S A 2001 3.66
27 TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell 1995 3.56
28 Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Proc Natl Acad Sci U S A 1999 3.49
29 Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A 2000 3.46
30 cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci U S A 1996 3.31
31 A signaling pathway to translational control. Cell 1996 3.29
32 Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Curr Biol 2001 3.26
33 Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry 1992 3.05
34 Molecular cloning and overexpression of the human FK506-binding protein FKBP. Nature 1990 3.02
35 Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex. Science 1991 2.83
36 Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 2001 2.80
37 ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci U S A 2001 2.75
38 Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs. Curr Opin Chem Biol 1997 2.73
39 FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. J Biol Chem 2000 2.72
40 Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc Natl Acad Sci U S A 2000 2.67
41 Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus. J Protein Chem 1991 2.62
42 Solution structure of the SH3 domain of Src and identification of its ligand-binding site. Science 1992 2.56
43 Immunosuppressants implicate protein phosphatase regulation of K+ channels in guard cells. Proc Natl Acad Sci U S A 1993 2.39
44 Lactacystin, proteasome function, and cell fate. J Biol Chem 1998 2.33
45 Dimeric ligands define a role for transcriptional activation domains in reinitiation. Nature 1996 2.29
46 Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proc Natl Acad Sci U S A 1996 2.20
47 Dimerization as a regulatory mechanism in signal transduction. Annu Rev Immunol 1998 2.17
48 Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis. Proc Natl Acad Sci U S A 1990 2.14
49 Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation. J Biol Chem 2001 2.08
50 Alpha 4 associates with protein phosphatases 2A, 4, and 6. Biochem Biophys Res Commun 1998 2.03
51 Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 1992 2.02
52 Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature 1997 1.95
53 Probing immunosuppressant action with a nonnatural immunophilin ligand. Science 1990 1.88
54 Three-part inventions: intracellular signaling and induced proximity. Trends Biochem Sci 1996 1.87
55 Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol 1993 1.85
56 Overproduction and dissection of proteins by the expression-cassette polymerase chain reaction. Proc Natl Acad Sci U S A 1990 1.77
57 Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin. Science 1991 1.70
58 Translation control: connecting mitogens and the ribosome. Curr Biol 1998 1.68
59 Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen. Proc Natl Acad Sci U S A 1997 1.66
60 FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line. J Biol Chem 1993 1.62
61 Signal transduction in T lymphocytes using a conditional allele of Sos. Proc Natl Acad Sci U S A 1995 1.61
62 Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization. Curr Biol 1996 1.60
63 Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13. Proc Natl Acad Sci U S A 1991 1.58
64 Target of rapamycin proteins and their kinase activities are required for meiosis. Proc Natl Acad Sci U S A 1997 1.57
65 Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands. Proc Natl Acad Sci U S A 1995 1.57
66 Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chem Biol 2000 1.55
67 High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chem Biol 1999 1.53
68 A general strategy for producing conditional alleles of Src-like tyrosine kinases. Proc Natl Acad Sci U S A 1995 1.49
69 Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin. Org Lett 2001 1.44
70 Structure of the PI3K SH3 domain and analysis of the SH3 family. Cell 1993 1.42
71 A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci U S A 1994 1.39
72 A one-bead, one-stock solution approach to chemical genetics: part 1. Chem Biol 2001 1.36
73 Model of the interactions of calichemicin gamma 1 with a DNA fragment from pBR322. Proc Natl Acad Sci U S A 1989 1.36
74 Understanding and controlling the cell cycle with natural products. Chem Biol 1996 1.35
75 Evidence for protein phosphatase 1 and 2A regulation of K+ channels in two types of leaf cells. Plant Physiol 1994 1.35
76 The PIK-related kinases intercept conventional signaling pathways. Chem Biol 1999 1.34
77 Kinase phosphorylation: Keeping it all in the family. Curr Biol 1999 1.32
78 Cyclic AMP stimulates K+ channel activity in mesophyll cells of Vicia faba L. Plant Physiol 1994 1.28
79 Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions. Mol Cell Biol 1995 1.26
80 Proximity versus allostery: the role of regulated protein dimerization in biology. Chem Biol 1994 1.25
81 Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. Biochemistry 1999 1.24
82 Light-regulated, tissue-specific immunophilins in a higher plant. Proc Natl Acad Sci U S A 1994 1.24
83 A one-bead, one-stock solution approach to chemical genetics: part 2. Chem Biol 2001 1.24
84 Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors. Proc Natl Acad Sci U S A 2001 1.23
85 Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. EMBO J 1997 1.23
86 GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha. J Biol Chem 1994 1.22
87 Transmembrane channels based on tartaric acid-gramicidin A hybrids. Science 1989 1.22
88 A rapamycin-selective 25-kDa immunophilin. Biochemistry 1992 1.20
89 pCyP B: a chloroplast-localized, heat shock-responsive cyclophilin from fava bean. Plant Cell 1994 1.20
90 Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase. Proc Natl Acad Sci U S A 1998 1.19
91 Inhibition of FKBP rotamase activity by immunosuppressant FK506: twisted amide surrogate. Science 1990 1.18
92 Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerization. Chem Biol 1996 1.16
93 Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. Chem Biol 1994 1.16
94 Molecular characterization of a FKBP-type immunophilin from higher plants. Proc Natl Acad Sci U S A 1996 1.13
95 Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. Proc Natl Acad Sci U S A 1992 1.11
96 Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis. Org Lett 2000 1.11
97 Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A. Structure 1994 1.11
98 Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription. Proc Natl Acad Sci U S A 1991 1.10
99 (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol 1996 1.10
100 Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale. Chem Biol 1997 1.08
101 An FKBP-rapamycin-sensitive, cyclin-dependent kinase activity that correlates with the FKBP-rapamycin-induced G1 arrest point in MG-63 cells. Ann N Y Acad Sci 1993 1.05
102 The effect of the immunosuppressant FK-506 on alternate pathways of T cell activation. Eur J Immunol 1991 1.05
103 Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743. Proc Natl Acad Sci U S A 1999 1.04
104 A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets. Proc Natl Acad Sci U S A 1997 1.04
105 Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface. Nature 1995 1.04
106 Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A 1990 1.03
107 FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. J Biol Chem 1993 1.03
108 Grb2 SH3 binding to peptides from Sos: evaluation of a general model for SH3-ligand interactions. Chem Biol 1995 1.02
109 Hepatotrophic properties in dogs of human FKBP, the binding protein for FK506 and rapamycin. Transplantation 1991 1.01
110 An alkylsilyl-tethered, high-capacity solid support amenable to diversity-oriented synthesis for one-bead, one-stock solution chemical genetics. J Comb Chem 2001 1.01
111 Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists. Proc Natl Acad Sci U S A 1994 1.01
112 Inhibition of liver, kidney, and intestine regeneration by rapamycin. Transplantation 1992 1.00
113 The identification of myriocin-binding proteins. Chem Biol 1999 1.00
114 A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells. Chem Biol 1997 1.00
115 Fas signal transduction triggers either proliferation or apoptosis in human fibroblasts. J Invest Dermatol 1997 1.00
116 Mechanisms of immunosuppression by FK506. Preservation of T cell transmembrane signal transduction. Transplantation 1990 1.00
117 cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. Biochem Biophys Res Commun 1992 0.98
118 Overproduction of proteins using expression-cassette polymerase chain reaction. Methods Enzymol 1993 0.97
119 Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein. Biochemistry 1991 0.97
120 Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A 1996 0.96
121 Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. J Biol Chem 1996 0.95
122 1H and 15N assignments and secondary structure of the Src SH3 domain. FEBS Lett 1993 0.95
123 Sequential assignment and structure determination of spider toxin omega-Aga-IVB. Biochemistry 1993 0.95
124 Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4. Biochemistry 1995 0.94
125 Structure-based design of a cyclophilin-calcineurin bridging ligand. Science 1993 0.94
126 Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis 2013 0.93
127 Fiber-derived butyrate and the prevention of colon cancer. Chem Biol 1997 0.93
128 The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core. Bioorg Med Chem 2000 0.93
129 Cyclosporine- and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. Circ Res 1993 0.91
130 TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins. Chem Biol 1998 0.90
131 Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment. Curr Biol 1998 0.89
132 P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. Biochemistry 1993 0.89
133 Photo-modulated ion channels based on covalently linked gramicidins. Biochim Biophys Acta 1991 0.87
134 Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays. J Am Chem Soc 2001 0.87
135 Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers. Curr Biol 1998 0.86
136 Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chem Biol 1996 0.86
137 Purification of gramicidin A. Anal Biochem 1990 0.85
138 Prevention of HIV-1 infection and preservation of CD4 function by the binding of CPFs to gp120. Science 1990 0.83
139 Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides. Chem Biol 1994 0.83
140 Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. Biochemistry 1994 0.82
141 Structural and synthetic studies of the spore germination autoinhibitor, gloeosporone. J Am Chem Soc 1988 0.82
142 A tricyclic ring system replaces the variable regions of peptides presented by three alleles of human MHC class I molecules. Chem Biol 1995 0.81
143 [2 + 2] photocycloadditions in the synthesis of chiral molecules. Science 1985 0.81
144 Synthesis and cellular characterization of the detransformation agent, (-)-depudecin. Chem Biol 1995 0.79
145 The interaction of CD4 with HIV-1 gp120. Semin Immunol 1991 0.79
146 Relationship of FKBP to PKCI-2. Nature 1991 0.78
147 Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine mimic of arginine. Proc Natl Acad Sci U S A 1996 0.78
148 1H and 15N assignments and secondary structure of the PI3K SH3 domain. FEBS Lett 1993 0.77
149 Specific inhibition of the chymotrypsin-like activity of the proteasome induces a bipolar morphology in neuroblastoma cells. Chem Biol 1996 0.77
150 Apoptosis-inducing natural products found in utero during murine pregnancy. Chem Biol 2000 0.76
151 Exploiting site-site interactions on solid support to generate dimeric molecules. Org Lett 2001 0.76
152 Signalling an interest. Nat Struct Biol 1994 0.76
153 CPF-DD is an inhibitor of infection by human immunodeficiency virus and other enveloped viruses in vitro. Virology 1992 0.75
154 Crystallization and preliminary X-ray analysis of twinned crystals of a chimeric FK506 binding protein 12 and 13 complexed with FK506. Acta Crystallogr D Biol Crystallogr 1996 0.75
155 Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. Biochem Biophys Res Commun 1992 0.75