Published in Nature on June 13, 1991
The histidine triad superfamily of nucleotide-binding proteins. J Cell Physiol (1999) 1.38
A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob Agents Chemother (2013) 0.86
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell (1991) 15.76
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science (1996) 12.64
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science (1999) 12.52
A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature (1994) 11.50
Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. J Mol Biol (1993) 11.24
Printing proteins as microarrays for high-throughput function determination. Science (2000) 10.77
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell (1997) 8.99
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science (1995) 8.58
fw2.2: a quantitative trait locus key to the evolution of tomato fruit size. Science (2000) 7.91
Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature (1995) 7.05
A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature (1989) 7.02
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell (1999) 6.82
Controlling signal transduction with synthetic ligands. Science (1993) 6.70
Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A (1999) 6.50
Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature (2001) 6.36
Structural basis for the binding of proline-rich peptides to SH3 domains. Cell (1994) 6.34
Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell (1997) 6.27
Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science (1999) 6.02
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science (1996) 5.92
Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc Natl Acad Sci U S A (1999) 5.89
Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature (1998) 5.84
Digital tomosynthesis in breast imaging. Radiology (1997) 5.82
Atomic structure of a thermostable subdomain of HIV-1 gp41. Proc Natl Acad Sci U S A (1997) 5.76
Self-monitoring of blood glucose levels and glycemic control: the Northern California Kaiser Permanente Diabetes registry. Am J Med (2001) 5.68
Separation of caveolae from associated microdomains of GPI-anchored proteins. Science (1995) 5.25
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J (1998) 5.25
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A (2000) 5.18
High fertilization and implantation rates after intracytoplasmic sperm injection. Hum Reprod (1993) 5.06
Comparing sequenced segments of the tomato and Arabidopsis genomes: large-scale duplication followed by selective gene loss creates a network of synteny. Proc Natl Acad Sci U S A (2000) 4.90
Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science (1994) 4.57
PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science (1995) 4.51
Genome sequence, comparative analysis, and population genetics of the domestic horse. Science (2009) 4.41
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Comorbidity of DSM-III-R major depressive disorder in the general population: results from the US National Comorbidity Survey. Br J Psychiatry Suppl (1996) 3.99
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci U S A (1995) 3.87
A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc Natl Acad Sci U S A (1998) 3.85
Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A (1996) 3.83
Ultralong single-wall carbon nanotubes. Nat Mater (2004) 3.83
Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nat Struct Biol (1999) 3.72
Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc Natl Acad Sci U S A (1990) 3.70
CoREST is an integral component of the CoREST- human histone deacetylase complex. Proc Natl Acad Sci U S A (2001) 3.66
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell (1995) 3.56
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Proc Natl Acad Sci U S A (1999) 3.49
Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A (2000) 3.46
A prognostic score for patients with lower risk myelodysplastic syndrome. Leukemia (2007) 3.45
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci U S A (1996) 3.31
Proton-pump inhibitors and risk of fractures: an update meta-analysis. Osteoporos Int (2016) 3.30
A signaling pathway to translational control. Cell (1996) 3.29
Developing a prediction rule from automated clinical databases to identify high-risk patients in a large population with diabetes. Diabetes Care (2001) 3.27
A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature (1989) 3.27
Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Curr Biol (2001) 3.26
Genetic analysis of salt tolerance in arabidopsis. Evidence for a critical role of potassium nutrition. Plant Cell (1998) 3.25
The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science (1999) 3.23
The major facilitator superfamily. J Mol Microbiol Biotechnol (1999) 3.17
Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry (1992) 3.05
Prevalence of diabetes and its risk factors in China, 1994. National Diabetes Prevention and Control Cooperative Group. Diabetes Care (1997) 3.03
Molecular cloning and overexpression of the human FK506-binding protein FKBP. Nature (1990) 3.02
Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem (1996) 3.01
Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects. Hum Brain Mapp (2000) 2.98
Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol (1999) 2.95
Genetic architecture of a morphological shape difference between two Drosophila species. Genetics (2000) 2.92
New tumor markers: CA125 and beyond. Int J Gynecol Cancer (2005) 2.92
SOS3 function in plant salt tolerance requires N-myristoylation and calcium binding. Plant Cell (2000) 2.91
Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol (1995) 2.88
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet (1998) 2.87
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting. Endocr Rev (2001) 2.84
Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex. Science (1991) 2.83
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem (2001) 2.80
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75
ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci U S A (2001) 2.75
Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs. Curr Opin Chem Biol (1997) 2.73
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. J Biol Chem (2000) 2.72
Toxicity of ALS-linked SOD1 mutants. Science (2000) 2.69
Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc Natl Acad Sci U S A (2000) 2.67
Survival of recipients of livers from donation after circulatory death who are relisted and undergo retransplant for graft failure. Am J Transplant (2014) 2.67
Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus. J Protein Chem (1991) 2.62
Solution structure of the SH3 domain of Src and identification of its ligand-binding site. Science (1992) 2.56
Sino-MONICA project: a collaborative study on trends and determinants in cardiovascular diseases in China, Part i: morbidity and mortality monitoring. Circulation (2001) 2.56
Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Mol Pharmacol (1993) 2.54
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 2.49
Intracytoplasmic single sperm injection of 1-day-old unfertilized human oocytes. Hum Reprod (1993) 2.46
Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases. J Biol Chem (1995) 2.41
Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nat Struct Biol (1997) 2.41
The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J Biol Chem (1998) 2.39
Immunosuppressants implicate protein phosphatase regulation of K+ channels in guard cells. Proc Natl Acad Sci U S A (1993) 2.39
Exploration of antigenic variation in gp120 from clades A through F of human immunodeficiency virus type 1 by using monoclonal antibodies. J Virol (1994) 2.36
Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. Am Rev Respir Dis (1993) 2.34
Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34
Inner ear defects induced by null mutation of the isk gene. Neuron (1996) 2.34
Lactacystin, proteasome function, and cell fate. J Biol Chem (1998) 2.33
Gate-voltage control of chemical potential and weak antilocalization in Bi₂Se₃. Phys Rev Lett (2010) 2.32
Dimeric ligands define a role for transcriptional activation domains in reinitiation. Nature (1996) 2.29
A comparative linkage map of oilseed rape and its use for QTL analysis of seed oil and erucic acid content. Theor Appl Genet (2006) 2.21
The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide. J Biol Chem (1995) 2.20
The cytoplasmic peptidoglycan precursor of vancomycin-resistant Enterococcus faecalis terminates in lactate. J Bacteriol (1992) 2.20
Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proc Natl Acad Sci U S A (1996) 2.20