Published in Nature on July 27, 1995
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity (2008) 9.61
Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat Struct Mol Biol (2005) 7.49
B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res (1997) 5.43
Conditional gene targeting. J Clin Invest (1996) 4.60
Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immunol (2007) 3.63
Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci U S A (1996) 2.71
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol (2002) 2.70
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med (2002) 2.68
In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol (2010) 2.63
Control systems and decision making for antibody production. Nat Immunol (2010) 2.60
Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization. J Exp Med (2005) 2.51
Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci U S A (1996) 2.34
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy. Cancer Discov (2015) 2.29
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol (2009) 2.29
Innate response activator B cells protect against microbial sepsis. Science (2012) 2.07
Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. J Immunol (2010) 1.98
Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments. EMBO J (1998) 1.96
Invariant NKT cells limit activation of autoreactive CD1d-positive B cells. J Exp Med (2010) 1.83
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol (2012) 1.82
Protective T cell-independent antiviral antibody responses are dependent on complement. J Exp Med (1999) 1.79
Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response. J Exp Med (2001) 1.62
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood (2005) 1.60
Normal lymphocyte development but delayed humoral immune response in CD81-null mice. J Exp Med (1997) 1.59
Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell (2012) 1.59
B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development. J Exp Med (1999) 1.55
Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A (2013) 1.53
Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J Exp Med (1996) 1.52
Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J (1997) 1.47
The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. Mol Cell Biol (2003) 1.44
Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc Natl Acad Sci U S A (1997) 1.42
The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. Mol Cell Biol (2000) 1.40
Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes. J Exp Med (1997) 1.37
The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proc Natl Acad Sci U S A (1995) 1.35
Humoral response to herpes simplex virus is complement-dependent. Proc Natl Acad Sci U S A (1999) 1.35
CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype. J Exp Med (1996) 1.35
CD19: a biomarker for B cell development, lymphoma diagnosis and therapy. Exp Hematol Oncol (2012) 1.32
Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization. J Exp Med (2006) 1.32
Negative regulation of activation-induced cytidine deaminase in B cells. Proc Natl Acad Sci U S A (2006) 1.30
B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood (2007) 1.30
Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation. Curr Opin Immunol (2011) 1.28
Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. Am J Pathol (2006) 1.28
CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. J Exp Med (1997) 1.26
Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels. J Biol Chem (2012) 1.25
CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody. Blood (2009) 1.25
OCA-B integrates B cell antigen receptor-, CD40L- and IL 4-mediated signals for the germinal center pathway of B cell development. EMBO J (1998) 1.25
Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. J Exp Med (1997) 1.25
CD19: a promising B cell target for rheumatoid arthritis. Nat Rev Rheumatol (2009) 1.24
IgM in microbial infections: taken for granted? Immunol Lett (2009) 1.23
Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity (2009) 1.23
CAR therapy: the CD19 paradigm. J Clin Invest (2015) 1.20
CD19 expression in B cells is important for suppression of contact hypersensitivity. Am J Pathol (2007) 1.20
The cytoskeleton coordinates the early events of B-cell activation. Cold Spring Harb Perspect Biol (2011) 1.17
B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase. Proc Natl Acad Sci U S A (2010) 1.15
Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage. PLoS One (2011) 1.12
B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta. J Exp Med (2001) 1.11
c-Myb is required for pro-B cell differentiation. J Immunol (2009) 1.10
CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis. J Clin Invest (2012) 1.09
Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD. J Exp Med (2007) 1.07
B-1 cell development: evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation. J Exp Med (1998) 1.06
Long-lasting complete regression of established mouse tumors by counteracting Th2 inflammation. J Immunother (2013) 1.04
Translational mini-review series on immunodeficiency: molecular defects in common variable immunodeficiency. Clin Exp Immunol (2007) 1.03
Rapid STAT phosphorylation via the B cell receptor. Modulatory role of CD19. J Biol Chem (1999) 1.00
B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen. J Immunol (2014) 0.99
A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice. J Immunol (2012) 0.99
Context-specific BAFF-R signaling by the NF-κB and PI3K pathways. Cell Rep (2013) 0.99
Macrophage and T cell produced IL-10 promotes viral chronicity. PLoS Pathog (2013) 0.98
Blinatumomab, a Bi-Specific Anti-CD19/CD3 BiTE(®) Antibody for the Treatment of Acute Lymphoblastic Leukemia: Perspectives and Current Pediatric Applications. Front Oncol (2014) 0.96
Marginal zone B cells regulate antigen capture by marginal zone macrophages. J Immunol (2011) 0.96
Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19. J Exp Med (1998) 0.96
Reduced receptor editing in lupus-prone MRL/lpr mice. J Exp Med (2007) 0.96
B cells participate in thymic negative selection of murine auto-reactive CD4+ T cells. PLoS One (2010) 0.95
B cells delay neutrophil migration toward the site of stimulus: tardiness critical for effective bacillus Calmette-Guérin vaccination against tuberculosis infection in mice. J Immunol (2009) 0.95
B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk. Elife (2014) 0.95
CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. Proc Natl Acad Sci U S A (1997) 0.95
CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. J Immunol (2009) 0.95
The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions. Front Immunol (2012) 0.95
Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity. J Immunol (2012) 0.94
The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. J Exp Med (1997) 0.93
Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity. Arthritis Res Ther (2012) 0.91
Cutting edge: Primary and secondary effects of CD19 deficiency on cells of the marginal zone. J Immunol (2009) 0.91
B Cell in Autoimmune Diseases. Scientifica (Cairo) (2012) 0.90
RhoA of the Rho family small GTPases is essential for B lymphocyte development. PLoS One (2012) 0.89
Role of beta-catenin in B cell development and function. J Immunol (2008) 0.89
Germinal center structure and function: lessons from CD19. Semin Immunol (2008) 0.89
The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells. Proc Natl Acad Sci U S A (2011) 0.89
The cellular location of self-antigen determines the positive and negative selection of autoreactive B cells. J Exp Med (2003) 0.89
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A (2000) 0.87
Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology (2012) 0.87
Impact of natural IgM concentration on gene therapy with adenovirus type 5 vectors. J Virol (2014) 0.87
Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proc Natl Acad Sci U S A (2013) 0.86
The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivo. J Virol (2010) 0.85
CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway. J Exp Med (2011) 0.85
CD19 and CD32b differentially regulate human B cell responsiveness. J Immunol (2014) 0.85
Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol (2017) 0.85
T cell-independent and T cell-dependent immunoglobulin G responses to polyomavirus infection are impaired in complement receptor 2-deficient mice. Virology (2006) 0.84
Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells. Immunity (2015) 0.84
Lymphotoxin α1β2 expression on B cells is required for follicular dendritic cell activation during the germinal center response. Eur J Immunol (2012) 0.83
Autonomous membrane IgE signaling prevents IgE-memory formation. Nat Immunol (2016) 0.83
Bar Mitzvah for B-1 cells: how will they grow up? J Exp Med (1997) 0.82
Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57
Inducible gene targeting in mice. Science (1995) 21.22
A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J Immunol (1979) 16.56
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science (1994) 13.47
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature (1991) 13.19
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res (1995) 12.21
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell (1993) 11.76
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region. Cell (1981) 9.54
Generation and analysis of interleukin-4 deficient mice. Science (1991) 8.80
Intraclonal generation of antibody mutants in germinal centres. Nature (1991) 7.39
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell (1997) 7.18
The requirement of more than one antigenic determinant for immunogenicity. J Exp Med (1969) 5.61
B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res (1997) 5.43
From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity (1999) 5.38
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A (1995) 5.06
Requirement of mammalian DNA polymerase-beta in base-excision repair. Nature (1996) 4.95
Induction of T and B cell immunity by anti-idiotypic antibody. Eur J Immunol (1975) 4.79
Conditional gene targeting. J Clin Invest (1996) 4.60
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity (2001) 4.09
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J (1993) 3.85
Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med (2000) 3.84
Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion. Nature (1992) 3.82
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell (1999) 3.76
Ku80 is required for immunoglobulin isotype switching. EMBO J (1998) 3.67
NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol Cell (2000) 3.60
Most peripheral B cells in mice are ligand selected. J Exp Med (1991) 3.50
Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response. Eur J Immunol (1978) 3.48
Hybrid cell lines secreting monoclonal antibody specific for major histocompatibility antigens of the mouse. Nature (1978) 3.45
Contribution of receptor editing to the antibody repertoire. Science (2001) 3.45
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest (1995) 3.43
Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma. N Engl J Med (1999) 3.37
Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J Exp Med (1998) 3.37
Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature (1994) 3.19
MHC class I expression in mice lacking the proteasome subunit LMP-7. Science (1994) 3.17
Maintenance of B-cell memory by long-lived cells generated from proliferating precursors. Nature (1990) 3.14
Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature (1996) 3.11
A critical role of lambda 5 protein in B cell development. Cell (1992) 3.09
Aberrant B cell development and immune response in mice with a compromised BCR complex. Science (1996) 3.01
Shutdown of class switch recombination by deletion of a switch region control element. Science (1993) 2.99
Cellular origin of human B-cell lymphomas. N Engl J Med (1999) 2.91
Memory B-cell persistence is independent of persisting immunizing antigen. Nature (2000) 2.90
Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies. Eur J Immunol (1979) 2.87
A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science (1995) 2.84
Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J (1988) 2.81
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature (1995) 2.78
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci U S A (1998) 2.76
Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med (1996) 2.75
The half-lives of serum immunoglobulins in adult mice. Eur J Immunol (1988) 2.73
Evidence for a large compartment of IgM-expressing memory B cells in humans. Blood (1997) 2.64
Expansion and functional activity of Ly-1+ B cells upon transfer of peritoneal cells into allotype-congenic, newborn mice. Eur J Immunol (1987) 2.60
Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow. J Exp Med (2001) 2.57
Antigen receptors of T helper cells. Contemp Top Immunobiol (1977) 2.54
PCR-based cDNA library construction: general cDNA libraries at the level of a few cells. Nucleic Acids Res (1989) 2.48
Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses. Cell (1987) 2.47
Recognition of idiotypes in lymphocyte interactions. II. Antigen-independent cooperation between T and B lymphocytes that possess similar and complementary idiotypes. Eur J Immunol (1978) 2.47
The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow. Proc Natl Acad Sci U S A (1990) 2.47
Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci U S A (1994) 2.41
Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity (2000) 2.40
B cell development under the condition of allelic inclusion. Immunity (1997) 2.39
A novel 34-kd protein co-isolated with the IgM molecule in surface IgM-expressing cells. EMBO J (1988) 2.38
Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A (1997) 2.37
Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J (1986) 2.35
Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity (1997) 2.35
Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways. Annu Rev Immunol (1989) 2.31
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes. EMBO J (1982) 2.31
Genetics, expression, and function of idiotypes. Annu Rev Immunol (1983) 2.28
Somatic hypermutation in the heavy chain locus correlates with transcription. Immunity (1998) 2.25
Evidence for surface-associated immunoglobulin on T and B lymphocytes. Eur J Immunol (1971) 2.25
Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice. Eur J Immunol (1985) 2.22
Somatic hypermutation in normal and transformed human B cells. Immunol Rev (1998) 2.22
TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity (2000) 2.21
V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science (1997) 2.21
Idiotypic analysis of the response of C57BL/6 mice to the (4-hydroxy-3-nitrophenyl)acetyl group. Eur J Immunol (1977) 2.21
Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development. Immunol Rev (1987) 2.19
How alpha beta T cells deal with induced TCR alpha ablation. Proc Natl Acad Sci U S A (2001) 2.19
Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions. Science (1993) 2.19
Somatic variants of murine immunoglobulin lambda light chains. Nature (1982) 2.15
Analysis of the B-cell progenitor compartment at the level of single cells. Curr Biol (1994) 2.15
Activation of mouse complement by monoclonal mouse antibodies. Eur J Immunol (1981) 2.11
Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med (1999) 2.11
Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody. J Exp Med (1976) 2.05
VH-gene expression in murine lipopolysaccharide blasts distributes over the nine known VH-gene groups and may be random. Eur J Immunol (1985) 2.03
Recombination between antibody heavy chain variable-region genes: evidence for gene conversion. Proc Natl Acad Sci U S A (1983) 2.03
DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation. Immunity (2000) 2.01
Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell (1993) 1.95
Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination. Curr Biol (1996) 1.94
Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse. Int Immunol (1989) 1.89
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation. Proc Natl Acad Sci U S A (1988) 1.87
The immune response to a hybrid protein molecule; specificity of secondary stimulation and of tolerance induction. J Exp Med (1967) 1.86
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response. EMBO J (1985) 1.86
Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life. Eur J Immunol (1993) 1.85
Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies. Curr Biol (1994) 1.83
The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses. Science (1997) 1.80
Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells. Proc Natl Acad Sci U S A (1997) 1.79