Published in Jpn J Hum Genet on June 01, 1995
A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20
Positional cloning of the Werner's syndrome gene. Science (1996) 10.98
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell (1995) 9.82
Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc Natl Acad Sci U S A (1994) 8.92
DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78
Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc Natl Acad Sci U S A (1994) 6.93
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science (1989) 4.79
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A (1989) 4.17
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science (1989) 4.08
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J Cell Biol (1999) 3.77
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet (2001) 3.51
A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci U S A (1991) 2.93
PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis. Brain (2007) 2.88
cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol (2000) 2.83
In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction. Nat Med (1997) 2.72
Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold. FEBS Lett (2001) 2.65
Functional genomics of Escherichia coli in Japan. Res Microbiol (2000) 2.59
BRCA1 is a component of the RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A (1997) 2.55
The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res (2003) 2.48
Frequency of choroidal abnormalities in neurofibromatosis type 1. Lancet (2000) 2.48
Cloning of replication, incompatibility, and stability functions of R plasmid NR1. J Bacteriol (1980) 2.40
Reduction of risk of pneumonia associated with use of angiotensin I converting enzyme inhibitors in elderly inpatients. Am J Hypertens (1999) 2.36
Mapping of the resistance genes of the R plasmid NR1. Mol Gen Genet (1978) 2.32
Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. Diabetologia (1996) 2.22
Disruption of the Bcl6 gene results in an impaired germinal center formation. J Exp Med (1997) 2.17
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion. J Biol Chem (2001) 2.14
Comparison of haemodynamic responses to tracheal intubation using the Airway Scope(®) and Macintosh laryngoscope in normotensive and hypertensive patients. Anaesthesia (2011) 2.13
Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem (1999) 2.12
Bacteriophage lambda carrying the Escherichia coli chromosomal region of the replication origin. Proc Natl Acad Sci U S A (1978) 2.11
A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways. EMBO J (1994) 2.09
Association between angiotensin II receptor gene polymorphism and serum angiotensin converting enzyme (SACE) activity in patients with sarcoidosis. Thorax (1998) 2.04
toxB gene on pO157 of enterohemorrhagic Escherichia coli O157:H7 is required for full epithelial cell adherence phenotype. Infect Immun (2001) 2.04
Body fat mass and lean mass as predictors of survival in hemodialysis patients. Kidney Int (2006) 2.04
Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. J Biol Chem (2000) 2.04
Archaeal DNA replication: identifying the pieces to solve a puzzle. Genetics (1999) 1.97
The genetics of alkaline phosphatase formation in Bacillus subtilis. Genetics (1965) 1.96
Crystal structure of an archaeal DNA sliding clamp: proliferating cell nuclear antigen from Pyrococcus furiosus. Protein Sci (2001) 1.94
Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci U S A (1993) 1.94
Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals. EMBO J (1993) 1.92
Hypersensitivity to Hg2+ and hyperbinding activity associated with cloned fragments of the mercurial resistance operon of plasmid NR1. J Bacteriol (1979) 1.90
Organization of the lexA gene of Escherichia coli and nucleotide sequence of the regulatory region. Nucleic Acids Res (1981) 1.90
Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway. J Cell Biol (2001) 1.85
Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science (2001) 1.84
The seasonal variation of blood pressure in patients with essential hypertension. Clin Exp Hypertens A (1982) 1.80
Control of cell division by sex factor F in Escherichia coli. I. The 42.84-43.6 F segment couples cell division of the host bacteria with replication of plasmid DNA. J Mol Biol (1984) 1.73
A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. Proc Natl Acad Sci U S A (1995) 1.71
A heterodimeric DNA polymerase: evidence that members of Euryarchaeota possess a distinct DNA polymerase. Proc Natl Acad Sci U S A (1998) 1.70
Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene (1999) 1.70
Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray. J Cancer Res Clin Oncol (2002) 1.69
Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. Cell (1994) 1.67
Potential role of hepatocyte growth factor in the maintenance of renal structure: anti-apoptotic action of HGF on epithelial cells. Kidney Int (1998) 1.64
Organization and nucleotide sequence of the DNA polymerase gene from the archaeon Pyrococcus furiosus. Nucleic Acids Res (1993) 1.63
Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. Biochem Mol Med (1997) 1.63
Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis. Gut (2003) 1.63
The nucleotide sequence surrounding the promoter region of colicin E1 gene. Gene (1981) 1.63
cis Element decoy against nuclear factor-kappaB attenuates development of experimental autoimmune myocarditis in rats. Circ Res (2001) 1.60
In vivo interactions of archaeal Cdc6/Orc1 and minichromosome maintenance proteins with the replication origin. Proc Natl Acad Sci U S A (2001) 1.60
Expression cloning of a human dual-specificity phosphatase. Proc Natl Acad Sci U S A (1992) 1.59
Copy-number mutants of the plasmid carrying the replication origin of the Escherichia coli chromosome: evidence for a control region of replication. Proc Natl Acad Sci U S A (1980) 1.58
Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics. Nat Genet (1996) 1.58
Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice. Circ Res (2001) 1.56
Western blot (immunoblot) assay of small, round-structured virus associated with an acute gastroenteritis outbreak in Tokyo. J Clin Microbiol (1989) 1.55
The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases. Proc Natl Acad Sci U S A (1990) 1.54
A novel DNA polymerase in the hyperthermophilic archaeon, Pyrococcus furiosus: gene cloning, expression, and characterization. Genes Cells (1997) 1.53
Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am J Hum Genet (1997) 1.52
Molecular basis of electrocardiographic ST-segment elevation. Circ Res (2000) 1.51
Organization of unc gene cluster of Escherichia coli coding for proton-translocating ATPase of oxidative phosphorylation. Proc Natl Acad Sci U S A (1980) 1.51
Loss of genes on the long arm of chromosome 22 in human meningiomas. Mol Biol Med (1988) 1.50
Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. Oncogene (2006) 1.49
Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Ther (2002) 1.49
Nucleotide sequence of the lig gene and primary structure of DNA ligase of Escherichia coli. Mol Gen Genet (1986) 1.49
A pilot case-control study on the alveolar bone density measurement in risk assessment for bisphosphonate-related osteonecrosis of the jaw. Osteoporos Int (2009) 1.48
Primary structure of the human fgr proto-oncogene product p55c-fgr. Mol Cell Biol (1988) 1.48
Alzheimer's disease and DLST genotype. Lancet (1997) 1.48
Autofluorescence endoscopy: feasibility of detection of GI neoplasms unapparent to white light endoscopy with an evolving technology. Gastrointest Endosc (2001) 1.48
Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest (1994) 1.48
Control of cell division by sex factor F in Escherichia coli. II. Identification of genes for inhibitor protein and trigger protein on the 42.84-43.6 F segment. J Mol Biol (1984) 1.48
Crystal structure of the archaeal holliday junction resolvase Hjc and implications for DNA recognition. Structure (2001) 1.47
A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. J Biol Chem (1996) 1.47
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. Proc Natl Acad Sci U S A (2001) 1.46
Crystal structure of an archaeal intein-encoded homing endonuclease PI-PfuI. J Mol Biol (2000) 1.46
Cloning and physical mapping of the dnaA region of the Escherichia coli chromosome. J Bacteriol (1979) 1.46
Functional interactions of a homolog of proliferating cell nuclear antigen with DNA polymerases in Archaea. J Bacteriol (1999) 1.45
Nucleotide sequence of the phoS gene, the structural gene for the phosphate-binding protein of Escherichia coli. J Bacteriol (1984) 1.45
Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. Kidney Int (1999) 1.45
A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. DNA Res (1996) 1.45
A Holliday junction resolvase from Pyrococcus furiosus: functional similarity to Escherichia coli RuvC provides evidence for conserved mechanism of homologous recombination in Bacteria, Eukarya, and Archaea. Proc Natl Acad Sci U S A (1999) 1.44
LMNA mutation in a 45 year old Japanese subject with Hutchinson-Gilford progeria syndrome. J Med Genet (2004) 1.43
Both RadA and RadB are involved in homologous recombination in Pyrococcus furiosus. J Biol Chem (2000) 1.42
Viral shedding and fecal IgA response after Norwalk virus infection. J Infect Dis (1995) 1.41
Antigenic characterization of small, round-structured viruses by immune electron microscopy. J Clin Microbiol (1990) 1.41
A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. DNA Res (1996) 1.41
Comparison of the myotonic dystrophy associated CTG repeat in European and Japanese populations. J Med Genet (1992) 1.41
Hanshin-Awaji earthquake and acute myocardial infarction. Lancet (1995) 1.40
PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia. Placenta (2013) 1.40