Published in Science on February 10, 1989
The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J (1990) 4.28
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A (1989) 4.17
Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Proc Natl Acad Sci U S A (1990) 3.11
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J (1992) 2.79
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A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci U S A (1991) 2.60
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Development of a highly efficient expression cDNA cloning system: application to oncogene isolation. Proc Natl Acad Sci U S A (1991) 2.48
Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma. EMBO J (1992) 2.47
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Diverse forms of a receptor for acidic and basic fibroblast growth factors. Mol Cell Biol (1990) 2.33
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor. Proc Natl Acad Sci U S A (1989) 2.33
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The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors. Proc Natl Acad Sci U S A (1992) 1.94
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Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. Proc Natl Acad Sci U S A (1991) 1.81
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Deletion of the c-kit protooncogene in the human developmental defect piebald trait. Proc Natl Acad Sci U S A (1991) 1.72
Crystal structure of human platelet-derived growth factor BB. EMBO J (1992) 1.69
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Structural and functional studies on platelet-derived growth factor. EMBO J (1992) 1.64
Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci U S A (1991) 1.61
B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase. Proc Natl Acad Sci U S A (1990) 1.60
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Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis. Mol Cell Biol (1989) 1.54
Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences. J Cell Biol (1992) 1.54
Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts. EMBO J (1993) 1.52
Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF. Proc Natl Acad Sci U S A (1991) 1.50
A distinctive family of embryonic protein-tyrosine kinase receptors. Proc Natl Acad Sci U S A (1990) 1.47
Expression of platelet-derived growth factor and its receptor in AIDS-related Kaposi sarcoma in vivo suggests paracrine and autocrine mechanisms of tumor maintenance. Proc Natl Acad Sci U S A (1992) 1.47
PDGF and PDGF receptors in glioma. Ups J Med Sci (2012) 1.43
Human microvascular endothelial cells express receptors for platelet-derived growth factor. Proc Natl Acad Sci U S A (1991) 1.40
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways. Proc Natl Acad Sci U S A (1989) 1.39
Macrophage colony-stimulating factor-induced tyrosine phosphorylation of c-fms proteins expressed in FDC-P1 and BALB/c 3T3 cells. Mol Cell Biol (1990) 1.38
Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor. J Cell Biol (1991) 1.38
Developmentally regulated use of alternative promoters creates a novel platelet-derived growth factor receptor transcript in mouse teratocarcinoma and embryonic stem cells. Mol Cell Biol (1989) 1.35
Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain. Cell Regul (1991) 1.34
Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes. Mol Cell Biol (1990) 1.34
Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors. Proc Natl Acad Sci U S A (1989) 1.29
Related fibroblast growth factor receptor genes exist in the human genome. Proc Natl Acad Sci U S A (1990) 1.29
Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction. Mol Cell Biol (1990) 1.27
Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line. Mol Cell Biol (1990) 1.25
Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1. Mol Biol Cell (1993) 1.24
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res (2009) 1.19
Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance. J Clin Invest (1990) 1.17
Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5. Proc Natl Acad Sci U S A (1991) 1.17
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Mol Cell Biol (1995) 1.15
Cell-specific cyclic AMP-mediated induction of the PDGF receptor. EMBO J (1990) 1.13
Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways. Mol Cell Biol (1991) 1.12
Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. Proc Natl Acad Sci U S A (1992) 1.11
PDGF and intracellular signaling in the timing of oligodendrocyte differentiation. J Cell Biol (1989) 1.10
Platelet-derived growth factor induces apoptosis in growth-arrested murine fibroblasts. Proc Natl Acad Sci U S A (1995) 1.10
Mitogenic effect of platelet-derived growth factor in human glomerular mesangial cells: modulation and/or suppression by inflammatory cytokines. Clin Exp Immunol (1991) 1.07
Human keratinocytes are a major source of cutaneous platelet-derived growth factor. J Clin Invest (1993) 1.06
Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy. J Clin Invest (1995) 1.05
Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium. Mol Cell Biol (1990) 1.02
Accumulation of PDGF B and cell-binding forms of PDGF A in the extracellular matrix. J Cell Biol (1993) 1.00
Platelet-derived growth factor activity and mRNA expression in healing vascular grafts in baboons. Association in vivo of platelet-derived growth factor mRNA and protein with cellular proliferation. J Clin Invest (1991) 1.00
Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin. Am J Pathol (1992) 1.00
PDGF induced microRNA alterations in cancer cells. Nucleic Acids Res (2011) 0.97
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Expression of growth factor receptors in human brain tumours. Br J Cancer (1991) 0.90
Expression of platelet-derived growth factor receptors in normal and diseased human kidney. An immunohistochemistry and in situ hybridization study. J Clin Invest (1994) 0.90
Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species. Mol Cell Biol (1989) 0.90
Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene. Mol Cell Biol (1990) 0.89
Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant. Mol Cell Biol (1993) 0.89
Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRβ aptamer. Mol Ther (2014) 0.89
Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation. Mol Cell Biol (1992) 0.88
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The ltk gene encodes a novel receptor-type protein tyrosine kinase. EMBO J (1991) 0.87
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The v-sis protein retains biological activity as a type II membrane protein when anchored by various signal-anchor domains, including the hydrophobic domain of the bovine papilloma virus E5 oncoprotein. J Cell Biol (1993) 0.86
Developmental expression of the platelet-derived growth factor alpha-receptor gene in mammalian central nervous system. Proc Natl Acad Sci U S A (1993) 0.85
Coexpression of platelet-derived growth factor (PDGF) B chain and PDGF B-type receptor in human gliomas. Childs Nerv Syst (1991) 0.84
PDGF function in diverse neural crest cell populations. Cell Adh Migr (2011) 0.84
A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity. Mol Cell Biol (1990) 0.84
Regulation of the proliferation and differentiation of Leydig stem cells in the adult testis. Biol Reprod (2014) 0.83
Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis. Proc Natl Acad Sci U S A (1990) 0.83
Two point mutations in the transmembrane domain of P68gag-ros inactive its transforming activity and cause a delay in membrane association. J Virol (1991) 0.83
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Expression of PDGF A-chain and beta-receptor genes during rat myoblast differentiation. J Cell Biol (1990) 0.82
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Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy. Proc Natl Acad Sci U S A (1990) 0.80
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