Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.

PubWeight™: 1.56‹?› | Rank: Top 4%

🔗 View Article (PMC 41189)

Published in Proc Natl Acad Sci U S A on August 29, 1995

Authors

C L Addison1, T Braciak, R Ralston, W J Muller, J Gauldie, F L Graham

Author Affiliations

1: Department of Biology, McMaster University, Hamilton, ON, Canada.

Articles citing this

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20

A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89

Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism. J Virol (1996) 2.52

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol (1998) 2.48

Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells. J Virol (1996) 2.38

CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes. Cancer Res (2010) 1.91

Emerging strategies for EphA2 receptor targeting for cancer therapeutics. Expert Opin Ther Targets (2011) 1.65

Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease. J Clin Invest (1997) 1.44

Phase I trial of recombinant adenovirus gene transfer in lung cancer. Longitudinal study of the immune responses to transgene and viral products. J Clin Invest (1997) 1.39

One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications. Mol Ther (2007) 1.36

CXC chemokine ligand 10 controls viral infection in the central nervous system: evidence for a role in innate immune response through recruitment and activation of natural killer cells. J Virol (2004) 1.23

Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy. Proc Natl Acad Sci U S A (2000) 1.14

Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation. Clin Exp Immunol (1998) 1.04

Adenoviral vector-based strategies for cancer therapy. Curr Drug ther (2009) 1.02

Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model. Virology (2009) 1.02

Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Elife (2017) 1.02

Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression. Proc Natl Acad Sci U S A (1997) 0.91

Overexpression of interleukin-2 by a recombinant herpes simplex virus type 1 attenuates pathogenicity and enhances antiviral immunity. J Virol (2002) 0.86

Immunomodulation of cancer: potential use of selectively replicating agents. J Clin Invest (2000) 0.84

Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy. Expert Rev Clin Immunol (2014) 0.84

Immune therapy for breast cancer in 2010-hype or hope? Curr Oncol (2011) 0.83

Development of an attenuated interleukin-2 fusion protein that can be activated by tumour-expressed proteases. Immunology (2011) 0.82

EphrinA1-EphA2 interaction-mediated apoptosis and FMS-like tyrosine kinase 3 receptor ligand-induced immunotherapy inhibit tumor growth in a breast cancer mouse model. J Gene Med (2012) 0.80

Comparative functional evaluation of immunocompetent mouse breast cancer models established from PyMT-tumors using small animal PET with [(18)F]FDG and [(18)F]FLT. Am J Nucl Med Mol Imaging (2011) 0.78

TK gene combined with mIL-2 and mGM-CSF genes in treatment of gastric cancer. World J Gastroenterol (2003) 0.78

Phase I clinical trial with IL-2-transfected xenogeneic cells administered in subcutaneous metastatic tumours: clinical and immunological findings. Br J Cancer (2000) 0.77

Effects of recombinant adenovirus-mediated expression of IL-2 and IL-12 in human B lymphoma cells on co-cultured PBMC. Genet Vaccines Ther (2004) 0.77

Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma. Mol Ther (2016) 0.76

The promise and reality of cancer gene therapy. Am J Hum Genet (1997) 0.75

Breast cancer gene therapy using an adenovirus encoding human IL-2 under control of mammaglobin promoter/enhancer sequences. Cancer Gene Ther (2016) 0.75

Antitumor efficacy of tumor-antigen-encoding recombinant poxvirus immunization in Dunning rat prostate cancer: implications for clinical genetic vaccine development. World J Urol (2000) 0.75

Oestradiol enhances tumour regression induced by B7-1/IL-2 adenoviral gene transfer in a murine model of breast cancer. Br J Cancer (2003) 0.75

Articles cited by this

A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res (1979) 214.95

Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol (1977) 41.93

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol (1992) 12.96

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc Natl Acad Sci U S A (1994) 8.92

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med (1991) 8.78

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. J Exp Med (1982) 8.74

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci U S A (1994) 8.13

Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo. Science (1991) 6.28

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell (1992) 5.85

In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science (1992) 5.47

Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science (1993) 5.30

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc Natl Acad Sci U S A (1994) 4.96

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell (1990) 3.98

Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science (1994) 3.96

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci U S A (1991) 3.84

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma. Nature (1994) 3.70

Tumor-specific cytolysis by lymphocytes infiltrating human melanomas. J Immunol (1989) 3.60

Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res (1975) 3.59

Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice. Nature (1993) 2.73

Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor. Cancer Res (1981) 2.49

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J Exp Med (1990) 2.41

Characteristics of cultured human melanocytes isolated from different stages of tumor progression. Cancer Res (1985) 1.85

Breast cancer epidemiology. Cancer Res (1988) 1.62

Cell-mediated cytotoxicity for bladder carcinoma: evaluation of a workshop. Cancer Res (1975) 1.51

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci U S A (1994) 1.46

Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther (1993) 1.44

Interleukin-2 toxicity. J Clin Oncol (1991) 1.40

Growth of 293 cells in suspension culture. J Gen Virol (1987) 1.33

Synergistic antitumor activity of tumor-infiltrating lymphocytes, interleukin 2, and local tumor irradiation. Studies on the mechanism of action. J Exp Med (1990) 1.28

T-cell recognition of human melanoma antigens. J Immunother Emphasis Tumor Immunol (1993) 1.22

Regression of bladder tumors in mice treated with interleukin 2 gene-modified tumor cells. J Exp Med (1993) 1.17

Transgenic mouse models of mammary tumorigenesis. Cancer Surv (1993) 1.14

Genes coding for tumor antigens recognized by human cytolytic T lymphocytes. J Immunother Emphasis Tumor Immunol (1993) 1.05

Immunoselection of a human melanoma resistant to specific lysis by autologous tumor-infiltrating lymphocytes. Possible mechanisms for immunotherapeutic failures. J Immunol (1990) 1.03

Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. Hum Gene Ther (1994) 1.01

T-cell antigens in cancer. Proc Natl Acad Sci U S A (1994) 1.01

The role of IL-2 secreted from genetically modified tumor cells in the establishment of antitumor immunity. J Immunol (1994) 0.93

Cytokine secretion by genetically modified nonimmunogenic murine fibrosarcoma. Tumor inhibition by IL-2 but not tumor necrosis factor. J Immunol (1993) 0.89

Clinical breast cancer, new developments in selection and endocrine treatment of patients. J Steroid Biochem Mol Biol (1992) 0.88

Current management of carcinoma of the breast. Ann Surg (1994) 0.87

Adenoviral interleukin-2 gene transfer into P815 tumor cells abrogates tumorigenicity and induces antitumoral immunity in mice. Hum Gene Ther (1993) 0.84

Complete recovery of mice from a pre-established tumor by direct intratumoral delivery of an adenovirus vector harboring the murine IL-2 gene. Gene Ther (1995) 0.83

Analysis of cytolytic effector cell response in vitro against autologous human tumor cells genetically altered to synthesize interleukin-2. Immunol Lett (1993) 0.79

Intratumoral rIL2-based immunotherapy in B16 melanoma. J Surg Res (1992) 0.78

The role of interleukin-2 in cancer immunotherapy. Compr Ther (1991) 0.78

Growth and autologous tumor lysis by tumor-infiltrating lymphocytes from metastatic melanoma expanded in interleukin-2 or interleukin-2 plus interleukin-4. J Immunother Emphasis Tumor Immunol (1993) 0.78

Cancer vaccines. Trends Pharmacol Sci (1993) 0.78

Articles by these authors

A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36

Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol (1977) 41.93

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol (1992) 12.96

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci U S A (1992) 8.59

Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40. Cold Spring Harb Symp Quant Biol (1975) 7.76

The acute phase response. Immunol Today (1994) 7.53

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest (1997) 5.77

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc Natl Acad Sci U S A (1994) 4.96

Transformation of rat cells by DNA of human adenovirus 5. Virology (1973) 4.85

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest (1998) 4.77

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology (1988) 4.72

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. Cell (1994) 4.70

Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA. Proc Natl Acad Sci U S A (1977) 4.35

Assay of transforming activity of tumor virus DNA. Methods Enzymol (1980) 4.31

A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer. EMBO J (1999) 3.79

A rapid and efficient procedure for the purification of DNA from agarose gels. Anal Biochem (1980) 3.77

Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci U S A (1994) 3.76

Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest (2001) 3.72

Defective transforming capacity of adenovirus type 5 host-range mutants. Virology (1978) 3.52

Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J Immunol (1992) 3.13

Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53. Mol Cell Biol (1985) 3.09

Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression. J Virol (1995) 3.06

Size and location of the transforming region in human adenovirus type 5 DNA. Nature (1974) 3.02

Polyomavirus origin for DNA replication comprises multiple genetic elements. J Virol (1983) 2.89

Transformation with specific fragments of adenovirus DNAs. I. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA. Gene (1977) 2.86

Packaging capacity and stability of human adenovirus type 5 vectors. J Virol (1993) 2.76

Mucosal mast cells. I. Isolation and functional characteristics of rat intestinal mast cells. J Immunol (1982) 2.66

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nat Genet (1998) 2.65

Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell (1998) 2.64

Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nat Med (2000) 2.61

Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter. Virus Res (1993) 2.61

The effect of-beta-D-arabinofuranosylcytosine on growth, viability, and DNA synthesis of mouse L-cells. Cancer Res (1970) 2.61

Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells. Virology (1992) 2.58

Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol (1993) 2.57

Studies in mouse L-cells on the incorporation of 1-beta-D-arabinofuranosylcytosine into DNA and on inhibition of DNA polymerase by 1-beta-D-arabinofuranosylcytosine 5'-triphosphate. Cancer Res (1970) 2.49

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol (1998) 2.48

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol (2000) 2.47

Human papillomavirus (HPV) type distribution and serological response to HPV type 6 virus-like particles in patients with genital warts. J Clin Microbiol (1995) 2.46

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proc Natl Acad Sci U S A (1999) 2.41

The peptide components of bee venom. Eur J Biochem (1976) 2.34

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors. Mol Cell Biol (1994) 2.32

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Oncogene (2007) 2.31

The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related. Nature (1984) 2.25

Identification and characterization of a novel herpes simplex virus glycoprotein, gK, involved in cell fusion. J Virol (1992) 2.21

Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Proc Natl Acad Sci U S A (2000) 2.19

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor. Proc Natl Acad Sci U S A (1985) 2.19

Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev (1994) 2.05

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. Mol Cell Biol (1994) 2.03

Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes. Am J Respir Cell Mol Biol (1994) 2.02

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol (2001) 2.02

Cloning and sequencing of the cellular-viral junctions from the human adenovirus type 5 transformed 293 cell line. Virology (1997) 2.02

Cytokine expression by neutrophils and macrophages in vivo: endotoxin induces tumor necrosis factor-alpha, macrophage inflammatory protein-2, interleukin-1 beta, and interleukin-6 but not RANTES or transforming growth factor-beta 1 mRNA expression in acute lung inflammation. Am J Respir Cell Mol Biol (1994) 1.99

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell (2000) 1.98

Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells. J Immunol (1987) 1.97

Late cutaneous allergic responses in isolated IgE-dependent reactions. J Allergy Clin Immunol (1973) 1.96

CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells. J Cell Physiol (1998) 1.93

Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Mol Biol Med (1990) 1.88

HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice. Cancer Res (2000) 1.86

IL-12 gene therapy protects mice in lethal Klebsiella pneumonia. J Immunol (1996) 1.85

Genome-wide scan for adult onset primary open angle glaucoma. Hum Mol Genet (2000) 1.82

pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells. J Biol Chem (1999) 1.82

Infectious herpesvirus DNA. Nat New Biol (1973) 1.82

Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. Am J Pathol (1998) 1.82

Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. J Clin Invest (1996) 1.81

Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector. Proc Natl Acad Sci U S A (1995) 1.81

Hemoglobin ontogeny during normal mouse fetal development. Proc Natl Acad Sci U S A (1979) 1.79

The acute-phase response of cultured rat hepatocytes. System characterization and the effect of human cytokines. Biochem J (1984) 1.78

Mucosal mast cells. II. Effects of anti-allergic compounds on histamine secretion by isolated intestinal mast cells. J Immunol (1982) 1.77

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene. Proc Natl Acad Sci U S A (1998) 1.76

Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis. Eur Respir J (2010) 1.75

Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target. Proc Natl Acad Sci U S A (1996) 1.73

Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissue. Am Rev Respir Dis (1988) 1.68

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer. Mol Cell Biol (2001) 1.68

High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity. Hum Gene Ther (1998) 1.67

Identification of an immunodominant cytotoxic T-lymphocyte recognition site in glycoprotein B of herpes simplex virus by using recombinant adenovirus vectors and synthetic peptides. J Virol (1991) 1.67

Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Mol Cell Biol (1997) 1.66

Mapping of a 14,000-dalton antigen to early region 4 of the human adenovirus 5 genome. J Virol (1983) 1.64

Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Mol Cell Biol (1992) 1.62

Subcellular location of an abundant substrate (p36) for tyrosine-specific protein kinases. Mol Cell Biol (1983) 1.61

Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. J Biol Chem (1998) 1.61

Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells. J Biol Chem (1987) 1.60

Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Am J Physiol Lung Cell Mol Physiol (2001) 1.60

The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis. Cancer Res (1998) 1.60

Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models. Hum Gene Ther (1999) 1.60

Inhibition of injury induced thromboatherosclerotic lesions by anti-platelet serum in rabbits. Thromb Haemost (1976) 1.60

Characterization of human adenovirus type 5 early region 1A polypeptides using antitumor sera and an antiserum specific for the carboxy terminus. Virology (1983) 1.58

Human lung fibroblast-derived granulocyte-macrophage colony stimulating factor (GM-CSF) mediates eosinophil survival in vitro. Am J Respir Cell Mol Biol (1989) 1.58

The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization. J Clin Invest (1977) 1.58

Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C. J Immunol (1993) 1.57

Secretory leukocyte proteinase inhibitor is preferentially increased in patients with acute respiratory distress syndrome. Eur Respir J (1999) 1.56

Protein IX, a minor component of the human adenovirus capsid, is essential for the packaging of full length genomes. EMBO J (1987) 1.56

Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung. J Immunol (1994) 1.53