Published in Hum Gene Ther on December 10, 1998
Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proc Natl Acad Sci U S A (1999) 2.41
Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci U S A (2001) 2.20
Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases. Proc Natl Acad Sci U S A (2000) 2.05
Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A model. J Thromb Haemost (2006) 1.97
Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo. J Virol (2004) 1.70
Optimization of the helper-dependent adenovirus system for production and potency in vivo. Proc Natl Acad Sci U S A (2000) 1.62
"Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung. J Virol (2001) 1.53
Functional correction of adult mdx mouse muscle using gutted adenoviral vectors expressing full-length dystrophin. Proc Natl Acad Sci U S A (2002) 1.47
Viral and nonviral delivery systems for gene delivery. Adv Biomed Res (2012) 1.42
Advances and future challenges in adenoviral vector pharmacology and targeting. Curr Gene Ther (2011) 1.42
Current strategies and future directions for eluding adenoviral vector immunity. Curr Gene Ther (2006) 1.42
Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci U S A (2005) 1.36
Transductional targeting of adenovirus vectors for gene therapy. Cancer Gene Ther (2006) 1.34
Comparison of replication-competent, first generation, and helper-dependent adenoviral vaccines. PLoS One (2009) 1.26
Effects of stuffer DNA on transgene expression from helper-dependent adenovirus vectors. J Virol (1999) 1.17
Neonatal helper-dependent adenoviral vector gene therapy mediates correction of hemophilia A and tolerance to human factor VIII. Proc Natl Acad Sci U S A (2011) 1.11
Short-term correction of arginase deficiency in a neonatal murine model with a helper-dependent adenoviral vector. Mol Ther (2009) 1.10
Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approach. J Pharmacol Exp Ther (2009) 1.09
Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci U S A (2005) 1.09
Adenoviral vector immunity: its implications and circumvention strategies. Curr Gene Ther (2011) 1.07
Gene transfer into rat brain using adenoviral vectors. Curr Protoc Neurosci (2010) 1.05
An improved helper-dependent adenoviral vector allows persistent gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus. Proc Natl Acad Sci U S A (2001) 1.04
Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction. Hum Gene Ther (2006) 1.02
Production of adenovirus vectors and their use as a delivery system for influenza vaccines. Expert Opin Biol Ther (2010) 1.01
Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B. Mol Ther (2010) 1.00
Current status of gene therapy for inherited lung diseases. Annu Rev Physiol (2002) 0.98
Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia. Proc Natl Acad Sci U S A (2003) 0.97
Assembly of helper-dependent adenovirus DNA into chromatin promotes efficient gene expression. J Virol (2011) 0.94
Cre levels limit packaging signal excision efficiency in the Cre/loxP helper-dependent adenoviral vector system. J Virol (2002) 0.94
Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector. Gene Ther (2006) 0.92
Immune recognition of gene transfer vectors: focus on adenovirus as a paradigm. Front Immunol (2011) 0.90
Chromosomal integration pattern of a helper-dependent minimal adenovirus vector with a selectable marker inserted into a 27.4-kilobase genomic stuffer. J Virol (2001) 0.89
Short-term rescue of neonatal lethality in a mouse model of propionic acidemia by gene therapy. Hum Gene Ther (2009) 0.88
Constitutive expression of short hairpin RNA in vivo triggers buildup of mature hairpin molecules. Hum Gene Ther (2011) 0.87
Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver. J Biol Chem (2014) 0.87
Variables affecting in vivo performance of high-capacity adenovirus vectors. J Virol (2002) 0.86
Efficient genome editing in hematopoietic stem cells with helper-dependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation. Mol Ther Methods Clin Dev (2015) 0.86
Helper-dependent adenoviral vectors in experimental gene therapy. Acta Biochim Pol (2005) 0.86
Robust hepatic gene silencing for functional studies using helper-dependent adenoviral vectors. Hum Gene Ther (2009) 0.83
Comparison of systemic and mucosal immunization with helper-dependent adenoviruses for vaccination against mucosal challenge with SHIV. PLoS One (2013) 0.83
Vector and helper genome rearrangements occur during production of helper-dependent adenoviral vectors. Hum Gene Ther Methods (2013) 0.82
Regulated and liver-specific tamarin alpha interferon gene delivery by a helper-dependent adenoviral vector. J Virol (2005) 0.80
Ad 2.0: a novel recombineering platform for high-throughput generation of tailored adenoviruses. Nucleic Acids Res (2015) 0.80
Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders. Int Rev Neurobiol (2003) 0.79
The role of chromatin in adenoviral vector function. Viruses (2013) 0.78
Methods, potentials, and limitations of gene delivery to regenerate central nervous system cells. Biologics (2009) 0.76
Gene Therapy for Alpha-1 Antitrypsin Deficiency Lung Disease. Ann Am Thorac Soc (2016) 0.75
Emerging Gene Therapies for Genetic Hearing Loss. J Assoc Res Otolaryngol (2017) 0.75
A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36
Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol (1977) 41.93
Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1. Nat Genet (1993) 7.97
Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40. Cold Spring Harb Symp Quant Biol (1975) 7.76
Essential role for oncogenic Ras in tumour maintenance. Nature (1999) 6.51
Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest (1997) 5.77
Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry. Nat Biotechnol (2001) 5.69
Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58
A tool for analyzing and annotating genomic sequences. Genomics (1997) 5.33
An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc Natl Acad Sci U S A (1994) 4.96
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron (1998) 4.92
Transformation of rat cells by DNA of human adenovirus 5. Virology (1973) 4.85
A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology (1988) 4.72
A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. Cell (1994) 4.70
De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. Nat Genet (1997) 4.65
Mutation analysis for heterozygote detection and the prenatal diagnosis of cystic fibrosis. N Engl J Med (1990) 4.60
Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA. Proc Natl Acad Sci U S A (1977) 4.35
Assay of transforming activity of tumor virus DNA. Methods Enzymol (1980) 4.31
Uniparental disomy as a mechanism for human genetic disease. Am J Hum Genet (1988) 4.21
Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Lancet (2001) 4.19
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell (1994) 4.15
Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region. Nat Genet (1994) 4.04
A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89
Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. J Exp Med (1995) 3.83
A rapid and efficient procedure for the purification of DNA from agarose gels. Anal Biochem (1980) 3.77
Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature (1997) 3.74
Increased vascularization in mice overexpressing angiopoietin-1. Science (1998) 3.67
Cytotoxic enterotoxin produced by Aeromonas hydrophila: relationship of toxigenic isolates to diarrheal disease. Infect Immun (1979) 3.65
Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1993) 3.57
Defective transforming capacity of adenovirus type 5 host-range mutants. Virology (1978) 3.52
Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons. Nat Genet (1997) 3.32
Exosomes from human saliva as a source of microRNA biomarkers. Oral Dis (2009) 3.11
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene (1997) 3.08
The American Society of Human Genetics statement on cystic fibrosis screening. Am J Hum Genet (1990) 3.07
Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression. J Virol (1995) 3.06
Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med (1996) 3.04
Size and location of the transforming region in human adenovirus type 5 DNA. Nature (1974) 3.02
CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell (1995) 3.00
Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. J Neurosci (1997) 2.87
Transformation with specific fragments of adenovirus DNAs. I. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA. Gene (1977) 2.86
Pleuropulmonary blastoma: a marker for familial disease. J Pediatr (1996) 2.83
Onset and rate of striatal atrophy in preclinical Huntington disease. Neurology (2004) 2.81
Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med (1998) 2.81
Packaging capacity and stability of human adenovirus type 5 vectors. J Virol (1993) 2.76
LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J Clin Invest (1997) 2.71
8-Azaguanine resistance in mammalian cells. I. Hypoxanthine-guanine phosphoribosyltransferase. Genetics (1972) 2.71
Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nat Genet (1998) 2.65
Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study. J Bone Miner Res (2001) 2.65
Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter. Virus Res (1993) 2.61
The effect of-beta-D-arabinofuranosylcytosine on growth, viability, and DNA synthesis of mouse L-cells. Cancer Res (1970) 2.61
Longitudinal studies of Aedes aegypti (Diptera: Culicidae) in Thailand and Puerto Rico: population dynamics. J Med Entomol (2000) 2.58
Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty. Arch Intern Med (1998) 2.58
Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science (1996) 2.55
Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease. J Biol Chem (1975) 2.55
Studies in mouse L-cells on the incorporation of 1-beta-D-arabinofuranosylcytosine into DNA and on inhibition of DNA polymerase by 1-beta-D-arabinofuranosylcytosine 5'-triphosphate. Cancer Res (1970) 2.49
Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol (1998) 2.48
Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proc Natl Acad Sci U S A (1999) 2.41
P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med (2000) 2.32
Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol (1993) 2.32
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol Cell Biol (1998) 2.28
Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo. J Clin Invest (1998) 2.28
Major bleeding after hospitalization for deep-venous thrombosis. Am J Med (1999) 2.25
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron (1999) 2.25
Identification and characterization of a novel herpes simplex virus glycoprotein, gK, involved in cell fusion. J Virol (1992) 2.21
Seven novel methylation guide small nucleolar RNAs are processed from a common polycistronic transcript by Rat1p and RNase III in yeast. Mol Cell Biol (1999) 2.20
Frequency and stability of chromosomal integration of adenovirus vectors. J Virol (1999) 2.18
The use of Medpor coated tear drainage tube in conjunctivodacryocystorhinostomy. Eye (Lond) (2007) 2.13
Prenatal diagnosis of cystic fibrosis by DNA amplification for detection of KM-19 polymorphism. Lancet (1988) 2.13
Microdeletion 15q13.3: a locus with incomplete penetrance for autism, mental retardation, and psychiatric disorders. J Med Genet (2009) 2.13
Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors. J Neurosci (1999) 2.12
A suppressor of TBP mutations encodes an RNA polymerase III transcription factor with homology to TFIIB. Cell (1992) 2.12
Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol Gastrointest Liver Physiol (2002) 2.10
Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator. Mol Cell (1999) 2.09
Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. J Exp Med (1997) 2.08
Context sequences of translation initiation codon in plants. Plant Mol Biol (1997) 2.05
Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases. Proc Natl Acad Sci U S A (2000) 2.05
A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J Clin Invest (1997) 2.04
Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex. Neuron (2000) 2.04
Cloning and sequencing of the cellular-viral junctions from the human adenovirus type 5 transformed 293 cell line. Virology (1997) 2.02
P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli. J Clin Invest (1995) 2.02
Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo. Virology (2000) 1.98
Methods for analysis of multiple cystic fibrosis mutations. Hum Genet (1991) 1.88
A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating. Am J Physiol (1997) 1.88
Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics. Am J Surg Pathol (2001) 1.86
Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Ann Intern Med (1998) 1.86
IL-12 gene therapy protects mice in lethal Klebsiella pneumonia. J Immunol (1996) 1.85
Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. J Exp Med (1996) 1.85
Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc Natl Acad Sci U S A (1999) 1.84
Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Kidney Int (2006) 1.83
Genome-wide scan for adult onset primary open angle glaucoma. Hum Mol Genet (2000) 1.82
Peptide chain termination with mammalian release factor. Proc Natl Acad Sci U S A (1970) 1.82