Published in Science on November 19, 1993
Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J (1994) 4.03
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J (1994) 3.32
Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Mol Cell Biol (1995) 3.10
Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A (1994) 2.81
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci U S A (1995) 2.52
Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor. EMBO J (2000) 2.24
Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha. EMBO J (2002) 2.01
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol Cell Biol (1994) 1.98
Transcriptional regulation by STAT6. Immunol Res (2011) 1.81
Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol Cell Biol (1996) 1.64
Thrombopoietin activates a STAT5-like factor in hematopoietic cells. EMBO J (1995) 1.55
Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. Proc Natl Acad Sci U S A (1999) 1.50
Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. EMBO J (1994) 1.50
Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. J Clin Invest (1997) 1.48
T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO J (1997) 1.47
The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals. EMBO J (1996) 1.45
Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways. EMBO J (1995) 1.42
Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells. J Clin Invest (1995) 1.37
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50. J Exp Med (1995) 1.33
Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J Exp Med (1999) 1.29
Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription. Mol Cell Biol (2002) 1.25
Cytokine transcriptional events during helper T cell subset differentiation. J Exp Med (1996) 1.23
Growth hormone and erythropoietin differentially activate DNA-binding proteins by tyrosine phosphorylation. Mol Cell Biol (1994) 1.16
Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity. Proc Natl Acad Sci U S A (1995) 1.16
Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression. Mol Cell Biol (1998) 1.15
Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter. BMC Mol Biol (2006) 1.15
Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells. Mol Cell Biol (1997) 1.11
STAT signaling in the pathogenesis and treatment of cancer. Mol Med (1999) 1.11
Receptor to nucleus signaling by prolactin and interleukin 2 via activation of latent DNA-binding factors. Proc Natl Acad Sci U S A (1994) 1.09
Nuclear localization and cell cycle regulation of a murine protein tyrosine phosphatase. Mol Cell Biol (1994) 1.07
Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation. Proc Natl Acad Sci U S A (1995) 1.05
Prolactin activates the interferon-regulated p91 transcription factor and the Jak2 kinase by tyrosine phosphorylation. Proc Natl Acad Sci U S A (1994) 1.03
Interleukin 4 signals through two related pathways. Proc Natl Acad Sci U S A (1995) 1.02
A novel STAT-like factor mediates lipopolysaccharide, interleukin 1 (IL-1), and IL-6 signaling and recognizes a gamma interferon activation site-like element in the IL1B gene. Mol Cell Biol (1996) 1.00
Live cell imaging reveals continuous STAT6 nuclear trafficking. J Immunol (2010) 1.00
Identification of latency-associated transcripts that map antisense to the ICP4 homolog gene of Marek's disease virus. J Virol (1994) 0.99
Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes. Proc Natl Acad Sci U S A (1995) 0.98
Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13. J Immunol (2005) 0.92
Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity. Proc Natl Acad Sci U S A (1997) 0.92
Promoter regions involved in density-dependent regulation of basic fibroblast growth factor gene expression in human astrocytic cells. Proc Natl Acad Sci U S A (1996) 0.89
Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6. Proc Natl Acad Sci U S A (1998) 0.89
Anti-inflammatory cytokine interleukin-4 inhibits inducible nitric oxide synthase gene expression in the mouse macrophage cell line RAW264.7 through the repression of octamer-dependent transcription. Mediators Inflamm (2013) 0.87
Polymorphisms of interleukin (IL)-4 receptor alpha and signal transducer and activator of transcription-6 (Stat6) are associated with increased IL-4Ralpha-Stat6 signalling in lymphocytes and elevated serum IgE in patients with Graves' disease. Clin Exp Immunol (2007) 0.85
Regulation of telomerase activity by interferon regulatory factors 4 and 8 in immune cells. Mol Cell Biol (2008) 0.83
Growth inhibition signalled through the interleukin-4/interleukin-13 receptor complex is associated with tyrosine phosphorylation of insulin receptor substrate-1. Biochem J (1996) 0.83
The key regulators of adult T helper cell responses, STAT6 and T-bet, are established in early life in mice. Eur J Immunol (2006) 0.79
Stimulation of sulphated glycosaminoglycan and decorin production in adult dermal fibroblasts by recombinant human interleukin-4. Biochem J (1995) 0.79
A novel IL-4 responsive element of the E alpha MHC class II promoter that binds to an inducible factor. Nucleic Acids Res (1995) 0.78
Calendar. Mediators Inflamm (1995) 0.75
IL-4 induces cAMP and cGMP in human monocytic cells. Mediators Inflamm (1995) 0.75
Growth regulation of a cellular tumour antigen, p53, in nontransformed cells. Nature (1984) 4.86
Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Mol Cell Biol (1998) 3.70
Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53. Mol Cell Biol (1983) 3.39
Monoclonal antibodies which recognize native and denatured forms of the adenovirus DNA-binding protein. Virology (1983) 2.69
Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol Cell Biol (2000) 2.24
Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor. EMBO J (2000) 2.24
The amino acid sequence of murine p53 determined from a c-DNA clone. Virology (1984) 2.15
Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element. Mol Cell Biol (1993) 2.03
IRF-3-dependent and augmented target genes during viral infection. Genes Immun (2007) 1.94
Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny. Mol Cell Biol (1982) 1.82
Repression of the interferon signal transduction pathway by the adenovirus E1A oncogene. Proc Natl Acad Sci U S A (1991) 1.54
Characterization of specific DNA-binding factors activated by double-stranded RNA as positive regulators of interferon alpha/beta-stimulated genes. J Biol Chem (1995) 1.48
Rac1 mediates STAT3 activation by autocrine IL-6. Proc Natl Acad Sci U S A (2001) 1.46
The epithelial cell response to rotavirus infection. J Immunol (1999) 1.44
Identification of STAT3 as a specific substrate of breast tumor kinase. Oncogene (2006) 1.40
Apoptosis is promoted by the dsRNA-activated factor (DRAF1) during viral infection independent of the action of interferon or p53. FASEB J (2001) 1.37
Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor. Proc Natl Acad Sci U S A (1992) 1.22
Specific interaction of the SV40 T antigen-cellular p53 protein complex with SV40 DNA. Virology (1982) 1.22
Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. J Biol Chem (1997) 1.20
Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells. Proc Natl Acad Sci U S A (1991) 1.19
Receptor to nucleus signaling by prolactin and interleukin 2 via activation of latent DNA-binding factors. Proc Natl Acad Sci U S A (1994) 1.09
Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J Interferon Cytokine Res (1999) 1.04
Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. J Biol Chem (1996) 1.04
Signal transduction and activation of gene transcription by interferons. Gene Expr (1995) 1.00
Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes. Proc Natl Acad Sci U S A (1995) 0.98
Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathway. J Interferon Cytokine Res (2001) 0.98
Characterization of the interleukin-4 nuclear activated factor/STAT and its activation independent of the insulin receptor substrate proteins. J Biol Chem (1995) 0.96
Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2. J Biol Chem (1997) 0.95
Interferon signal transduction. Biotherapy (1996) 0.85
Receptor to nucleus signaling via tyrosine phosphorylation of the p91 transcription factor. Trends Endocrinol Metab (2008) 0.82
Interferon alpha (IFN alpha) signaling in cells expressing the variant form of the type I IFN receptor. J Biol Chem (1994) 0.81