Published in Mol Cell Biol on October 01, 1996
Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res (1997) 2.24
Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4. J Exp Med (1997) 2.15
Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med (2008) 1.83
Transcriptional regulation by STAT6. Immunol Res (2011) 1.81
Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J (2002) 1.65
The significance of tetramerization in promoter recruitment by Stat5. Mol Cell Biol (1999) 1.62
JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis. J Am Soc Nephrol (2015) 1.51
Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6. J Exp Med (2014) 1.51
Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. Proc Natl Acad Sci U S A (1999) 1.50
A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus. J Virol (2003) 1.49
T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO J (1997) 1.47
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription. Mol Cell Biol (1998) 1.45
Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci U S A (2002) 1.42
Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. EMBO J (2003) 1.39
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood (2008) 1.32
STAT6 mediates interleukin-4 growth inhibition in human breast cancer cells. Neoplasia (2002) 1.32
Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor. Proc Natl Acad Sci U S A (2006) 1.29
Regulation of inflammation by interleukin-4: a review of "alternatives". J Leukoc Biol (2012) 1.20
T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. Mol Cell Biol (2007) 1.20
Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter. BMC Mol Biol (2006) 1.15
Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells. Mol Cell Biol (1997) 1.11
STAT signaling in the pathogenesis and treatment of cancer. Mol Med (1999) 1.11
Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation. Mol Cell Biol (2000) 1.04
Genome-wide approaches reveal functional interleukin-4-inducible STAT6 binding to the vascular cell adhesion molecule 1 promoter. Mol Cell Biol (2011) 1.00
Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism. J Exp Med (2002) 0.98
Characterization of RNA helicase A as component of STAT6-dependent enhanceosome. Nucleic Acids Res (2006) 0.95
p300- and Myc-mediated regulation of glioblastoma multiforme cell differentiation. Oncotarget (2010) 0.93
E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Rep (2014) 0.91
The transcription factor PU.1 promotes alternative macrophage polarization and asthmatic airway inflammation. J Mol Cell Biol (2015) 0.90
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation. Arthritis Res (1999) 0.87
Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2009) 0.86
Inhibition of TGF-β signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol. Invest New Drugs (2011) 0.85
Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6 (STAT6). FASEB J (2014) 0.85
PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1. J Biol Chem (2010) 0.84
Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. BMC Genomics (2013) 0.82
PARP-14 binds specific DNA sequences to promote Th2 cell gene expression. PLoS One (2013) 0.81
Interleukin-4 suppresses IL-1-induced expression of matrix metalloproteinase-3 in human gingival fibroblasts. J Periodontol (2004) 0.79
Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells. J Biol Chem (2008) 0.79
Transcriptional regulation of the pendrin gene. Cell Physiol Biochem (2011) 0.78
Microbial metabolite butyrate facilitates M2 macrophage polarization and function. Sci Rep (2016) 0.77
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The fungal secondary metabolite trichodimerol inhibits TGF-β dependent cellular effects and tube formation of MDA-MB-231 cells. Invest New Drugs (2008) 0.77
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Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide. PLoS One (2015) 0.76
Focal adhesion kinase (FAK) and mechanical stimulation negatively regulate the transition of airway smooth muscle tissues to a synthetic phenotype. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Synergistic activation of Arg1 gene by retinoic acid and IL-4 involves chromatin remodeling for transcription initiation and elongation coupling. Nucleic Acids Res (2016) 0.75
STAT6 and PARP Family Members in the Development of T Cell-dependent Allergic Inflammation. Immune Netw (2016) 0.75
1,6-O,O-Diacetylbritannilactone Inhibits Eotaxin-1 and ALOX15 Expression Through Inactivation of STAT6 in A549 Cells. Inflammation (2017) 0.75
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science (1994) 26.02
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science (1991) 12.93
Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci U S A (1989) 11.76
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science (1994) 11.33
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell (1996) 10.49
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell (1996) 10.44
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem (1995) 8.52
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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity (1996) 8.16
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Essential role of Stat6 in IL-4 signalling. Nature (1996) 6.56
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science (1993) 6.44
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature (1996) 6.17
STATs: signal transducers and activators of transcription. Cell (1996) 6.10
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell (1994) 5.79
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Cytokine receptor signalling. Nature (1995) 5.46
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science (1995) 4.90
An interleukin-4-induced transcription factor: IL-4 Stat. Science (1994) 4.71
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev (1995) 4.11
Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J (1994) 4.03
The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity (1995) 3.99
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature (1993) 3.73
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med (1995) 3.37
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J (1994) 3.32
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc Natl Acad Sci U S A (1995) 2.92
Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). EMBO J (1994) 2.82
Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A (1994) 2.81
Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci U S A (1995) 2.79
Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. Proc Natl Acad Sci U S A (1995) 2.42
Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction. J Biol Chem (1996) 2.39
Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science (1993) 2.00
Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity (1995) 2.00
Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3. Proc Natl Acad Sci U S A (1995) 1.93
Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity (1995) 1.90
Function of Stat2 protein in transcriptional activation by alpha interferon. Mol Cell Biol (1996) 1.79
Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity (1995) 1.77
Nuclear factor I and mammary gland factor (STAT5) play a critical role in regulating rat whey acidic protein gene expression in transgenic mice. Mol Cell Biol (1995) 1.37
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50. J Exp Med (1995) 1.33
Cytokines and STATs: how can signals achieve specificity? Immunity (1995) 1.19
A rapid method for the isolation of DNA-binding proteins from purified nuclei of tissues and cells in culture. Nucleic Acids Res (1992) 1.13
Characterization of the interleukin-4 nuclear activated factor/STAT and its activation independent of the insulin receptor substrate proteins. J Biol Chem (1995) 0.96
Signal transduction pathway of interleukin-4 and interleukin-13 in human B cells derived from X-linked severe combined immunodeficiency patients. J Biol Chem (1996) 0.92
Human interleukin-13 activates the interleukin-4-dependent transcription factor NF-IL4 sharing a DNA binding motif with an interferon-gamma-induced nuclear binding factor. FEBS Lett (1994) 0.89
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site. J Immunol (1994) 0.84
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell (1996) 10.49
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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity (1996) 8.16
Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science (1995) 7.37
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An interleukin-4-induced transcription factor: IL-4 Stat. Science (1994) 4.71
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