Characterization of the interleukin-4 nuclear activated factor/STAT and its activation independent of the insulin receptor substrate proteins.

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Published in J Biol Chem on August 18, 1995

Authors

H Kotanides1, M Moczygemba, M F White, N C Reich

Author Affiliations

1: Graduate Program in Molecular and Cellular Biology, State University of New York, Stony Brook 11794-8691, USA.

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Calmodulin activates phosphatidylinositol 3-kinase. J Biol Chem (1997) 1.25

Characterization of an endogenous substrate of the insulin receptor in cultured cells. J Biol Chem (1987) 1.24

Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. Cancer Res (1998) 1.24

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J Biol Chem (1995) 1.23

Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor. Proc Natl Acad Sci U S A (1992) 1.22

Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells. Proc Natl Acad Sci U S A (1987) 1.22

Specific interaction of the SV40 T antigen-cellular p53 protein complex with SV40 DNA. Virology (1982) 1.22

Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts. J Biol Chem (1982) 1.22

The two analogous phosphoglycerate mutases of Escherichia coli. FEBS Lett (1999) 1.20

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Requirement of protein kinase C zeta for stimulation of protein synthesis by insulin. Mol Cell Biol (1997) 1.20

M-plasty techniques. J Dermatol Surg (1976) 1.19