Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.

PubWeight™: 2.99‹?› | Rank: Top 1%

🔗 View Article (PMC 188280)

Published in Antimicrob Agents Chemother on December 01, 1994

Authors

M B Kurtz1, C Douglas, J Marrinan, K Nollstadt, J Onishi, S Dreikorn, J Milligan, S Mandala, J Thompson, J M Balkovec

Author Affiliations

1: Department of Infectious Disease Research, Merck Research Laboratories, Rahway, NJ 07065-0900.

Articles citing this

In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872). Antimicrob Agents Chemother (1997) 5.76

Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob Agents Chemother (1997) 4.87

Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors. Antimicrob Agents Chemother (1997) 4.14

Platforms for antibiotic discovery. Nat Rev Drug Discov (2013) 3.66

Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol Cell Biol (1995) 3.27

Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies. Infect Immun (1996) 3.08

In vitro activities of caspofungin compared with those of fluconazole and itraconazole against 3,959 clinical isolates of Candida spp., including 157 fluconazole-resistant isolates. Antimicrob Agents Chemother (2003) 2.92

In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Antimicrob Agents Chemother (2000) 2.73

Evaluation of water-soluble pneumocandin analogs L-733560, L-705589, and L-731373 with mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob Agents Chemother (1995) 2.62

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci U S A (2007) 2.43

In vitro evaluation of the pneumocandin antifungal agent L-733560, a new water-soluble hybrid of L-705589 and L-731373. Antimicrob Agents Chemother (1995) 2.37

Treatment of murine disseminated candidiasis with L-743,872. Antimicrob Agents Chemother (1997) 1.87

Treatment of murine Candida krusei or Candida glabrata infection with L-743,872. Antimicrob Agents Chemother (1997) 1.83

Isolation of a gene involved in 1,3-beta-glucan synthesis in Aspergillus nidulans and purification of the corresponding protein. J Bacteriol (1996) 1.82

Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis. Antimicrob Agents Chemother (1995) 1.75

Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors. Antimicrob Agents Chemother (2000) 1.66

Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin. Antimicrob Agents Chemother (2002) 1.57

In vitro activities of semisynthetic pneumocandin L-733,560 against fluconazole-resistant and -susceptible Candida albicans isolates. Antimicrob Agents Chemother (1996) 1.28

Cloning and characterization of GNS1: a Saccharomyces cerevisiae gene involved in synthesis of 1,3-beta-glucan in vitro. J Bacteriol (1995) 1.21

Treatment of histoplasmosis with MK-991 (L-743,872). Antimicrob Agents Chemother (1998) 1.16

Comparison of the echinocandin caspofungin with amphotericin B for treatment of histoplasmosis following pulmonary challenge in a murine model. Antimicrob Agents Chemother (2000) 1.10

Key issues concerning fungistatic versus fungicidal drugs. Eur J Clin Microbiol Infect Dis (1997) 1.04

Defects in assembly of the extracellular matrix are responsible for altered morphogenesis of a Candida albicans phr1 mutant. J Bacteriol (1998) 0.95

Cellular accumulation, localization, and activity of a synthetic cyclopeptamine in fungi. Antimicrob Agents Chemother (1998) 0.77

Effect of the echinocandin caspofungin on expression of Candida albicans secretory aspartyl proteinases and phospholipase in vitro. Antimicrob Agents Chemother (2002) 0.77

Deletion of GBG1/AYR1 Alters Cell Wall Biogenesis in Saccharomyces cerevisiae. Mycobiology (2010) 0.75

Articles cited by this

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81

Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase. Antimicrob Agents Chemother (1994) 6.45

In vitro and in vivo anti-Candida activity and toxicology of LY121019. J Antibiot (Tokyo) (1984) 3.68

The function of chitin synthases 2 and 3 in the Saccharomyces cerevisiae cell cycle. J Cell Biol (1991) 3.65

Synthesis and antifungal activity of novel cationic pneumocandin B(o) derivatives. J Med Chem (1994) 3.52

Growth and metabolism of inositol-starved Saccharomyces cerevisiae. J Bacteriol (1977) 2.75

Effect of polyoxin D on chitin synthesis and septum formation in Saccharomyces cerevisiae. J Bacteriol (1974) 2.50

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin. Antimicrob Agents Chemother (1992) 2.39

Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors. Proc Natl Acad Sci U S A (1990) 2.37

Lysis of growing yeast-form cells of Candida albicans by echinocandin: a cytological study. Sabouraudia (1981) 2.32

Myristoyl CoA:protein N-myristoyltransferase activities from rat liver and yeast possess overlapping yet distinct peptide substrate specificities. J Biol Chem (1988) 2.17

Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity. Antimicrob Agents Chemother (1988) 1.89

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Proc Natl Acad Sci U S A (1993) 1.89

Anti-Candida activity and toxicology of LY121019, a novel semisynthetic polypeptide antifungal antibiotic. Ann N Y Acad Sci (1988) 1.75

LY121019 inhibits Neurospora crassa growth and (1-3)-beta-D-glucan synthase. J Antibiot (Tokyo) (1988) 1.53

Papulacandin B: an inhibitor of glucan synthesis in yeast spheroplasts. Eur J Biochem (1979) 1.49

Studies on the mechanism of antifungal action of aculeacin A. J Antibiot (Tokyo) (1982) 1.41

Sphingofungins E and F: novel serinepalmitoyl transferase inhibitors from Paecilomyces variotii. J Antibiot (Tokyo) (1992) 1.36

Pneumocandins from Zalerion arboricola. I. Discovery and isolation. J Antibiot (Tokyo) (1992) 1.35

Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP). J Med Chem (1992) 1.31

L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity. J Antibiot (Tokyo) (1991) 1.23

The effect of aculeacin A and papulacandin B on morphology and cell wall ultrastructure in Candida albicans. Can J Microbiol (1984) 1.22

L-671,329, a new antifungal agent. II. Structure determination. J Antibiot (Tokyo) (1989) 1.14

Characterization of the Na+/H+ antiporter of alkalophilic bacilli in vivo: delta psi-dependent 22Na+ efflux from whole cells. J Bacteriol (1983) 1.13

Effect of papulacandin B on glucan synthesis in Paracoccidioides brasiliensis. J Med Vet Mycol (1986) 1.12

Activity of cilofungin (LY 121019), a new lipopeptide antibiotic, on the cell wall and cytoplasmic membrane of Candida albicans. Structural modifications in scanning and transmission electron microscopy. J Med Vet Mycol (1990) 1.12

Effect of aculeacin A, a wall-active antibiotic, on synthesis of the yeast cell wall. Microbiol Immunol (1985) 1.11

Synthesis and evaluation of LY121019, a member of a series of semisynthetic analogues of the antifungal lipopeptide echinocandin B. Ann N Y Acad Sci (1988) 1.10

Chitin synthase from Saccharomyces cerevisiae. Methods Enzymol (1987) 0.95

A kinetic study on the regeneration of Candida albicans protoplasts in the presence of cell wall synthesis inhibitors. FEMS Microbiol Lett (1993) 0.88

Effects of spermine and spermidine on cell division and wall morphogenesis in Saccharomyces cerevisiae. Microbios (1993) 0.83

Articles by these authors

Apparatus for Collecting and Measuring the Gases evolved during Fermentation. Biochem J (1911) 157.76

The genome of black cottonwood, Populus trichocarpa (Torr. & Gray). Science (2006) 21.03

Sequence and characteristics of IS900, an insertion element identified in a human Crohn's disease isolate of Mycobacterium paratuberculosis. Nucleic Acids Res (1989) 6.92

Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase. Antimicrob Agents Chemother (1994) 6.45

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med (1999) 6.09

Prescribing trends in psychotropic medications: primary care, psychiatry, and other medical specialties. JAMA (1998) 5.09

Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob Agents Chemother (1997) 4.87

An integrative genomics approach to the reconstruction of gene networks in segregating populations. Cytogenet Genome Res (2004) 4.16

Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors. Antimicrob Agents Chemother (1997) 4.14

The effect of glucocorticosteroids on the kinetics of mononuclear phagocytes. J Exp Med (1970) 4.09

The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem Sci (1993) 3.89

Phosphoenolpyruvate and 2-phosphoglycerate: endogenous energy source(s) for sugar accumulation by starved cells of Streptococcus lactis. J Bacteriol (1977) 3.73

A case of cholera in Texas, 1973. Am J Epidemiol (1974) 3.71

Efficacy of antibiotic prophylaxis for prevention of native-valve endocarditis. Lancet (1992) 3.58

Synthesis and antifungal activity of novel cationic pneumocandin B(o) derivatives. J Med Chem (1994) 3.52

Rhizobium meliloti genes required for nodule development are related to chromosomal virulence genes in Agrobacterium tumefaciens. Proc Natl Acad Sci U S A (1986) 3.38

ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J Biol Chem (1997) 3.38

The use of DNA probes identifying restriction-fragment-length polymorphisms to examine the Mycobacterium avium complex. Mol Microbiol (1987) 3.23

Molecular interactions between Anopheles stephensi midgut cells and Plasmodium berghei: the time bomb theory of ookinete invasion of mosquitoes. EMBO J (2000) 3.22

Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: retrospective study of the Camelford water incident. BMJ (1999) 3.16

Heterogeneity of malignant cells from a human colonic carcinoma. Cancer Res (1981) 3.12

Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies. Infect Immun (1996) 3.08

Primary structures and catalytic properties of isoenzymes encoded by the two 4-coumarate: CoA ligase genes in parsley. Eur J Biochem (1988) 3.05

Induction of human IgE synthesis in B cells by mast cells and basophils. Nature (1993) 2.97

DNA probes demonstrate a single highly conserved strain of Mycobacterium avium infecting AIDS patients. Lancet (1989) 2.91

Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy. J Infect Dis (2000) 2.90

Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1. Kidney Int (2007) 2.87

Innovation in general practice: is the gap between training and non-training practices getting wider? Br J Gen Pract (1995) 2.74

A central role for P48/45 in malaria parasite male gamete fertility. Cell (2001) 2.73

A locus for febrile seizures (FEB3) maps to chromosome 2q23-24. Ann Neurol (1999) 2.73

Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol (2009) 2.71

Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B. Mol Cell Biol (1995) 2.69

Epidemiology of bacterial endocarditis in The Netherlands. I. Patient characteristics. Arch Intern Med (1992) 2.67

Clinico-neuropathological correlation of Alzheimer's disease in a community-based case series. J Am Geriatr Soc (1999) 2.63

Characterization of in vitro proton pumping by microsomal vesicles isolated from corn coleoptiles. Plant Physiol (1982) 2.59

stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. Mol Biochem Parasitol (1998) 2.58

Acquired precursors of cutaneous malignant melanoma. The familial dysplastic nevus syndrome. N Engl J Med (1985) 2.54

Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization. Biochemistry (1986) 2.52

The British Ophthalmological Surveillance Unit: an evaluation of the first 3 years. Eye (Lond) (2003) 2.50

In vivo regulation of glycolysis and characterization of sugar: phosphotransferase systems in Streptococcus lactis. J Bacteriol (1978) 2.42

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther (2004) 2.42

Embryonic erythroid differentiation in the human leukemic cell line K562. Proc Natl Acad Sci U S A (1981) 2.42

Differentiating between audit and research: postal survey of health authorities' views. BMJ (1999) 2.41

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin. Antimicrob Agents Chemother (1992) 2.39

Regulation of methyl-beta-d-thiogalactopyranoside-6-phosphate accumulation in Streptococcus lactis by exclusion and expulsion mechanisms. J Bacteriol (1981) 2.36

General outbreaks of infectious intestinal disease in England and Wales: 1995 and 1996. Commun Dis Public Health (1998) 2.35

Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol (2000) 2.34

Characteristics and energy requirements of an alpha-aminoisobutyric acid transport system in Streptococcus lactis. J Bacteriol (1976) 2.32

Isolation of hem3 mutants from Candida albicans by sequential gene disruption. Mol Gen Genet (1989) 2.26

The in-training examination in internal medicine. Ann Intern Med (1994) 2.23

The phosphoenolpyruvate:sugar phosphotransferase system in gram-positive bacteria: properties, mechanism, and regulation. Crit Rev Microbiol (1988) 2.19

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin Genet (2007) 2.15

Epidemiology and clinical impact of parainfluenza virus infections in otherwise healthy infants and young children < 5 years old. J Infect Dis (1997) 2.12

Substandard and falsified anti-tuberculosis drugs: a preliminary field analysis. Int J Tuberc Lung Dis (2013) 2.11

Nuclear retention of IkappaBalpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation. J Biol Chem (1999) 2.05

Pneumocandins from Zalerion arboricola. IV. Biological evaluation of natural and semisynthetic pneumocandins for activity against Pneumocystis carinii and Candida species. J Antibiot (Tokyo) (1992) 2.02

A microbiological comparison between acute and complicated appendicitis. Clin Infect Dis (1992) 2.02

Functions of Na+ and K+ in the active transport of -aminoisobutyric acid in a marine pseudomonad. J Biol Chem (1971) 2.02

Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures. Epilepsia (2000) 2.02

The effect of glucocorticosteroids on the proliferation and kinetics of promonocytes and monocytes of the bone marrow. J Exp Med (1973) 2.01

Nutrition and metabolism of marine bacteria. XVII. Ion-dependent retention of alpha-aminoisobutyric acid and its relation to Na+ dependent transport in a marine pseudomonad. J Biol Chem (1969) 2.00

Differing virulence of H1N1 and H3N2 influenza strains. Am J Epidemiol (1980) 1.97

Alternative splicing generates a secreted form of N-CAM in muscle and brain. Cell (1988) 1.97

Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine. J Biol Chem (2000) 1.93

Prevention of neonatal respiratory distress syndrome by tracheal instillation of surfactant: a randomized clinical trial. Pediatrics (1985) 1.92

Lactose metabolism in Streptococcus lactis: phosphorylation of galactose and glucose moieties in vivo. J Bacteriol (1979) 1.91

Deletion of purE attenuates Brucella melitensis infection in mice. Infect Immun (1996) 1.88

Genes necessary for expression of a virulence determinant and for transmission of Plasmodium falciparum are located on a 0.3-megabase region of chromosome 9. Proc Natl Acad Sci U S A (1993) 1.88

Regulation of lactose-phosphoenolpyruvate-dependent phosphotransferase system and beta-D-phosphogalactoside galactohydrolase activities in Lactobacillus casei. J Bacteriol (1983) 1.88

Use of 31P nuclear magnetic resonance spectroscopy and 14C fluorography in studies of glycolysis and regulation of pyruvate kinase in Streptococcus lactis. J Bacteriol (1984) 1.87

An alternative interpretation of nanobacteria-induced biomineralization. Proc Natl Acad Sci U S A (2000) 1.87

Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children. J Infect Dis (1997) 1.86

Catabolite inhibition and sequential metabolism of sugars by Streptococcus lactis. J Bacteriol (1978) 1.84

A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. J Exp Med (2000) 1.83

Argon laser iridotomy in the treatment of patients with primary angle-closure or pupillary block glaucoma: a clinicopathologic study. Ophthalmology (1978) 1.82

Relationship between topotecan systemic exposure and tumor response in human neuroblastoma xenografts. J Natl Cancer Inst (1998) 1.82

Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo. J Biol Chem (1996) 1.82

Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications. J Clin Endocrinol Metab (1999) 1.81

Novel phosphoenolpyruvate-dependent futile cycle in Streptococcus lactis: 2-deoxy-D-glucose uncouples energy production from growth. J Bacteriol (1982) 1.78

Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis. Mol Gen Genet (1985) 1.77

Adenovirus infections in young children. Pediatrics (1985) 1.76

Structural studies of the vacuolar membrane ATPase from Neurospora crassa and comparison with the tonoplast membrane ATPase from Zea mays. Proc Natl Acad Sci U S A (1986) 1.73

Galactose transport systems in Streptococcus lactis. J Bacteriol (1980) 1.72

Patient participation. J R Coll Gen Pract (1980) 1.70

Endoscopic balloon dilatation versus endoscopic sphincterotomy for the removal of bile duct stones: a prospective randomised trial. Gut (2003) 1.70

Biochemical characterization of resistance determinants cloned from antibiotic-producing streptomycetes. J Bacteriol (1982) 1.70

A randomized controlled study of iron supplementation in patients treated with erythropoietin. Kidney Int (1996) 1.70

Severe retinopathy of prematurity and its association with different rates of survival in infants of less than 1251 g birth weight. Arch Dis Child Fetal Neonatal Ed (2000) 1.69

A live attenuated bovine parainfluenza virus type 3 vaccine is safe, infectious, immunogenic, and phenotypically stable in infants and children. J Infect Dis (1995) 1.68

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors. Antimicrob Agents Chemother (2000) 1.66

Plastic bronchitis occurring late after the Fontan procedure: treatment with aerosolized urokinase. Crit Care Med (2000) 1.66