Published in Am J Pathol on April 01, 1995
Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments. Proc Natl Acad Sci U S A (1997) 1.89
Parkinson's disease and parkinsonism: neuropathology. Cold Spring Harb Perspect Med (2012) 1.41
Neuropathology of non-Alzheimer degenerative disorders. Int J Clin Exp Pathol (2009) 1.27
Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. Am J Pathol (2002) 1.11
Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain. Proc Biol Sci (2016) 0.94
C9orf72 hexanucleotide repeat expansion and Guam amyotrophic lateral sclerosis-Parkinsonism-dementia complex. JAMA Neurol (2013) 0.86
beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease. Am J Pathol (1996) 0.84
Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Sci Rep (2016) 0.76
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
The distribution of tau in the mammalian central nervous system. J Cell Biol (1985) 7.47
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet (1994) 7.07
A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Science (1991) 5.60
A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc Natl Acad Sci U S A (1990) 4.26
The fine structure of some intraganglionic alterations. Neurofibrillary tangles, granulovacuolar bodies and "rod-like" structures as seen in Guam amyotrophic lateral sclerosis and parkinsonism-dementia complex. J Neuropathol Exp Neurol (1968) 4.14
The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region. EMBO J (1992) 3.04
Aberrant neurofilament phosphorylation in Alzheimer disease. Proc Natl Acad Sci U S A (1985) 2.96
Amyotrophic lateral sclerosis and Parkinsonism-dementia complex on Guam. Further pathologic studies. Arch Neurol (1966) 2.58
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron (1994) 2.13
Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol (1994) 1.84
Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments. J Neurol Sci (1986) 1.69
Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam. Proc Natl Acad Sci U S A (1984) 1.66
Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam. Science (1982) 1.63
Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex. J Comp Neurol (1990) 1.58
Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration. Am J Pathol (1994) 1.40
Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins. Acta Neuropathol (1990) 1.31
Abnormal Tau proteins in progressive supranuclear palsy. Similarities and differences with the neurofibrillary degeneration of the Alzheimer type. Acta Neuropathol (1991) 1.28
Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau. Proc Natl Acad Sci U S A (1992) 1.26
Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins). Lab Invest (1992) 1.16
Characterization of two pathological tau protein, variants in Alzheimer brain cortices. J Neurol Sci (1989) 1.12
Guam ALS/parkinsonism-dementia: a long-latency neurotoxic disorder caused by "slow toxin(s)" in food? Can J Neurol Sci (1987) 1.11
The disordered neuronal cytoskeleton in Alzheimer's disease. Curr Opin Neurobiol (1992) 1.05
Amyotrophic lateral sclerosis and Parkinson's disease complex on Guam linked to an environmental neurotoxin. Trends Neurosci (1988) 1.05
Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam. Neurological reevaluation. Arch Neurol (1966) 1.02
Amyotrophic lateral sclerosis. A comparison of Guam and classical cases. Arch Neurol (1967) 1.01
Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathologic changes. Neurosci Lett (1993) 0.99
Alzheimer's disease: a new evidence for common epitopes between microtubule associated protein Tau and paired helical filaments (PHF): demonstration at the electron microscope level by a double immunogold labelling. Virchows Arch A Pathol Anat Histopathol (1988) 0.98
Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Ann Neurol (1989) 0.94
Biochemical mapping of neurofibrillary degeneration in a case of progressive supranuclear palsy: evidence for general cortical involvement. Acta Neuropathol (1994) 0.90
Neurofibrillary tangle distribution in the cerebral cortex of parkinsonism-dementia cases from Guam: differences with Alzheimer's disease. Brain Res (1991) 0.89
The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis. Brain Res (1994) 0.87
Tau phosphorylation in human, primate, and rat brain: evidence that a pool of tau is highly phosphorylated in vivo and is rapidly dephosphorylated in vitro. J Neurochem (1994) 0.87
Pacific paradigms of environmentally-induced neurological disorders: clinical, epidemiological and molecular perspectives. Neurotoxicology (1991) 0.86
Mapping of neurofibrillary degeneration in Alzheimer's disease: evaluation of heterogeneity using the quantification of abnormal tau proteins. Acta Neuropathol (1992) 0.86
Apolipoprotein E allele in Chamorros with amyotrophic lateral sclerosis/parkinsonism-dementia complex. Lancet (1994) 0.84
Amyotrophic lateral sclerosis and parkinsonism-dementia from Guam: differences in neurofibrillary tangle distribution and density in the hippocampal formation and neocortex. Brain Res (1994) 0.84
Presence of abnormally phosphorylated Tau proteins in the entorhinal cortex of aged non-demented subjects. Neurosci Lett (1992) 0.83
Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders. Acta Neuropathol (1994) 0.82
Dementia in the oldest-old: quantitative analysis of 12 cases from a psychiatric hospital. Dementia (1995) 0.80
Patterns of Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia on Guam. Contemp Neurol Ser (1975) 0.77
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev (2000) 5.40
Life and death of neurons in the aging brain. Science (1997) 4.52
Pneumocystis carinii pneumonia in the United States. Epidemiologic, diagnostic, and clinical features. Ann Intern Med (1974) 4.10
Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med (1995) 3.64
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology (2003) 3.62
The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease. Neurology (1999) 3.49
A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Neuroscience (2005) 3.41
Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA (1999) 3.22
Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease. Arch Neurol (1998) 3.20
New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales. Neuroscience (2005) 3.06
Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex. Neuroscience (2004) 3.06
Design-based stereology in neuroscience. Neuroscience (2005) 2.90
A neuronal morphologic type unique to humans and great apes. Proc Natl Acad Sci U S A (1999) 2.81
Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (1995) 2.79
Human cingulate cortex: surface features, flat maps, and cytoarchitecture. J Comp Neurol (1995) 2.71
Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease. Nat Genet (1995) 2.66
Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science (1980) 2.45
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry (2013) 2.25
Regulation of vimentin by SIP1 in human epithelial breast tumor cells. Oncogene (2006) 2.09
The evolution of diagnosis in early Parkinson disease. Parkinson Study Group. Arch Neurol (2000) 2.08
Mice transgenic for the human myotonic dystrophy region with expanded CTG repeats display muscular and brain abnormalities. Hum Mol Genet (2001) 2.08
The pathology of Legionnaires' disease. Fourteen fatal cases from the 1977 outbreak in Vermont. Arch Pathol Lab Med (1978) 2.06
Rising mortality from motoneuron disease in the USA, 1962-84. Lancet (1989) 2.05
Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease. Arch Neurol (1999) 2.02
Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers. Neurology (2006) 1.89
Evidence of neuronal oxidative damage in Alzheimer's disease. Am J Pathol (1996) 1.87
Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach. J Chem Neuroanat (2000) 1.82
Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. Am J Psychiatry (2000) 1.81
Neurotrophic factors in Alzheimer's disease: role of axonal transport. Genes Brain Behav (2008) 1.80
MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression. FASEB J (2002) 1.77
Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital. Cereb Cortex (1994) 1.73
Association of plasma amyloid beta with risk of dementia: the prospective Three-City Study. Neurology (2009) 1.70
Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch Neurol (1995) 1.69
Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments. J Neurol Sci (1986) 1.69
Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery. Neuroscience (2009) 1.68
Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease. Neurology (2006) 1.68
Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam. Science (1982) 1.63
Neuropeptide abnormalities in patients with early Alzheimer disease. Arch Gen Psychiatry (1999) 1.62
Dysregulation of human brain microtubule-associated tau mRNA maturation in myotonic dystrophy type 1. Hum Mol Genet (2001) 1.62
Neuroanatomic correlates of visual agnosia in Alzheimer's disease: a clinicopathologic study. Neurology (1999) 1.61
Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study. Neurology (1996) 1.60
Prediction of pathology in primary progressive language and speech disorders. Neurology (2009) 1.57
Two decades of increasing mortality from Parkinson's disease among the US elderly. Arch Neurol (1990) 1.56
Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease. Brain Pathol (1999) 1.53
Investigation of a fatality from nonoccupational aluminum phosphide exposure: measurement of aluminum in tissue and body fluids as a marker of exposure. J Lab Clin Med (1993) 1.53
Neuropeptide deficits in schizophrenia vs. Alzheimer's disease cerebral cortex. Biol Psychiatry (1996) 1.52
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. Mol Psychiatry (2009) 1.51
Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): report of 2 cases and review of the literature. Ann Neurol (1978) 1.50
Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains. EMBO Rep (2000) 1.49
An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease. Experientia (1992) 1.49
A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease. Acta Neuropathol (1992) 1.49
Study of the 10-nm-filament fraction isolated during the standard microtubule preparation. Biochem J (1980) 1.49
Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients. J Neuropathol Exp Neurol (1988) 1.49
Anterior cingulate cortex pathology in schizophrenia and bipolar disorder. Acta Neuropathol (2001) 1.48
Magnocellular and parvocellular visual pathways are both affected in a macaque monkey model of glaucoma. Aust N Z J Ophthalmol (1997) 1.47
Airway epithelial cell migration dynamics. MMP-9 role in cell-extracellular matrix remodeling. J Cell Biol (1999) 1.46
Protein nitration in Parkinson's disease. J Neuropathol Exp Neurol (1998) 1.45
Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J Neurochem (1995) 1.41
Abnormal tau species are produced during Alzheimer's disease neurodegenerating process. FEBS Lett (1989) 1.41
Progressive dementia and gait disorder in a 78 year old woman. J Neurol Neurosurg Psychiatry (2000) 1.39
Alzheimer's disease: A beta or ApoE amyloidosis? Lancet (1995) 1.39
Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: a postmortem neuropathologic study of 100 cases. Arch Gen Psychiatry (1998) 1.39
A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer. Oncogene (2011) 1.38
Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases. Acta Neuropathol (1992) 1.38
Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms. J Neurochem (1999) 1.33
Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study. Ann Neurol (1992) 1.33
Visual cortical projections and chemoarchitecture of macaque monkey pulvinar. J Comp Neurol (2000) 1.32
Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia. Neurology (2007) 1.31
Abnormal Tau proteins in progressive supranuclear palsy. Similarities and differences with the neurofibrillary degeneration of the Alzheimer type. Acta Neuropathol (1991) 1.28
Spindle neurons of the human anterior cingulate cortex. J Comp Neurol (1995) 1.27
Does Alzheimer's disease begin in the brainstem? Neuropathol Appl Neurobiol (2009) 1.26
Epithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions. Mol Hum Reprod (2006) 1.26
Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders. Acta Neuropathol (1994) 1.26
Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat. Proc Natl Acad Sci U S A (1980) 1.25
1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides. J Biol Chem (2001) 1.24
Postmortem studies in schizophrenia. Schizophr Bull (1998) 1.23
Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease. Neuroscience (2003) 1.22
Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease. Arch Neurol (1995) 1.22
Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. Mol Psychiatry (2012) 1.20
Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease. Hum Mol Genet (1998) 1.20
Specific pathological Tau protein variants characterize Pick's disease. J Neuropathol Exp Neurol (1996) 1.18
Distribution of cortical neurofibrillary tangles in progressive supranuclear palsy: a quantitative analysis of six cases. Acta Neuropathol (1992) 1.18
Glial reaction in the hippocampal formation is highly correlated with aging in human brain. Neurosci Lett (1997) 1.17
Clinical validity of Braak neuropathological staging in the oldest-old. Acta Neuropathol (2000) 1.17
Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice. J Comp Neurol (2000) 1.17
Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease. Acta Neuropathol (1994) 1.16
The polypeptides of isolated brain 10nm filaments and their association with polymerized tubulin. Biochem J (1979) 1.16
Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Acta Neuropathol (1998) 1.14