Published in Development on March 01, 1995
A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A (1996) 11.37
GSK3 takes centre stage more than 20 years after its discovery. Biochem J (2001) 7.74
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev (1997) 3.80
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A (2000) 3.61
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol Cell Biol (1999) 3.17
Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J Cell Biol (1996) 3.01
Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. EMBO J (1996) 2.93
GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci (2009) 2.87
Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus. J Cell Biol (1996) 2.86
Signal transduction by the Wnt family of ligands. Biochem J (1998) 2.66
Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos. Proc Natl Acad Sci U S A (1995) 2.42
Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. J Cell Biol (1997) 2.42
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc Natl Acad Sci U S A (1997) 2.36
Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. Mol Cell Biol (1998) 2.29
Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev (1999) 2.24
Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A (2001) 2.22
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway. Mol Cell Biol (2002) 1.91
Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. PLoS One (2009) 1.87
An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. J Cell Biol (2002) 1.78
beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex. J Cell Biol (1996) 1.70
Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol (2000) 1.63
Regulation of protein stability by GSK3 mediated phosphorylation. Cell Cycle (2009) 1.63
Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action. Proc Natl Acad Sci U S A (1997) 1.56
Regulation of glycogen synthase kinase 3beta and downstream Wnt signaling by axin. Mol Cell Biol (1999) 1.50
Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3. Genes Dev (2004) 1.46
Endostatin is a potential inhibitor of Wnt signaling. J Cell Biol (2002) 1.34
Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells. Proc Natl Acad Sci U S A (1996) 1.28
Identification of targets of the Wnt pathway destruction complex in addition to beta-catenin. Proc Natl Acad Sci U S A (2009) 1.25
Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis. J Cell Biol (1997) 1.25
Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice. J Clin Invest (2011) 1.20
Genetic networks that regulate development in Dictyostelium cells. Microbiol Rev (1996) 1.20
Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant. Mol Cell Biol (1996) 1.13
Inhibition of Tcf3 binding by I-mfa domain proteins. Mol Cell Biol (2001) 1.10
Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo. BMC Dev Biol (2007) 1.02
Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro. PLoS One (2013) 0.98
Autonomous and nonautonomous regulation of axis formation by antagonistic signaling via 7-span cAMP receptors and GSK3 in Dictyostelium. Genes Dev (1997) 0.94
Regulation of ribosomal S6 protein kinase-p90(rsk), glycogen synthase kinase 3, and beta-catenin in early Xenopus development. Mol Cell Biol (1999) 0.94
Fezf2 promotes neuronal differentiation through localised activation of Wnt/β-catenin signalling during forebrain development. Development (2014) 0.92
A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity. J Biol Chem (2010) 0.87
Modulation of β-catenin signaling by the inhibitors of MAP kinase, tyrosine kinase, and PI3-kinase pathways. Int J Med Sci (2013) 0.85
The C. elegans rab family: identification, classification and toolkit construction. PLoS One (2012) 0.82
xBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development. Dev Biol (2005) 0.81
Xenopus Nkx6.1 and Nkx6.2 are required for mid-hindbrain boundary development. Dev Genes Evol (2013) 0.80
The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity. Dev Biol (2007) 0.79
Phosphorylation-dependent ubiquitination of paraxial protocadherin (PAPC) controls gastrulation cell movements. PLoS One (2015) 0.75
Reversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids. Proc Natl Acad Sci U S A (2017) 0.75
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev (1996) 7.78
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev (1997) 3.80
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J (1999) 3.18
Crystal structure of a beta-catenin/Tcf complex. Cell (2000) 2.93
Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. J Neurosci (2000) 2.70
E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related. J Virol (1985) 2.59
XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. Development (1999) 2.56
Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. J Cell Biol (1997) 2.42
A homeobox gene essential for zebrafish notochord development. Nature (1995) 2.25
The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle. Cell (1987) 2.22
GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell (1998) 2.03
From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus. Bioessays (1998) 1.91
Expression of the human fibroblast interferon gene in Escherichia coli. Proc Natl Acad Sci U S A (1980) 1.84
Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes. Development (1998) 1.77
Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol (2000) 1.63
Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene. Genes Dev (1993) 1.56
Activation of Siamois by the Wnt pathway. Dev Biol (1996) 1.47
Individual adenovirus type 5 early region 1A gene products elicit distinct alterations of cellular morphology and gene expression. J Virol (1985) 1.38
Tcf4 can specifically recognize beta-catenin using alternative conformations. Nat Struct Biol (2001) 1.35
Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development (2000) 1.35
The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish. Development (2001) 1.27
Calculation of protein tertiary structure. J Mol Biol (1976) 1.27
Activin-mediated mesoderm induction requires FGF. Development (1994) 1.20
GSK-3: new thoughts on an old enzyme. Dev Biol (2000) 1.09
Regulation of dorsal-ventral patterning: the ventralizing effects of the novel Xenopus homeobox gene Vox. Development (1996) 1.09
A role for notochord in axial vascular development revealed by analysis of phenotype and the expression of VEGR-2 in zebrafish flh and ntl mutant embryos. Mech Dev (1997) 1.08
Patterning the early zebrafish by the opposing actions of bozozok and vox/vent. Dev Biol (2000) 1.04
The role of the yolk syncytial layer in germ layer patterning in zebrafish. Development (2000) 1.02
Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo. Dev Biol (1995) 1.01
Identification of adenovirus 12-encoded E1A tumor antigens synthesized in infected and transformed mammalian cells and in Escherichia coli. J Virol (1984) 1.01
The retinoid X receptor ligand, 9-cis-retinoic acid, is a potential regulator of early Xenopus development. Proc Natl Acad Sci U S A (1994) 1.00
v-erbA and citral reduce the teratogenic effects of all-trans retinoic acid and retinol, respectively, in Xenopus embryogenesis. Development (1993) 0.99
Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning. Development (1995) 0.99
Protein-lipid interactions. Studies of the M13 coat protein in dimyristoylphosphatidylcholine vesicles using parinaric acid. Biochemistry (1979) 0.99
A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation. Dev Biol (2000) 0.97
Spatial regulation of floating head expression in the developing notochord. Dev Dyn (1997) 0.96
FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction. Development (1995) 0.92
Conservation of intracellular Wnt signaling components in dorsal-ventral axis formation in zebrafish. Dev Genes Evol (1999) 0.92
Regulation of dorsal gene expression in Xenopus by the ventralizing homeodomain gene Vox. Dev Biol (1999) 0.91
The pitx2 homeobox protein is required early for endoderm formation and nodal signaling. . Dev Biol (2001) 0.90
Temporal distribution, localization and metabolism of all-trans-retinol, didehydroretinol and all-trans-retinal during Xenopus development. Biochem J (1994) 0.89
Dorsal-ventral differences in Xcad-3 expression in response to FGF-mediated induction in Xenopus. Dev Biol (1994) 0.88
Fibroblast growth factor, but not activin, is a potent activator of mitogen-activated protein kinase in Xenopus explants. Proc Natl Acad Sci U S A (1994) 0.88
The Xenopus laevis homeobox gene Xgbx-2 is an early marker of anteroposterior patterning in the ectoderm. Mech Dev (1996) 0.86
Overlapping expression of zebrafish T-brain-1 and eomesodermin during forebrain development. Mech Dev (2001) 0.85
Synthesis in Escherichia coli of human adenovirus type 12 transforming proteins encoded by early region 1A 13S mRNA and 12S mRNA. Proc Natl Acad Sci U S A (1984) 0.84
BMP-4 regulates the dorsal-ventral differences in FGF/MAPKK-mediated mesoderm induction in Xenopus. Dev Biol (1995) 0.82
COUP-TFI is a potential regulator of retinoic acid-modulated development in Xenopus embryos. Mech Dev (1995) 0.81
Combinatorial signaling in development. Bioessays (1994) 0.79
A novel general approach to eucaryotic mutagenesis functionally identifies conserved regions within the adenovirus 13S E1A polypeptide. Mol Cell Biol (1986) 0.78
Overexpression of Xgsk-3 disrupts anterior ectodermal patterning in Xenopus. Dev Biol (1996) 0.78
Xenopus laevis: a model system for the study of embryonic retinoid metabolism. I. Embryonic metabolism of 9-cis- and all-trans-retinals and retinols to their corresponding acid forms. Drug Metab Dispos (1995) 0.78
Xenopus laevis: a model system for the study of embryonic retinoid metabolism. II. Embryonic metabolism of all-trans-3,4-didehydroretinol to all-trans-3,4-didehydroretinoic acid. Drug Metab Dispos (1995) 0.75
NIEHS/EPA Workshops. Pattern formation. Reprod Toxicol (1997) 0.75