Published in Cell on May 05, 1995
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43
Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol Cell Biol (2000) 3.84
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. Genes Dev (1999) 2.34
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev (2004) 2.16
Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A (2004) 1.81
Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Natl Acad Sci U S A (1998) 1.76
Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev (2007) 1.74
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog. Genes Dev (1997) 1.73
Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol (2000) 1.63
Holoprosencephaly: a paradigm for the complex genetics of brain development. J Inherit Metab Dis (1998) 1.56
Shaping sound in space: the regulation of inner ear patterning. Development (2012) 1.48
Positive and negative regulation of muscle cell identity by members of the hedgehog and TGF-beta gene families. J Cell Biol (1997) 1.48
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification. Genes Dev (2002) 1.46
Different proximal and distal rearrangements of chromosome 7q associated with holoprosencephaly. J Med Genet (1997) 1.44
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One (2009) 1.42
The mouse bagpipe gene controls development of axial skeleton, skull, and spleen. Proc Natl Acad Sci U S A (1999) 1.42
Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol (2006) 1.36
Phosphorylation of the fused protein kinase in response to signaling from hedgehog. Proc Natl Acad Sci U S A (1996) 1.23
Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc Natl Acad Sci U S A (2001) 1.22
Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Rep (2013) 1.18
Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev (1997) 1.18
Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. J Neurosci (1998) 1.17
GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS One (2009) 1.10
Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha. J Cell Biol (1996) 1.07
A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies. J Anat (2005) 1.04
Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair. Am J Pathol (2010) 0.96
The Role of Glycogen Synthase Kinase 3 Beta in Neuroinflammation and Pain. J Pharm Pharmacol (Los Angel) (2013) 0.88
Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling. Sensors (Basel) (2011) 0.87
The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development. PLoS One (2009) 0.86
A gradient of Shh establishes mutually repressing somitic cell fates induced by Nkx3.2 and Pax3. Dev Biol (2008) 0.86
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway. J Biol (2002) 0.84
Ethanol teratogenesis in Japanese medaka: effects at the cellular level. Comp Biochem Physiol B Biochem Mol Biol (2007) 0.83
Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome. Development (2009) 0.83
An experimental system for analyzing response to a morphogen gradient. Proc Natl Acad Sci U S A (1996) 0.80
Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development. J Biol Chem (2009) 0.78
Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Proc Natl Acad Sci U S A (2015) 0.78
Molecular basis for skeletal variation: insights from developmental genetic studies in mice. Birth Defects Res B Dev Reprod Toxicol (2007) 0.78
Noggin is novel inducer of mesenchymal stem cell adipogenesis: implications for bone health and obesity. J Biol Chem (2012) 0.78
A critical role of noggin in developing folate-nonresponsive NTD in Fkbp8 -/- embryos. Childs Nerv Syst (2014) 0.76
Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae. Development (2016) 0.76
Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer. Front Oncol (2017) 0.75
Molecular Validation of Chondrogenic Differentiation and Hypoxia Responsiveness of Platelet-Lysate Expanded Adipose Tissue-Derived Human Mesenchymal Stromal Cells. Cartilage (2016) 0.75
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature (2000) 10.04
The Hedgehog and Wnt signalling pathways in cancer. Nature (2001) 9.19
Molecular Genetics of the Bithorax Complex in Drosophila melanogaster. Science (1983) 7.94
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell (2000) 6.08
Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet (2001) 5.67
Cholesterol modification of hedgehog signaling proteins in animal development. Science (1996) 5.66
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell (1996) 5.45
Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell (1999) 5.42
Teratogen-mediated inhibition of target tissue response to Shh signaling. Science (1998) 5.28
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell (1999) 5.07
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell (1994) 5.05
Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell (1997) 4.77
Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell (1994) 4.74
Patched acts catalytically to suppress the activity of Smoothened. Nature (2002) 4.69
Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell (1996) 4.63
Segmental distribution of bithorax complex proteins during Drosophila development. Nature (1985) 4.55
A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell (1999) 4.25
Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell (1998) 4.00
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol (2001) 3.82
Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol (1999) 3.62
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature (1997) 3.57
Sonic hedgehog is essential to foregut development. Nat Genet (1998) 3.50
Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science (2001) 3.44
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science (1998) 3.42
Top-down processing mediated by interareal synchronization. Proc Natl Acad Sci U S A (2000) 3.30
Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature (1997) 3.17
Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature (2001) 3.07
Autoproteolysis in hedgehog protein biogenesis. Science (1994) 2.87
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell (1995) 2.85
Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. Cell (1999) 2.80
Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons. Neuron (1996) 2.69
cAMP-dependent growth cone guidance by netrin-1. Neuron (1997) 2.60
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science (2001) 2.58
Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron (1997) 2.55
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr Biol (1995) 2.54
Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell (1996) 2.39
Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell (1998) 2.39
Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1. Nature (1999) 2.37
Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat Neurosci (2000) 2.36
Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila. EMBO J (1991) 2.34
Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell (1999) 2.34
The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J (1994) 2.33
Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. EMBO J (1992) 2.32
Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila. Genes Dev (1989) 2.30
Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins. Cell (1997) 2.25
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature (1995) 2.24
Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell (1994) 2.23
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell (1992) 2.20
Electrical activity modulates growth cone guidance by diffusible factors. Neuron (2001) 2.14
Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science (2001) 2.14
Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Cell (2000) 2.11
Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron (1995) 2.08
Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. Neuron (1997) 2.07
Regulation and products of the Ubx domain of the bithorax complex. Cold Spring Harb Symp Quant Biol (1985) 2.06
Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions. Science (2001) 2.05
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc Natl Acad Sci U S A (1999) 2.04
Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC. Neuron (1997) 2.00
The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell (1995) 1.99
Calcium signalling in the guidance of nerve growth by netrin-1. Nature (2000) 1.96
The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell (1993) 1.96
Letter: Acute respiratory distress following formalin inhalation. Lancet (1975) 1.95
A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature (1995) 1.95
Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axons. Neuron (1999) 1.90
Genetics of ventral forebrain development and holoprosencephaly. Curr Opin Genet Dev (2000) 1.90
Slit proteins: key regulators of axon guidance, axonal branching, and cell migration. Curr Opin Neurobiol (2000) 1.85
Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Neuron (2001) 1.77
A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell (1999) 1.77
En passant neurotrophic action of an intermediate axonal target in the developing mammalian CNS. Nature (1999) 1.77
Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Neuron (2000) 1.76
Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. Prog Brain Res (1991) 1.74
Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron (1996) 1.73
Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord. Neuron (1995) 1.72
Anorectal malformations caused by defects in sonic hedgehog signaling. Am J Pathol (2001) 1.72
Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. Neuron (1999) 1.69
Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron (1999) 1.65
Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Development (1994) 1.64
Function of an axonal chemoattractant modulated by metalloprotease activity. Science (2000) 1.63
Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. Neuron (1998) 1.60
C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor. Neuron (2001) 1.59
Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science (1997) 1.54
Urodynamics and the etiology of post-prostatectomy urinary incontinence: the initial Columbia experience. J Urol (1995) 1.53
Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. J Neurosci (2001) 1.51
Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles. Neuroscience (2002) 1.51
Splenic rupture from colonoscopy. A report of two cases and review of the literature. Surg Endosc (1997) 1.48
Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection. J Neurosci (2000) 1.48