Published in Cell on January 23, 1998
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67
The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature (2001) 3.45
MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet (2010) 3.12
Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Science (2004) 3.01
Mechanisms and molecules of neuronal wiring: a primer. Cold Spring Harb Perspect Biol (2011) 2.62
The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia. PLoS Genet (2005) 2.02
Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion. Genes Dev (2000) 1.86
Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet (2007) 1.85
Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev (2001) 1.83
A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance. Science (2009) 1.79
Quantitative trait loci affecting starvation resistance in Drosophila melanogaster. Genetics (2004) 1.76
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol (2009) 1.73
roundabout4 is essential for angiogenesis in vivo. Proc Natl Acad Sci U S A (2005) 1.69
Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Proc Natl Acad Sci U S A (2001) 1.65
A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci U S A (2003) 1.60
Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP. J Cell Biol (1999) 1.59
MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling. Circ Res (2010) 1.56
Structural insights into the Slit-Robo complex. Proc Natl Acad Sci U S A (2007) 1.54
Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Proc Natl Acad Sci U S A (2008) 1.51
In silico cloning of novel endothelial-specific genes. Genome Res (2000) 1.42
Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers. Br J Cancer (2004) 1.42
Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Genes Dev (2004) 1.41
Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells. J Leukoc Biol (2007) 1.39
ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist (2007) 1.38
Genetics of developmental dyslexia. Eur Child Adolesc Psychiatry (2009) 1.38
CDO, a robo-related cell surface protein that mediates myogenic differentiation. J Cell Biol (1998) 1.37
A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development (2011) 1.31
Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors. FASEB J (2008) 1.29
Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc Natl Acad Sci U S A (2005) 1.28
Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics (2006) 1.27
Midline signalling systems direct the formation of a neural map by dendritic targeting in the Drosophila motor system. PLoS Biol (2009) 1.25
Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2. J Cell Biol (2005) 1.25
Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Res (2011) 1.24
Navigating intermediate targets: the nervous system midline. Cold Spring Harb Perspect Biol (2010) 1.21
Brain asymmetry is encoded at the level of axon terminal morphology. Neural Dev (2008) 1.21
Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals. Development (2008) 1.20
Unidirectional startle responses and disrupted left-right co-ordination of motor behaviors in robo3 mutant zebrafish. Genes Brain Behav (2009) 1.18
Slit-Robo interactions during cortical development. J Anat (2007) 1.16
The genetics of reading disabilities: from phenotypes to candidate genes. Front Psychol (2013) 1.12
Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. Am J Pathol (2004) 1.07
R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons. J Neurosci (2003) 1.04
Molecules and mechanisms involved in the generation and migration of cortical interneurons. ASN Neuro (2010) 1.04
Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration. Proc Natl Acad Sci U S A (2009) 1.03
Slit/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila. Cell Rep (2014) 1.02
Transient cell-cell interactions in neural circuit formation. Nat Rev Neurosci (2009) 1.02
The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline. Development (2010) 1.02
Slit proteins, potential endogenous modulators of inflammation. J Neurovirol (2002) 1.02
Neuronal migration and molecular conservation with leukocyte chemotaxis. Genes Dev (2002) 1.02
Slit/Robo signaling modulates the proliferation of central nervous system progenitors. Neuron (2012) 1.01
Roundabout 2 regulates migration of sensory neurons by signaling in trans. Curr Biol (2004) 1.00
Flotillin-mediated endocytic events dictate cell type-specific responses to semaphorin 3A. J Neurosci (2010) 0.99
Roundabout receptors are critical for foregut separation from the body wall. Dev Cell (2013) 0.98
Slit2, a branching-arborization factor for sensory axons in the Mammalian CNS. J Neurosci (2002) 0.98
ROBO2 gene variants are associated with familial vesicoureteral reflux. J Am Soc Nephrol (2008) 0.98
The corticofugal neuron-associated genes ROBO1, SRGAP1, and CTIP2 exhibit an anterior to posterior gradient of expression in early fetal human neocortex development. Cereb Cortex (2010) 0.98
Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance. J Neurosci (2010) 0.97
Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm. Curr Opin Hematol (2011) 0.97
Developmental angiogenesis of the central nervous system. Lymphat Res Biol (2008) 0.96
Silencing of directional migration in roundabout4 knockdown endothelial cells. BMC Cell Biol (2008) 0.96
F-spondin is a contact-repellent molecule for embryonic motor neurons. Proc Natl Acad Sci U S A (2001) 0.96
Midline governs axon pathfinding by coordinating expression of two major guidance systems. Genes Dev (2009) 0.95
Turtle functions downstream of Cut in differentially regulating class specific dendrite morphogenesis in Drosophila. PLoS One (2011) 0.95
Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing. Neural Dev (2008) 0.95
SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease. J Cell Mol Med (2015) 0.94
Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nat Commun (2014) 0.94
Expression of Slit and Robo genes in the developing mouse heart. Dev Dyn (2010) 0.93
Redundant mechanisms for regulation of midline crossing in Drosophila. PLoS One (2008) 0.92
Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons. Elife (2015) 0.91
Genome-wide analysis of pain-, nerve- and neurotrophin -related gene expression in the degenerating human annulus. Mol Pain (2012) 0.91
Slit2 prevents neutrophil recruitment and renal ischemia-reperfusion injury. J Am Soc Nephrol (2013) 0.91
Reexpression of LGI1 in glioma cells results in dysregulation of genes implicated in the canonical axon guidance pathway. Genomics (2009) 0.91
14-3-3ε couples protein kinase A to semaphorin signaling and silences plexin RasGAP-mediated axonal repulsion. Neuron (2012) 0.90
Genome scan of a nonword repetition phenotype in families with dyslexia: evidence for multiple loci. Behav Genet (2008) 0.90
Reception of Slit requires only the chondroitin-sulphate-modified extracellular domain of Syndecan at the target cell surface. Proc Natl Acad Sci U S A (2009) 0.90
The Slit receptor Robo1 is predominantly expressed via the Dutt1 alternative promoter in pioneer neurons in the embryonic mouse brain and spinal cord. Gene Expr Patterns (2007) 0.89
High structural resolution hydroxyl radical protein footprinting reveals an extended Robo1-heparin binding interface. J Biol Chem (2015) 0.89
Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway. J Biol Chem (2006) 0.89
The role of SLIT-ROBO signaling in proliferative diabetic retinopathy and retinal pigment epithelial cells. Mol Vis (2011) 0.88
Genetic dissection of a regionally differentiated network for exploratory behavior in Drosophila larvae. Curr Biol (2015) 0.88
The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage. J Biol Chem (2010) 0.88
Molecular/genetic manipulation of extrinsic axon guidance factors for CNS repair and regeneration. Exp Neurol (2007) 0.88
RabGDI controls axonal midline crossing by regulating Robo1 surface expression. Neural Dev (2012) 0.88
Genetic dissection of Anopheles gambiae gut epithelial responses to Serratia marcescens. PLoS Pathog (2014) 0.88
Slit-Dependent Endocytic Trafficking of the Robo Receptor Is Required for Son of Sevenless Recruitment and Midline Axon Repulsion. PLoS Genet (2015) 0.88
The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control. Hum Mol Genet (2013) 0.87
Glial and neuronal functions of the Drosophila homolog of the human SWI/SNF gene ATR-X (DATR-X) and the jing zinc-finger gene specify the lateral positioning of longitudinal glia and axons. Genetics (2006) 0.87
A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. Dev Biol (2011) 0.87
Slit/Robo pathway: a promising therapeutic target for cancer. Drug Discov Today (2014) 0.87
Molecular characterization of Pegarn: a Drosophila homolog of UNC-51 kinase. Mol Biol Rep (2008) 0.87
The transcriptome of an amphioxus, Asymmetron lucayanum, from the Bahamas: a window into chordate evolution. Genome Biol Evol (2014) 0.86
New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye. BMC Neurosci (2011) 0.86
Heparan sulfate proteoglycan specificity during axon pathway formation in the Drosophila embryo. Dev Neurobiol (2011) 0.86
A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion. J Cell Biol (2001) 0.86
The role of Robo3 in the development of cortical interneurons. Cereb Cortex (2009) 0.86
Mis-expression of L1 on pre-crossing spinal commissural axons disrupts pathfinding at the ventral midline. Mol Cell Neurosci (2007) 0.86
The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors. Cell Rep (2014) 0.85
Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish. J Biol Chem (2011) 0.84
Slits and Robos in the developing chicken inner ear. Dev Dyn (2008) 0.84
Crossing the embryonic midline: molecular mechanisms regulating axon responsiveness at an intermediate target. Wiley Interdiscip Rev Dev Biol (2015) 0.83
Mesenchymal stem cells as cellular vectors for pediatric neurological disorders. Brain Res (2014) 0.83
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med (1996) 17.51
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci U S A (1993) 11.95
The molecular biology of axon guidance. Science (1996) 11.90
Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet (2001) 5.67
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell (1996) 5.45
Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell (1999) 5.42
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell (1999) 5.07
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell (1994) 5.05
Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell (1997) 4.77
Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell (1994) 4.74
Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell (1996) 4.63
Slit is the midline repellent for the robo receptor in Drosophila. Cell (1999) 4.29
A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell (1999) 4.25
Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance. Neuron (1994) 4.08
Expression of engrailed proteins in arthropods, annelids, and chordates. Cell (1989) 3.98
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature (1997) 3.57
The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell (1993) 3.48
Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science (2001) 3.44
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science (1998) 3.42
Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature (1997) 3.17
Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature (2001) 3.07
The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. Cell (1988) 3.06
Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron (1996) 3.05
The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell (1991) 3.00
Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release. Neuron (1997) 2.91
Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell (2000) 2.88
The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell (1990) 2.83
Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. Cell (1999) 2.80
Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature (2001) 2.70
Highwire regulates synaptic growth in Drosophila. Neuron (2000) 2.70
Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons. Neuron (1996) 2.69
Characterization and cloning of fasciclin III: a glycoprotein expressed on a subset of neurons and axon pathways in Drosophila. Cell (1987) 2.69
frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell (1996) 2.69
Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells. Proc Natl Acad Sci U S A (1995) 2.68
Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron (1993) 2.65
cAMP-dependent growth cone guidance by netrin-1. Neuron (1997) 2.60
Genes that control neuromuscular specificity in Drosophila. Cell (1993) 2.59
Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron (1997) 2.55
Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1. Cell (1989) 2.44
Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell (1998) 2.39
Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1. Nature (1999) 2.37
Sequence analysis and neuronal expression of fasciclin I in grasshopper and Drosophila. Cell (1988) 2.36
The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance. Cell (1991) 2.26
glial cells missing: a genetic switch that controls glial versus neuronal fate. Cell (1995) 2.25
slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev (1990) 2.25
Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule. Cell (1991) 2.25
Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell (1994) 2.23
Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis. Science (1988) 2.23
Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance. Neuron (2000) 2.21
Antibiotic prophylaxis and open groin hernia repair. World J Surg (1997) 2.20
Spontaneous deletion formation at the aprt locus of hamster cells: the presence of short sequence homologies and dyad symmetries at deletion termini. EMBO J (1986) 2.20
Electrical activity modulates growth cone guidance by diffusible factors. Neuron (2001) 2.14
Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science (2001) 2.14
Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Cell (2000) 2.11
From grasshopper to Drosophila: a common plan for neuronal development. Nature (1984) 2.09
Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron (1995) 2.08
Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. Neuron (1997) 2.07
Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell (1990) 2.06
Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system. Cell (1988) 2.05
Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling. Neuron (2001) 2.05
Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions. Science (2001) 2.05
Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity. Neuron (1996) 2.05
Early events in insect neurogenesis. II. The role of cell interactions and cell lineage in the determination of neuronal precursor cells. Dev Biol (1985) 2.04
Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix. Neuron (2001) 2.01
Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC. Neuron (1997) 2.00
Genetic analysis of Fasciclin II in Drosophila: defasciculation, refasciculation, and altered fasciculation. Neuron (1994) 1.99
The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell (1995) 1.99
Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration. Science (2001) 1.98
Calcium signalling in the guidance of nerve growth by netrin-1. Nature (2000) 1.96
Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila. Cell (1995) 1.96
A neural tetraspanin, encoded by late bloomer, that facilitates synapse formation. Science (1996) 1.95
Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position. Cell (2000) 1.93
Genetic analysis of myoblast fusion: blown fuse is required for progression beyond the prefusion complex. J Cell Biol (1997) 1.91
Identification of maxillary factor, a maxillary process-derived chemoattractant for developing trigeminal sensory axons. Neuron (1999) 1.90
Watching a synapse grow: noninvasive confocal imaging of synaptic growth in Drosophila. Neuron (1999) 1.88
Slit proteins: key regulators of axon guidance, axonal branching, and cell migration. Curr Opin Neurobiol (2000) 1.85
Growth cone guidance in insects: fasciclin II is a member of the immunoglobulin superfamily. Science (1988) 1.85