Published in Proc Natl Acad Sci U S A on June 01, 1976
Analysis of chromosomal integration and deletions of yeast plasmids. Nucleic Acids Res (1977) 16.66
Functional expression in yeast of the Escherichia coli plasmid gene coding for chloramphenicol acetyltransferase. Proc Natl Acad Sci U S A (1980) 3.74
The presence of a defective LEU2 gene on 2 mu DNA recombinant plasmids of Saccharomyces cerevisiae is responsible for curing and high copy number. J Bacteriol (1983) 2.55
Nucleosome organization of the yeast 2-micrometer DNA plasmid: a eukaryotic minichromosome. Proc Natl Acad Sci U S A (1979) 1.86
Occurrence of crossed strand-exchange forms in yeast DNA during meiosis. Proc Natl Acad Sci U S A (1979) 1.78
Sequence of 1019 nucleotides encompassing one of the inverted repeats from the yeast 2 micrometer plasmid. Nucleic Acids Res (1979) 1.74
Isolation of a maltase structural gene from Saccharomyces carlsbergensis. J Bacteriol (1982) 1.60
Deoxyribonucleic acid sequence organization of a yeast plasmid. J Bacteriol (1977) 1.54
Physicochemical characterization of mitochondrial DNA from soybean. Plant Physiol (1978) 1.47
In vivo ligation of linear DNA molecules to circular forms in the yeast Saccharomyces cerevisiae. J Bacteriol (1983) 1.43
2-micrometers DNA-like plasmids in the osmophilic haploid yeast Saccharomyces rouxii. J Bacteriol (1982) 1.29
A stable plasmid carrying the yeast Leu2 gene and containing only yeast deoxyribonucleic acid. J Bacteriol (1980) 1.15
Hybridizable sequences between cytoplasmic ribosomal RNAs and 3 micron circular DNAs of Saccharomyces cerevisiae and Torulopsis glabrata. Nucleic Acids Res (1980) 1.14
Sensitivity to the Yeast Plasmid 2mu DNA is conferred by the nuclear allele nibl. Mol Cell Biol (1982) 1.12
Saccharomyces cerevisiae plasmid, Scp or 2 mum: intracellular distribution, stability and nucleosomal-like packaging. Nucleic Acids Res (1980) 1.00
Inverted repeated sequences in yeast nuclear DNA. Nucleic Acids Res (1980) 0.97
Curing of the 2 mu DNA plasmid from Saccharomyces cerevisiae. J Bacteriol (1981) 0.95
Cloning arg3, the gene for ornithine carbamoyltransferase from Saccharomyces cerevisiae: expression in Escherichia coli requires secondary mutations; production of plasmid beta-lactamase in yeast. Proc Natl Acad Sci U S A (1981) 0.95
Purification of the FLP site-specific recombinase by affinity chromatography and re-examination of basic properties of the system. Nucleic Acids Res (1987) 0.93
Genetic analysis of Saccharomyces cerevisiae transformed by plasmid containing a supressor transfer ribonucleic acid gene. J Bacteriol (1980) 0.79
Sequence of 863 nucleotides encompassing the PstI site of the yeast 2 micron plasmid. Nucleic Acids Res (1980) 0.75
Sequencing long DNA fragments cloned in bacteriophage M13 by using internal primers. The sequence analysis of a yeast DNA fragment containing a replication origin. Biochem J (1981) 0.75
Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. Proc Natl Acad Sci U S A (1975) 77.46
Transduction of linked genetic characters of the host by bacteriophage P1. Virology (1955) 71.88
Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA. Proc Natl Acad Sci U S A (1972) 57.06
Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. J Bacteriol (1972) 46.61
Plasmid ColEl as a molecular vehicle for cloning and amplification of DNA. Proc Natl Acad Sci U S A (1974) 32.46
Stimulation by cyclic adenosine monophosphate of plasmid deoxyribonucleic acid replication and catabolite repression of the plasmid deoxyribonucleic acid-protein relaxation complex. J Bacteriol (1973) 30.43
An evaluation of film detection methods for weak beta-emitters, particularly tritium. Anal Biochem (1970) 27.80
Circular DNA forms of colicinogenic factors E1, E2 and E3 from Escherichia coli. J Mol Biol (1968) 23.73
Studies on the cleavage of bacteriophage lambda DNA with EcoRI Restriction endonuclease. J Mol Biol (1975) 19.67
A new method for the large scale purification of Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase. J Biol Chem (1969) 12.49
The gel electrophoresis of DNA. Biochim Biophys Acta (1972) 11.85
A freeze-squeeze method for recovering long DNA from agarose gels. Anal Biochem (1975) 11.28
Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition. J Mol Biol (1975) 11.14
Partial denaturation of thymine- and 5-bromouracil-containing lambda DNA in alkali. J Mol Biol (1970) 5.81
Mitochondrial DNA. V. A 25 micron closed circular duplex DNA molecule in wild-type yeast mitochondria. Stucture and genetic complexity. Biochim Biophys Acta (1970) 3.67
Localization and quantification of circular DNA in yeast. Eur J Biochem (1974) 3.29
GENE TRANSFER BY BROKEN MOLECULES OF LAMBDA-DNA: ACTIVITY OF THE LEFT HALF-MOLECULE. J Mol Biol (1963) 3.22
Mitochondrial-satellite and circular DNA filaments in yeast. Science (1967) 2.99
Replicating circular DNA molecules in yeast. Cell (1975) 2.35
Characterization of a new class of circular DNA molecules in yeast. Biochem Biophys Res Commun (1971) 2.33
Mitochondrial DNA's from respiratory-sufficient and cytoplasmic respiratory-deficient mutant yeast. J Mol Biol (1970) 2.19
Circular, repetitive DNA in yeast. Biochim Biophys Acta (1972) 1.88
Size distribution of circular DNA from petite-mutant yeast lacking rho DNA. Eur J Biochem (1973) 1.82
Replication of bacteriophage PM2 deoxyribonucleic acid: a closed circular double-stranded molecule. J Mol Biol (1971) 1.72
Mapping of cleavage sites for restriction endonucleases in lambdadv plasmids. Eur J Biochem (1975) 1.23
Construction and characterization of a chimeric plasmid composed of DNA Pfrom Escherichia coli and Drosophila melanogaster. Biochemistry (1975) 1.22
Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. FEBS Lett (1999) 3.86
Mitochondrial DNA. V. A 25 micron closed circular duplex DNA molecule in wild-type yeast mitochondria. Stucture and genetic complexity. Biochim Biophys Acta (1970) 3.67
Complete DNA sequence of yeast chromosome XI. Nature (1994) 3.51
An efficient transformation procedure enabling long-term storage of competent cells of various yeast genera. Yeast (1991) 3.41
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest (1997) 3.22
The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants. EMBO J (1994) 3.10
Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med (1997) 2.88
The presence of a defective LEU2 gene on 2 mu DNA recombinant plasmids of Saccharomyces cerevisiae is responsible for curing and high copy number. J Bacteriol (1983) 2.55
Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. Genes Dev (2000) 2.54
The molecular genetics of hexose transport in yeasts. FEMS Microbiol Rev (1997) 2.26
Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet (1999) 2.26
Saccharomyces cerevisiae ribosomes recognize non-AUG initiation codons. Mol Cell Biol (1984) 2.22
Molecular cloning and characterization of a gene coding for methanol oxidase in Hansenula polymorpha. Nucleic Acids Res (1985) 2.19
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. EMBO J (1996) 2.06
Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J Clin Invest (1996) 2.00
Complete DNA sequence of yeast chromosome II. EMBO J (1994) 1.97
Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones. Science (1985) 1.83
High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. Blood (1996) 1.82
Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression. Cell (1984) 1.80
Isolation and characterization of the Pichia stipitis xylitol dehydrogenase gene, XYL2, and construction of a xylose-utilizing Saccharomyces cerevisiae transformant. Curr Genet (1990) 1.75
Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1. EMBO J (1992) 1.74
Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p. Science (1996) 1.74
Cardiocyte storage and hypertrophy as a sole manifestation of Fabry's disease. Report on a case simulating hypertrophic non-obstructive cardiomyopathy. Virchows Arch A Pathol Anat Histopathol (1990) 1.62
Nucleotide sequence of the Bacillus subtilis xylose isomerase gene: extensive homology between the Bacillus and Escherichia coli enzyme. Nucleic Acids Res (1985) 1.57
Genes encoding the T-cell receptor alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny. Proc Natl Acad Sci U S A (1985) 1.47
Cloning of the structural gene (ompA) for an integral outer membrane protein of Escherichia coli K-12. Proc Natl Acad Sci U S A (1979) 1.46
Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae. Mol Cell Biol (1991) 1.45
Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate. J Bacteriol (1997) 1.45
Cloning and characterization of the DAS gene encoding the major methanol assimilatory enzyme from the methylotrophic yeast Hansenula polymorpha. Nucleic Acids Res (1985) 1.41
Purification and NH2-terminal amino acid sequencing of the beta subunit of a human T-cell antigen receptor. Proc Natl Acad Sci U S A (1984) 1.41
Biosynthesis and regulation of the peroxisomal methanol oxidase from the methylotrophic yeast Hansenula polymorpha. Mol Gen Genet (1984) 1.41
Niemann-Pick disease type A and B are clinically but also enzymatically heterogeneous: pitfall in the laboratory diagnosis of sphingomyelinase deficiency associated with the mutation Q292 K. Neuropediatrics (2003) 1.39
Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. J Cell Sci (1995) 1.36
Expression and processing of bacterial beta-lactamase in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1981) 1.35
Selective cloning of Bacillus subtilis xylose isomerase and xylulokinase in Escherichia coli genes by IS5-mediated expression. EMBO J (1984) 1.32
Analysis of the primary structure and promoter function of a pyruvate decarboxylase gene (PDC1) from Saccharomyces cerevisiae. Nucleic Acids Res (1986) 1.31
Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. Int J Cancer (1995) 1.31
STE50, a novel gene required for activation of conjugation at an early step in mating in Saccharomyces cerevisiae. Mol Gen Genet (1992) 1.29
Clonotypic surface structure on human T lymphocytes: functional and biochemical analysis of the antigen receptor complex. Immunol Rev (1984) 1.24
Functional isotypes are not encoded by the constant region genes of the beta subunit of the T cell receptor for antigen/major histocompatibility complex. J Exp Med (1984) 1.24
Positive regulation of the beta-galactosidase gene from Kluyveromyces lactis is mediated by an upstream activation site that shows homology to the GAL upstream activation site of Saccharomyces cerevisiae. Mol Cell Biol (1987) 1.23
Transcription of the bacterial beta-lactamase gene in Saccharomyces cerevisiae. Gene (1982) 1.20
Sphingolipid activator protein deficiency in a 16-week-old atypical Gaucher disease patient and his fetal sibling: biochemical signs of combined sphingolipidoses. Eur J Pediatr (1989) 1.20
Saccharomyces cerevisiae 2-mum DNA. An analysis of the monomer and its multimers by electron microscopy. Mol Gen Genet (1977) 1.18
Cloning and characterization of three genes (SUT1-3) encoding glucose transporters of the yeast Pichia stipitis. Mol Microbiol (1999) 1.17
The HTR1 gene is a dominant negative mutant allele of MTH1 and blocks Snf3- and Rgt2-dependent glucose signaling in yeast. J Bacteriol (2000) 1.17
Precursor of beta-lactamase is enzymatically inactive. Accumulation of the preprotein in Saccharomyces cerevisiae. J Biol Chem (1985) 1.15
Ste50p is involved in regulating filamentous growth in the yeast Saccharomyces cerevisiae and associates with Ste11p. Mol Gen Genet (1998) 1.14
Multiple nuclear proteins bind upstream sequences in the promotor region of a T-cell receptor beta-chain variable-region gene: evidence for tissue specificity. Proc Natl Acad Sci U S A (1987) 1.13
Analysis of a eukaryotic beta-galactosidase gene: the N-terminal end of the yeast Kluyveromyces lactis protein shows homology to the Escherichia coli lacZ gene product. Nucleic Acids Res (1984) 1.12
Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters. J Biol Chem (2001) 1.12
Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae. Mol Microbiol (1996) 1.11
Chromosomal location of human T-cell receptor gene Ti beta. Science (1984) 1.10
Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal-effect locus. Dev Biol (1986) 1.10
Application of yeasts in gene expression studies: a comparison of Saccharomyces cerevisiae, Hansenula polymorpha and Kluyveromyces lactis -- a review. Gene (1997) 1.08
High-level expression of foreign genes in Hansenula polymorpha. Biotechnol Adv (1992) 1.08
Identification of 5-methylcytosine in DNA fragments immobilized on nitrocellulose paper. Proc Natl Acad Sci U S A (1980) 1.08
Mutations in the SAM domain of STE50 differentially influence the MAPK-mediated pathways for mating, filamentous growth and osmotolerance in Saccharomyces cerevisiae. Mol Genet Genomics (2001) 1.07
Heterologous gene expression in Hansenula polymorpha: efficient secretion of glucoamylase. Biotechnology (N Y) (1991) 1.07
Catabolite inactivation of the high-affinity hexose transporters Hxt6 and Hxt7 of Saccharomyces cerevisiae occurs in the vacuole after internalization by endocytosis. FEBS Lett (1998) 1.05
Expression of the NKTa clonotype in a series of human natural killer clones with identical cytotoxic specificity. J Exp Med (1986) 1.04
Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils. Blood (1999) 1.04
ERA, a novel cis-acting element required for autoregulation and ethanol repression of PDC1 transcription in Saccharomyces cerevisiae. Mol Microbiol (1996) 1.03
Xylose isomerase from Actinoplanes missouriensis: primary structure of the gene and the protein. Nucleic Acids Res (1989) 1.03
Simultaneous expression of the S and L surface antigens of hepatitis B, and formation of mixed particles in the methylotrophic yeast, Hansenula polymorpha. Yeast (1991) 1.02
Transcription in yeast: a factor that stimulates yeast RNA polymerases. Proc Natl Acad Sci U S A (1972) 1.00
Transformation of Kluyveromyces fragilis. J Bacteriol (1984) 1.00
Cloning with 2-micrometer DNA vectors and the expression of foreign genes in Saccharomyces cerevisiae. Curr Top Microbiol Immunol (1982) 0.99
Inheritance of multiple drug resistance in Saccharomyces cerevisiae: linkage to leu1 and analyses of 2 micron DNA in partial revertants. Mol Gen Genet (1979) 0.99
The glucose-and ethanol-dependent regulation of PDC1 from Saccharomyces cerevisiae are controlled by two distinct promoter regions. Curr Genet (1988) 0.99
A positive regulatory element is involved in the induction of the beta-galactosidase gene from Kluyveromyces lactis. EMBO J (1985) 0.97
Sphingolipid activator protein 1 deficiency in metachromatic leucodystrophy with normal arylsulphatase A activity. A clinical, morphological, biochemical, and immunological study. Eur J Pediatr (1991) 0.96
The glutamate dehydrogenases of yeast: extra-mitochondrial enzymes. Biochim Biophys Acta (1970) 0.96
pdc1(0) mutants of Saccharomyces cerevisiae give evidence for an additional structural PDC gene: cloning of PDC5, a gene homologous to PDC1. J Bacteriol (1990) 0.96
Nuclear YB-1 expression as a negative prognostic marker in nonsmall cell lung cancer. Eur Respir J (2004) 0.95
The unusual properties of mtDNA from a "low-density" petite mutant of yeast. Biochim Biophys Acta (1972) 0.95
A structural analysis of Balbiani ring dna sequences in Chironomus tentans. Chromosoma (1981) 0.95
Cloning of the Schwanniomyces occidentalis glucoamylase gene (GAM1) and its expression in Saccharomyces cerevisiae. Gene (1990) 0.94
Cloning and sequencing of the ura3 locus of the methylotrophic yeast Hansenula polymorpha and its use for the generation of a deletion by gene replacement. Appl Microbiol Biotechnol (1993) 0.94
A putative P-type Cu(2+)-transporting ATPase gene on chromosome II of Saccharomyces cerevisiae. Yeast (1994) 0.93
Mapping of regions on cloned Saccharomyces cerevisiae 2-mum DNA coding for polypeptides synthesized in Escherichia coli minicells. Mol Gen Genet (1978) 0.93
Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis. Int J Cancer (1996) 0.93
Proportionate representation of rDNA and Balbiani ring DNA in polytene chromosomes of Chironomus tentans. Chromosoma (1976) 0.92
The human T-cell receptor. J Clin Immunol (1985) 0.92
Congenital sucrase-isomaltase deficiency. Identification of a glutamine to proline substitution that leads to a transport block of sucrase-isomaltase in a pre-Golgi compartment. J Clin Invest (1996) 0.92
Transcriptional control of yeast phosphofructokinase gene expression. FEBS Lett (1991) 0.92
LRG1 is expressed during sporulation in Saccharomyces cerevisiae and contains motifs similar to LIM and rho/racGAP domains. Nucleic Acids Res (1994) 0.91
Transaldolase mutants in the yeast Kluyveromyces lactis provide evidence that glucose can be metabolized through the pentose phosphate pathway. Mol Microbiol (1993) 0.91
Galactose induction in yeast involves association of Gal80p with Gal1p or Gal3p. Mol Gen Genet (1999) 0.91
Heterologous protein production in yeast. Antonie Van Leeuwenhoek (1992) 0.90
Isolation and characterization of the Pichia stipitis transketolase gene and expression in a xylose-utilising Saccharomyces cerevisiae transformant. Appl Microbiol Biotechnol (1994) 0.90
Identification of sequences responsible for transcriptional regulation of the strongly expressed methanol oxidase-encoding gene in Hansenula polymorpha. Gene (1994) 0.90