Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition.

PubWeight™: 11.14‹?› | Rank: Top 0.1%

🔗 View Article (PMID 1102715)

Published in J Mol Biol on October 05, 1975

Authors

N Kleckner, R K Chan, B K Tye, D Botstein

Articles citing this

(truncated to the top 100)

Nucleotide sequence of an insertion element, IS1. Proc Natl Acad Sci U S A (1978) 11.43

Hfr formation directed by tn10. Genetics (1979) 9.56

Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements. Proc Natl Acad Sci U S A (1979) 7.80

Linkage map of Salmonella typhimurium, edition V. Microbiol Rev (1978) 6.81

Properties of the translocatable tetracycline-resistance element Tn10 in Escherichia coli and bacteriophage lambda. Genetics (1978) 6.73

Extrachromosomal elements as possible agents of adaptation and development. Bacteriol Rev (1976) 5.62

Genetic transposition and insertional mutagenesis in Bacillus subtilis with Streptococcus faecalis transposon Tn917. Proc Natl Acad Sci U S A (1983) 5.57

Escherichia coli K-12 auxotrophs induced by insertion of the transposable element Tn5. Genetics (1979) 5.49

Deletions affecting the transposition of an antibiotic resistance gene. Proc Natl Acad Sci U S A (1977) 5.48

The product of a newly identified gene, gInF, is required for synthesis of glutamine synthetase in Salmonella. Proc Natl Acad Sci U S A (1977) 5.19

Transposition of a deoxyribonucleic acid sequence encoding trimethoprim and streptomycin resistances from R483 to other replicons. J Bacteriol (1976) 4.88

Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons. Proc Natl Acad Sci U S A (1981) 4.85

Conjugal transfer system of plasmid RP4: analysis by transposon 7 insertion. J Bacteriol (1978) 4.85

Molecular genetics of bacteriophage P22. Microbiol Rev (1978) 4.51

Regulation of fatty acid degradation in Escherichia coli: isolation and characterization of strains bearing insertion and temperature-sensitive mutations in gene fadR. J Bacteriol (1980) 4.26

Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance: independence from host rec functions and orientation of insertion. J Bacteriol (1976) 4.13

Selected translocation of plasmid genes: frequency and regional specificity of translocation of the Tn3 element. J Bacteriol (1977) 4.08

DNA sequence organization of IS10-right of Tn10 and comparison with IS10-left. Proc Natl Acad Sci U S A (1982) 4.05

Transposon Tn10 provides a promoter for transcription of adjacent sequences. Proc Natl Acad Sci U S A (1982) 4.05

Organization of structural and regulatory genes that mediate tetracycline resistance in transposon Tn10. J Bacteriol (1979) 3.88

Osmoregulation of gene expression in Salmonella typhimurium: proU encodes an osmotically induced betaine transport system. J Bacteriol (1985) 3.67

Nitrogen control of Salmonella typhimurium: co-regulation of synthesis of glutamine synthetase and amino acid transport systems. J Bacteriol (1979) 3.54

Endonuclease recognition sites mapped on Zea mays chloroplast DNA. Proc Natl Acad Sci U S A (1976) 3.54

Packaging specific segments of the Salmonella chromosome with locked-in Mud-P22 prophages. Genetics (1988) 3.33

Regulation of glutamine synthetase formation in Escherichia coli: characterization of mutants lacking the uridylyltransferase. J Bacteriol (1978) 3.07

Molecular nature of two beta-lactamase-specifying plasmids isolated from Haemophilus influenzae type b. J Bacteriol (1976) 3.03

Site-specific methylases induce the SOS DNA repair response in Escherichia coli. J Bacteriol (1987) 2.94

Characterization of a translocation unit encoding resistance to mercuric ions that occurs on a nonconjugative plasmid in Pseudomonas aeruginosa. J Bacteriol (1977) 2.80

Identification of the tetracycline resistance promoter and repressor in transposon Tn10. J Bacteriol (1981) 2.77

Determination of the functions of hemolytic plasmid pHly152 of Escherichia coli. J Bacteriol (1981) 2.77

Characterization of amber and ochre suppressors in Salmonella typhimurium. J Bacteriol (1979) 2.68

Distribution of Tn551 insertion sites responsible for auxotrophy on the Staphylococcus aureus chromosome. J Bacteriol (1981) 2.66

Role of gene duplications in the adaptation of Salmonella typhimurium to growth on limiting carbon sources. Genetics (1989) 2.58

Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences. Proc Natl Acad Sci U S A (1976) 2.57

Bacterial resistance to the tetracyclines. Microbiol Rev (1978) 2.52

Restriction enzyme cleavage map of Tn10, a transposon which encodes tetracycline resistance. J Bacteriol (1979) 2.51

Characterization of 2-mum DNA of Saccharomyces cerevisiae by restriction fragment analysis and integration in an Escherichia coli plasmid. Proc Natl Acad Sci U S A (1976) 2.47

Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence. J Bacteriol (1993) 2.46

Functional interchangeability of DNA replication genes in Salmonella typhimurium and Escherichia coli demonstrated by a general complementation procedure. Genetics (1984) 2.42

Relationships among some R plasmids found in Haemophilus influenzae. J Bacteriol (1977) 2.34

Generation of a Tn5 promoter probe and its use in the study of gene expression in Caulobacter crescentus. Proc Natl Acad Sci U S A (1984) 2.34

Expression of the thymidylate synthetase gene of the Bacillus subtilis bacteriophage Phi-3-T in Escherichia coli. Proc Natl Acad Sci U S A (1976) 2.32

Transposon insertion sequencing: a new tool for systems-level analysis of microorganisms. Nat Rev Microbiol (2013) 2.22

Polypeptides expressed in Escherichia coli K-12 minicells by transposition elements Tn1 and Tn3. J Bacteriol (1979) 2.17

fii, a bacterial locus required for filamentous phage infection and its relation to colicin-tolerant tolA and tolB. J Bacteriol (1986) 2.16

Chromosomal mutations of Escherichia coli that alter expression of conjugative plasmid functions. Proc Natl Acad Sci U S A (1980) 2.16

Nucleotide sequence of the repressor gene of the TN10 tetracycline resistance determinant. Nucleic Acids Res (1984) 2.10

A BlnI restriction map of the Salmonella typhimurium LT2 genome. J Bacteriol (1992) 2.08

Physiological characterization of polar Tn5-induced isoleucine-valine auxotrophs in Escherichia coli K.12: evidence for an internal promoter in the ilvOGEDA operon. Genetics (1979) 2.07

Escherichia coli mutants deficient in deoxyuridine triphosphatase. J Bacteriol (1978) 2.02

Identification and mapping of a second proline permease Salmonella typhimurium. J Bacteriol (1980) 1.91

Transposon Tn10 contains two structural genes with opposite polarity between tetA and IS10R. J Bacteriol (1984) 1.85

Relationship between colicin V activity and virulence in Escherichia coli. Infect Immun (1979) 1.85

Mutations that alter the covalent modification of glutamine synthetase in Salmonella typhimurium. J Bacteriol (1978) 1.84

Tn402: a new transposable element determining trimethoprim resistance that inserts in bacteriophage lambda. J Bacteriol (1977) 1.83

Overproduction of transposon Tn10-encoded tetracycline resistance protein results in cell death and loss of membrane potential. J Bacteriol (1989) 1.72

Molecular nature of two Haemophilus influenzae R factors containing resistances and the multiple integration of drug resistance transposons. J Bacteriol (1979) 1.66

A bacterial gene, fip, required for filamentous bacteriophage fl assembly. J Bacteriol (1983) 1.66

Genetic and physical map of plasmid NR1: comparison with other IncFII antibiotic resistance plasmids. Microbiol Rev (1988) 1.65

Fine-structure map of the histidine transport genes in Salmonella typhimurium. J Bacteriol (1977) 1.64

Involvement of DNA-dependent RNA polymerase in a recA-independent pathway of genetic recombination in Escheria coli. Proc Natl Acad Sci U S A (1977) 1.63

Electron microscope study of a plasmid chimera containing the replication region of the Escherichia coli F plasmid. J Bacteriol (1976) 1.63

Characterization of the cloned fip gene and its product. J Bacteriol (1984) 1.63

Genetic characterization and molecular cloning of the tripeptide permease (tpp) genes of Salmonella typhimurium. J Bacteriol (1984) 1.59

Genetic map of the opp (Oligopeptide permease) locus of Salmonella typhimurium. J Bacteriol (1983) 1.58

Isolation of inverted repeat sequences, including IS1, IS2, and IS3, in Escherichia coli plasmids. Proc Natl Acad Sci U S A (1976) 1.55

Major outer membrane protein in Salmonella typhimurium induced by maltose. J Bacteriol (1978) 1.54

Deoxyribonucleic acid sequence organization of a yeast plasmid. J Bacteriol (1977) 1.54

Mutations that improve the ant promoter of Salmonella phage P22. Genetics (1985) 1.52

Recombination genes on the Escherichia coli sex factor specific for transposable elements. Proc Natl Acad Sci U S A (1980) 1.51

The evolution of insertion sequences within enteric bacteria. Genetics (1992) 1.50

Mechanisms of activation of the cryptic cel operon of Escherichia coli K12. Genetics (1990) 1.46

Escherichia coli DNA topoisomerase I catalyzed linking of single-stranded rings of complementary base sequences. Nucleic Acids Res (1978) 1.46

Transposition of Tn904 encoding streptomycin resistance into the octopine Ti plasmid of Agrobacterium tumefaciens. J Bacteriol (1980) 1.45

Evolution of multiple-antibiotic-resistance plasmids mediated by transposable plasmid deoxyribonucleic acid sequences. J Bacteriol (1979) 1.44

A refined map of the hisG gene of Salmonella typhimurium. Genetics (1979) 1.43

Identification of a novel composite transposable element, Tn5280, carrying chlorobenzene dioxygenase genes of Pseudomonas sp. strain P51. J Bacteriol (1991) 1.42

DNA double-strand break repair: genetic determinants of flanking crossing-over. Proc Natl Acad Sci U S A (1994) 1.32

Adjacent insertion sequences IS2 and IS5 in bacteriophage Mu mutants and an IS5 in a lambda darg bacteriophage. J Bacteriol (1978) 1.32

Spontaneous mutators of salmonella typhimurium LT2 generated by insertion of transposable elements. J Bacteriol (1981) 1.27

Polarity effects in the hisG gene of salmonella require a site within the coding sequence. Genetics (1988) 1.26

Identification of repressor binding sites controlling expression of tetracycline resistance encoded by Tn10. J Bacteriol (1983) 1.26

Additive recombination in bacteria. Bacteriol Rev (1977) 1.26

Direct cloning of the trxB gene that encodes thioredoxin reductase. J Bacteriol (1985) 1.26

Presence of multiple sites containing polar material in spherical Escherichia coli cells that lack MreB. J Bacteriol (2005) 1.26

Bacteriophage conversion of heat-labile enterotoxin in Escherichia coli. J Bacteriol (1978) 1.25

Genetic mapping of IS200 copies in Salmonella typhimurim strain LT2. Genetics (1983) 1.24

Organization and regulation of the ilvGEDA operon in Salmonella typhimurium LT2. J Bacteriol (1981) 1.22

Internal promoters of the his operon in Salmonella typhimurium. J Bacteriol (1983) 1.22

Mapping of the pin locus coding for a site-specific recombinase that causes flagellar-phase variation in Escherichia coli K-12. J Bacteriol (1983) 1.19

Transcriptional activity of the transposable element Tn10 in the Salmonella typhimurium ilvGEDA operon. Proc Natl Acad Sci U S A (1982) 1.19

Tn10 tet operator mutations affecting Tet repressor recognition. Nucleic Acids Res (1986) 1.18

Salmonella typhimurium mutants with altered glutamate dehydrogenase and glutamate synthase activities. J Bacteriol (1980) 1.17

Transfer of a plasmid-specified beta-lactamase gene from Haemophilus influenzae. Antimicrob Agents Chemother (1977) 1.17

Bacteriophage chi sensitivity and motility of Escherichia coli K-12 and Salmonella typhimurium Fla- mutants possessing the hook structure. J Bacteriol (1984) 1.16

Efficient read-through of Tn9 and IS1 by RNA polymerase molecules that initiate at rRNA promoters. J Bacteriol (1983) 1.15

Selection for Tn10 tet repressor binding to tet operator in Escherichia coli: isolation of temperature-sensitive mutants and combinatorial mutagenesis in the DNA binding motif. Genetics (1991) 1.14

Motility development of Salmonella typhimurium cells with flaV mutations after addition of exogenous flagellin. J Bacteriol (1983) 1.10

Substrate channeling: alpha-ketobutyrate inhibition of acetohydroxy acid synthase in Salmonella typhimurium. J Bacteriol (1980) 1.07

Occurrence and properties of composite transposon Tn2672: evolution of multiple drug resistance transposons. J Bacteriol (1982) 1.05

Articles by these authors

Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52

Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A (1998) 192.97

Molecular portraits of human breast tumours. Nature (2000) 94.14

Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics (1989) 79.44

Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet (1980) 75.25

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature (2000) 64.32

Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol Biol Cell (1998) 62.20

The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res (2004) 54.37

The transcriptional program of sporulation in budding yeast. Science (1998) 37.23

Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell (2000) 36.09

Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertase. Cell (1982) 25.10

Improved single and multicopy lac-based cloning vectors for protein and operon fusions. Gene (1987) 24.38

Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet (2000) 24.22

Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature (2001) 21.55

Genetic and physical maps of Saccharomyces cerevisiae. Nature (1997) 21.48

Missing value estimation methods for DNA microarrays. Bioinformatics (2001) 20.84

Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. J Mol Biol (1977) 20.29

SGD: Saccharomyces Genome Database. Nucleic Acids Res (1998) 20.26

A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene (1987) 19.68

Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene (1979) 19.39

The transcriptional program in the response of human fibroblasts to serum. Science (1999) 19.19

Exploring the new world of the genome with DNA microarrays. Nat Genet (1999) 19.05

Integrating functional genomic information into the Saccharomyces genome database. Nucleic Acids Res (2000) 18.52

Singular value decomposition for genome-wide expression data processing and modeling. Proc Natl Acad Sci U S A (2000) 18.42

New Tn10 derivatives for transposon mutagenesis and for construction of lacZ operon fusions by transposition. Gene (1984) 17.36

Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A (2001) 17.36

A common language for physical mapping of the human genome. Science (1989) 17.36

Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet (1999) 14.96

A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics (1987) 14.69

Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci U S A (1999) 14.16

Using the Saccharomyces Genome Database (SGD) for analysis of protein similarities and structure. Nucleic Acids Res (1999) 13.65

Transposable elements in prokaryotes. Annu Rev Genet (1981) 13.41

A gene expression database for the molecular pharmacology of cancer. Nat Genet (2000) 13.31

Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat Genet (2001) 13.05

Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science (1987) 12.20

DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell (1992) 10.48

Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell (1997) 10.32

Structure and function of the yeast URA3 gene: expression in Escherichia coli. Gene (1984) 10.07

Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms. Proc Natl Acad Sci U S A (1986) 9.51

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae. Cell (1990) 9.24

Translocatable elements in procaryotes. Cell (1977) 9.12

Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell (1985) 8.53

Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map. Cold Spring Harb Symp Quant Biol (1986) 8.22

Uses of transposons with emphasis on Tn10. Methods Enzymol (1991) 8.13

Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Cell (1990) 7.85

The Stanford Microarray Database. Nucleic Acids Res (2001) 7.77

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery. Cell (1988) 7.39

Meiotic chromosomes: integrating structure and function. Annu Rev Genet (1999) 7.33

Plasmid construction by homologous recombination in yeast. Gene (1987) 7.26

Diverse effects of beta-tubulin mutations on microtubule formation and function. J Cell Biol (1988) 6.88

Lethal disruption of the yeast actin gene by integrative DNA transformation. Science (1982) 6.88

Evidence for transcriptional regulation of orotidine-5'-phosphate decarboxylase in yeast by hybridization of mRNA to the yeast structural gene cloned in Escherichia coli. Proc Natl Acad Sci U S A (1979) 6.81

Properties of the translocatable tetracycline-resistance element Tn10 in Escherichia coli and bacteriophage lambda. Genetics (1978) 6.73

Organization of DNA sequences and replication origins at yeast telomeres. Cell (1983) 6.43

Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol Biol Cell (2001) 6.39

Comparison of the complete protein sets of worm and yeast: orthology and divergence. Science (1998) 6.28

Isolation of the beta-tubulin gene from yeast and demonstration of its essential function in vivo. Cell (1983) 6.22

Specialized transduction of tetracycline resistance by phage P22 in Salmonella typhimurium. II. Properties of a high-frequency-transducing lysate. Virology (1972) 6.21

Mutants of yeast defective in sucrose utilization. Genetics (1981) 6.20

Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiae. Cell (1991) 6.15

DNA topoisomerase II is required at the time of mitosis in yeast. Cell (1985) 6.08

Genetic organization of transposon Tn10. Cell (1981) 6.04

The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination. Cell (2001) 5.94

Yeast actin-binding proteins: evidence for a role in morphogenesis. J Cell Biol (1988) 5.46

Systematic changes in gene expression patterns following adaptive evolution in yeast. Proc Natl Acad Sci U S A (1999) 5.45

Uracil incorporation: a source of pulse-labeled DNA fragments in the replication of the Escherichia coli chromosome. Proc Natl Acad Sci U S A (1978) 5.30

'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns. Genome Biol (2000) 5.29

A rapid, efficient method for isolating DNA from yeast. Gene (1986) 5.20

Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol (1994) 5.14

Secretion of beta-lactamase requires the carboxy end of the protein. Cell (1980) 5.03

Systematic mutational analysis of the yeast ACT1 gene. Genetics (1992) 5.02

Translational control of IS10 transposition. Cell (1983) 4.94

Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast. Proc Natl Acad Sci U S A (1977) 4.86

Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA. Proc Natl Acad Sci U S A (1977) 4.83

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med (2001) 4.83

Identification of double Holliday junctions as intermediates in meiotic recombination. Cell (1995) 4.82

Yeast genes fused to beta-galactosidase in Escherichia coli can be expressed normally in yeast. Proc Natl Acad Sci U S A (1981) 4.79

Excision repair of uracil incorporated in DNA as a result of a defect in dUTPase. J Mol Biol (1977) 4.68

The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med (2000) 4.67

Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics (1982) 4.66

Construction and use of gene fusions to lacZ (beta-galactosidase) that are expressed in yeast. Methods Enzymol (1983) 4.63

Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones. Mol Cell Biol (1982) 4.54

Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth. Nature (2000) 4.52

Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins. Proc Natl Acad Sci U S A (1975) 4.52

Molecular genetics of bacteriophage P22. Microbiol Rev (1978) 4.51

A group of interacting yeast DNA replication genes. Genes Dev (1991) 4.45

IS10 transposition is regulated by DNA adenine methylation. Cell (1985) 4.41

Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics (1984) 4.39

A symmetrical six-base-pair target site sequence determines Tn10 insertion specificity. Cell (1982) 4.36

Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins. Mol Cell Biol (1986) 4.33

Many random sequences functionally replace the secretion signal sequence of yeast invertase. Science (1987) 4.33

Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast. Proc Natl Acad Sci U S A (2000) 4.30

Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway. Cell (1997) 4.30

Chromosome pairing via multiple interstitial interactions before and during meiosis in yeast. Cell (1994) 4.23

Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol (2000) 4.17

Cohesins bind to preferential sites along yeast chromosome III, with differential regulation along arms versus the centric region. Cell (1999) 4.17