Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

PubWeight™: 1.37‹?› | Rank: Top 10%

🔗 View Article (PMC 2191868)

Published in J Exp Med on February 01, 1995

Authors

A Sette1, S Southwood, J Miller, E Appella

Author Affiliations

1: Department of Immunology, Cytel, San Diego, CA 92121.

Articles citing this

Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms. Science (2013) 3.27

Editing of the HLA-DR-peptide repertoire by HLA-DM. EMBO J (1996) 1.74

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP). J Exp Med (1996) 1.65

Endogenous antigen processing drives the primary CD4(+) T cell response to influenza. Nat Med (2015) 1.45

Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes. J Cell Biol (1997) 1.30

Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. J Exp Med (1997) 1.25

A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules. EMBO J (1998) 1.13

Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM. J Immunol (2008) 1.10

Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins. Viral Immunol (2010) 1.02

Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes. Proc Natl Acad Sci U S A (2001) 1.01

MultiRTA: a simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes. BMC Bioinformatics (2010) 0.98

Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1. Proc Natl Acad Sci U S A (1995) 0.98

A structural transition in class II major histocompatibility complex proteins at mildly acidic pH. J Exp Med (1996) 0.97

Motifs and supermotifs for MHC class II binding peptides. J Exp Med (1995) 0.96

On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes. Expert Rev Mol Med (2012) 0.95

DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms. Immunology (2010) 0.91

Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41. Proc Natl Acad Sci U S A (1995) 0.91

Direct observation of disordered regions in the major histocompatibility complex class II-associated invariant chain. Proc Natl Acad Sci U S A (1995) 0.90

An insulin peptide that binds an alternative site in class II major histocompatibility complex. J Exp Med (1996) 0.89

Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) region. EMBO J (1997) 0.89

Mtv-1 superantigen trafficks independently of major histocompatibility complex class II directly to the B-cell surface by the exocytic pathway. J Virol (1998) 0.87

In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM. Proc Natl Acad Sci U S A (1997) 0.85

I-Ag7 is subject to post-translational chaperoning by CLIP. Int Immunol (2010) 0.85

Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation. Proc Natl Acad Sci U S A (2002) 0.85

A general model of invariant chain association with class II major histocompatibility complex proteins. Proc Natl Acad Sci U S A (1995) 0.84

MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer (2000) 0.84

An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice. J Immunol (2008) 0.82

Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes. Proc Natl Acad Sci U S A (1996) 0.82

The Repertoires of Peptides Presented by MHC-II in the Thymus and in Peripheral Tissue: A Clue for Autoimmunity? Front Immunol (2013) 0.81

pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity. Sci Rep (2015) 0.76

Novel mutants define genes required for the expression of human histocompatibility leukocyte antigen DM: evidence for loci on human chromosome 6p. J Exp Med (1997) 0.75

CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol (2017) 0.75

Human leukocyte Antigen-DM polymorphisms in autoimmune diseases. Open Biol (2016) 0.75

A cell-based high-throughput screening assay system for inhibitor compounds of antigen presentation by HLA class II molecule. Sci Rep (2017) 0.75

Articles cited by this

THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J (1963) 61.56

Sequence analysis of peptides bound to MHC class II molecules. Nature (1991) 5.99

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J Exp Med (1993) 4.99

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size. Nature (1992) 3.85

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell (1990) 3.85

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules. Cell (1993) 3.80

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding. Nature (1990) 3.54

Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. Science (1992) 3.39

Intracellular transport of class II MHC molecules directed by invariant chain. Nature (1990) 3.35

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature (1992) 2.54

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules. Nature (1994) 2.41

Mice lacking the MHC class II-associated invariant chain. Cell (1993) 2.30

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression. J Exp Med (1993) 2.27

Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line. J Biol Chem (1987) 2.27

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways. Nature (1990) 2.11

Structural analysis of peptides capable of binding to more than one Ia antigen. J Immunol (1989) 1.85

HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. Nature (1994) 1.80

Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment. J Cell Biol (1994) 1.73

Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients. J Clin Invest (1993) 1.73

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A (1992) 1.70

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail. J Cell Sci (1993) 1.69

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy. J Exp Med (1994) 1.67

Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. Science (1992) 1.63

Comparison of peptides bound to spleen and thymus class II. J Exp Med (1993) 1.59

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J Exp Med (1994) 1.59

The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44. Cell (1993) 1.58

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. Nature (1990) 1.50

Effect of pH on MHC class II-peptide interactions. J Immunol (1992) 1.46

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41. Nature (1992) 1.41

Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment. Proc Natl Acad Sci U S A (1991) 1.40

Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. EMBO J (1994) 1.37

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines. J Cell Biol (1994) 1.34

Stable surface expression of invariant chain prevents peptide presentation by HLA-DR. EMBO J (1992) 1.33

Mapping functional regions in the lumenal domain of the class II-associated invariant chain. J Exp Med (1994) 1.32

Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain. Science (1994) 1.32

The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides. Proc Natl Acad Sci U S A (1993) 1.32

MHC class II antigen processing: biology of invariant chain. Curr Opin Immunol (1994) 1.26

Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain. EMBO J (1994) 1.12

High affinity for class II molecules as a necessary but not sufficient characteristic of encephalitogenic determinants. Int Immunol (1992) 1.10

Selective release of some invariant chain-derived peptides from HLA-DR1 molecules at endosomal pH. J Exp Med (1994) 1.06

A disease-related epitope of Torpedo acetylcholine receptor. Residues involved in I-Ab binding, self-nonself discrimination, and TCR antagonism. J Immunol (1994) 1.04

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides. J Exp Med (1994) 1.02

Invariant chain prevents the HLA-DR-restricted presentation of a cytosolic peptide. J Immunol (1994) 0.98

Enhanced antigen presentation in the absence of the invariant chain endosomal localization signal. J Exp Med (1993) 0.96

Invariant chain influences post-translational processing of HLA-DR molecules. J Immunol (1991) 0.94

Putting together an MHC class I molecule. Curr Opin Immunol (1993) 0.91

Articles by these authors

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J (1985) 20.39

A physical map of 30,000 human genes. Science (1998) 12.43

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90

The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med (2001) 11.48

A new system for grading recommendations in evidence based guidelines. BMJ (2001) 11.13

Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science (2001) 9.09

HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation. Science (1992) 8.68

DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78

Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J Exp Med (1988) 7.12

A comprehensive genetic map of the mouse genome. Nature (1996) 6.94

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc Natl Acad Sci U S A (1994) 6.93

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc Natl Acad Sci U S A (1979) 6.93

Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci U S A (1987) 6.90

The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes. Science (1989) 6.89

Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs. Proc Natl Acad Sci U S A (1981) 6.67

Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science (1992) 5.99

DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev (1997) 5.76

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes. J Exp Med (1994) 5.67

Multi-system neurological disease is common in patients with OPA1 mutations. Brain (2010) 5.37

A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science (1991) 5.14

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature (1988) 5.11

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90

Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. FEBS Lett (1989) 4.75

Rapid analysis of amino acid phenylthiohydantoins by high-performance liquid chromatography. Anal Biochem (1977) 4.64

Effects of a decision support system on the diagnostic accuracy of users: a preliminary report. J Am Med Inform Assoc (1997) 4.61

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. J Immunol (1994) 4.37

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression. J Immunol (1995) 4.31

Several common HLA-DR types share largely overlapping peptide binding repertoires. J Immunol (1998) 3.95

Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis. Lancet (1972) 3.90

Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants. J Exp Med (1989) 3.89

NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science (1993) 3.74

Health literacy and health-related knowledge among persons living with HIV/AIDS. Am J Prev Med (2000) 3.70

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol (1992) 3.68

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A (1990) 3.53

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J (1999) 3.46

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues. J Immunol (1996) 3.45

Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. Science (1992) 3.39

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J (2001) 3.37

Divided attention: evidence for coactivation with redundant signals. Cogn Psychol (1982) 3.28

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J (1990) 3.27

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature (2001) 3.25

Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41. J Cell Biol (1998) 3.23

H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBO J (1992) 3.21

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc Natl Acad Sci U S A (1990) 3.20

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci U S A (1997) 3.19

Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus. Mol Cell Biol (1992) 3.10

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. J Clin Invest (1997) 2.99

A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. J Exp Med (1996) 2.99

Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure. J Mol Biol (1996) 2.98

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR. Science (1994) 2.98

DNA sequence of the E. coli gyrB gene: application of a new sequencing strategy. Nucleic Acids Res (1987) 2.93

Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides. Immunity (1994) 2.90

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J Exp Med (1995) 2.80

Refined solution structure of the oligomerization domain of the tumour suppressor p53. Nat Struct Biol (1995) 2.75

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases. J Biol Chem (1987) 2.73

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis. Proc Natl Acad Sci U S A (1989) 2.73

Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST Study. Ann Oncol (2010) 2.64

Contribution of antigen-presenting cell major histocompatibility complex gene products to the specificity of antigen-induced T cell activation. J Exp Med (1982) 2.58

Evidence for high-energy extraterrestrial neutrinos at the IceCube detector. Science (2013) 2.56

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain. J Exp Med (1986) 2.55

A radiation hybrid map of the rat genome containing 5,255 markers. Nat Genet (1999) 2.54

Widespread West Nile virus activity, eastern United States, 2000. Emerg Infect Dis (2001) 2.52

On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs. J Immunol (1991) 2.49

A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group. Transplantation (1997) 2.46

Expression of H-2Dd and H-2Ld mouse major histocompatibility antigen genes in L cells after DNA-mediated gene transfer. J Immunol (1983) 2.45

Identification of a binding site for the human immunodeficiency virus type 1 nucleocapsid protein. Proc Natl Acad Sci U S A (1993) 2.41

Three-dimensional structure of interleukin 8 in solution. Biochemistry (1990) 2.40

Properties of monocyte chemotactic and activating factor (MCAF) purified from a human fibrosarcoma cell line. J Exp Med (1990) 2.40

Autocrine saturation of pro-urokinase receptors on human A431 cells. Cell (1986) 2.38

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J (2000) 2.38

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med (1994) 2.37

A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome. AIDS (2000) 2.36

Prolonged expiratory apnoea: a disorder resulting in episodes of severe arterial hypoxaemia in infants and young children. Lancet (1985) 2.36

Diffusion tensor imaging of normal and injured developing human brain - a technical review. NMR Biomed (2002) 2.36

Identification of Db- and Kb-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice. Virology (1998) 2.31

Strength of the cement-bone interface. Clin Orthop Relat Res (1982) 2.31

Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes. J Exp Med (1996) 2.31

Isolation and characterization of the human pulmonary surfactant apoprotein gene. Nature (1985) 2.27

Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol (1996) 2.24

Comparison of laparoscopic and open ventral herniorrhaphy. Am Surg (1999) 2.23

Control of expression of histocompatibility antigens (H-2) and beta 2-microglobulin in F9 teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 2.22

Prognostic importance of emotional support for elderly patients hospitalized with heart failure. Circulation (1998) 2.21

Osteopenia in HIV-infected men: association with asymptomatic lactic acidemia and lower weight pre-antiretroviral therapy. AIDS (2001) 2.17

Puerperal thromboembolism in relation to the inhibition of lactation by oestrogen therapy. Br Med J (1968) 2.17

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes. J Exp Med (1996) 2.17

Dead crow densities and human cases of West Nile virus, New York State, 2000. Emerg Infect Dis (2001) 2.17

Intraosseous infusion: an alternative route of pediatric intravascular access. Ann Emerg Med (1985) 2.14

Morphometric analysis of recombinant soluble CD4-mediated release of the envelope glycoprotein gp120 from HIV-1. AIDS Res Hum Retroviruses (1990) 2.13

Purification and amino acid analysis of two human monocyte chemoattractants produced by phytohemagglutinin-stimulated human blood mononuclear leukocytes. J Immunol (1989) 2.12

Amino acid sequences of two mouse immunoglobulin lambda chains. Proc Natl Acad Sci U S A (1971) 2.12

Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. Nature (1987) 2.11

Definition of specific peptide motifs for four major HLA-A alleles. J Immunol (1994) 2.11

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res (1991) 2.09

Infectious complications among 620 consecutive heart transplant patients at Stanford University Medical Center. Clin Infect Dis (2001) 2.09

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J Biol Chem (2000) 2.08

Prenatal diagnosis of genetic disease in Canada: report of a collaborative study. Can Med Assoc J (1976) 2.07

A mouse tumor-specific transplantation antigen is a heat shock-related protein. Proc Natl Acad Sci U S A (1986) 2.06

Seasonality of births in schizophrenia and bipolar disorder: a review of the literature. Schizophr Res (1997) 2.06

A model for melanosome biogenesis based on the purification and analysis of early melanosomes. Proc Natl Acad Sci U S A (2001) 2.06